JP2007501817A5 - - Google Patents

Info

Publication number

JP2007501817A5

JP2007501817A5 JP2006522915A JP2006522915A JP2007501817A5 JP 2007501817 A5 JP2007501817 A5 JP 2007501817A5 JP 2006522915 A JP2006522915 A JP 2006522915A JP 2006522915 A JP2006522915 A JP 2006522915A JP 2007501817 A5 JP2007501817 A5 JP 2007501817A5

Authority

JP

Japan

Prior art keywords

solution according

present

zinc

aqueous

aqueous pharmaceutical

Prior art date

2004-07-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• HUCJFAOMUPXHDK-UHFFFAOYSA-N Xylometazoline Chemical compound CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCCN1 HUCJFAOMUPXHDK-UHFFFAOYSA-N 0.000 claims 14
• WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims 14
• 239000003186 pharmaceutical solution Substances 0.000 claims 13
• 239000007864 aqueous solution Substances 0.000 claims 7
• 239000000337 buffer salt Substances 0.000 claims 7
• 229960001528 oxymetazoline Drugs 0.000 claims 7
• 229960000833 xylometazoline Drugs 0.000 claims 7
• 239000000243 solution Substances 0.000 claims 5
• 239000002253 acid Substances 0.000 claims 4
• 150000003751 zinc Chemical class 0.000 claims 4
• WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims 3
• 239000011670 zinc gluconate Substances 0.000 claims 3
• 235000011478 zinc gluconate Nutrition 0.000 claims 3
• 229960000306 zinc gluconate Drugs 0.000 claims 3
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical group [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims 2
• QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
• CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims 1
• ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims 1
• 150000007513 acids Chemical class 0.000 claims 1
• 150000001450 anions Chemical class 0.000 claims 1
• 150000001768 cations Chemical class 0.000 claims 1
• 239000007979 citrate buffer Substances 0.000 claims 1
• 150000003840 hydrochlorides Chemical class 0.000 claims 1
• 210000002850 nasal mucosa Anatomy 0.000 claims 1
• 239000001509 sodium citrate Substances 0.000 claims 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
• WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims 1
• 239000011701 zinc Substances 0.000 claims 1
• 229910052725 zinc Inorganic materials 0.000 claims 1
• 239000004246 zinc acetate Substances 0.000 claims 1
• 229960000314 zinc acetate Drugs 0.000 claims 1
• 229940062776 zinc aspartate Drugs 0.000 claims 1
• 239000011592 zinc chloride Substances 0.000 claims 1
• 235000005074 zinc chloride Nutrition 0.000 claims 1
• 229960001939 zinc chloride Drugs 0.000 claims 1
• 239000011746 zinc citrate Substances 0.000 claims 1
• 235000006076 zinc citrate Nutrition 0.000 claims 1
• 229940068475 zinc citrate Drugs 0.000 claims 1
• 239000011576 zinc lactate Substances 0.000 claims 1
• 235000000193 zinc lactate Nutrition 0.000 claims 1
• 229940050168 zinc lactate Drugs 0.000 claims 1
• 229940046253 zinc orotate Drugs 0.000 claims 1
• NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims 1
• 229960001763 zinc sulfate Drugs 0.000 claims 1
• 229910000368 zinc sulfate Inorganic materials 0.000 claims 1
• POEVDIARYKIEGF-CEOVSRFSSA-L zinc;(2s)-2-aminobutanedioate;hydron Chemical compound [Zn+2].[O-]C(=O)[C@@H](N)CC(O)=O.[O-]C(=O)[C@@H](N)CC(O)=O POEVDIARYKIEGF-CEOVSRFSSA-L 0.000 claims 1
• YNMDOZLVAPMCBD-UHFFFAOYSA-L zinc;2,4-dioxo-1h-pyrimidine-6-carboxylate Chemical compound [Zn+2].[O-]C(=O)C1=CC(=O)NC(=O)N1.[O-]C(=O)C1=CC(=O)NC(=O)N1 YNMDOZLVAPMCBD-UHFFFAOYSA-L 0.000 claims 1