JP2006527729A5 - - Google Patents
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- Publication number
- JP2006527729A5 JP2006527729A5 JP2006515988A JP2006515988A JP2006527729A5 JP 2006527729 A5 JP2006527729 A5 JP 2006527729A5 JP 2006515988 A JP2006515988 A JP 2006515988A JP 2006515988 A JP2006515988 A JP 2006515988A JP 2006527729 A5 JP2006527729 A5 JP 2006527729A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- dimethylbenzamide
- pyrrolidinyl
- thienyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 45
- -1 substituent halogen Chemical class 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
- 125000005842 heteroatom Chemical group 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 229940123583 Factor Xa inhibitor Drugs 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 230000001668 ameliorated effect Effects 0.000 claims 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
- 150000002367 halogens Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000000979 2-amino-2-oxoethyl group Chemical group [H]C([*])([H])C(=O)N([H])[H] 0.000 claims 1
- UFUJISJRGTVNEN-KAMXEHQASA-N 4-[(3s)-3-[[(e)-2-(5-chlorothiophen-2-yl)ethenyl]sulfonyl-methylamino]-2-oxopyrrolidin-1-yl]-3-fluoro-n,n-dimethylbenzamide Chemical compound FC1=CC(C(=O)N(C)C)=CC=C1N1C(=O)[C@@H](N(C)S(=O)(=O)\C=C\C=2SC(Cl)=CC=2)CC1 UFUJISJRGTVNEN-KAMXEHQASA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0314299.9A GB0314299D0 (en) | 2003-06-19 | 2003-06-19 | Chemical compounds |
| PCT/EP2004/006592 WO2004110435A1 (en) | 2003-06-19 | 2004-06-17 | 1-phenyl-2-oxo-3-sulfonylamino-pyrrolidine derivatives and related compounds as factor xa inhibitors for the treatment of acute vascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006527729A JP2006527729A (ja) | 2006-12-07 |
| JP2006527729A5 true JP2006527729A5 (enExample) | 2007-08-09 |
Family
ID=27636926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006515988A Withdrawn JP2006527729A (ja) | 2003-06-19 | 2004-06-17 | 急性血管疾患の治療用のｘａ因子阻害剤としての１−フェニル−２−オキソ−３−スルホニルアミノ−ピロリジン誘導体および関連化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7329685B2 (enExample) |
| EP (1) | EP1635817B1 (enExample) |
| JP (1) | JP2006527729A (enExample) |
| AT (1) | ATE345795T1 (enExample) |
| DE (1) | DE602004003380T2 (enExample) |
| ES (1) | ES2276307T3 (enExample) |
| GB (1) | GB0314299D0 (enExample) |
| WO (1) | WO2004110435A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0314370D0 (en) * | 2003-06-19 | 2003-07-23 | Glaxo Group Ltd | Chemical compounds |
| PE20071085A1 (es) * | 2005-11-24 | 2007-12-16 | Glaxo Group Ltd | COMPUESTOS 2-OXO-3-PIRRODINIL COMO INHIBIDORES DEL FACTOR Xa |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5202344A (en) | 1990-12-11 | 1993-04-13 | G. D. Searle & Co. | N-substituted lactams useful as cholecystokinin antagonists |
| US6034093A (en) | 1995-06-07 | 2000-03-07 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted sulfonic acid N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds |
| US5827875A (en) | 1996-05-10 | 1998-10-27 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| EP1294684A2 (en) | 2000-06-29 | 2003-03-26 | Bristol-Myers Squibb Pharma Company | THROMBIN OR FACTOR Xa INHIBITORS |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| US6348600B1 (en) | 2001-02-20 | 2002-02-19 | Toray Industries, Inc. | Methods for making optically active 3-aminopyrrolidine-2,5-dione derivative and optically active 3-aminopyrrolidine derivative |
| AU2002303264A1 (en) | 2001-04-09 | 2002-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic inhibitors of factor xa |
| GB0127568D0 (en) | 2001-11-16 | 2002-01-09 | Glaxo Group Ltd | Chemical compounds |
| GB0130705D0 (en) | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Chemical compounds |
| TW200307667A (en) * | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
-
2003
- 2003-06-19 GB GBGB0314299.9A patent/GB0314299D0/en not_active Ceased
-
2004
- 2004-06-17 JP JP2006515988A patent/JP2006527729A/ja not_active Withdrawn
- 2004-06-17 WO PCT/EP2004/006592 patent/WO2004110435A1/en not_active Ceased
- 2004-06-17 ES ES04736979T patent/ES2276307T3/es not_active Expired - Lifetime
- 2004-06-17 DE DE602004003380T patent/DE602004003380T2/de not_active Expired - Fee Related
- 2004-06-17 US US10/561,545 patent/US7329685B2/en not_active Expired - Fee Related
- 2004-06-17 AT AT04736979T patent/ATE345795T1/de not_active IP Right Cessation
- 2004-06-17 EP EP04736979A patent/EP1635817B1/en not_active Expired - Lifetime