JP2007246492A - Humectant, cell activator and antioxidant - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a humectant, a cell activator or an antioxidant that is obtained by finding an active ingredient having excellent moisture retaining action, cell activating action or antioxidant action and is widely applicable in the field of skin care preparation, food and beverage, etc. <P>SOLUTION: The humectant, the cell activator or the antioxidant comprises an extract of a plant of the family Fouquieriaceae having excellent moisture retaining action, cell activating action and antioxidant action. Various compositions exhibiting excellent moisture retaining action, cell activating action or antioxidant action are obtained by mixing an extract of plant of the family Fouquieriaceae with compositions of skin care preparation, food and beverage, etc. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a humectant, a cell activator, and an antioxidant. More specifically, the present invention relates to a moisturizer, a cell activator, and an antioxidant containing an extract of a fulquiaceae plant, and an external preparation for skin and a food containing an extract of a focus area family.

  Causes of skin symptoms such as aging, ultraviolet rays, stress, wrinkles, stains, skin elasticity decrease, dryness, decreased cellular function, melanin production and pigmentation due to ultraviolet rays, decrease or degeneration of dermal matrix components, ultraviolet rays, etc. Examples include oxidative damage. In order to prevent and ameliorate such skin symptoms, search for various active ingredients and formulation studies have been conventionally conducted. As the cell activator, the essence of Ponkan (see Patent Document 1) is known, and as the antioxidant, an extract of the plant belonging to the genus Sarogase (see Patent Document 2) is known.

  In addition, the prior art regarding a moisturizer, a cell activator, and an antioxidant containing an extract of a fulquiaceae plant as an active ingredient was not recognized.

JP 2001-131045 A Japanese Patent Laid-Open No. 10-182413

  Naturally-derived components are known to have various pharmacological and cosmetic effects, and so far many plants and fungi have been widely applied to fields such as external preparations for skin and foods and drinks. However, there are many naturally-derived components whose effects are not yet known, and the development of an effective component having an excellent moisturizing action, cell activation action or antioxidant action has been expected. The present invention has been made in order to find such an active ingredient, and provides a moisturizer, a cell activator, and an antioxidant that can be widely applied to fields such as external preparations for skin and foods and drinks. Objective.

  In order to find a moisturizer, a cell activator, and an antioxidant that can be widely applied to fields such as external preparations for skin and foods and drinks, the present inventors have examined various naturally-derived substances. As a result, the present inventors have found an excellent moisturizing action, cell activation action, and antioxidant action for the extract of the Fauqueriaceae plant, and have further studied to complete the present invention. That is, the present invention relates to a skin containing a moisturizer, a cell activator, an antioxidant, and an extract of one or more plants of the focuiaceae family, comprising the fouciaceae family plant as an active ingredient. It provides external preparations and foods.

  According to the present invention, it is possible to provide a moisturizer, a cell activator, and an antioxidant that have excellent effects. By blending these into a composition such as a skin external preparation or food, wrinkles, tarmi, It is possible to provide various compositions that exhibit an excellent effect in preventing and improving various skin symptoms such as skin firmness, spots, and kusumi.

It is a plant used as the raw material of the present invention Fou Quy area Plants (Fouquieriaceae) is Fou Quy area genus (Fouquieria) including 11 species of plants are known. The Fou Quy area plants of the genus, Fou Quy area Korumunarisu (Fouquieria columnaris), Fou Quy area Supurendensu (Fouquieria splendens), Fou Quy area micro Philadelphia (Fouquieria microphylla), Fou Quy area Schlesinger Way (Fouquieria shrevei) Etc. are known.

  The plant used as a raw material used in the present invention is not particularly limited as long as it is a foucoliaceae plant. However, for reasons such as availability and effectiveness, foucia area, microphylla and foucia area. -It is particularly preferable to use a shreway.

  In the present invention, the extract of the focus area family plant includes the active substance and the dried product of the focus area family plant, but it is preferable to use an extract extracted with various solvents. For extraction, you can use any part of the trunk, branch, leaf, flower, seed, bark, sap, root, stem, bud, etc. Use it. In the extraction, it may be used as it is, but considering the extraction efficiency, it is preferable to perform the extraction after performing processing such as shredding, drying, and pulverization. The extraction can be performed by immersing in an extraction solvent or by an extraction method using a supercritical fluid or a subcritical fluid. In order to increase the extraction efficiency, homogenization may be performed in stirring or an extraction solvent. The extraction temperature is suitably about 5 ° C. to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but it is appropriate to set it to about 1 hour to 14 days.

  Extraction solvents include water, lower alcohols such as methanol, ethanol, propanol and isopropanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin, ethers such as ethyl ether and propyl ether. , Solvents such as esters such as butyl acetate and ethyl acetate, and ketones such as acetone and ethyl methyl ketone can be used, and one or more of these can be selected and used. Further, physiological saline, phosphate buffer, phosphate buffered saline, or the like may be used. Furthermore, you may use 1 type, or 2 or more types of supercritical fluids and subcritical fluids, such as water, a carbon dioxide, ethylene, propylene, ethanol, methanol, ammonia.

  Extracts from the above-mentioned solvents of Fauqueriaceae plants can be used as they are, but the concentrated and dried solids can be used again by dissolving them in water or a polar solvent, which impairs their physiological functions. It may be used after performing purification treatment such as decolorization, deodorization, desalting, etc., or fractionation treatment by column chromatography or the like within a range. The said extract of Fauquiliaceae plant, its processed material, and the fractionation thing can also be freeze-dried after each processing and fractionation, and can also be melt | dissolved and used at the time of use.

  The extract of Fauquiliaceae plant has excellent moisturizing action, cell activation action, and antioxidant action, and can be used as a moisturizing agent, cell activator, and antioxidant. In addition, moisturizers, cell activators, and antioxidants that contain extracts from Fouquilliaceae plants as active ingredients can be used not only for the skin but also for hair and can be taken orally. It can also be applied to beverages or pharmaceuticals.

  A moisturizing agent containing an extract of a fauqueriaceae plant as an active ingredient exhibits an excellent moisturizing effect on the skin and hair, and in particular has a high moisturizing effect on the skin.

  A cell activator comprising an extract of a fauqueriaceae plant as an active ingredient exerts an excellent activation action on various cells, but particularly exhibits an excellent effect on dermal fibroblasts.

  Antioxidants containing an extract of a fulquiaceae plant as an active ingredient exhibit an excellent antioxidant effect, but in particular exhibit an excellent effect on free radical scavenging action.

  In addition, by blending the extract of Fauqueriaceae plant into the external preparation for skin, it exhibits an excellent effect in preventing and improving skin symptoms such as wrinkles, tarmi, skin firmness, spots, kumi, dryness, and fine wrinkles. A skin external preparation can be obtained, and can also be used as a moisturizing skin external preparation or a skin external preparation for anti-aging improvement. Furthermore, the extract of Fauqueriaceae plants can also be used for foods intended for beauty, health maintenance or nutritional supplementation. In addition, a drink is also contained in the foodstuff of this invention.

  The blending amount of the extract of Fauqueriaceae plant in the skin external preparation can be adjusted according to the type of skin external preparation and the purpose of use. 0.0001 to 50.0% by weight is preferable, and 0.001 to 25.0% by weight is more preferable.

  The dosage form of the external preparation for skin containing the extract of Fouquiria family plant is arbitrary, and for example, it can be provided as a solubilizing system such as lotion, an emulsifying system such as cream or emulsion, or a dispersing system such as calamine lotion. it can. Furthermore, it can also be provided in various dosage forms such as aerosols, ointments, powders and granules filled with a propellant.

  In addition to the extract of Fauquilia family plants, the preparation for external use for skin containing the extract of Fauquilia family plants usually contains drugs, quasi-drugs, skin cosmetics, and hair as needed. Oily ingredients, moisturizers, powders, pigments, emulsifiers, solubilizers, detergents, UV absorbers, thickeners, drugs, perfumes, resins, antibacterial and antifungal agents, blended in cosmetics and detergents, Alcohols etc. can be mix | blended suitably. Moreover, in the range which does not impair the effect of this invention, combined use with another moisturizer, a cell activator, or an antioxidant is also possible.

  In the following, a production example of an extract of Fouquilia family plant, a test for evaluating each action, a prescription example as a skin external preparation or food, and a use test will be described in more detail, but the technical scope of the present invention is This is not a limitation.

[Production Example 1]
10 kg of a 50 wt% aqueous ethanol solution was added to 1 kg of a dry pulverized product of Fauquiliaceae and immersed for 7 days at room temperature. The extract was collected by filtration, and after removing the solvent, an extract of Fauquiliaceae was obtained.

[Production Example 2]
Nine liters of water was added to 1 kg of a dry pulverized product of Fauqueriaceae and extracted by refluxing at 90 ° C. for 6 hours. The extract was collected by filtration, and after removing the solvent, an extract of Fauquiliaceae was obtained.

[Production Example 3]
Nine liters of methanol was added to 1 kg of a dry pulverized product of Fauqueriaceae and immersed for 7 days at room temperature. The extract was collected by filtration, and after removing the solvent, an extract of Fauquiliaceae was obtained.

[Production Example 4]
A foucillaceae plant was introduced into a supercritical extraction apparatus, and extraction was performed using a supercritical fluid of carbon dioxide at 40 ° C. under a pressure of 15 MPa. The extract was collected to obtain an extract of the Fauqueriaceae plant.

  First, it shows about the cell activation effect | action of the extract of a Fauquilia family plant. The sample was evaluated by extracting the faux quillia microfila leaves according to Production Example 1 as samples.

The evaluation was performed according to the following procedure. Normal human dermal fibroblasts were seeded in a 96-well microplate at 2.0 × 10 ⁴ cells per well. The seeding medium used was Dulbecco's modified Eagle medium (DMEM) supplemented with 1% fetal bovine serum. After culturing for 24 hours, the culture medium was replaced with a test medium to which a sample having an arbitrary concentration was added, and further cultured for 48 hours. Subsequently, the medium containing 400 μg / mL of 3- (4,5-dimethyl-2-thiazolyl) -2,5-diphenyltetrazolium bromide (MTT) was exchanged and cultured for 2 hours. Formazan generated by the opening of the tetrazolium ring was removed. Extraction was performed with 2-propanol, and absorbance at 550 nm was measured with a microplate reader. At the same time, the absorbance at 650 nm was measured as turbidity, and the cell activation effect was evaluated by the difference between the two measured values. The evaluation results are shown in Table 1 as relative values with the cell activation effect in the blank with no sample as 100. In the table, * and ** indicate a significance probability of less than 1% (P <0.05) and a significance probability of less than 1% (P <0.01), respectively, with respect to the significance P value in the t test. This is indicated by *.

  As is clear from Table 1, a significant dermal fibroblast activation effect was observed in the medium supplemented with the extract of Fauquiliaceae plants. From this, it was clarified that the extract of the Fauqueriaceae plant has an excellent cell activation effect.

  Next, it shows about the antioxidant effect of the extract of Fauquiliaceae plant. The sample was evaluated by extracting the faux quillia microfila leaves according to Production Example 1 as samples.

The evaluation was performed according to the following procedure. 100 μL of an extract solution of Fauquiliaceae plant diluted to an arbitrary concentration with a 50 wt% ethanol aqueous solution was added to a 96-well microplate. Next, 100 μL of a 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution prepared in ethanol to a concentration of 0.2 mM was added to a 96-well microplate. The mixture was left in the dark with stirring, and the absorbance at 516 nm was measured after 24 hours. When the absorbance of the blank with no sample added was (A) and the absorbance when the sample was added was (B), the value of formula (1) was defined as the radical elimination rate. The evaluation results are shown in Table 2.
Formula (1) {1- (B) / (A)} × 100 (%)

  As is clear from Table 2, it was found that the extract of Fauqueriaceae plant has an antioxidant action based on radical scavenging.

  Then, the prescription example of the skin external preparation which mix | blended the extract of the Fauquilia family plant based on this invention is shown.

[Formulation Example 1] Emulsion (1) Squalane 10.0 (wt%)
(2) Methylphenylpolysiloxane 4.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Polyoxyethylene monostearate
Sorbitan (20E.O.) 1.3
(6) Sorbitan monostearate 1.0
(7) Glycerin 4.0
(8) Methyl paraoxybenzoate 0.1
(9) Carboxyvinyl polymer 0.15
(10) Purified water 57.85
(11) Arginine (1 wt% aqueous solution) 20.0
(12) Fouqui area family plant extract [Production Example 1] 1.0
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. After emulsification, start cooling and add (11) and (12) sequentially and mix uniformly.

[Prescription Example 2] Lotion (1) Ethanol 15.0 (% by weight)
(2) Polyoxyethylene (40E.O.) hydrogenated castor oil 0.3
(3) Fragrance 0.1
(4) Purified water 82.38
(5) Citric acid 0.02
(6) Sodium citrate 0.1
(7) Glycerin 1.0
(8) Hydroxyethyl cellulose 0.1
(9) Extract of Fouquilliaceae plant [Production Example 3] 1.0
Production method: (2) and (3) are dissolved in (1). After dissolution, (4) to (8) are sequentially added, and then sufficiently stirred, (9) is added and mixed uniformly.

[Prescription Example 3] Cream (1) Squalane 10.0 (% by weight)
(2) Stearic acid 2.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Cetanol 3.6
(6) Lipophilic glyceryl monostearate 2.0
(7) Glycerin 10.0
(8) Methyl paraoxybenzoate 0.1
(9) Arginine (20% by weight aqueous solution) 15.0
(10) Purified water 40.7
(11) Carboxyvinyl polymer (1% by weight aqueous solution) 15.0
(12) Fouqui area family plant extract [Production Example 1] 1.0
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. After the emulsification is completed, add (11), start cooling, add (12) at 40 ° C., and mix uniformly.

[Formulation Example 4] Cosmetic liquid (1) Purified water 27.45 (% by weight)
(2) Glycerol 14.0
(3) Sucrose fatty acid ester 1.3
(4) Carboxyvinyl polymer (1% by weight aqueous solution) 17.5
(5) Sodium alginate (1 wt% aqueous solution) 15.0
(6) Polyglyceryl monolaurate 1.0
(7) Macadamia nut oil fatty acid phytosteryl 3.0
(8) N-lauroyl-L-glutamic acid di (phytosteryl-2-octyldodecyl) 2.0
(9) Hardened palm oil 2.0
(10) Squalane (from olive) 1.0
(11) Behenyl alcohol 0.75
(12) Beeswax 1.0
(13) Jojoba oil 1.0
(14) 1,3-butylene glycol 10.0
(15) L-arginine (10% by weight aqueous solution) 2.0
(16) Extract of Fouquilliaceae plant [Production Example 1] 1.0
Production method: The aqueous phase components (1) to (6) are mixed and dissolved by heating at 75 ° C. On the other hand, the oil phase components (7) to (14) are mixed and dissolved by heating at 75 ° C. Next, the oil phase component is added to the aqueous phase component and preliminary emulsification is performed, followed by uniform emulsification with a homomixer. Cooling is started after completion of emulsification, and (15) is added at 50 ° C. Cool further to 40 ° C, add (16) and mix evenly.

[Formulation Example 5] Aqueous gel (1) Carboxyvinyl polymer 0.5 (% by weight)
(2) Purified water 86.7
(3) Sodium hydroxide (10% by weight aqueous solution) 0.5
(4) Ethanol 10.0
(5) Methyl paraoxybenzoate 0.1
(6) Fragrance 0.1
(7) Fouqui area family plant extract [Production Example 4] 2.0
(8) Polyoxyethylene (60E.O.) hydrogenated castor oil 0.1
Manufacturing method: (1) is added to (2), and after stirring uniformly, (3) is added. After stirring uniformly, (5) previously dissolved in (4) is added. After stirring uniformly, the previously mixed (6) to (8) are added and stirred and mixed uniformly.

[Formulation Example 6] Cleansing Fee (1) Squalane 81.0 (wt%)
(2) Polyoxyethylene glyceryl isostearate 15.0
(3) Purified water 3.0
(4) Extract of Fouquilliaceae plant [Production Example 4] 1.0
Manufacturing method: (1) and (2) are uniformly dissolved. (3) and (4) are sequentially added to this and mixed uniformly.

[Prescription Example 7] Face-wash foam (1) Stearic acid 16.0 (% by weight)
(2) Myristic acid 16.0
(3) Lipophilic glyceryl monostearate 2.0
(4) Glycerin 20.0
(5) Sodium hydroxide 7.5
(6) Palm oil fatty acid amidopropyl betaine 1.0
(7) Purified water 36.5
(8) Fouqui area family plant extract [Production Example 3] 1.0
Production method: The oil phase components (1) to (4) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (5) to (7) are heated and dissolved at 80 ° C., and mixed and stirred uniformly with the oil phase components. Cooling is started, and (8) is added at 40 ° C. and mixed uniformly.

[Prescription Example 8] Make-up base cream (1) Squalane 10.0 (% by weight)
(2) Cetanol 2.0
(3) Glycerin tri-2-ethylhexanoate 2.5
(4) Lipophilic glyceryl monostearate 1.0
(5) Propylene glycol 11.0
(6) Sucrose fatty acid ester 1.3
(7) Purified water 69.4
(8) Titanium oxide 1.0
(9) Bengala 0.1
(10) Yellow iron oxide 0.4
(11) Fragrance 0.1
(12) Extract of Fouquilliaceae plant [Production Example 2] 1.2
Production method: The oil phase components (1) to (4) are mixed and dissolved by heating at 75 ° C. On the other hand, the aqueous phase components (5) to (7) are mixed and dissolved by heating at 75 ° C., and the pigments (8) to (10) are added thereto and dispersed uniformly with a homomixer. The oil phase component is added to the water phase component and emulsified with a homomixer. Cooling is started after the emulsification is completed, and the components (11) and (12) are added at 40 ° C. and mixed uniformly.

[Formulation Example 9] Emulsion foundation (1) Methylpolysiloxane 2.0 (wt%)
(2) Squalane 5.0
(3) Octyldodecyl myristate 5.0
(4) Cetanol 1.0
(5) Polyoxyethylene (20E.O.)
Sorbitan monostearate 1.3
(6) Sorbitan monostearate 0.7
(7) 1,3-butylene glycol 8.0
(8) Xanthan gum 0.1
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 57.4
(11) Titanium oxide 9.0
(12) Talc 7.4
(13) Bengala 0.5
(14) Yellow iron oxide 1.1
(15) Black iron oxide 0.1
(16) Fragrance 0.1
(17) Extract from Fouquilliaceae plant [Production Example 4] 1.0
Production method: The oil phase components (1) to (6) are mixed and dissolved by heating at 75 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and dissolved by heating at 75 ° C., and the pigments (11) to (15) are added thereto and uniformly dispersed with a homomixer. Add oil phase ingredients and emulsify. Cooling is started after the emulsification is completed, and components (16) and (17) are sequentially added at 40 ° C. and mixed uniformly.

[Formulation Example 10] Water-in-oil emollient cream (1) Liquid paraffin 30.0 (% by weight)
(2) Microcrystalline wax 2.0
(3) Vaseline 5.0
(4) Diglycerin oleate 5.0
(5) Sodium chloride 1.3
(6) Potassium chloride 0.1
(7) Propylene glycol 3.0
(8) 1,3-butylene glycol 5.0
(9) Methyl paraoxybenzoate 0.1
(10) Fouqui area family plant extract [Production Example 1] 1.0
(11) Purified water 47.4
(12) Fragrance 0.1
Production method: Dissolve (5) and (6) in a part of (11) to 50 ° C., and gradually add to (4) heated to 50 ° C. with stirring. After mixing this, it disperse | distributes uniformly to (1)-(3) heated and melt | dissolved at 70 degreeC. (7) to (10) are added to the remainder of (11) heated and dissolved at 70 ° C. while stirring and emulsified with a homomixer. Cooling is started after completion of emulsification, and (12) is added at 40 ° C. and mixed uniformly.

[Prescription Example 11] Pack (1) Purified water 62.9 (% by weight)
(2) Polyvinyl alcohol 12.0
(3) Ethanol 17.0
(4) Glycerin 5.0
(5) Polyethylene glycol (average molecular weight 1000) 2.0
(6) Fouqui area family plant extract [Production Example 2] 1.0
(7) Fragrance 0.1
Production method: (2) and (3) are mixed, heated to 80 ° C, and then dissolved in (1) heated to 80 ° C. After uniformly dissolving, add (4) and (5), and start cooling while stirring. Cool to 40 ° C, add (6) and (7) and mix uniformly.

[Prescription Example 12] Bath agent (1) Fragrance 0.3 (% by weight)
(2) Fouqui area family plant extract [Production Example 1] 1.0
(3) Sodium bicarbonate 50.0
(4) Sodium sulfate 48.7
Production method: (1) to (4) are mixed uniformly.

[Prescription Example 13] Hair wax (1) Stearic acid 3.0 (% by weight)
(2) Microcrystalline wax 2.0
(3) Cetyl alcohol 3.0
(4) Highly polymerized methylpolysiloxane 2.0
(5) Methylpolysiloxane 5.0
(6) Poly (oxyethylene / oxypropylene)
Methylpolysiloxane copolymer 1.0
(7) Methyl paraoxybenzoate 0.1
(8) 1,3-butylene glycol 7.5
(9) Arginine 0.7
(10) Purified water 74.6
(11) Fouqui area family plant extract [Production Example 1] 1.0
(12) Fragrance 0.1
Production method: The oil phase components (1) to (6) are mixed and heated and dissolved at 75 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 75 ° C., the oil phase component is added, and the mixture is emulsified with a homomixer. Cooling is started after the emulsification is completed, and the components (11) and (12) are added at 40 ° C. and mixed uniformly.

[Prescription Example 14] Hair artic (1) Ethanol 50.0 (% by weight)
(2) Purified water 48.9
(3) Fouqui area family plant extract [Production Example 3] 1.0
(4) Fragrance 0.1
Production method: Components (1) to (4) are mixed and homogenized.

[Prescription Example 15] Tablet (1) Extract from Fauquilariaceae [Production Example 1] 100.0 (mg)
(2) Reduced maltose starch syrup 461.0
(3) Corn starch 15.0
(4) Glycerin fatty acid ester 12.0
(5) Fragrance 12.0
Production method: (1) to (3) were sieved and mixed, and then (4) to (5) were added and mixed. Thereafter, tableting was performed by a conventional method to obtain a tablet having a total amount of 600 mg.

  Next, a use test was conducted using a formulation in which an extract of a fauque area family plant was blended, and an improvement effect was evaluated for rough skin caused by drying. At that time, the extract of Fauquiliaceae plant listed in Table 3 was blended in the emulsion formulation shown in Formulation Example 1, and the use test was conducted as Examples 1-2. Moreover, the extract of the Fauquilia family plant was replaced with purified water, and a use test was simultaneously conducted as Comparative Example 1.

  For each sample, 20 female panelists with dry skin in their 30s to 50s whose skin symptom was remarkably recognized were grouped and used for one week blindly, and the skin condition before and after use was observed and evaluated. . As an index of skin symptoms, rough skin due to dryness was evaluated in three stages of “improvement”, “slight improvement”, and “no change”, and Table 4 shows the number of panelists that obtained each evaluation.

From Table 4, in the comparative example use group that does not contain the extract of the focus area family plant, an improvement was not recognized in more than 80% of the panelists, but the use of the example in which the extract of the focus area family plant was blended In the group, more than 70% of panelists showed a clear improvement in rough skin. From this, it was clarified that the extract of the Fauqueriaceae plant has an excellent moisturizing effect.

Claims (5)

A moisturizing agent containing as an active ingredient an extract of one or more kinds of plants selected from Fouquiria family plants. A cell activator comprising, as an active ingredient, an extract of one or more kinds of plants selected from Fouqui area family plants. The antioxidant which uses the extract of 1 type, or 2 or more types of plants chosen from a Fauquilia family plant as an active ingredient. A skin external preparation containing an extract of one or two or more kinds of plants selected from the Fauquilia family plants. A food containing an extract of one or two or more kinds of plants selected from Fouqui area family plants.