JP2007307376A - 薬剤注入器 - Google Patents

薬剤注入器 Download PDF

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JP2007307376A
JP2007307376A JP2007131544A JP2007131544A JP2007307376A JP 2007307376 A JP2007307376 A JP 2007307376A JP 2007131544 A JP2007131544 A JP 2007131544A JP 2007131544 A JP2007131544 A JP 2007131544A JP 2007307376 A JP2007307376 A JP 2007307376A
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handpiece
tip
drug
drive mechanism
liquid
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Bruno Dacquay
ダックワイ ブルーノ
Michael A Zica
エー．ジーカ マイケル
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Alcon Inc
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Alcon Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546—Front-loading type injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0266—Shape memory materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8262—Internal energy supply devices connectable to external power source, e.g. connecting to automobile battery through the cigarette lighter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0612—Eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/48—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
    • A61M5/484—Regulating injection pressure

Abstract

【課題】モータ駆動式ハンドピースに接続された薬剤注入先端を有している注射器のような装置を提供する。
【解決手段】先端は、液体又は相転移薬剤を事前に充填されていてもよいし、空で輸送してユーザにより液体又は相転移薬剤が充填されてもよい。モータ駆動式ハンドピースが適切なセンサと、先端を正確に作動するためのコントローラとを含んでいて、液体又は相転移薬剤を制御して先端に注入するようになっている。ハンドピースはバッテリのような内部電源を含んでいてもよいし、又は外部電源及び／又はコントロールユニットに接続されていてもよい。
【選択図】図１

Description

本発明は眼の背後に薬剤活性物質を注入するもの、特に制御された背圧及び流量条件で適切な量の液体又は相転移薬剤を注入するための装置に関する。
年に伴なう黄斑変性症（ＡＲＭＤ）は老人の失明の主原因である。それは視野の中心を襲い、視野をぼんやりさせ読書、運転、細かい仕事を困難あるいは不可能なものにする。７５才以上の人口の約４０％、６０才以上の人口の約２０％が黄斑変性症を発病している。最も頻繁に失明をおこすタイプの“ウェット（ｗｅｔ）”ＡＲＭＤにおいて、新しく形成された脈絡膜の血管（ＣＮＶ）が流体をリークし、そして網膜に致命的損傷を引きおこす。現在の二つの主な治療方法は、（ａ）光凝固法と（ｂ）血管形成阻害薬の使用である。
光凝固法は網膜にとって有害であり、ＣＮＶが陥凹部近傍にある場合実際的なものではない。さらに光凝固法はたいていの場合時間がたてば、再発する。
血管形成阻害薬は、眼内注入又は眼球外サブ−テノン（ｓｕｂ−Ｔｅｎｎｏｎ注入又は局部注入により経口投与することができる。サブ−テノン注入法において、医者は湾曲した針の先端を眼の斑紋近くの周囲に配置し、そして正確な量の薬剤を注入する。しかしながら、サブ−テノン注入の問題は以下のとおりであって、薬剤を針周囲から漏れ出さないようにして細胞組織内に保持するために、比較的低圧でゆっくりと投与されねばならないことである。
従って、眼科分野において、人間の眼に薬剤を制御して注入するための改善された装置の必要性がある。
米国特許第６９４０２０９号明細書
本発明の目的は、薬剤を注入する先端を有している注射器のような装置を提供することである。
本発明の別の目的は、人間の眼に薬剤を注入するための装置であってモータ駆動式ハンドピースにより作動される薬剤注入先端を有している装置を提供することである。
本発明の別の目的は、注入する薬剤の流量を制御することのできる薬剤注入装置を提供することである。
本発明の別の目的は、注入する薬剤の量を制御することのできる薬剤注入装置を提供することである。
前述の目的はモータ駆動式ハンドピースに接続された薬剤注入先端を有している注射器のような装置を提供することにより達成されている。先端は、液体又は相転移薬剤を事前に充填されていてもよいし、空で輸送してユーザにより液体又は相転移薬剤が充填されてもよい。モータ駆動式ハンドピースが適切なセンサと、先端を正確に作動するためのコントローラとを含んでいて、液体又は相転移薬剤を制御して先端に注入するようになっている。ハンドピースはバッテリのような内部電源を含んでいてもよいし、又は外部電源及び／又はコントロールユニットに接続されていてもよい。
本発明の目的及び利点を以下に詳述する。
図１に図示するように、本発明における薬剤注入器１０は先端１２及びハンドピース１４を備えている。先端１２は注入カニューレ又は針１６と、本体１８とを含んでいる。針１６は従来構造の適切ないずれのサイズの針であってもよい。本体１８は、例えばガラス、金属又は適切なプラスチックで作られた円筒状で管状の標準的な皮下注射器と同様な構造である。本体１８は適切な量の液体又は相転移薬剤を保持するべくサイズ及び形状決めされている。ハンドピース１４は例えば円筒状の本体１８と同様のサイズと形状であって、先端１２が機械的にハンドピース１４に接続できるようになっている先端部２０を有している。ハンドピース１４が駆動エレクトロニクス２４に接続された駆動機構２２を含んでいて、本体１８におけるプランジャ２１を押し、本体２４に入っている液体又は相転移薬剤を針１６の外へ押し出すようになっている。適切な駆動機構は、例えば従来技術のモータ（特許文献１に記載されている）で米国ニューヨーク州、ビクターのＮｅｗ Ｓｃａｌｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ社から入手可能な、圧電式リニアモータを含んでいる。図１における実施形態において、駆動機構２２用及び制御エレクトロニクス２４用の電力はバッテリのようなハンドピース１４内部に設置された電源２６から供給される。そのような構造は、プランジャ２１の非常に精密で制御された移動を可能にしている。さらに、エレクトロニクス２４はフィードバック機構を備えていてもよくて、そのフィードバック機構は針１６から放出される薬剤に作用する背圧を検知し、そしてモータ２２の速度と方向とを適切に調節するようになっている。
図２に図示するように、本発明における薬剤注入器１１０は先端１１２及びハンドピース１１４を備えている。先端１１２は放出カニューレ又は針１１６と、本体１１８とを含んでいる。針１１６は従来構造の適切ないずれのサイズの針であってもよい。本体１１８は、例えばガラス、金属又は適切なプラスチックで作られた円筒状で管状の標準的な皮下注射器と同様な構造である。本体１１８は適切な量の液体又は相転移薬剤を保持するべくサイズ及び形状決めされている。ハンドピース１１４は例えば円筒状の本体１１８と同様のサイズと形状であって、先端１１２が機械的にハンドピース１１４に接続できるようになっている先端部１２０を有している。ハンドピース１１４が駆動エレクトロニクス１２４に接続された駆動機構１２２を含んでいて、本体１１８におけるプランジャ１２１を押し本体１２４に入っている液体又は相転移薬剤を針１１６の外へ押し出すようになっている。図２における実施形態において、制御エレクトロニクス１２４はハンドピース１１４の外側に設置されていて、電力と制御信号とはケーブル１２３を介して駆動機構１２２に供給されるようになっている。駆動機構１２２用とエレクトロニクス１２４用との電力は外部電源１２６から電力ケーブル１２８を介して供給されている。そのような構造はより小型のハンドピース１１４を可能なものにしている。
本説明は説明用のものであって、当業者おいては、本発明はその範囲と精神を逸脱することなく変更できることが理解できるであろう。
図１は、本発明における薬剤注入器の第一実施形態の拡大概略図である。 図２は、本発明における薬剤注入器の第二実施形態の拡大概略図である。
符号の説明
１０ 薬剤注入器
１２ 先端
１４ ハンドピース
１６ 針
１８ 本体
２１ プランジャ

Claims (6)

  1. ａ）ハンドピースと；
    ｂ）本体を有している先端であって、前記本体が取り外し可能に前記ハンドピースに取り付けられている先端と；
    ｃ）前記ハンドピースに対向して前記本体に設置されている針と；
    ｄ）前記先端の本体に設置されたプランジャと；
    ｅ）前記ハンドピースの中に設置された駆動機構であって、前記先端が前記ハンドピースに接続されている場合、前記プランジャを移動するようになっている駆動機構と；
    を具備している、薬剤注入器。
  2. 前記薬剤注入器が、圧電式リニアモータを備えている、請求項１に記載の薬剤注入器。
  3. 前記ハンドピースが、さらに前記駆動機構用の内部電源を備えている、請求項１に記載の薬剤注入器。
  4. 前記ハンドピースが、さらに前記駆動機構用の内部制御エレクトロニクスを備えている、請求項１に記載の薬剤注入器。
  5. さらに前記駆動機構用の外部制御エレクトロニクスを備えている、請求項１に記載の薬剤注入器。
  6. 前記ハンドピースが、さらに前記駆動機構用の外部電源を備えている、請求項１に記載の薬剤注入器。
JP2007131544A 2006-05-17 2007-05-17 薬剤注入器 Pending JP2007307376A (ja)

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EP (1) EP1857130A1 (ja)
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KR (1) KR20070111394A (ja)
CN (1) CN101073682A (ja)
AR (1) AR061002A1 (ja)
AU (1) AU2007202216A1 (ja)
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CA (1) CA2588519A1 (ja)
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