JP2007064987A5 - - Google Patents

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Publication number
JP2007064987A5
JP2007064987A5 JP2006242365A JP2006242365A JP2007064987A5 JP 2007064987 A5 JP2007064987 A5 JP 2007064987A5 JP 2006242365 A JP2006242365 A JP 2006242365A JP 2006242365 A JP2006242365 A JP 2006242365A JP 2007064987 A5 JP2007064987 A5 JP 2007064987A5
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JP
Japan
Prior art keywords
polypeptide
cell
antibody
binding
sample
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JP2006242365A
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English (en)
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JP2007064987A (ja
JP4602954B2 (ja
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Priority claimed from PCT/US2000/023328 external-priority patent/WO2001016318A2/en
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Publication of JP2007064987A publication Critical patent/JP2007064987A/ja
Publication of JP2007064987A5 publication Critical patent/JP2007064987A5/ja
Application granted granted Critical
Publication of JP4602954B2 publication Critical patent/JP4602954B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Claims (8)

  1. ＩＬ-２２Ｒポリペプチド又はＩＬ-１０Ｒβポリペプチドを含有すると思われる試料中でのＩＬ-２２Ｒポリペプチド又はＩＬ-１０Ｒβポリペプチドを検出する方法であって、前記試料をＩＬ-２２ポリペプチドと接触させ、前記試料中でのＩＬ-２２Ｒ／ＩＬ-２２ポリペプチドコンジュゲート又はＩＬ-１０Ｒβ／ＩＬ-２２ポリペプチドコンジュゲートの形成を確かめることを含んでなる、前記コンジュゲートの形成が前記試料中でのＩＬ-２２Ｒポリペプチド又はＩＬ-１０Ｒβポリペプチドの存在を示す、前記方法。
  2. 前記試料がＩＬ-２２Ｒポリペプチド又はＩＬ-１０Ｒβポリペプチドを発現すると思われる細胞を含む、請求項１に記載の方法。
  3. 前記ＩＬ-２２ポリペプチドが検出可能な標識で標識されるか、又は固体支持体に付着している、請求項１に記載の方法。
  4. 生物活性分子をＩＬ-２２Ｒポリペプチド又はＩＬ-１０Ｒβポリペプチドを発現する細胞と結合させる方法であって、前記細胞を前記生物活性分子と結合しているＩＬ-２２ポリペプチドと接触させ、前記ＩＬ-２２ポリペプチドと前記ＩＬ-２２Ｒ、又は前記ＩＬ-２２ポリペプチドと前記ＩＬ-１０Ｒβポリペプチドの結合を可能にすることを含んでなり、それによって前記生物活性分子と前記細胞を結合させる前記方法。
  5. 前記生物活性分子が毒素、放射標識又は抗体である、請求項４に記載の方法。
  6. 前記生物活性分子が前記細胞の死を引き起こす、請求項５に記載の方法。
  7. ＩＬ-２２Ｒポリペプチド又はＩＬ-１０Ｒβポリペプチドを発現する細胞の少なくとも１つの生物学的活性を調節する方法であって、前記細胞を（ａ）ＩＬ-２２ポリペプチド、（ｂ）抗-ＩＬ-２２Ｒポリペプチド抗体又は（ｃ）抗-ＩＬ-１０Ｒβポリペプチド抗体と接触させることを含み、前記（ａ）ＩＬ-２２ポリペプチド、（ｂ）抗-ＩＬ-２２Ｒポリペプチド抗体又は（ｃ）抗-ＩＬ-１０Ｒβポリペプチド抗体を前記ＩＬ-２２Ｒポリペプチド又はＩＬ-１０Ｒβポリペプチドと結合させることにより、前記細胞の少なくとも１つの生物活性を調節する方法。
  8. 前記細胞が死滅する、請求項７に記載の方法。
JP2006242365A 2000-08-24 2006-09-07 インターロイキン−２２ポリペプチド及びそれに結合する抗体の使用 Expired - Lifetime JP4602954B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/023328 WO2001016318A2 (en) 1999-09-01 2000-08-24 Secreted and transmembrane polypeptides and nucleic acids encoding the same

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2002522282A Division JP3886899B2 (ja) 2000-08-24 2001-05-30 インターロイキン−２２ポリペプチド、それをコードする核酸並びに膵臓疾患の治療方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010177460A Division JP2011019519A (ja) 2000-08-24 2010-08-06 インターロイキン−２２ポリペプチド、それをコードする核酸並びに膵臓疾患の治療方法

Publications (3)

Publication Number Publication Date
JP2007064987A JP2007064987A (ja) 2007-03-15
JP2007064987A5 true JP2007064987A5 (ja) 2008-07-17
JP4602954B2 JP4602954B2 (ja) 2010-12-22

Family

ID=21741709

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2005363921A Pending JP2006104212A (ja) 2000-08-24 2005-12-16 腫瘍の診断と治療のための組成物と方法
JP2006242365A Expired - Lifetime JP4602954B2 (ja) 2000-08-24 2006-09-07 インターロイキン−２２ポリペプチド及びそれに結合する抗体の使用
JP2006252159A Pending JP2007077155A (ja) 2000-08-24 2006-09-19 腫瘍の診断と治療のための組成物と方法
JP2010177460A Pending JP2011019519A (ja) 2000-08-24 2010-08-06 インターロイキン−２２ポリペプチド、それをコードする核酸並びに膵臓疾患の治療方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2005363921A Pending JP2006104212A (ja) 2000-08-24 2005-12-16 腫瘍の診断と治療のための組成物と方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2006252159A Pending JP2007077155A (ja) 2000-08-24 2006-09-19 腫瘍の診断と治療のための組成物と方法
JP2010177460A Pending JP2011019519A (ja) 2000-08-24 2010-08-06 インターロイキン−２２ポリペプチド、それをコードする核酸並びに膵臓疾患の治療方法

Country Status (6)

Country Link
EP (2) EP2014298A3 (ja)
JP (4) JP2006104212A (ja)
AT (1) ATE412009T1 (ja)
AU (1) AU2006230703A1 (ja)
DE (1) DE60136281D1 (ja)
ZA (2) ZA200301202B (ja)

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CA2710471C (en) 2007-12-26 2018-06-05 Biotest Ag Immunoconjugates targeting cd138 and uses thereof
KR101626416B1 (ko) 2007-12-26 2016-06-01 바이오테스트 아게 Ｃｄ138 표적 물질 및 이의 용도
CN101945892B (zh) 2007-12-26 2017-11-24 生物测试股份公司 用于改进对表达cd138的肿瘤细胞的靶向的方法和试剂
EP3546943A4 (en) * 2016-11-24 2020-09-16 Huvet Bio, Inc. DIAGNOSIS OF DISEASES
KR102536314B1 (ko) * 2018-05-23 2023-05-25 주식회사 휴벳바이오 질환의 진단용 조성물
ES2911075T3 (es) * 2018-11-07 2022-05-17 Applied Molecular Transport Inc Constructos de administración para transcitosis y métodos relacionados

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