JP2006527185A5 - - Google Patents

Info

Publication number

JP2006527185A5

JP2006527185A5 JP2006508438A JP2006508438A JP2006527185A5 JP 2006527185 A5 JP2006527185 A5 JP 2006527185A5 JP 2006508438 A JP2006508438 A JP 2006508438A JP 2006508438 A JP2006508438 A JP 2006508438A JP 2006527185 A5 JP2006527185 A5 JP 2006527185A5

Authority

JP

Japan

Prior art keywords

glycyrrhizin

derivative

agent

sars

membered heterocycle

Prior art date

2004-06-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 19
• 125000000623 heterocyclic group Chemical group 0.000 claims description 10
• 150000003839 salts Chemical class 0.000 claims description 6
• 150000001875 compounds Chemical class 0.000 claims description 4
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 3
• LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims 14
• 229960004949 glycyrrhizic acid Drugs 0.000 claims 14
• 239000004378 Glycyrrhizin Substances 0.000 claims 12
• 239000003795 chemical substances by application Substances 0.000 claims 12
• UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims 12
• 235000019410 glycyrrhizin Nutrition 0.000 claims 12
• 241000008910 Severe acute respiratory syndrome-related coronavirus Species 0.000 claims 8
• 239000004480 active ingredient Substances 0.000 claims 5
• 208000001528 Coronaviridae Infections Diseases 0.000 claims 4
• 229940079593 drug Drugs 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 239000003443 antiviral agent Substances 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 125000000896 monocarboxylic acid group Chemical group 0.000 claims 2
• 239000002245 particle Substances 0.000 claims 2
• 230000003449 preventive effect Effects 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 230000000069 prophylactic effect Effects 0.000 claims 2
• 208000024891 symptom Diseases 0.000 claims 2
• AYORUWNJMKYNAD-JEDNCBNOSA-N 2-aminoacetic acid;(2s)-2-amino-4-methylpentanoic acid Chemical compound NCC(O)=O.CC(C)C[C@H](N)C(O)=O AYORUWNJMKYNAD-JEDNCBNOSA-N 0.000 claims 1
• IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
• FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
• 208000026278 immune system disease Diseases 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 229960000329 ribavirin Drugs 0.000 claims 1
• HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 229940035893 uracil Drugs 0.000 claims 1