JP2007502259A - マトリックスメタロプロテイナーゼの阻害剤 - Google Patents

マトリックスメタロプロテイナーゼの阻害剤 Download PDF

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Publication number
JP2007502259A
JP2007502259A JP2006522996A JP2006522996A JP2007502259A JP 2007502259 A JP2007502259 A JP 2007502259A JP 2006522996 A JP2006522996 A JP 2006522996A JP 2006522996 A JP2006522996 A JP 2006522996A JP 2007502259 A JP2007502259 A JP 2007502259A
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JP
Japan
Prior art keywords
formula
compound
alkyl
optionally substituted
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006522996A
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English (en)
Japanese (ja)
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JP2007502259A5 (enExample
Inventor
ホームズ，イアン，ピーター
ワトソン，スティーヴン，ポール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
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Glaxo Group Ltd
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Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JP2007502259A publication Critical patent/JP2007502259A/ja
Publication of JP2007502259A5 publication Critical patent/JP2007502259A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Indole Compounds (AREA)
JP2006522996A 2003-08-14 2004-08-12 マトリックスメタロプロテイナーゼの阻害剤 Pending JP2007502259A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0319069.1A GB0319069D0 (en) 2003-08-14 2003-08-14 Therapeutically useful compounds
PCT/EP2004/009087 WO2005016868A2 (en) 2003-08-14 2004-08-12 Matrix metalloproteinase inhibitors

Publications (2)

Publication Number Publication Date
JP2007502259A true JP2007502259A (ja) 2007-02-08
JP2007502259A5 JP2007502259A5 (enExample) 2007-08-30

Family

ID=28052480

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006522996A Pending JP2007502259A (ja) 2003-08-14 2004-08-12 マトリックスメタロプロテイナーゼの阻害剤

Country Status (5)

Country Link
US (1) US7476759B2 (enExample)
EP (1) EP1654218A2 (enExample)
JP (1) JP2007502259A (enExample)
GB (1) GB0319069D0 (enExample)
WO (1) WO2005016868A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0321538D0 (en) * 2003-09-13 2003-10-15 Glaxo Group Ltd Therapeutically useful compounds
US20140316336A1 (en) * 2011-01-11 2014-10-23 Abu Dhabi National Industrial Projects Co. Auto-disable safety syringe
CN107793415A (zh) * 2016-12-01 2018-03-13 湖南省食品药品检验研究院 酒石酸唑吡坦杂质的合成方法

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5053364A (enExample) * 1973-09-11 1975-05-12
JPS5312851A (en) * 1976-07-22 1978-02-04 Hexachimie Novel phenoxyhydroxypropylamine* its preparation and its application for medical treatment
JPS58180473A (ja) * 1982-04-16 1983-10-21 Shikoku Chem Corp イミダゾリル琥珀酸化合物および該化合物を用いるエポキシ樹脂硬化方法
JPS60105645A (ja) * 1983-11-12 1985-06-11 Yasumitsu Tamura アリ−ルコハク酸エステルの製造法
JPS6456763A (en) * 1987-07-01 1989-03-03 Ciba Geigy Ag Photosensitive epoxy resin and its use
DD271903A1 (de) * 1988-05-17 1989-09-20 Univ Halle Wittenberg Verfahren zur herstellung stabiler, 2-unsubstituierter imidazol-3-oxide
WO1998031697A1 (en) * 1997-01-15 1998-07-23 Sankyo Company, Limited Aryl c-glycoside compounds and sulfated esters thereof
JP2000271485A (ja) * 1999-03-24 2000-10-03 Kazuhiko Saigo オレフィン類のビスアルコキシカルボニル化触媒、及びコハク酸エステル誘導体の製造法
JP2002508345A (ja) * 1997-12-17 2002-03-19 カイロテック・テクノロジー・リミテッド 不斉水素化
JP2002541138A (ja) * 1999-04-02 2002-12-03 デュポン ファーマシューティカルズ カンパニー マトリックスメタロプロテアーゼ、ＴＮＦ−α、およびアグレカナーゼの阻害剤としての新規アミド誘導体
WO2003006670A2 (en) * 2001-07-09 2003-01-23 Axys Pharmaceuticals, Inc. 2-[5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinic acid derivatives as factor viia inhibitors
JP2003523931A (ja) * 1998-12-04 2003-08-12 スミスクライン・ビーチャム・コーポレイション ビトロネクチンレセプター拮抗物質
JP2007525516A (ja) * 2004-02-27 2007-09-06 アムジエン・インコーポレーテツド 代謝疾患の治療に使用するための、化合物、薬学的組成物及び方法

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SE367181B (enExample) 1969-05-14 1974-05-20 Takeda Chemical Industries Ltd
US3644479A (en) * 1970-02-09 1972-02-22 Bristol Myers Co 1-indancarboxylic acids and derivatives
US3663627A (en) * 1970-06-01 1972-05-16 Bristol Myers Co 1-indanmethanols
CH585687A5 (enExample) * 1972-08-24 1977-03-15 Ciba Geigy Ag
ZA98376B (en) * 1997-01-23 1998-07-23 Hoffmann La Roche Sulfamide-metalloprotease inhibitors
US5804581A (en) * 1997-05-15 1998-09-08 Bayer Corporation Inhibition of matrix metalloproteases by substituted phenalkyl compounds
US6130220A (en) * 1997-10-16 2000-10-10 Syntex (Usa) Inc. Sulfamide-metalloprotease inhibitors
US20010039287A1 (en) * 1997-11-14 2001-11-08 Thomas E Barta Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US20010014688A1 (en) * 1997-11-14 2001-08-16 Thomas E. Barta Aromatic sulfone hydroxamic acid metalloprotease inhibitor
PA8469501A1 (es) * 1998-04-10 2000-09-29 Pfizer Prod Inc Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
ES2220004T3 (es) * 1998-04-10 2004-12-01 Pfizer Products Inc. Derivados del acido ciclobutil-ariloxiarilsulfonilaminohidroxamico.
AU775701B2 (en) * 1999-02-08 2004-08-12 G.D. Searle & Co. Sulfamato hydroxamic acid metalloprotease inhibitor
CZ20013338A3 (cs) * 1999-03-18 2002-03-13 Celgene Corporation Substituované 1-oxo-a l,3-dioxoisoindoliny a jejich pouľití ve farmaceutických prostředcích pro sníľení koncentrací zánětlivých cytokinů
EP1181286B1 (en) * 1999-05-28 2003-11-12 Pfizer Products Inc. 3-(arylsulfonylamino)-tetrahydropyran-3-carboxylic acid hydroxamides
HN2000000052A (es) * 1999-05-28 2001-02-02 Pfizer Prod Inc Hidroxiamidas de acidos 3- (arilsulfonilamino)- tetrahidrofuran-3-carboxilicos.
US6387901B1 (en) * 1999-07-06 2002-05-14 Pfizer Inc Alkyne containing metalloproteinase inhibitors
GB9916562D0 (en) * 1999-07-14 1999-09-15 Pharmacia & Upjohn Spa 3-Arylsulfonyl-2-(substituted-methyl) propanoic acid derivatives as matrix metalloproteinase inhibitora
US20010049449A1 (en) * 1999-12-23 2001-12-06 Becker Daniel P. Aromatic sulfonyl alpha-cycloamino hydroxamates and their use as MMP inhibitors
US6458822B2 (en) * 2000-03-13 2002-10-01 Pfizer Inc. 2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases
JP2006506446A (ja) * 2002-11-19 2006-02-23 ガルデルマ・リサーチ・アンド・デヴェロップメント・エス・エヌ・セ ＰＰＡＲ−γ型レセプターを活性化する新規二芳香族化合物、および化粧品組成物または薬剤組成物におけるその使用

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5053364A (enExample) * 1973-09-11 1975-05-12
JPS5312851A (en) * 1976-07-22 1978-02-04 Hexachimie Novel phenoxyhydroxypropylamine* its preparation and its application for medical treatment
JPS58180473A (ja) * 1982-04-16 1983-10-21 Shikoku Chem Corp イミダゾリル琥珀酸化合物および該化合物を用いるエポキシ樹脂硬化方法
JPS60105645A (ja) * 1983-11-12 1985-06-11 Yasumitsu Tamura アリ−ルコハク酸エステルの製造法
JPS6456763A (en) * 1987-07-01 1989-03-03 Ciba Geigy Ag Photosensitive epoxy resin and its use
DD271903A1 (de) * 1988-05-17 1989-09-20 Univ Halle Wittenberg Verfahren zur herstellung stabiler, 2-unsubstituierter imidazol-3-oxide
WO1998031697A1 (en) * 1997-01-15 1998-07-23 Sankyo Company, Limited Aryl c-glycoside compounds and sulfated esters thereof
JP2002508345A (ja) * 1997-12-17 2002-03-19 カイロテック・テクノロジー・リミテッド 不斉水素化
JP2003523931A (ja) * 1998-12-04 2003-08-12 スミスクライン・ビーチャム・コーポレイション ビトロネクチンレセプター拮抗物質
JP2000271485A (ja) * 1999-03-24 2000-10-03 Kazuhiko Saigo オレフィン類のビスアルコキシカルボニル化触媒、及びコハク酸エステル誘導体の製造法
JP2002541138A (ja) * 1999-04-02 2002-12-03 デュポン ファーマシューティカルズ カンパニー マトリックスメタロプロテアーゼ、ＴＮＦ−α、およびアグレカナーゼの阻害剤としての新規アミド誘導体
WO2003006670A2 (en) * 2001-07-09 2003-01-23 Axys Pharmaceuticals, Inc. 2-[5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinic acid derivatives as factor viia inhibitors
JP2007525516A (ja) * 2004-02-27 2007-09-06 アムジエン・インコーポレーテツド 代謝疾患の治療に使用するための、化合物、薬学的組成物及び方法

Also Published As

Publication number Publication date
EP1654218A2 (en) 2006-05-10
US20060235074A1 (en) 2006-10-19
WO2005016868A2 (en) 2005-02-24
GB0319069D0 (en) 2003-09-17
WO2005016868A3 (en) 2005-05-19
US7476759B2 (en) 2009-01-13

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