JP2006528663A5 - - Google Patents
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- Publication number
- JP2006528663A5 JP2006528663A5 JP2006521860A JP2006521860A JP2006528663A5 JP 2006528663 A5 JP2006528663 A5 JP 2006528663A5 JP 2006521860 A JP2006521860 A JP 2006521860A JP 2006521860 A JP2006521860 A JP 2006521860A JP 2006528663 A5 JP2006528663 A5 JP 2006528663A5
- Authority
- JP
- Japan
- Prior art keywords
- zvegf3
- residues
- seq
- antibody
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 11
- 239000005557 antagonist Substances 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 3
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 230000005907 cancer growth Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002297 mitogenic effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49004703P | 2003-07-25 | 2003-07-25 | |
| US60/490,047 | 2003-07-25 | ||
| PCT/US2004/021835 WO2005011742A1 (en) | 2003-07-25 | 2004-07-09 | Method of treating hepatocellular carcinoma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006528663A JP2006528663A (ja) | 2006-12-21 |
| JP2006528663A5 true JP2006528663A5 (enExample) | 2007-11-08 |
| JP4709145B2 JP4709145B2 (ja) | 2011-06-22 |
Family
ID=34115347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006521860A Expired - Fee Related JP4709145B2 (ja) | 2003-07-25 | 2004-07-09 | 肝細胞癌を治療する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20050191304A1 (enExample) |
| EP (1) | EP1660135B1 (enExample) |
| JP (1) | JP4709145B2 (enExample) |
| AT (1) | ATE432716T1 (enExample) |
| CA (1) | CA2529798C (enExample) |
| DE (1) | DE602004021395D1 (enExample) |
| DK (1) | DK1660135T3 (enExample) |
| ES (1) | ES2326978T3 (enExample) |
| WO (1) | WO2005011742A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6893637B1 (en) * | 1999-10-21 | 2005-05-17 | Zymogenetics, Inc. | Method of treating fibrosis |
| CA2871528A1 (en) * | 2012-04-24 | 2013-10-31 | Thrombogenics N.V. | Anti-pdgf-c antibodies |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2354325C (en) * | 1998-12-07 | 2011-08-16 | Zymogenetics, Inc. | Growth factor homolog zvegf3 |
| US6432673B1 (en) * | 1998-12-07 | 2002-08-13 | Zymogenetics, Inc. | Growth factor homolog ZVEGF3 |
| US6893637B1 (en) * | 1999-10-21 | 2005-05-17 | Zymogenetics, Inc. | Method of treating fibrosis |
-
2004
- 2004-07-09 WO PCT/US2004/021835 patent/WO2005011742A1/en not_active Ceased
- 2004-07-09 JP JP2006521860A patent/JP4709145B2/ja not_active Expired - Fee Related
- 2004-07-09 DK DK04777732T patent/DK1660135T3/da active
- 2004-07-09 US US10/888,610 patent/US20050191304A1/en not_active Abandoned
- 2004-07-09 CA CA2529798A patent/CA2529798C/en not_active Expired - Fee Related
- 2004-07-09 DE DE602004021395T patent/DE602004021395D1/de not_active Expired - Lifetime
- 2004-07-09 AT AT04777732T patent/ATE432716T1/de active
- 2004-07-09 EP EP04777732A patent/EP1660135B1/en not_active Expired - Lifetime
- 2004-07-09 ES ES04777732T patent/ES2326978T3/es not_active Expired - Lifetime
-
2006
- 2006-10-24 US US11/552,228 patent/US20070054858A1/en not_active Abandoned
-
2008
- 2008-09-10 US US12/207,647 patent/US20090028865A1/en not_active Abandoned
-
2010
- 2010-03-23 US US12/729,941 patent/US20110052588A1/en not_active Abandoned