JP2007204383A5 - - Google Patents
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- Publication number
- JP2007204383A5 JP2007204383A5 JP2006021967A JP2006021967A JP2007204383A5 JP 2007204383 A5 JP2007204383 A5 JP 2007204383A5 JP 2006021967 A JP2006021967 A JP 2006021967A JP 2006021967 A JP2006021967 A JP 2006021967A JP 2007204383 A5 JP2007204383 A5 JP 2007204383A5
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- JP
- Japan
- Prior art keywords
- general formula
- compound
- formula
- reacting
- represent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 phenyl halide compound Chemical class 0.000 claims description 21
- 238000006243 chemical reaction Methods 0.000 claims description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 9
- 125000000524 functional group Chemical group 0.000 claims description 7
- PYLWMHQQBFSUBP-UHFFFAOYSA-N monofluorobenzene Chemical group FC1=CC=CC=C1 PYLWMHQQBFSUBP-UHFFFAOYSA-N 0.000 claims description 7
- 239000002287 radioligand Substances 0.000 claims description 7
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- OZLBDYMWFAHSOQ-UHFFFAOYSA-N diphenyliodanium Chemical class C=1C=CC=CC=1[I+]C1=CC=CC=C1 OZLBDYMWFAHSOQ-UHFFFAOYSA-N 0.000 claims description 6
- 150000004795 grignard reagents Chemical class 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000003446 ligand Substances 0.000 claims description 6
- 238000003786 synthesis reaction Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 125000005147 toluenesulfonyl group Chemical group C=1(C(=CC=CC1)S(=O)(=O)*)C 0.000 claims description 4
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 claims description 3
- 239000007818 Grignard reagent Substances 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
- YCOXTKKNXUZSKD-UHFFFAOYSA-N as-o-xylenol Natural products CC1=CC=C(O)C=C1C YCOXTKKNXUZSKD-UHFFFAOYSA-N 0.000 claims description 3
- 230000003796 beauty Effects 0.000 claims description 3
- 239000003054 catalyst Substances 0.000 claims description 3
- 125000005842 heteroatom Chemical group 0.000 claims description 3
- 150000002431 hydrogen Chemical class 0.000 claims description 3
- 229910052749 magnesium Inorganic materials 0.000 claims description 3
- 239000011777 magnesium Substances 0.000 claims description 3
- 150000004682 monohydrates Chemical class 0.000 claims description 3
- 230000001590 oxidative effect Effects 0.000 claims description 3
- 229910052763 palladium Inorganic materials 0.000 claims description 3
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 claims description 3
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 6
- 238000007336 electrophilic substitution reaction Methods 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002372 labelling Methods 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- 238000010534 nucleophilic substitution reaction Methods 0.000 description 2
- 0 Cc1c(*)c(F)c(*)c(*)c1* Chemical compound Cc1c(*)c(F)c(*)c(*)c1* 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- PYLWMHQQBFSUBP-JZRMKITLSA-N fluoranylbenzene Chemical class [18F]C1=CC=CC=C1 PYLWMHQQBFSUBP-JZRMKITLSA-N 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 238000007344 nucleophilic reaction Methods 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- ODOPKAJVFRHHGM-UHFFFAOYSA-N phenyltin Chemical class [Sn]C1=CC=CC=C1 ODOPKAJVFRHHGM-UHFFFAOYSA-N 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000007348 radical reaction Methods 0.000 description 1
- 239000012217 radiopharmaceutical Substances 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006021967A JP4931181B2 (ja) | 2006-01-31 | 2006-01-31 | １８ｆ標識フルオロベンゼン環を有する放射性リガンドの合成法 |
| PCT/JP2006/323805 WO2007088670A1 (ja) | 2006-01-31 | 2006-11-29 | １８ｆ標識フルオロベンゼン環を有する放射性リガンドの合成法 |
| US12/161,974 US8067648B2 (en) | 2006-01-31 | 2006-11-29 | Method for synthesizing radioactive ligand having 18F-labeled fluorobenzene ring |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006021967A JP4931181B2 (ja) | 2006-01-31 | 2006-01-31 | １８ｆ標識フルオロベンゼン環を有する放射性リガンドの合成法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007204383A JP2007204383A (ja) | 2007-08-16 |
| JP2007204383A5 true JP2007204383A5 (enExample) | 2008-11-20 |
| JP4931181B2 JP4931181B2 (ja) | 2012-05-16 |
Family
ID=38327254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006021967A Expired - Fee Related JP4931181B2 (ja) | 2006-01-31 | 2006-01-31 | １８ｆ標識フルオロベンゼン環を有する放射性リガンドの合成法 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US8067648B2 (enExample) |
| JP (1) | JP4931181B2 (enExample) |
| WO (1) | WO2007088670A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2268609B1 (en) * | 2008-02-28 | 2013-01-30 | GE Healthcare Limited | Synthesis of a PEG-6 moiety from commercial low-cost chemicals |
| JP2009298725A (ja) * | 2008-06-12 | 2009-12-24 | Natl Inst Of Radiological Sciences | 蛍光標識フェニルオキシアニリン誘導体及び蛍光標識プローブ |
| EP3284736B1 (en) * | 2008-10-21 | 2021-03-03 | NUtech Ventures | Fluorination of aromatic ring systems |
| GB201011408D0 (en) * | 2010-07-06 | 2010-08-18 | Isis Innovation | Fluorine radiolabelling process |
| KR101441406B1 (ko) * | 2011-05-25 | 2014-11-04 | 주식회사 바이오이미징코리아 | 디아릴이오도늄 염 전구체를 이용한 플로오린-18이 표지된 플루마제닐의 제조 방법 |
| CN106982161B (zh) | 2012-11-22 | 2020-07-24 | 华为技术有限公司 | 环网保护中标签保持和删除的方法及设备 |
| US10005794B2 (en) * | 2013-12-17 | 2018-06-26 | Stella Pharma Corporation | Production method for 2-fluoro-4-borono-L-phenylalanine, and precursor of 2-fluoro-4-borono-L-phenylalanine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4513137A (en) * | 1981-04-09 | 1985-04-23 | The University Of Akron | Iodonium salts |
| US5073643A (en) * | 1990-08-30 | 1991-12-17 | Polyset Corporation | High yield synthesis of hydroxyl-containing cationic photoinitiators |
| JP4297716B2 (ja) * | 2003-03-31 | 2009-07-15 | カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ | Ｃ−ｃ結合の形成方法 |
-
2006
- 2006-01-31 JP JP2006021967A patent/JP4931181B2/ja not_active Expired - Fee Related
- 2006-11-29 WO PCT/JP2006/323805 patent/WO2007088670A1/ja not_active Ceased
- 2006-11-29 US US12/161,974 patent/US8067648B2/en not_active Expired - Fee Related
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