CA2527989A1 - Glycyrrhizin or derivatives thereof for treating or preventing severe acute respiratory syndrome (sars) - Google Patents
Glycyrrhizin or derivatives thereof for treating or preventing severe acute respiratory syndrome (sars) Download PDFInfo
- Publication number
- CA2527989A1 CA2527989A1 CA002527989A CA2527989A CA2527989A1 CA 2527989 A1 CA2527989 A1 CA 2527989A1 CA 002527989 A CA002527989 A CA 002527989A CA 2527989 A CA2527989 A CA 2527989A CA 2527989 A1 CA2527989 A1 CA 2527989A1
- Authority
- CA
- Canada
- Prior art keywords
- glycyrrhizin
- sars
- derivative
- infection
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
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- 125000004305 thiazinyl group Chemical group S1NC(=CC=C1)* 0.000 description 1
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- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- ZEMGGZBWXRYJHK-UHFFFAOYSA-N thiouracil Chemical compound O=C1C=CNC(=S)N1 ZEMGGZBWXRYJHK-UHFFFAOYSA-N 0.000 description 1
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- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
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- 229960004764 zafirlukast Drugs 0.000 description 1
- MWLSOWXNZPKENC-SSDOTTSWSA-N zileuton Chemical compound C1=CC=C2SC([C@H](N(O)C(N)=O)C)=CC2=C1 MWLSOWXNZPKENC-SSDOTTSWSA-N 0.000 description 1
- 229960005332 zileuton Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910000166 zirconium phosphate Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47690803P | 2003-06-06 | 2003-06-06 | |
| US60/476,908 | 2003-06-06 | ||
| PCT/IB2004/002393 WO2004108122A1 (en) | 2003-06-06 | 2004-06-07 | Glycyrrhizin or derivatives thereof for treating or preventing severe acute respiratory syndrome (sars) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2527989A1 true CA2527989A1 (en) | 2004-12-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002527989A Abandoned CA2527989A1 (en) | 2003-06-06 | 2004-06-07 | Glycyrrhizin or derivatives thereof for treating or preventing severe acute respiratory syndrome (sars) |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070099855A1 (enExample) |
| EP (2) | EP1660059A1 (enExample) |
| JP (1) | JP2006527185A (enExample) |
| KR (1) | KR20060025549A (enExample) |
| CN (1) | CN1838947A (enExample) |
| CA (1) | CA2527989A1 (enExample) |
| WO (1) | WO2004108122A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111084806A (zh) * | 2020-02-13 | 2020-05-01 | 遵义医科大学 | 一种治疗或预防冠状病毒感染的药物组合物 |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110009352A1 (en) * | 2009-07-09 | 2011-01-13 | Minophagen Pharmaceutical Co., Ltd. | Restorative agent for antibacterial peptide production ability |
| EP2726606A1 (en) * | 2011-06-28 | 2014-05-07 | Leukocare Ag | Novel stabilisation method for viruses or bacteria |
| RU2504397C1 (ru) * | 2012-10-25 | 2014-01-20 | Леонид Леонидович Клопотенко | Фармацевтическая композиция, содержащая фермент рибонуклеазу и глицирризиновую кислоту или ее соли: глицирризинат аммония, или дикалия, или тринатрия |
| US12447166B2 (en) | 2016-02-25 | 2025-10-21 | Applied Biological Laboratories, Inc. | Compositions and methods for protecting against airborne pathogens and irritants |
| MY200875A (en) | 2016-02-25 | 2024-01-20 | Applied Biological Laboratories Inc | Compositions and methods for protecting against airborne pathogens and irritants |
| CN106420695A (zh) * | 2016-09-09 | 2017-02-22 | 南京农业大学 | 甘草素抗猪流行性腹泻病毒感染的应用 |
| CN111686253A (zh) * | 2020-02-20 | 2020-09-22 | 田中民 | 一种预防和消杀冠状病毒的新方法 |
| WO2021188504A1 (en) * | 2020-03-18 | 2021-09-23 | Flow Pharma, Inc. | Injectable formulation of poly(lactic-co-glycolic (plga)) microspheres encapsulating siltuximab |
| US20230218548A1 (en) * | 2020-03-19 | 2023-07-13 | Eumentis Therapeutics, Inc. | Nitro-aminoadamantane compounds for the treatment of betacoronavirus infections |
| EP3888662A1 (en) * | 2020-04-02 | 2021-10-06 | Vossensteyn | Compounds, compositions and devices for use in the treatment of coronavirus infections |
| EP4144363A4 (en) * | 2020-04-27 | 2024-05-29 | Guangzhou Century Clinical Research Co., Ltd | Drug, food and application of anti-coronavirus infection |
| CN112135625B (zh) * | 2020-04-27 | 2021-07-06 | 广州新创忆药物临床研究有限公司 | 一种预防或治疗covid-19新冠肺炎的药物及其应用 |
| EP3939585A4 (en) * | 2020-05-20 | 2022-03-02 | Syntekabio, Inc. | PREVENTIVE OR THERAPEUTIC COMPOSITION FOR INFECTIOUS DISEASES WITH SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 |
| KR102169476B1 (ko) * | 2020-05-20 | 2020-10-23 | (주)신테카바이오 | 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물 |
| GB202007928D0 (en) * | 2020-05-27 | 2020-07-08 | Attgeno Ab | New uses and methods |
| WO2022051557A1 (en) * | 2020-09-02 | 2022-03-10 | Applied Biological Laboratories, Inc. | Glycyrrhizin for the treatment or prophylaxis of viral infection |
| CN112457363B (zh) * | 2020-11-23 | 2021-12-24 | 华南农业大学 | 一种马铃薯三糖齐墩果酸皂苷衍生物及其制备方法和应用 |
| CN115192590B (zh) * | 2021-04-13 | 2023-10-20 | 北京大学 | 甘草皂苷a3对新型冠状病毒刺突蛋白的抑制及其药物用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0312222B1 (en) * | 1987-10-14 | 1992-08-05 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of diseases caused by viruses |
| US5156973A (en) * | 1988-11-23 | 1992-10-20 | Edward Shanbrom | Antiviral blood sampling process and apparatus |
| JP3007665B2 (ja) * | 1990-09-18 | 2000-02-07 | 日清製粉株式会社 | コロナウィルス感染症の予防および治療剤ならびに消毒薬 |
| RU2024542C1 (ru) * | 1991-03-04 | 1994-12-15 | Институт органической химии РАН | ГЛИКОПЕПТИД β-ГЛИЦИРРИЗИНОВОЙ КИСЛОТЫ С МЕТИЛОВЫМ ЭФИРОМ ГЛИЦИЛ-L-ВАЛИНА, ПРОЯВЛЯЮЩИЙ АНТИ-СПИД-АКТИВНОСТЬ |
| US5356880A (en) * | 1991-05-30 | 1994-10-18 | Sanwa Kagaku Kenkyusho Co., Ltd. | Glycyrrhetinic acid derivatives |
-
2004
- 2004-06-07 CN CNA2004800190316A patent/CN1838947A/zh active Pending
- 2004-06-07 JP JP2006508438A patent/JP2006527185A/ja not_active Withdrawn
- 2004-06-07 CA CA002527989A patent/CA2527989A1/en not_active Abandoned
- 2004-06-07 US US10/559,495 patent/US20070099855A1/en not_active Abandoned
- 2004-06-07 KR KR1020057023445A patent/KR20060025549A/ko not_active Withdrawn
- 2004-06-07 EP EP04744051A patent/EP1660059A1/en not_active Withdrawn
- 2004-06-07 EP EP06010935A patent/EP1719515A3/en not_active Withdrawn
- 2004-06-07 WO PCT/IB2004/002393 patent/WO2004108122A1/en not_active Ceased
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111084806A (zh) * | 2020-02-13 | 2020-05-01 | 遵义医科大学 | 一种治疗或预防冠状病毒感染的药物组合物 |
| CN111084806B (zh) * | 2020-02-13 | 2021-09-07 | 遵义医科大学 | 一种治疗或预防冠状病毒感染的药物组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1719515A2 (en) | 2006-11-08 |
| US20070099855A1 (en) | 2007-05-03 |
| KR20060025549A (ko) | 2006-03-21 |
| EP1719515A3 (en) | 2006-11-29 |
| JP2006527185A (ja) | 2006-11-30 |
| EP1660059A1 (en) | 2006-05-31 |
| CN1838947A (zh) | 2006-09-27 |
| WO2004108122A1 (en) | 2004-12-16 |
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