JP2006528144A5 - - Google Patents
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- Publication number
- JP2006528144A5 JP2006528144A5 JP2006520736A JP2006520736A JP2006528144A5 JP 2006528144 A5 JP2006528144 A5 JP 2006528144A5 JP 2006520736 A JP2006520736 A JP 2006520736A JP 2006520736 A JP2006520736 A JP 2006520736A JP 2006528144 A5 JP2006528144 A5 JP 2006528144A5
- Authority
- JP
- Japan
- Prior art keywords
- pramipexole
- active ingredient
- tts
- tts according
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 claims 20
- 229960003089 pramipexole Drugs 0.000 claims 20
- 239000004480 active ingredient Substances 0.000 claims 19
- 239000010410 layer Substances 0.000 claims 11
- 229920000642 polymer Polymers 0.000 claims 9
- 230000001575 pathological effect Effects 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 4
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 4
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 4
- 239000000178 monomer Substances 0.000 claims 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 3
- -1 polydimethylsiloxane Polymers 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000005793 Restless legs syndrome Diseases 0.000 claims 2
- 206010044565 Tremor Diseases 0.000 claims 2
- 230000001773 anti-convulsant effect Effects 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 206010013663 drug dependence Diseases 0.000 claims 2
- 230000004907 flux Effects 0.000 claims 2
- 239000012458 free base Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000002969 morbid Effects 0.000 claims 2
- 230000000324 neuroprotective effect Effects 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 229920000058 polyacrylate Polymers 0.000 claims 2
- 235000013772 propylene glycol Nutrition 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 230000007863 steatosis Effects 0.000 claims 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- JHPBZFOKBAGZBL-UHFFFAOYSA-N (3-hydroxy-2,2,4-trimethylpentyl) 2-methylprop-2-enoate Chemical group CC(C)C(O)C(C)(C)COC(=O)C(C)=C JHPBZFOKBAGZBL-UHFFFAOYSA-N 0.000 claims 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 229920002367 Polyisobutene Polymers 0.000 claims 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 1
- 125000005396 acrylic acid ester group Chemical group 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims 1
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
- QQQMUBLXDAFBRH-UHFFFAOYSA-N dodecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)O QQQMUBLXDAFBRH-UHFFFAOYSA-N 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
- 229920001083 polybutene Polymers 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10333393.2 | 2003-07-23 | ||
| DE10333393A DE10333393A1 (de) | 2003-07-23 | 2003-07-23 | Transdermales Therapeutisches System mit dem Wirkstoff Pramipexol |
| PCT/EP2004/007770 WO2005011687A1 (de) | 2003-07-23 | 2004-07-14 | Transdermales therapeutisches system mit dem wirkstoff pramipexol |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006528144A JP2006528144A (ja) | 2006-12-14 |
| JP2006528144A5 true JP2006528144A5 (enExample) | 2007-09-06 |
| JP4925823B2 JP4925823B2 (ja) | 2012-05-09 |
Family
ID=34088745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520736A Expired - Fee Related JP4925823B2 (ja) | 2003-07-23 | 2004-07-14 | プラミペキソール活性剤を含む経皮治療システム |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20060182791A1 (enExample) |
| EP (1) | EP1651215A1 (enExample) |
| JP (1) | JP4925823B2 (enExample) |
| KR (1) | KR20060113638A (enExample) |
| CN (1) | CN100450482C (enExample) |
| AU (1) | AU2004260583B2 (enExample) |
| BR (1) | BRPI0412240A (enExample) |
| CA (1) | CA2532904A1 (enExample) |
| DE (1) | DE10333393A1 (enExample) |
| WO (1) | WO2005011687A1 (enExample) |
| ZA (1) | ZA200600206B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602006009670D1 (de) * | 2005-08-15 | 2009-11-19 | Univ Virginia | Neurorestauration mit r(+) pramipexol |
| US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| ES2379117T3 (es) * | 2006-05-16 | 2012-04-20 | Knopp Neurosciences, Inc. | Composiciones de R(+) y S(-) pramipexol y métodos de utilización de las mismas |
| WO2008001200A2 (en) * | 2006-06-29 | 2008-01-03 | Antares Pharma Ipl Ag | Transdermal composition having enhanced color stability |
| US20080254118A1 (en) * | 2007-04-11 | 2008-10-16 | Hans-Werner Wernersbach | Process for preparing pramipexole dihydrochloride tablets |
| US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| WO2008113056A2 (en) | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
| CA2680800A1 (en) * | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Modified release formulations of (6r)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| US20080254117A1 (en) * | 2007-04-10 | 2008-10-16 | Noel Cotton | Process for preparing pramipexole dihydrochloride tablets |
| WO2010010141A1 (en) * | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Pramipexole for treating cardiomyopathy |
| CN102186350A (zh) | 2008-08-19 | 2011-09-14 | 诺普神经科学股份有限公司 | 使用(r)-普拉克索的组合物与方法 |
| JP5652867B2 (ja) * | 2009-11-20 | 2015-01-14 | 日東電工株式会社 | 医療用粘着剤組成物 |
| JP5665116B2 (ja) * | 2009-11-20 | 2015-02-04 | 日東電工株式会社 | 貼付剤および貼付製剤 |
| WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| DE102012205493A1 (de) | 2012-04-03 | 2013-10-10 | Acino Ag | Einen Dopamin-Agonisten enthaltendes transdermales Applikationssystem |
| US20140045801A1 (en) * | 2012-08-09 | 2014-02-13 | Mylan Inc. | Pramipexole transdermal delivery for severe headaches |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| EP2999444A4 (en) * | 2013-05-20 | 2016-10-12 | Mylan Inc | ADVANCED TRANSDERMAL DOSAGE OF PRAMIPEXOL FOR THE TREATMENT OF NEUROLOGICAL DISEASES |
| SMT202100119T1 (it) | 2013-07-12 | 2021-05-07 | Knopp Biosciences Llc | Trattamento dei livelli elevati di eosinofili e/o basofili |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| EP3038467B1 (en) | 2013-08-13 | 2020-07-29 | Knopp Biosciences LLC | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
| AU2014306597B2 (en) | 2013-08-13 | 2018-05-17 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
| CN103610666A (zh) * | 2013-12-11 | 2014-03-05 | 中国药科大学 | 一种盐酸普拉克索透皮贴剂及其制备方法 |
| MX2016011152A (es) * | 2014-02-27 | 2016-12-09 | Medrx Co Ltd | Parche transdermico que contiene pramipexol para tratamiento de enfermedad neurodegenerativa. |
| US9837244B2 (en) * | 2014-12-26 | 2017-12-05 | Industrial Technology Research Insitute | Sample holding device for studying light-driven reactions and sample analysis method using the same |
| CN104510725B (zh) * | 2015-01-22 | 2021-04-27 | 中国药科大学 | 一种普拉克索周效透皮贴剂及其制备方法 |
| EP3522843B1 (en) * | 2016-10-07 | 2022-09-21 | Transwell Biotech Co., Ltd. | Pramipexole transdermal delivery system and uses thereof |
| CN109999012A (zh) * | 2019-03-26 | 2019-07-12 | 大道隆达（北京）医药科技发展有限公司 | 一种普拉克索透皮贴剂及其制备方法 |
| CN111904950B (zh) * | 2019-05-07 | 2023-05-05 | 上海京新生物医药有限公司 | 一种普拉克索透皮贴剂 |
| CN117860708A (zh) * | 2022-10-11 | 2024-04-12 | 姜钦治 | 含有普拉克索和雷沙吉兰的透皮贴片 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3315272C2 (de) * | 1983-04-27 | 1986-03-27 | Lohmann Gmbh & Co Kg, 5450 Neuwied | Pharmazeutisches Produkt und Verfahren zu seiner Herstellung |
| US5238944A (en) * | 1988-12-15 | 1993-08-24 | Riker Laboratories, Inc. | Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine |
| DE3937271A1 (de) * | 1989-11-09 | 1991-05-16 | Boehringer Ingelheim Kg | Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol |
| US5650420A (en) * | 1994-12-15 | 1997-07-22 | Pharmacia & Upjohn Company | Pramipexole as a neuroprotective agent |
| US5562917A (en) * | 1994-12-23 | 1996-10-08 | Pentech Pharmaceuticals, Inc. | Transdermal administration of apomorphine |
| WO1996040087A2 (en) * | 1995-06-07 | 1996-12-19 | Cygnus, Inc. | Pressure sensitive acrylate adhesive composition cross-linked with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group |
| US6365178B1 (en) * | 1996-09-06 | 2002-04-02 | Watson Pharmaceuticals, Inc. | Method of making pressure sensitive adhesive matrix patches for transdermal drug delivery using hydrophilic salts of drugs and hydrophobic pressure sensitive adhesive dispersions |
| US6465004B1 (en) * | 1999-06-05 | 2002-10-15 | Noven Pharmaceuticals, Inc. | Solubility enhancement of drugs in transdermal drug delivery systems and methods of use |
| JP2003512414A (ja) * | 1999-10-28 | 2003-04-02 | スリーエム イノベイティブ プロパティズ カンパニー | 経皮薬物送達装置 |
| DE10033853A1 (de) * | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
| KR100846642B1 (ko) * | 2001-03-07 | 2008-07-16 | 히사미쓰 세이야꾸 가부시키가이샤 | 첩부제 |
| DE10137082A1 (de) * | 2001-07-28 | 2003-02-13 | Hexal Ag | Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol |
| DE10137162A1 (de) * | 2001-07-30 | 2003-02-20 | Hexal Ag | Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol |
-
2003
- 2003-07-23 DE DE10333393A patent/DE10333393A1/de not_active Ceased
-
2004
- 2004-07-14 WO PCT/EP2004/007770 patent/WO2005011687A1/de not_active Ceased
- 2004-07-14 KR KR1020067001495A patent/KR20060113638A/ko not_active Ceased
- 2004-07-14 CA CA002532904A patent/CA2532904A1/en not_active Abandoned
- 2004-07-14 BR BRPI0412240-2A patent/BRPI0412240A/pt not_active IP Right Cessation
- 2004-07-14 US US10/564,932 patent/US20060182791A1/en not_active Abandoned
- 2004-07-14 AU AU2004260583A patent/AU2004260583B2/en not_active Ceased
- 2004-07-14 CN CNB2004800210396A patent/CN100450482C/zh not_active Expired - Fee Related
- 2004-07-14 EP EP04740987A patent/EP1651215A1/de not_active Withdrawn
- 2004-07-14 JP JP2006520736A patent/JP4925823B2/ja not_active Expired - Fee Related
-
2006
- 2006-01-09 ZA ZA200600206A patent/ZA200600206B/en unknown
-
2012
- 2012-05-17 US US13/473,724 patent/US20120225103A1/en not_active Abandoned
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