JP2006523181A5 - - Google Patents
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- Publication number
- JP2006523181A5 JP2006523181A5 JP2004555869A JP2004555869A JP2006523181A5 JP 2006523181 A5 JP2006523181 A5 JP 2006523181A5 JP 2004555869 A JP2004555869 A JP 2004555869A JP 2004555869 A JP2004555869 A JP 2004555869A JP 2006523181 A5 JP2006523181 A5 JP 2006523181A5
- Authority
- JP
- Japan
- Prior art keywords
- cys
- xaa1
- amino acid
- lys leu
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- PINHPJWGVBKQII-SRVKXCTJSA-N Lys-Leu-Cys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](CCCCN)N PINHPJWGVBKQII-SRVKXCTJSA-N 0.000 claims 10
- DKJWUIYLMLUBDX-XPUUQOCRSA-N Gly-Val-Cys Chemical compound NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)O DKJWUIYLMLUBDX-XPUUQOCRSA-N 0.000 claims 9
- 108010004073 cysteinylcysteine Proteins 0.000 claims 9
- 108010059898 glycyl-tyrosyl-lysine Proteins 0.000 claims 9
- YKKHFPGOZXQAGK-QWRGUYRKSA-N Cys-Gly-Tyr Chemical compound SC[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 YKKHFPGOZXQAGK-QWRGUYRKSA-N 0.000 claims 8
- 208000002193 Pain Diseases 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical group OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims 5
- 150000001408 amides Chemical class 0.000 claims 5
- 150000001413 amino acids Chemical group 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 208000004296 neuralgia Diseases 0.000 claims 4
- 208000021722 neuropathic pain Diseases 0.000 claims 4
- ODHCTXKNWHHXJC-GSVOUGTGSA-N 5-oxo-D-proline Chemical compound OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 claims 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 208000000094 Chronic Pain Diseases 0.000 claims 3
- 150000008574 D-amino acids Chemical class 0.000 claims 3
- HBGKOLSGLYMWSW-DCAQKATOSA-N His-Pro-Cys Chemical compound C1C[C@H](N(C1)C(=O)[C@H](CC2=CN=CN2)N)C(=O)N[C@@H](CS)C(=O)O HBGKOLSGLYMWSW-DCAQKATOSA-N 0.000 claims 3
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 208000019695 Migraine disease Diseases 0.000 claims 3
- 208000019022 Mood disease Diseases 0.000 claims 3
- 102000008092 Norepinephrine Plasma Membrane Transport Proteins Human genes 0.000 claims 3
- 108010049586 Norepinephrine Plasma Membrane Transport Proteins Proteins 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 208000005298 acute pain Diseases 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 3
- 229960002591 hydroxyproline Drugs 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 206010027599 migraine Diseases 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 230000001537 neural effect Effects 0.000 claims 3
- 208000014001 urinary system disease Diseases 0.000 claims 3
- QRXPIKKZQGWJMW-ZETCQYMHSA-N 4-O-methyl-L-dopa zwitterion Chemical compound COC1=CC=C(C[C@H](N)C(O)=O)C=C1O QRXPIKKZQGWJMW-ZETCQYMHSA-N 0.000 claims 2
- OOWSBIOUKIUWLO-RCOVLWMOSA-N Asn-Gly-Val Chemical compound [H]N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C(C)C)C(O)=O OOWSBIOUKIUWLO-RCOVLWMOSA-N 0.000 claims 2
- ZJBWJHQDOIMVLM-WHFBIAKZSA-N Cys-Cys-Gly Chemical compound SC[C@H](N)C(=O)N[C@@H](CS)C(=O)NCC(O)=O ZJBWJHQDOIMVLM-WHFBIAKZSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 230000002485 urinary effect Effects 0.000 claims 2
- XUJNEKJLAYXESH-UWTATZPHSA-N D-Cysteine Chemical compound SC[C@@H](N)C(O)=O XUJNEKJLAYXESH-UWTATZPHSA-N 0.000 claims 1
- 229930195710 D‐cysteine Natural products 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000028389 Nerve injury Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- FMXFHNSFABRVFZ-BZSNNMDCSA-N Tyr-Lys-Leu Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O FMXFHNSFABRVFZ-BZSNNMDCSA-N 0.000 claims 1
- 208000012931 Urologic disease Diseases 0.000 claims 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 108050003126 conotoxin Proteins 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 210000000578 peripheral nerve Anatomy 0.000 claims 1
- 229940043131 pyroglutamate Drugs 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43030602P | 2002-12-02 | 2002-12-02 | |
| PCT/AU2003/001605 WO2004050690A1 (en) | 2002-12-02 | 2003-12-02 | NOVEL χ-CONOTOXIN PEPTIDES (-I) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006523181A JP2006523181A (ja) | 2006-10-12 |
| JP2006523181A5 true JP2006523181A5 (https=) | 2006-11-24 |
| JP4565087B2 JP4565087B2 (ja) | 2010-10-20 |
Family
ID=32469446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004555869A Expired - Fee Related JP4565087B2 (ja) | 2002-12-02 | 2003-12-02 | 新規なχ−コノトキシン・ペプチド（−Ｉ） |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7851444B2 (https=) |
| EP (1) | EP1572725B1 (https=) |
| JP (1) | JP4565087B2 (https=) |
| AT (1) | ATE547424T1 (https=) |
| AU (1) | AU2003302609B9 (https=) |
| CA (1) | CA2508129C (https=) |
| CY (1) | CY1112839T1 (https=) |
| DK (1) | DK1572725T3 (https=) |
| ES (1) | ES2383358T3 (https=) |
| NZ (1) | NZ540518A (https=) |
| PT (1) | PT1572725E (https=) |
| SI (1) | SI1572725T1 (https=) |
| WO (1) | WO2004050690A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPP627498A0 (en) * | 1998-10-02 | 1998-10-22 | University Of Queensland, The | Novel peptides - i |
| EP2412719A1 (en) * | 2002-12-02 | 2012-02-01 | Xenome Ltd | Chi-conotoxin peptides |
| US8062623B2 (en) * | 2004-10-15 | 2011-11-22 | Velocys | Stable, catalyzed, high temperature combustion in microchannel, integrated combustion reactors |
| US20070154360A1 (en) * | 2005-10-13 | 2007-07-05 | Velocys Inc. | Microchannel apparatus comprising a platinum aluminide layer and chemical processes using the apparatus |
| CN102752032B (zh) | 2011-04-22 | 2015-04-22 | 艾利森电话股份有限公司 | 同频负载均衡方法及其设备 |
| WO2016191200A1 (en) * | 2015-05-22 | 2016-12-01 | Clemson University | Conotoxin peptides for use in biofouling deterrence |
| CN119462881A (zh) * | 2024-12-20 | 2025-02-18 | 深圳肽盛生物科技有限公司 | μ型芋螺毒素肽及其药物组合物和应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5051403A (en) | 1989-11-22 | 1991-09-24 | Neurex Corporation | Method of treating ischemia-related neuronal damage |
| PH30083A (en) | 1991-02-25 | 1996-12-27 | Lilly Co Eli | Treatment of lower urinary tract disorders |
| SG50624A1 (en) * | 1991-12-30 | 1998-07-20 | Neurex Corp | Methods of producing analgesia and enhancing opiate analgesia |
| AU715165B2 (en) | 1994-11-03 | 2000-01-20 | Novartis Ag | Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them |
| WO1996040064A1 (en) | 1995-06-07 | 1996-12-19 | Nexstar Pharmaceuticals, Inc. | Liposomal cyclosporin formulations as agents for immunosuppression and multiple drug resistant indications |
| DE69627153T2 (de) | 1995-06-27 | 2003-12-04 | Elan Pharmaceuticals, Inc.(N.D.Ges.D.Staates Delaware) | Zusammensetzungen zur erzielung von analgesie und zur hemmung der progression neuropathischer schmerzerkrankungen |
| JP3238414B2 (ja) | 1996-02-22 | 2001-12-17 | ニューロサーチ・アクティーゼルスカブ | トロパン―誘導体、その製造方法及びその使用方法 |
| GB9614902D0 (en) | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
| CZ288739B6 (cs) | 1996-08-01 | 2001-08-15 | Galena, A. S. | Cyklosporin obsahující léčivé přípravky |
| WO1998022126A1 (en) | 1996-11-18 | 1998-05-28 | University Of Utah Research Foundation | USE OF CONOTOXIN PEPTIDES ImI AND MII AS CARDIOVASCULAR AGENTS |
| WO1998051668A1 (en) | 1997-05-14 | 1998-11-19 | Neurosearch A/S | Piperidine derivatives as neurotransmitter re-uptake inhibitors |
| AUPP627498A0 (en) * | 1998-10-02 | 1998-10-22 | University Of Queensland, The | Novel peptides - i |
| US6767896B1 (en) * | 1999-01-29 | 2004-07-27 | Cognetix, Inc. | Conotoxin peptides |
| AU3473800A (en) | 1999-01-29 | 2000-08-18 | University Of Utah Research Foundation | Conotoxin peptides |
| US20010036943A1 (en) | 2000-04-07 | 2001-11-01 | Coe Jotham W. | Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines |
| US20030170222A1 (en) * | 2001-01-29 | 2003-09-11 | University Of Utah Research Foundation | Beta-superfamily conotoxins |
| WO2002064740A2 (en) | 2001-02-09 | 2002-08-22 | Cognetix, Inc. | Cone snail peptides |
| EP2412719A1 (en) | 2002-12-02 | 2012-02-01 | Xenome Ltd | Chi-conotoxin peptides |
-
2003
- 2003-12-02 WO PCT/AU2003/001605 patent/WO2004050690A1/en not_active Ceased
- 2003-12-02 JP JP2004555869A patent/JP4565087B2/ja not_active Expired - Fee Related
- 2003-12-02 CA CA2508129A patent/CA2508129C/en not_active Expired - Fee Related
- 2003-12-02 ES ES03812100T patent/ES2383358T3/es not_active Expired - Lifetime
- 2003-12-02 US US10/537,704 patent/US7851444B2/en not_active Expired - Fee Related
- 2003-12-02 AU AU2003302609A patent/AU2003302609B9/en not_active Ceased
- 2003-12-02 EP EP03812100A patent/EP1572725B1/en not_active Expired - Lifetime
- 2003-12-02 DK DK03812100.0T patent/DK1572725T3/da active
- 2003-12-02 PT PT03812100T patent/PT1572725E/pt unknown
- 2003-12-02 NZ NZ540518A patent/NZ540518A/en not_active IP Right Cessation
- 2003-12-02 SI SI200332154T patent/SI1572725T1/sl unknown
- 2003-12-02 AT AT03812100T patent/ATE547424T1/de active
-
2012
- 2012-05-29 CY CY20121100484T patent/CY1112839T1/el unknown
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