JP4931452B2 - Moisturizer, cell activator, whitening agent, and antioxidant - Google Patents

Description

  The present invention relates to a humectant, a cell activator, a whitening agent, and an antioxidant. More specifically, the present invention relates to a moisturizer, a cell activator, a whitening agent, and an antioxidant containing an extract of a plant of the family Rosaceae, and an external preparation for skin and a food containing the extract of the plant of the family Rosaceae.

  Causes of skin symptoms such as aging, ultraviolet rays, stress, wrinkles, stains, skin elasticity decrease, dryness, decreased cellular function, melanin production and pigmentation due to ultraviolet rays, decrease or degeneration of dermal matrix components, ultraviolet rays, etc. Examples include oxidative damage. In order to prevent and ameliorate such skin symptoms, search for various active ingredients and formulation studies have been conventionally conducted. As the cell activator, the essence of Ponkan (see Patent Document 1), as the whitening agent, water and / or organic solvent extract of Hakutsuru Reishi (see Patent Document 2), and as the antioxidant, the genus Sarogase Plant extracts (see Patent Document 3) are known.

  In addition, the prior art regarding a moisturizer, a cell activator, a whitening agent, and an antioxidant containing an extract of a plant of the family Rosaceae as an active ingredient was not recognized.

JP 2001-131045 A JP 2003-89630 A Japanese Patent Laid-Open No. 10-182413

  Naturally-derived components are known to have various pharmacological and cosmetic effects, and so far many plants and fungi have been widely applied to fields such as external preparations for skin and foods and drinks. However, there are many naturally-derived ingredients whose effects are not yet known, and the development of effective ingredients having excellent moisturizing action, cell activation action, whitening action or antioxidant action has been expected. The present invention has been made in order to find such an active ingredient, and provides a moisturizer, a cell activator, a whitening agent, and an antioxidant that can be widely applied to fields such as external preparations for skin and foods and drinks. The purpose is to do.

  In order to find a moisturizer, a cell activator, a whitening agent, and an antioxidant that can be widely applied to fields such as external preparations for skin and foods and drinks, the present inventors have studied various substances derived from nature. It was. As a result, the present inventors have found a moisturizing action, a cell activation action, a whitening action, and an antioxidation action that are excellent in extracts of the plant of the family Rosaceae, and have further studied and completed the present invention. That is, the present invention relates to a topical skin containing a moisturizer, a cell activator, a whitening agent, an antioxidant, and an extract of one or more plants of the plant of the plant of the family Rosaceae. It provides drugs and foods.

  According to the present invention, it is possible to provide a moisturizer, a cell activator, a whitening agent, and an antioxidant having an excellent effect, and by blending them in a composition such as a skin external preparation or food, It is possible to provide various compositions that exhibit an excellent effect in preventing and improving various skin symptoms such as talmi, skin firmness, spots, and kusumi.

Polemoniaceae plant is a plant used as a raw material of the present invention (Polemoniaceae) is Hanashinobu genus (Polemonium), Phlox paniculata genus (Phlox), Himehanashinobu genus (Gilia), Kantua genus (Cantua), Kobaea genus (Cobaea), Plants such as Linanthus are known. As plants of the genus Hanashinobu, Hanashinobu ( Polemonium kiusianum ), Hanashinobu ( Polemonium caeruleum ), etc. are known,
As plants of the genus Oleander, Shilozakura ( Phlox subulata ) and the like are known, and as plants of the genus Himehanashinobu, Himehanashinobu ( Gilia tricolor ), Gielia elegans ( Gilia elegans ) and the like are known as plants, , such as Kantua-Bukushiforia (Cantua buxifolia) is known.

  The plant used as a raw material for the present invention is not particularly limited as long as it is a plant belonging to the family Rosaceae, but for reasons such as being relatively easily available and effective, plants belonging to the genus Hanashinobu, Oleander genus, Himehanashinobu It is preferable to use Hanashi Nobu, Shibazakura, Hime Hanashi Nobu, Gilead Elegance from the viewpoint of effectiveness.

  In the present invention, the extract of the plant of the family Rosaceae includes the active substance and the dried product of the plant of the family Rosaceae, but it is preferable to use an extract extracted using various solvents. For extraction, any part of the leaves, flowers, seeds, roots, stems, buds, and the like may be used for extraction, but whole plants may be used for convenient use. In the extraction, it may be used as it is, but considering the extraction efficiency, it is preferable to perform the extraction after performing processing such as shredding, drying, and pulverization. The extraction can be performed by immersing in an extraction solvent or by an extraction method using a supercritical fluid or a subcritical fluid. In order to increase the extraction efficiency, the mixture may be homogenized in stirring or an extraction solvent. The extraction temperature is suitably about 5 ° C. to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but it is appropriate to set it to about 1 hour to 14 days.

  Extraction solvents include water, lower alcohols such as methanol, ethanol, propanol and isopropanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin, ethers such as ethyl ether and propyl ether. And solvents such as esters such as butyl acetate and ethyl acetate, and ketones such as acetone and ethyl methyl ketone can be used, and one or more of these can be selected and used. Further, physiological saline, phosphate buffer, phosphate buffered saline, or the like may be used. Furthermore, you may use 1 type, or 2 or more types of supercritical fluids and subcritical fluids, such as water, a carbon dioxide, ethylene, propylene, ethanol, methanol, ammonia.

  Extracts of the above-mentioned Solanaceae plants using the above solvents can be used as they are, but the concentrated and dried solids can be used again by dissolving them in water or a polar solvent, and their physiological effects are not impaired. It may be used after performing purification treatment such as decolorization, deodorization and desalting, and fractionation treatment by column chromatography. The above extract of the genus Rosaceae, its processed product and fractions thereof can be lyophilized after each treatment and fractionation and dissolved and used at the time of use.

  The extract of a plant of the family Rosaceae has an excellent moisturizing action, cell activation action, whitening action and antioxidant action, and can be used as a moisturizing agent, cell activator, whitening agent and antioxidant. In addition, moisturizers, cell activators, whitening agents, and antioxidants, which are made from the extracts of the plants of the family Rosaceae, can be used not only for the skin but also for the hair and can be taken orally. It can be applied to foods, beverages, pharmaceuticals, and the like.

  A moisturizing agent comprising an extract of a plant of the quinaceae family as an active ingredient exhibits an excellent moisturizing action on the skin and hair, and has a particularly high moisturizing effect on the skin.

  A cell activator comprising an extract of a plant of the family Rosacynoaceae exhibits an excellent activation action on various cells, but particularly an excellent effect on dermal fibroblasts.

  A whitening agent comprising an extract of a plant of the genus Rosaniaceae as an active ingredient is effective in improving pigmentation symptoms such as spots and freckles, and is particularly effective in suppressing the production of melanin.

  An antioxidant comprising an extract of a plant of the family Rosaceae as an active ingredient exhibits an excellent antioxidant action, but particularly exhibits an excellent effect on scavenging free radicals.

  In addition, by blending the extract of the plant of the family Tanabinoaceae into an external preparation for skin, it is effective for the prevention and improvement of skin symptoms such as wrinkles, tarmi, skin firmness, spots, kumi, dryness, fine lines, etc. And can be used as a moisturizing skin external preparation, a whitening skin external preparation, or an anti-aging skin external preparation. Further, the extract of the plant of the family Rosaceae can be used for foods intended for beauty, health maintenance or nutritional supplementation. In addition, a drink is also contained in the foodstuff of this invention.

  The blending amount of the extract of the plant genus plant can be adjusted according to the type of skin external preparation and the purpose of use, but it is 0 with respect to the total amount from the viewpoint of the effect and stability. 0.0001 to 50.0% by weight is preferable, and 0.001 to 25.0% by weight is more preferable.

  The dosage form of the external preparation for skin containing the extract of the plant of the family Rosaceae is arbitrary. For example, it can be provided as a solubilizing system such as lotion, an emulsifying system such as cream or emulsion, or a dispersing system such as calamine lotion. Furthermore, it can also be provided in various dosage forms such as aerosols, ointments, powders and granules filled with a propellant.

  In addition, for the topical skin preparation containing the extract of the plant of the family Benashinobu, in addition to the extract of the plant of the family Rosanobaceae, if necessary, it is usually a pharmaceutical, a quasi-drug, a skin cosmetic, a cosmetic for hair and a washing. Oil components, moisturizers, powders, pigments, emulsifiers, solubilizers, cleaning agents, UV absorbers, thickeners, drugs, fragrances, resins, antibacterial and antifungal agents, alcohols, etc. It can mix | blend suitably. Moreover, in the range which does not impair the effect of this invention, combined use with another moisturizer, a cell activator, a whitening agent, or an antioxidant is also possible.

  In the following, the production examples of the extract of the plant of the family Rosaceae, the test for evaluating each action, the formulation example as a skin external preparation and food, and the use test will be described in more detail, but the technical scope of the present invention is based on this. It is not limited at all.

[Production Example 1]
10 kg of a 50 wt% aqueous ethanol solution was added to 1 kg of a dried ground pulverized plant of the pine plant and immersed for 7 days at room temperature. The extract was collected by filtration, and after removing the solvent, an extract of a plant of the family Rosaceae was obtained.

[Production Example 2]
Nine liters of water was added to 1 kg of a dried crushed plant of the quinceae and extracted by refluxing at 90 ° C. for 6 hours. The extract was collected by filtration, and after removing the solvent, an extract of a plant of the family Rosaceae was obtained.

[Production Example 3]
Nine liters of methanol was added to 1 kg of dried pulverized plant of Papaveraceae and soaked at room temperature for 7 days. The extract was collected by filtration, and after removing the solvent, an extract of a plant of the family Rosaceae was obtained.

[Production Example 4]
The plant was placed in a supercritical extraction apparatus and extracted using a supercritical fluid of carbon dioxide at 40 ° C. under a pressure of 15 MPa. The extract was collected to obtain an extract of a plant of the family Rosaceae.

  First, it shows about the cell activation effect | action of the extract of a Hanashinobu family plant. The sample was evaluated by extracting the whole plant of Gilia elegance according to Production Example 1 as a sample.

The evaluation was performed according to the following procedure. Normal human dermal fibroblasts were seeded in a 96-well microplate at 2.0 × 10 ⁴ cells per well. The seeding medium used was Dulbecco's modified Eagle medium (DMEM) supplemented with 1% fetal bovine serum. After culturing for 24 hours, the culture medium was replaced with a test medium to which a sample having an arbitrary concentration was added, and further cultured for 48 hours. Next, the medium containing 3- (4,5-dimethyl-2-thiazolyl) -2,5-diphenyltetrazolium bromide (MTT) was replaced with a medium containing 400 μg / mL and cultured for 2 hours. Extraction was performed with 2-propanol, and absorbance at 550 nm was measured with a microplate reader. At the same time, the absorbance at 650 nm was measured as turbidity, and the cell activation effect was evaluated by the difference between the two measured values. The evaluation results are shown in Table 1 as relative values with the cell activation effect in the blank with no sample as 100. In the table, * and ** indicate a significance probability of less than 1% (P <0.05) and a significance probability of less than 1% (P <0.01), respectively, with respect to the significance P value in the t test. This is indicated by *.

  As is clear from Table 1, a significant dermal fibroblast activation effect was observed in the medium supplemented with the extract of the plant of the family Rosaceae. From this, it was clarified that the extract of the plant of the family Rosaceae has an excellent cell activation effect.

  Next, the evaluation of the tyrosinase activity inhibitory action of the plant extract of the family Rosaceae is shown. The sample was evaluated by extracting the whole plant of Gilia elegance according to Production Example 1 as a sample.

The evaluation was performed according to the following procedure. Normal human epidermal melanocytes manufactured by Kurabo Industries Co., Ltd. were seeded in a 96-well microplate so as to be 3.0 × 10 ⁴ cells per well. As a seeding medium, Medium154S manufactured by Kurabo Industries Co., Ltd. was used. After 24 hours, the medium was replaced with a medium to which each concentration of sample was added, and further cultured for 48 hours. Next, 75 μL of 1 wt% Triton-X-containing phosphate buffer was exchanged to completely lyse the cells, and 50 μL was used as a crude enzyme solution. To the crude enzyme solution, 50 μL of a 0.05 wt% L-dopa-containing phosphate buffer as a substrate was added and allowed to stand at 37 ° C. for 2 hours. The absorbance at 405 nm was measured immediately after the addition of the substrate and at the end of the reaction with a microplate reader, and the amount of produced dopamelanin was calculated. The tyrosinase activity inhibition rate of the sample is shown in Table 2 as a relative value to the tyrosinase activity inhibition rate in the blank with no sample added.

  As is apparent from Table 2, when a medium supplemented with an extract of the plant of the family Rosaceae was used, a decrease in the melanin production rate was observed. From this, it was revealed that the extract of the plant of the family Rosaceae has an excellent tyrosinase activity inhibitory action.

  Next, it shows about the antioxidant effect of the extract of a plant of the family Rosaceae. The sample was evaluated by extracting the whole plant of Gilia elegance according to Production Example 1 as a sample.

The evaluation was performed according to the following procedure. 100 μL of an extract solution of a plant of the family Rosaceae, diluted to an arbitrary concentration with a 50% by weight aqueous ethanol solution, was added to a 96-well microplate. Next, 100 μL of a 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution prepared in ethanol to a concentration of 0.2 mM was added to a 96-well microplate. The mixture was left in the dark with stirring, and the absorbance at 516 nm was measured after 24 hours. When the absorbance of the blank with no sample added was (A) and the absorbance when the sample was added was (B), the value of formula (1) was defined as the radical elimination rate. The evaluation results are shown in Table 3.
Formula (1) {1- (B) / (A)} × 100 (%)

  As is clear from Table 3, it was found that the extract of the plant Rosaceae has an antioxidant action based on radical scavenging.

  Then, the example of a skin external preparation and the foodstuff which mix | blended the extract of the plant of the Rosaceae family concerning this invention is shown.

[Formulation Example 1] Emulsion (1) Squalane 10.0 (wt%)
(2) Methylphenylpolysiloxane 4.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Polyoxyethylene monostearate
Sorbitan (20E.O.) 1.3
(6) Sorbitan monostearate 1.0
(7) Glycerin 4.0
(8) Methyl paraoxybenzoate 0.1
(9) Carboxyvinyl polymer 0.15
(10) Purified water 57.85
(11) Arginine (1 wt% aqueous solution) 20.0
(12) An extract of a plant of the family Rosaceae [Production Example 1] 1.0
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. After emulsification, start cooling and add (11) and (12) sequentially and mix uniformly.

[Prescription Example 2] Lotion (1) Ethanol 15.0 (% by weight)
(2) Polyoxyethylene (40E.O.) hydrogenated castor oil 0.3
(3) Fragrance 0.1
(4) Purified water 82.38
(5) Citric acid 0.02
(6) Sodium citrate 0.1
(7) Glycerin 1.0
(8) Hydroxyethyl cellulose 0.1
(9) An extract of a plant of the family Rosaceae [Production Example 3] 1.0
Production method: (2) and (3) are dissolved in (1). After dissolution, (4) to (8) are sequentially added, and then sufficiently stirred, (9) is added and mixed uniformly.

[Prescription Example 3] Cream (1) Squalane 10.0 (% by weight)
(2) Stearic acid 2.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Cetanol 3.6
(6) Lipophilic glyceryl monostearate 2.0
(7) Glycerin 10.0
(8) Methyl paraoxybenzoate 0.1
(9) Arginine (20% by weight aqueous solution) 15.0
(10) Purified water 40.7
(11) Carboxyvinyl polymer (1% by weight aqueous solution) 15.0
(12) An extract of a plant of the family Rosaceae [Production Example 1] 1.0
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. After the emulsification is completed, add (11), start cooling, add (12) at 40 ° C., and mix uniformly.

[Formulation Example 4] Cosmetic liquid (1) Purified water 27.45 (% by weight)
(2) Glycerol 14.0
(3) Sucrose fatty acid ester 1.3
(4) Carboxyvinyl polymer (1% by weight aqueous solution) 17.5
(5) Sodium alginate (1 wt% aqueous solution) 15.0
(6) Polyglyceryl monolaurate 1.0
(7) Macadamia nut oil fatty acid phytosteryl 3.0
(8) N-lauroyl-L-glutamic acid di (phytosteryl-2-octyldodecyl) 2.0
(9) Hardened palm oil 2.0
(10) Squalane (from olive) 1.0
(11) Behenyl alcohol 0.75
(12) Beeswax 1.0
(13) Jojoba oil 1.0
(14) 1,3-butylene glycol 10.0
(15) L-arginine (10% by weight aqueous solution) 2.0
(16) An extract of the plant of the family Rosaceae [Production Example 1] 1.0
Production method: The aqueous phase components (1) to (6) are mixed and dissolved by heating at 75 ° C. On the other hand, the oil phase components (7) to (14) are mixed and dissolved by heating at 75 ° C. Next, the oil phase component is added to the aqueous phase component and preliminary emulsification is performed, followed by uniform emulsification with a homomixer. Cooling is started after completion of emulsification, and (15) is added at 50 ° C. Cool further to 40 ° C, add (16) and mix evenly.

[Formulation Example 5] Aqueous gel (1) Carboxyvinyl polymer 0.5 (% by weight)
(2) Purified water 86.7
(3) Sodium hydroxide (10% by weight aqueous solution) 0.5
(4) Ethanol 10.0
(5) Methyl paraoxybenzoate 0.1
(6) Fragrance 0.1
(7) An extract of the plant of the family Rosaceae [Production Example 4] 2.0
(8) Polyoxyethylene (60E.O.) hydrogenated castor oil 0.1
Manufacturing method: (1) is added to (2), and after stirring uniformly, (3) is added. After stirring uniformly, (5) previously dissolved in (4) is added. After stirring uniformly, the previously mixed (6) to (8) are added and stirred and mixed uniformly.

[Formulation Example 6] Cleansing Fee (1) Squalane 81.0 (wt%)
(2) Polyoxyethylene glyceryl isostearate 15.0
(3) Purified water 3.0
(4) An extract of a plant of the family Rosaceae [Production Example 4] 1.0
Manufacturing method: (1) and (2) are uniformly dissolved. (3) and (4) are sequentially added to this and mixed uniformly.

[Prescription Example 7] Face-wash foam (1) Stearic acid 16.0 (% by weight)
(2) Myristic acid 16.0
(3) Lipophilic glyceryl monostearate 2.0
(4) Glycerin 20.0
(5) Sodium hydroxide 7.5
(6) Palm oil fatty acid amidopropyl betaine 1.0
(7) Purified water 36.5
(8) An extract of a plant of the family Rosaceae [Production Example 3] 1.0
Production method: The oil phase components (1) to (4) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (5) to (7) are heated and dissolved at 80 ° C., and mixed and stirred uniformly with the oil phase components. Cooling is started, and (8) is added at 40 ° C. and mixed uniformly.

[Prescription Example 8] Make-up base cream (1) Squalane 10.0 (% by weight)
(2) Cetanol 2.0
(3) Glycerin tri-2-ethylhexanoate 2.5
(4) Lipophilic glyceryl monostearate 1.0
(5) Propylene glycol 11.0
(6) Sucrose fatty acid ester 1.3
(7) Purified water 69.4
(8) Titanium oxide 1.0
(9) Bengala 0.1
(10) Yellow iron oxide 0.4
(11) Fragrance 0.1
(12) An extract of a plant of the family Rosaceae [Production Example 2] 1.2
Production method: The oil phase components (1) to (4) are mixed and dissolved by heating at 75 ° C. On the other hand, the aqueous phase components (5) to (7) are mixed and dissolved by heating at 75 ° C., and the pigments (8) to (10) are added thereto and dispersed uniformly with a homomixer. The oil phase component is added to the water phase component and emulsified with a homomixer. Cooling is started after the emulsification is completed, and the components (11) and (12) are added at 40 ° C. and mixed uniformly.

[Formulation Example 9] Emulsion foundation (1) Methylpolysiloxane 2.0 (wt%)
(2) Squalane 5.0
(3) Octyldodecyl myristate 5.0
(4) Cetanol 1.0
(5) Polyoxyethylene (20E.O.)
Sorbitan monostearate 1.3
(6) Sorbitan monostearate 0.7
(7) 1,3-butylene glycol 8.0
(8) Xanthan gum 0.1
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 57.4
(11) Titanium oxide 9.0
(12) Talc 7.4
(13) Bengala 0.5
(14) Yellow iron oxide 1.1
(15) Black iron oxide 0.1
(16) Fragrance 0.1
(17) An extract of a plant of the family Rosaceae [Production Example 4] 1.0
Production method: The oil phase components (1) to (6) are mixed and dissolved by heating at 75 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and dissolved by heating at 75 ° C., and the pigments (11) to (15) are added thereto and uniformly dispersed with a homomixer. Add oil phase ingredients and emulsify. Cooling is started after the emulsification is completed, and components (16) and (17) are sequentially added at 40 ° C. and mixed uniformly.

[Formulation Example 10] Water-in-oil emollient cream (1) Liquid paraffin 30.0 (% by weight)
(2) Microcrystalline wax 2.0
(3) Vaseline 5.0
(4) Diglycerin oleate 5.0
(5) Sodium chloride 1.3
(6) Potassium chloride 0.1
(7) Propylene glycol 3.0
(8) 1,3-butylene glycol 5.0
(9) Methyl paraoxybenzoate 0.1
(10) An extract of a plant of the family Rosaceae [Production Example 1] 1.0
(11) Purified water 47.4
(12) Fragrance 0.1
Production method: Dissolve (5) and (6) in a part of (11) to 50 ° C., and gradually add to (4) heated to 50 ° C. with stirring. After mixing this, it disperse | distributes uniformly to (1)-(3) heated and melt | dissolved at 70 degreeC. (7) to (10) are added to the remainder of (11) heated and dissolved at 70 ° C. while stirring and emulsified with a homomixer. Cooling is started after completion of emulsification, and (12) is added at 40 ° C. and mixed uniformly.

[Prescription Example 11] Pack (1) Purified water 62.9 (% by weight)
(2) Polyvinyl alcohol 12.0
(3) Ethanol 17.0
(4) Glycerin 5.0
(5) Polyethylene glycol (average molecular weight 1000) 2.0
(6) An extract of a plant of the family Rosaceae [Production Example 2] 1.0
(7) Fragrance 0.1
Production method: (2) and (3) are mixed, heated to 80 ° C, and then dissolved in (1) heated to 80 ° C. After uniformly dissolving, add (4) and (5), and start cooling while stirring. Cool to 40 ° C, add (6) and (7) and mix uniformly.

[Prescription Example 12] Bath agent (1) Fragrance 0.3 (% by weight)
(2) An extract of a plant of the family Rosaceae [Production Example 1] 1.0
(3) Sodium bicarbonate 50.0
(4) Sodium sulfate 48.7
Production method: (1) to (4) are mixed uniformly.

[Prescription Example 13] Hair wax (1) Stearic acid 3.0 (% by weight)
(2) Microcrystalline wax 2.0
(3) Cetyl alcohol 3.0
(4) Highly polymerized methylpolysiloxane 2.0
(5) Methylpolysiloxane 5.0
(6) Poly (oxyethylene / oxypropylene)
Methylpolysiloxane copolymer 1.0
(7) Methyl paraoxybenzoate 0.1
(8) 1,3-butylene glycol 7.5
(9) Arginine 0.7
(10) Purified water 74.6
(11) An extract of a plant of the family Rosaceae [Production Example 1] 1.0
(12) Fragrance 0.1
Production method: The oil phase components (1) to (6) are mixed and heated and dissolved at 75 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 75 ° C., the oil phase component is added, and the mixture is emulsified with a homomixer. Cooling is started after the emulsification is completed, and the components (11) and (12) are added at 40 ° C. and mixed uniformly.

[Prescription Example 14] Hair artic (1) Ethanol 50.0 (% by weight)
(2) Purified water 48.9
(3) An extract of a plant of the family Rosaceae [Production Example 3] 1.0
(4) Fragrance 0.1
Production method: Components (1) to (4) are mixed and homogenized.

[Prescription Example 15] Tablet (1) Extract from the plant of the family Rosaceae [Production Example 1] 100.0 (mg)
(2) Reduced maltose starch syrup 461.0
(3) Corn starch 15.0
(4) Glycerin fatty acid ester 12.0
(5) Fragrance 12.0
Production method: (1) to (3) were sieved and mixed, and then (4) to (5) were added and mixed. Thereafter, tableting was performed by a conventional method to obtain a tablet having a total amount of 600 mg.

  Next, a use test was conducted using a prescription blended with an extract of a plant of the family Rosacynoaceae, and the improvement effect was evaluated for rough skin due to drying. At that time, the extract of the plant of the family Rosaceae described in Table 4 was added to the formulation of the emulsion shown in Formulation Example 1, and the use test was conducted as Examples 1-2. In addition, the extract of the plant of the family Rosaceae was replaced with purified water, and a use test was simultaneously conducted as Comparative Example 1.

  For each sample, 20 female panelists with dry skin in their 30s to 50s whose skin symptom was remarkably recognized were grouped and used blindly for 1 week, and the skin condition before and after use was observed and evaluated. . As an index of skin symptom, rough skin due to dryness was evaluated in three stages of “improved”, “slightly improved”, and “no change”, and Table 5 shows the number of panelists that obtained each evaluation.

From Table 5, in the comparative example use group that does not contain the extract of the plant of the family Rosaceae, no improvement was observed in 70% or more of the panelists, More than 70% of panelists showed a clear improvement in rough skin. From this, it was clarified that the extract of the plant of the family Rosaceae has an excellent moisturizing effect.

Claims (6)

A moisturizing agent comprising an aqueous ethanol extract of Gilia elegans as an active ingredient. A cell activator comprising, as an active ingredient, an aqueous ethanol extract of Gilia elegans . A whitening agent containing, as an active ingredient, an aqueous ethanol extract of Gilia elegans . An antioxidant containing an aqueous ethanol extract of Gilia elegans as an active ingredient. An external preparation for skin containing an aqueous ethanol extract of Gilia elegans . A food containing an aqueous ethanol extract of Gilia elegans .