JP2006524187A - 哺乳類のケラチン組織の外観を改善する手段 - Google Patents
哺乳類のケラチン組織の外観を改善する手段 Download PDFInfo
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- JP2006524187A JP2006524187A JP2005518371A JP2005518371A JP2006524187A JP 2006524187 A JP2006524187 A JP 2006524187A JP 2005518371 A JP2005518371 A JP 2005518371A JP 2005518371 A JP2005518371 A JP 2005518371A JP 2006524187 A JP2006524187 A JP 2006524187A
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- 229960000401 tranexamic acid Drugs 0.000 description 1
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Classifications
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Abstract
Description
既存の技術には、本発明の利点及び効果をすべて提供する包装製品は開示されていない。
a)1つまたは複数の次のものを含む経口消費に好適な製品:
i)安全且つ有効な量の1つまたは複数の必須脂肪酸;
ii)安全且つ有効な量の糖アミン又はこれらの製薬上許容できる塩;及び
iii)安全且つ有効な量の酸化防止剤、
b)皮膚及び/又は毛髪への局所適用に好適な製品、
ここで、a)及びb)は個々に含まれた後、単一形態で共に包装される。
a)1つまたは複数の次のもの:安全且つ有効な量の1つまたは複数の脂肪酸;安全且つ有効な量の糖アミン又はこれらの製薬上許容できる塩;及び安全且つ有効な量の酸化防止剤;を含む経口消費に好適な製品を哺乳類に1日約3回経口投与する工程;
b)皮膚及び/又は毛髪に適用するのに好適な製品を前記哺乳類に1日約2回局所適用する工程。
本明細書で使用する百分率及び割合はすべて総組成物の重量によるものであり、測定はすべて他に明示されない限り、25℃で行われる。
本明細書で引用する全ての刊行物は、その全体を参考として本明細書に組み込む。
本発明の必須及び任意の構成成分を含むキットを、以下で詳細に記載する。
(I)必須脂肪酸
本発明のキットは、安全且つ有効な量の1つまたは複数の必須脂肪酸を含む経口消費に好適な製品を含むことができる。本明細書で使用するとき、「必須脂肪酸」とは、体が生成できないので食事に必須であり、ω−3脂肪酸又はω−6脂肪酸のいずれかとして分類される脂肪のことを指す。好ましくは、1日の用量は、少なくとも約0.1g〜約3g、より好ましくは約0.75g〜約2.5g、さらにより好ましくは約1g〜約2gの必須脂肪酸である。
本明細書で有用なω−6脂肪酸の例としては、リノール酸、γ−リノレン酸、アラキドン酸、及びこれらの混合物が挙げられる。好ましくは、ω−6脂肪酸は、γ−リノレン酸である。
さらに、2つ以上の必須脂肪酸の組み合わせを使用してもよい。
本発明のキットは、安全且つ有効な量の糖アミン又はこれらの製薬上許容できる塩を含む経口消費に好適な製品を含む。本明細書で使用するとき、「糖アミン」とは、6炭素の糖のアミン誘導体のことをいう。好ましくは、1日の用量は、約0.1g〜約3g、より好ましくは約0.75g〜約2.5g、さらにより好ましくは約1g〜約2gの糖アミンある。
本発明のキットは、安全且つ有効な量の酸化防止剤を含む経口消費に好適な製品を含む。好ましくは、1日の用量は、約0.00001g〜約1g、より好ましくは約0.0001g〜約0.5g、さらにより好ましくは約0.0005g〜約0.1gの酸化防止剤である。
本発明のキットはまた、安全且つ有効な量のビタミン又はプロビタミン(例えば、β−カロテン)を含む経口消費に好適な製品を含むことができる。好ましくは、1日の用量は、約0.00001g〜約1g、より好ましくは約0.0001g〜約0.5g、さらにより好ましくは約0.0005g〜約0.1gのビタミンである。
本明細書で有用なビタミンB化合物の例としては、ビタミンB1、ビタミンB2、ビタミンB3、ビタミンB5、ビタミンB6、ビタミンB12、ビタミンB15、これらの誘導体、及びこれらの混合物が挙げられる。
ビタミン化合物は、実質的には純粋な物質として、又は自然源(例えば、植物)から好適な物理的及び/もしくは化学的単離をすることによって得られる抽出物として、含まれてもよい。
ビタミンB6化合物が、本発明のキットに存在する場合、1日の用量は、約0.00001g〜約1g、より好ましくは約0.0001g〜約0.5g、さらにより好ましくは約0.0005g〜約0.1gのビタミンB6化合物である。
本発明のキットはまた、微量栄養素金属を含んでいてもよい。本明細書で使用するとき、「微量栄養素金属」とは、適切な全栄養に必要な栄養素を哺乳類の体に与える金属のことを指す。好ましくは、1日の用量は、約0.00001g〜約1g、より好ましくは約0.0001g〜約0.5g、さらにより好ましくは約0.0005g〜約0.1gの微量栄養素金属である。
本発明のキットはまた、プロバイオティクス菌を含んでいてもよい。本明細書で使用するとき、「プロバイオティクス菌」とは、腸管の健康及びバランスに寄与する有機体のことを指す。好ましくは、1日の用量は、約0.00001g〜約1g、より好ましくは約0.0001g〜約0.5g、さらにより好ましくは約0.0005g〜約0.1gのプロバイオティクス菌である。
本明細書に有用なプロバイオティクス菌の例としては、乳酸桿菌及びビフィズス菌が挙げられる。加えて、2つ以上のプロバイオティクス菌の組み合わせを使用してもよい。
本発明のキットはまた、プレバイオティクスを含んでいてもよい。本明細書で使用するとき、「プレバイオティクス」とは、バクテリア(すなわち、プロバイオティクス菌)が送り込まれる基質のことを指す。好ましくは、1日の用量は、約0.00001g〜約1g、より好ましくは約0.0001g〜約0.5g、さらにより好ましくは約0.0005g〜約0.1gのプレバイオティクスである。
本明細書に有用なプレバイオティクスの例としては、イヌリン及びフラクトオリゴ糖が挙げられる。加えて、2つ以上のプレバイオティクスの組み合わせを使用してもよい。
本発明のキットは、哺乳類のケラチン組織に局所適用できるスキン及び/又はヘアケア製品を含む。本明細書に有用なこうした製品の例としては、化粧用クリーム、顔及び/又は身体用保湿剤、顔及び/又は身体用洗浄剤、シャンプー、コンディショナー、ヘアボリューム増加剤、ヘアスプレー、毛髪光沢剤、染毛剤、ジェル、ポマード、ローションなどが挙げられるが、これらに限定されない。
本発明の局所適用組成物は、所与の製品の種類に従来用いられる他の様々な成分を、それらが本発明の効果を容認できないほど変更しないという条件で含有してもよい。
安全且つ有効な量、より好ましくは組成物の約0.01重量%〜約10重量%、さらにより好ましくは約0.5重量%〜約5重量%、また好ましくは約0.1重量%〜約2重量%の落屑活性物質を本発明の組成物に添加してもよい。落屑活性物質は、本発明の皮膚外観効果を増進させる。例えば、落屑活性物質は皮膚のきめ(例えば、滑らかさ)を改善する傾向がある。本明細書に用いるのに好適な1つの落屑系は、スルフヒドリル化合物及び双性界面活性剤を含み、PCT特許出願95/08136(PCT Application No.U.S.95/08136)(1995年6月29日出願)に相当する同時係属の出願番号08/480,632(ドナルド・L・ビッセット(Donald L.Bissett)、1995年6月7日出願)に記載されている。本明細書での使用に好適な別の落屑系は、サリチル酸及び双性界面活性剤を含み、PCT特許出願94/12745(PCT Application No.94/12745)(1994年11月4日出願、1995年5月18日公開)に対応し、出願番号08/209,401(ビセット(Bissett)、1994年3月9日出願)の継続である、同時係属の特許出願番号08/554,944(1995年11月13日出願)に記載されている。これらの特許出願に記載されているような双性界面活性剤はまた、本明細書においても落屑剤として有用であり、セチルベタインが特に好ましい。
本発明の組成物は、安全且つ有効な量の1つまたは複数の抗ニキビ活性物質を含んでもよい。有用な抗ニキビ活性物質の例には、レゾルシノール、イオウ、サリチル酸、エリスロマイシン、亜鉛などが挙げられる。好適な抗ニキビ活性物質のさらなる例は、米国特許第5,607,980号(マックアティ(McAtee)ら、1997年3月4日発行)にさらに詳細に記載されている。
本発明の組成物は、安全且つ有効な量の1つもしくは複数の抗しわ活性物質又は抗皮膚萎縮活性物質をさらに含んでもよい。本発明の組成物に用いるのに好適な代表的な抗しわ/抗皮膚萎縮活性物質には、イオウ含有D及びLアミノ酸及びこれらの誘導体と塩、特にN−アセチル誘導体が挙げられ、その好ましい例は、N−アセチル−L−システインであり;チオール、例えば、エタンチオール;ヒドロキシ酸(例えば、サリチル酸、グリコール酸)、ケト酸(例えば、ピルビン酸)、アスコルビン酸(ビタミンC)、フィチン酸、リポ酸;リソフォスファチド酸、皮膚剥離剤(例えば、フェノールなど)、フラボノイド(例えば、フラバノン、カルコン、イソフラボン、フラボンなど)、スチルベン、シンナメート、レスベラトロル、カイネチン、ゼアチン、ジメチルアミノエタノール、自然源(例えば、大豆ペプチド)からのペプチド、糖酸の塩(例えば、グルコン酸マンガン)、テルペンアルコール(例えば、ファルネソール)、特にケラチン組織の状態、例えば、皮膚の状態を調整する場合に本発明のケラチン組織の外観の効果を強化するペプチド及びレチノイド、並びにその他のビタミンB化合物(例えば、チアミン(ビタミンB1)、パントテン酸(ビタミンB5)、カルニチン(ビタミンBt)、リボフラビン(ビタミンB2)、コバラミン(ビタミンB12)、パンガム酸又はジイソプロピルアミンジクロロアセテート(ビタミンB15群)、並びにこれらの誘導体及び塩(例えば、HCl塩又はカルシウム塩))が挙げられる。
本発明の組成物は、安全且つ有効な量の酸化防止剤/ラジカルスカベンジャーを含んでもよい。酸化防止剤/ラジカルスカベンジャーは、鱗屑の剥がれの増加又は角質層のきめの変化の原因となり得る紫外線に対して、またその他の皮膚損傷の原因となり得る環境要因に対して、特に有用に防御する。
本発明の組成物はまた、安全且つ有効な量のキレーター又はキレート剤を含んでもよい。本明細書で使用するとき、「キレーター」又は「キレート剤」とは、金属イオンが容易に化学反応に加わったり、化学反応を触媒したりしないように、錯体を形成することによって系から金属イオンを除くことができる活性物質を意味する。キレート剤を含むことは、過剰な鱗屑又はきめの変化の一因となり得るような紫外線照射から、また皮膚の損傷を起こし得るようなその他の環境化学物質から、保護するためにとりわけ有用である。
本発明の組成物は、任意にフラボノイド化合物を含んでもよい。フラボノイドは、米国特許第5,686,082号及び第5,686,367号に広範に開示されており、これらを共に本明細書に参考として組み込む。本発明で使用するのに適しているフラボノイドの例は、非置換フラバノン、モノ−置換フラバノン、及びこれらの混合物からなる群から選択されるフラバノン;非置換カルコン、モノ−置換カルコン、ジ−置換カルコン、トリ−置換カルコン、及びこれらの混合物からなる群から選択されるカルコン;非置換フラボン、モノ−置換フラボン、ジ−置換フラボン、及びこれらの混合物からなる群から選択されるフラボン;1つまたは複数のイソフラボン;非置換クマリン、モノ−置換クマリン、ジ−置換クマリン、及びこれらの混合物からなる群から選択されるクマリン;非置換クロモン、モノ−置換クロモン、ジ−置換クロモン、及びこれらの混合物からなる群から選択されるクロモン;1つまたは複数のジクマロール;1つまたは複数のクロマノン;1つまたは複数のクロマノール;これらの異性体(例えば、シス/トランス異性体);並びにこれらの混合物である。本明細書で使用するとき、用語「置換した」とは、フラボノイドの1個又は複数個の水素原子が独立して、ヒドロキシル、C1〜C8アルキル、C1〜C4アルコキシル、O−グリコシド等、又はこれら置換基の混合で置換されるフラボノイドを意味する。
本明細書に記載したフラボノイド化合物は、本発明中では、好ましくは約0.01%〜約20%、さらに好ましくは約0.1%〜約10%、最も好ましくは約0.5%〜約5%の濃度で存在している。
安全且つ有効な量の抗炎症剤を本発明の組成物に加えることができ、その量は、好ましくは組成物の約0.01%〜約10%、より好ましくは約0.5%〜約5%である。抗炎症剤は、本発明における皮膚の外観に関する利点を高め、例えばそのような薬剤は、さらに均一で好ましい皮膚の色調又は色に寄与する。そのような薬剤は効力が様々に異なるために、組成物中で使用される抗炎症剤の正確な量は、利用する特定の抗炎症剤によって決まる。
組成物に有用な第二の部類の抗炎症剤は、非ステロイド性抗炎症剤を含む。この群に含まれる様々な化合物は、当業者に周知である。非ステロイド性抗炎症剤の化学的構造、合成、副作用などの詳細な開示については、抗炎症及び抗リウマチ薬(Anti-inflammatory and Anti-Rheumatic Drugs)、K.D.レインスフォード(K.D.Rainsford)、第I〜III巻、CRCプレス(CRC Press)、ボーカラトーン(Boca Raton)、(1985)、及び抗炎症剤、化学及び薬理学(Anti-inflammatory Agents,Chemistry and Pharmacology)、1、R.A.シェラー(R.A.Scherrer)ら、アカデミック・プレス(Academic Press)、ニューヨーク(1974)を含む標準教科書を参照してもよい。
これらの抗炎症剤の活性構成成分(例えば、ビアボロール、グリチルレチネートエステル)はさらに、自然源の抽出物から得られるか又は合成により調製されてもよい。
本発明の組成物はまた、安全且つ有効な量の抗セルライト剤を含んでもよい。好適な抗セルライト剤としては、キサンチン化合物(例えば、カフェイン、テオフィリン、テオブロミン、及びアミノフィリン)を挙げることができるが、これらに限定されない。
本発明の組成物はまた、安全且つ有効な量の局所麻酔剤を含んでもよい。局所麻酔剤の例としては、ベンゾカイン、リドカイン、ブピバカイン、クロルプロカイン、ジブカイン、エチドカイン、メピバカイン、テトラカイン、ジクロニン、ヘキシルカイン、プロカイン、コカイン、ケタミン、プロモキシン、フェノール、及び製薬上許容できるこれらの塩が挙げられる。
本発明の組成物は、日焼け活性物質を含んでもよい。存在する場合、組成物は、組成物の約0.1重量%〜約20重量%、さらに好ましくは約2重量%〜約7重量%、最も好ましくは約3重量%〜約6重量%のジヒドロキシアセトンを人工の日焼け活性物質として含むのが好ましい。
本発明の組成物は美白剤を含んでもよい。使用する場合、組成物は、好ましくは組成物の約0.1重量%〜約10重量%、より好ましくは約0.2重量%〜約5重量%、さらに好ましくは約0.5重量%〜約2重量%の美白剤を含む。好適な美白剤としては、コウジ酸、アルブチン、トラネキサム酸、アスコルビン酸及び誘導体、例えば、アスコルビン酸リン酸マグネシウム、アスコルビン酸リン酸ナトリウム、又はリン酸アスコルビルのその他の塩、アスコルビルグルコシドなどを含む、当該技術分野において既知のものが挙げられる。本明細書に用いるのに好適な他の美白物質としては、ウンデシルエノイルフェニルアラニン(SEPPICからのセピホワイト(Sepiwhite)(登録商標))、アロエシン(aloesin)、アクチホワイト(Actiwhite)(登録商標)(コーニス(Cognis))、エンブリカ(Emblica)(登録商標)(??)、及びアゼログリシナ(Azeloglicina)(??)が挙げられる。本明細書に用いるのに好適な美白剤にはまた、同時係属中の特許出願番号08/479,935(ヒレブランド(Hillebrand)、1995年6月7日出願(PCT特許出願U.S.95/07432((PCT Application No.U.S.95/07432))(1995年6月12日出願)に対応);及び同時係属中の特許出願番号08/390,152(カラL.クバルンズ(Kalla L.Kvalnes)、ミッチェルA.デロング(Mitchell A.DeLong)、バートンJ.ブラッドバリー(Barton J.Bradbury)、カーチスB.モートレイ(Curtis B.Motley)、及びジョンD.カーター(John D.Carter)、1995年2月24日出願(PCT特許出願U.S.95/02809(PCT Application No.U.S.95/02809)(1995年3月1日出願、1995年9月8日公開)に対応)に記載されるものが含まれる。
本発明の組成物は、抗菌又は抗カビ活性物質を含んでもよい。このような活性物質は、微生物を駆除し、微生物の発生を防止し、又は微生物の病原作用を防止し得る。安全且つ有効な量の抗菌又は抗カビ活性物質は、本発明の組成物に、好ましくは約0.001%〜約10%、さらに好ましくは約0.01%〜約5%、最も好ましくは約0.05%〜約2%加えてもよい。
紫外線に曝されることによって、角質層の過度の鱗屑ときめの変化を招き得る。したがって、本発明の組成物は、任意に日焼け止め活性物質を含有してもよい。本明細書で使用するとき、「日焼け止め活性物質」とは、日焼け止め剤及び物理的日焼け防止剤の両方を含む。好適な日焼け止め活性物質は、有機又は無機であってよい。
本発明の組成物は、湿潤剤、加湿剤、又は皮膚コンディショナーからなる群から選択されるコンディショニング剤を含んでもよい。これらの様々な物質を使用することができ、それぞれ、組成物の約0.01重量%〜約20重量%、より好ましくは約0.1重量%〜約10重量%、最も好ましくは約0.5重量%〜約7重量%の濃度で存在し得る。これらの物質には、グアニジン;尿素;グリコール酸及びグリコール酸塩(例えば、アンモニウム及び四級アルキルアンモニウム);サリチル酸;乳酸及び乳酸塩(例えば、アンモニウム及び四級アルキルアンモニウム);様々な形態のうちのいずれかのアロエベラ(例えば、アロエベラゲル);ソルビトール、マンニトール、グリセロール、ヘキサントリオール、ブタントリオール、プロピレングリコール、ブチレングリコール、ヘキシレングリコールなどのようなポリヒドロキシ化合物;ポリエチレングリコール;糖類(例えば、メリビオース)及びデンプン;糖及びデンプン誘導体(例えば、アルコキシル化グルコース、フルクトース、スクロースなど);ヒアルロン酸;ラクトアミドモノエタノールアミン;アセトアミドモノエタノールアミン;並びにこれらの混合物が挙げられるが、これらに限定されない。本明細書に有用なものはまた、米国特許第4,976,953号(オーア(Orr)ら、1990年12月11日発行)に記載されるプロポキシル化グリセロールである。
本発明の組成物は、好ましくは組成物の約0.1重量%〜約5重量%、より好ましくは約0.1重量%〜約3重量%、最も好ましくは約0.25重量%〜約2重量%の1つまたは複数の濃厚剤を含むことができる。
非限定的な濃厚剤の種類は以下からなる群から選択されるものが挙げられる:
(i)カルボン酸ポリマー
このポリマーは、アクリル酸、置換アクリル酸、及びこれらのアクリル酸や置換アクリル酸の塩及びエステルに由来する1つまたは複数のモノマーを含有する架橋した化合物であるが、ここで架橋剤は2つ以上の炭素間二重結合を含有し、また多価アルコールに由来する。本発明に有用なポリマーは、米国特許第5,087,445号(ハフィ(Haffey)ら、1992年2月11日発行);米国特許第4,509,949号(ハング(Huang)ら、1985年4月5日発行);米国特許第2,798,053号(ブラウン(Brown)、1957年7月2日発行);及びCTFA国際化粧品製品辞書(CTFA International Cosmetic Ingredient Dictionary)、第4版、1991年、12及び80頁により完全に記載されている。
本発明の組成物は、陽イオン性及び非イオン性ポリマーを含む、増粘剤又はゲル化剤として有用な架橋ポリアクリレートポリマーを任意に含むことができるが、陽イオン性ポリマーが一般に好ましい。有用な架橋非イオン性ポリアクリレートポリマー及び架橋陽イオン性ポリアクリレートポリマーの例は、米国特許第5,100,660号(ハウ(Hawe)ら、1992年3月31日発行);米国特許第4,849,484号(ハード(Heard)、1989年7月18日発行);米国特許第4,835,206号(ファーラー(Farrar)ら、1989年5月30日発行);米国特許第4,628,078号(グローバー(Glover)ら、1986年12月9日発行);米国特許第4,599,379号(フレッシャー(Flesher)ら、1986年7月8日発行);及びEP228,868(ファーラー(Farrar)ら、1987年7月15日発行)に記載されるものである。
本発明の組成物は、ポリアクリルアミドポリマー、特に置換分枝又は非分枝ポリマーを含む、非イオン性ポリアクリルアミドポリマーを任意に含むことができる。これらのポリアクリルアミドポリマーのうち最も好ましいのは、非イオン性ポリマーであるCTFA指定ポリアクリルアミド及びイソパラフィン及びラウレス7であり、商品名セピゲル(Sepigel)305でセピック社(Seppic Corporation)(ニュージャージー州フェアフィールド(Fairfield))より市販されている。
多種多様な多糖類が本明細書で有用である。「多糖類」とは、繰り返す糖(すなわち、炭水化物)単位の主鎖を含有するゲル化剤のことをいう。多糖類ゲル化剤の非限定的な例としては、セルロース、カルボキシメチルヒドロキシエチルセルロース、プロピオン酸カルボン酸セルロースアセテート、ヒドロキシエチルセルロース、ヒドロキシエチルエチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、メチルヒドロキシエチルセルロース、微結晶セルロース、セルロース硫酸ナトリウム、及びこれらの混合物からなる群から選択されるものが挙げられる。本明細書においてさらに有用なものは、アルキル置換セルロースである。これらのポリマーでは、セルロースポリマーのヒドロキシ基は、ヒドロキシアルキル化(好ましくは、ヒドロキシエチル化又はヒドロキシプロピル化)して、ヒドロキシアルキル化セルロースを形成し、次いでさらにC10〜C30直鎖又は分枝鎖アルキル基によって、エーテル結合を通じて修飾される。典型的には、これらのポリマーは、C10〜C30の直鎖又は分枝鎖アルコールとヒドロキシアルキルセルロースとのエーテルである。本明細書で有用なアルキル基の例としては、ステアリル、イソステアリル、ラウリル、ミリスチル、セチル、イソセチル、ココイル(すなわち、ココヤシ油のアルコールに由来するアルキル基)、パルミチル、オレイル、リノレイル、リノレニル、リシノレイル、ベヘニル、及びこれらの混合物からなる群から選択されるものが挙げられる。アルキルヒドロキシアルキルセルロースエーテルの中でも好ましいのは、CTFA表記セチルヒドロキシエチルセルロースの物質であり、これはセチルアルコールとヒドロキシエチルセルロースとのエーテルである。この物質は、アクアロン社(Aqualon Corporation)(デラウェア州ウィルミントン)から、商品名ナトロゾル(Natrosol)(登録商標)CSプラス(Plus)で販売されている。
本明細書において有用なその他の濃厚剤及びゲル化剤には、主として自然源より誘導される物質が挙げられる。このようなゲル化剤ゴムの非限定的な例としては、アカシア、アガー、アルギン、アルギン酸、アルギン酸アンモニウム、アミロペクチン、アルギン酸カルシウム、カラゲナンカルシウム、カルニチン、カラゲナン、デキストリン、ゼラチン、ゲランゴム、グアーガム、ヒドロキシプロピルトリモニウム塩化グアー、ヘクトライト、ヒアルロン酸、水酸化ケイ素、ヒドロキシプロピルキトサン、ヒドロキシプロピルグアー、カラヤゴム、ケルプ、イナゴマメゴム、納豆ゴム、アルギン酸カリウム、カラゲナンカリウム、アルギン酸プロピレングリコール、スクレロチンゴム、カルボキシメチルデキストランナトリウム、カラゲナンナトリウム、トラガカントゴム、キサンタンゴム、及びその混合物からなる群から選択される物質が挙げられる。
本発明のパーソナルケアキットは、哺乳類のケラチン組織状態の調整に有用である。このような調整には、予防的及び治療的な調整が含まれる。例えば、このような調整方法は、哺乳類の皮膚のクモ状血管及び/又は赤斑の外観の予防及び/又は遅延、腫れた目及び/又は哺乳類の目の下の黒い隈の外観の予防及び/又は遅延、哺乳類の皮膚の落屑、哺乳類の皮膚の血色の悪さの予防及び/又は遅延、哺乳類の皮膚の弛みの予防及び/又は遅延、湿疹の予防及び/又は遅延、哺乳類の唇、毛髪及び爪の軟化及び/又は平滑化、哺乳類の皮膚のかゆみの予防及び/又は緩和、毛髪のUV損傷の予防及び/又は治療、脱毛症及び/又はその他の発毛異常(すなわち、毛髪の薄化、もろさの増大)の予防及び/又は治療、くすみの予防及び/又は治療、並びに乾燥したかゆみのある頭皮の予防及び/又は治療を対象とする。
製品A(脂肪酸経口補助食品)
1カプセル、全部で1000mg
カプセルAは、次のように配合される:
局所用製品Bは、化粧用クリーム、顔及び/又は身体用保湿剤、顔及び/又は身体用洗浄剤、シャンプー、コンディショナー、ヘアボリューム増加剤、ヘアスプレー、毛髪光沢剤、染毛剤、ジェル、ポマード、ローションなどから成る群から選択できる。
本発明の特定の実施形態を例示し記載したが、本発明の精神及び範囲から逸脱することなく他の様々な変更及び修正を実施できることが、当業者には自明であろう。したがって、本発明の範囲内にあるそのようなすべての変更及び修正を添付の特許請求の範囲で扱うものとする。
Claims (20)
- 次のものを含む別々の容器を単一形態で共に包装したパーソナルケアキットであって:
a)1つまたは複数の次のものを含む経口消費に好適な製品:
i)安全且つ有効な量の1つまたは複数の必須脂肪酸;
ii)安全且つ有効な量の糖アミン又はこれらの製薬上許容できる塩;及び
iii)安全且つ有効な量の酸化防止剤、
b)皮膚及び/又は毛髪への局所適用に好適な製品
ここで、a)及びb)が個々に含まれた後、単一形態で共に包装されるキット。 - 前記必須脂肪酸が、ω−3脂肪酸、ω−6脂肪酸、及びこれらの混合物からなる群から選択される、請求項1に記載のキット。
- 前記ω−3脂肪酸が、α−リノレン酸、ステアリドン酸、エイコサペンタン酸、ドコサヘキサン酸、及びこれらの混合物からなる群から選択される、請求項2に記載のキット。
- 前記ω−6脂肪酸が、リノール酸、γ−リノレン酸、アラキドン酸、及びこれらの混合物からなる群から選択される、請求項2に記載のキット。
- 前記必須脂肪酸が、EPA、DHA、及びこれらの混合物からなる群から選択される、請求項1に記載のキット。
- a)項の前記糖アミンが、グルコサミン、グルコサミン誘導体、N−アセチルグルコサミン、ガラクトサミン、ガラクトサミン誘導体、N−アセチルガラクトサミン、マンノサミン、マンノサミン誘導体、N−アセチルマンノサミン、及びこれらの混合物からなる群から選択される、請求項1に記載のキット。
- 前記糖アミンがグルコサミンである、請求項6に記載のキット。
- a)項の前記酸化防止剤が、ブドウ種抽出物、エステル−C+、β−カロチン、リコピン、ルテイン、ビタミンE、ビタミンC;これらの誘導体;これらの塩;及びこれらの混合物からなる群から選択される、請求項1に記載のキット。
- a)項の前記酸化防止剤がビタミンEである、請求項1に記載のキット。
- ビタミンA、ビタミンB、ビタミンC、ビタミンD、ビタミンK;これらの誘導体;及びこれらの混合物からなる群から選択されるビタミンをさらに含む、請求項1に記載のキット。
- 前記ビタミンBが、ビタミンB1、ビタミンB2、ビタミンB3、ビタミンB5、ビタミンB6、ビタミンB12、ビタミンB15、これらの誘導体、及びこれらの混合物からなる群から選択される、請求項10に記載のキット。
- 銅、鉄、亜鉛、セレン、マンガン、及びこれらの混合物からなる群から選択される微量栄養素金属をさらに含む、請求項10に記載のキット。
- 前記微量栄養素金属が、銅、セレン、マンガン、及びこれらの混合物からなる群から選択される、請求項12に記載のキット。
- 局所適用に好適な前記製品が、化粧用クリーム、顔及び/又は身体用保湿剤、顔及び/又は身体用洗浄剤、シャンプー、コンディショナー、ヘアボリューム増加剤(hair volumizers)、ヘアスプレー、毛髪光沢剤(hair shines)、染毛剤、ジェル、ポマード、ローションなどからなる群から選択される、請求項1に記載のキット。
- 請求項1に記載のパーソナルケアキットを利用することによって皮膚及び/又は毛髪の状態を改善する方法であって、前記方法が次の工程を含む方法:
i)哺乳類にa)項の前記製品を1日3回まで経口投与する工程;及び
ii)前記哺乳類にb)項の前記製品を1日2回まで局所適用する工程。 - 工程i)の前記経口投与を食事と組み合わせる、請求項15に記載の方法。
- 次のものを含むパーソナルケア製品:
A)(a)約1g〜約3gの必須脂肪酸、(b)約1g〜約3gの糖アミン、及び(c)約0.0005g〜約0.1gの酸化防止剤を含む、カプセル、錠剤、粉末、液体、又は栄養食料品の形態の単位包装;並びに
B)皮膚及び/又は毛髪への局所適用に好適な製品
C)哺乳類の皮膚及び/又は毛髪の状態を改善するための日々のレジメンに従って、前記製品A)は、前記製品A)と併用して少なくとも1日1回使用されるべき前記製品B)と共に、1日3回まで一緒に摂取されるべきであることを示す書面及び/又は図による説明書。 - 処置レジメンに従うように消費者を説得する方法であって、前記処置レジメンが請求項17に記載のパーソナルケア製品を含む方法。
- 処置レジメンに従うように消費者を説得する方法であって、前記処置レジメンは、皮膚及び/又は毛髪に局所適用するのに好適な製品の使用を含み、前記局所用製品が、1つまたは複数の次のもの:
i)安全且つ有効な量の1つまたは複数の必須脂肪酸;
ii)安全且つ有効な量の糖アミン又はこれらの製薬上許容できる塩;及び
iii)安全且つ有効な量の酸化防止剤
を含む経口栄養補助食品と併用して少なくとも1日1回使用されるべきであることを示す追加の書面及び/又は図による説明書を伴う方法。 - 処置レジメンに従うように消費者を説得する方法であって、前記処理レジメンが、1つまたは複数の次のもの:
i)安全且つ有効な量の1つまたは複数の必須脂肪酸;
ii)安全且つ有効な量の糖アミン又はこれらの製薬上許容できる塩;及び
iii)安全且つ有効な量の酸化防止剤、
を含む経口消費に好適な製品の使用を含み、
前記経口製品は皮膚及び/又は毛髪への局所適用に好適な製品と共に1日3回まで一緒に摂取されるべきであることを示す追加の書面及び/又は図による説明書を伴う方法。
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EP (1) | EP1587377A2 (ja) |
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US20040254095A1 (en) * | 2002-09-11 | 2004-12-16 | Martin Kenneth A. | Supplement for treating musculoskeletal disorders |
US6660308B1 (en) * | 2002-09-11 | 2003-12-09 | Kenneth A. Martin | Beverage and additive for the ill |
US20040253227A1 (en) * | 2002-09-11 | 2004-12-16 | Martin Kenneth A. | Perioperative multivitamin protein beverage and additive for use in preparing an individual for fast surgical recovery |
-
2004
- 2004-01-28 EP EP04706018A patent/EP1587377A2/en not_active Withdrawn
- 2004-01-28 CN CNA2004800030694A patent/CN1816287A/zh active Pending
- 2004-01-28 MX MXPA05008216A patent/MXPA05008216A/es unknown
- 2004-01-28 JP JP2005518371A patent/JP2006524187A/ja active Pending
- 2004-01-28 WO PCT/US2004/002361 patent/WO2004068970A2/en active Application Filing
- 2004-01-30 US US10/769,280 patent/US20040258645A1/en not_active Abandoned
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JPH01268617A (ja) * | 1988-02-26 | 1989-10-26 | L'oreal Sa | ポリビタミン混合物から成る皮膚美容改善化粧品 |
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Cited By (7)
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JP2015042653A (ja) * | 2007-05-31 | 2015-03-05 | アメリカ合衆国 | 治療薬としてのn−アセチルマンノサミン |
WO2010027028A1 (ja) * | 2008-09-04 | 2010-03-11 | 国立大学法人 東京大学 | 脳機能低下の改善剤 |
JP5553168B2 (ja) * | 2008-09-04 | 2014-07-16 | 国立大学法人 東京大学 | 脳機能低下の改善剤 |
US8987232B2 (en) | 2008-09-04 | 2015-03-24 | The University Of Tokyo | Agent for ameliorating brain hypofunction |
US9271995B2 (en) | 2008-09-04 | 2016-03-01 | The University Of Tokyo | Agent for ameliorating brain hypofunction |
US10813868B2 (en) | 2014-11-13 | 2020-10-27 | Conopco, Inc. | Method of improving hair volume |
KR102552134B1 (ko) * | 2023-02-20 | 2023-07-06 | (주)아모레퍼시픽 | 모발용 조성물 및 이를 이용한 모발 처리방법 |
Also Published As
Publication number | Publication date |
---|---|
MXPA05008216A (es) | 2005-10-05 |
EP1587377A2 (en) | 2005-10-26 |
WO2004068970A3 (en) | 2006-03-09 |
WO2004068970A2 (en) | 2004-08-19 |
US20040258645A1 (en) | 2004-12-23 |
CN1816287A (zh) | 2006-08-09 |
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