JP2006522006A - モダフィニルの医薬製剤 - Google Patents
モダフィニルの医薬製剤 Download PDFInfo
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- JP2006522006A JP2006522006A JP2004536184A JP2004536184A JP2006522006A JP 2006522006 A JP2006522006 A JP 2006522006A JP 2004536184 A JP2004536184 A JP 2004536184A JP 2004536184 A JP2004536184 A JP 2004536184A JP 2006522006 A JP2006522006 A JP 2006522006A
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Abstract
Description
1.本発明のモダフィニルの量
一つの態様では、本発明の組成物はモダフィニルの薬剤組成物を含む。薬剤組成物は、さらに、モダフィニルの少なくとも1つの薬剤単位投薬物(以後「単位投薬物」とする)、典型的には固体単位投薬物剤型、例えば錠剤またはカプセルを含むことができる。以下に記載する理由により、本発明の組成物は、約250〜約350mgの間のモダフィニルまたは約250〜約450mgの間のモダフィニルを含むことができる。別の態様では、組成物は、約275〜約325mgの間のモダフィニルまたは約325〜約425mgの間のモダフィニルを含むことができる。別の態様では、組成物は、約255mgのモダフィニル、約300mgのモダフィニル、約340mgのモダフィニルまたは約425mgのモダフィニルを含むことができる。さらに別の態様では、本発明の組成物は約250、255、260、265、270、275、280、285、290、295、300、305、310、315、320、325、330、335、340、345、または350mg、または約355、360、365、370、375、380、385、390、395、400、405、410、415、420、425、430、435、440、445、または450mgのモダフィニルを含むことができる。好ましくは、単位投薬物は約255、300、340または425mgのモダフィニルを含むことができる。最も好ましくは、単位投薬物は355、300、340または425mgのモダフィニルを含むことができる。
2.本発明のモダフィニルの組成物
上記のように、本発明は約250〜約350mgの間のモダフィニルまたは約250〜約450mgの間のモダフィニルを含む薬剤組成物ならびに約275〜約325mgの間のモダフィニル、約325〜425mgの間のモダフィニルまたは約255、300、340または425mgのモダフィニルを含む組成物を提供する。本発明の薬剤組成物はモダフィニルの単位投薬物、そして本発明の好ましい態様では、250〜350mgのモダフィニル、250〜450mgのモダフィニル、275〜325mgのモダフィニル、325〜425mgのモダフィニル、255mgのモダフィニル、300mgのモダフィニル、340mgのモダフィニルまたは425mgのモダフィニルを含む錠剤またはカプセル剤型であるモダフィニルの単位投薬物であることができる。
3.実施例
Claims (44)
- 約250〜約450mgのモダフィニルから本質的になる薬剤単位投薬物。
- 約250〜約350mgのモダフィニルから本質的になる薬剤単位投薬物。
- 約275〜約325mgのモダフィニルから本質的になる、請求項1の単位投薬物。
- 約325〜約450mgのモダフィニルから本質的になる、請求項1の単位投薬物。
- 275〜325mgのモダフィニルから本質的になる、請求項1の単位投薬物。
- 325〜450mgのモダフィニルから本質的になる、請求項1の単位投薬物。
- 255mgのモダフィニルから本質的になる、請求項1の単位投薬物。
- 300mgのモダフィニルから本質的になる、請求項1の単位投薬物。
- 340mgのモダフィニルから本質的になる、請求項1の単位投薬物。
- 425mgのモダフィニルから本質的になる、請求項1の単位投薬物。
- ヒト患者に24時間以内に約250〜約450mgのモダフィニルの単回投薬を投与する段階を含んでなる、ヒト患者のADHDを処置する方法。
- ヒト患者に24時間以内に約250〜約350mgのモダフィニルの単回投薬を投与する段階を含んでなる、ヒト患者のADHDを処置する方法。
- 患者が小児科患者である、請求項11の方法。
- 約425mgのモダフィニルを患者に投与する、請求項11の方法。
- 約340mgのモダフィニルを患者に投与する、請求項11の方法。
- 約300mgのモダフィニルを患者に投与する、請求項11の方法。
- 約255mgのモダフィニルを患者に投与する、請求項11の方法。
- ヒトへの経口投与の後、本質的に図3に示されるようなモダフィニルの血中プロフィールがもたらされる、モダフィニルの薬剤単位投薬物。
- 本質的に図3に示されるようなモダフィニルの血中プロフィールを誘導するために十分なモダフィニルの単回投薬を24時間の期間内に患者に投与する段階を含んでなる、モダフィニルを用いるヒト患者内のADHDを処置する方法。
- 単位投薬物中のモダフィニルの量が、250、255、260、265、270、275、280、285、290、295、300、305、310、315、320、325、330、335、340、345および350mgのモダフィニルから本質的になる群から選択される、請求項1の単位投薬物。
- 単位投薬物中のモダフィニルの量が、355、360、365、370、375、380、385、390、395、400、405、410、415、420、425、430、435、440、445、および450mgのモダフィニルから本質的になる群から選択される、請求項1の単位投薬物。
- 薬剤単位投薬物中のモダフィニルの量が、255、300、340、および425mgのモダフィニルからなる群から選択される、請求項1の単位投薬物。
- 全錠剤重量の約70〜75%がモダフィニルである、請求項1の単位投薬物。
- 全錠剤重量の約80%がモダフィニルである、請求項1の単位投薬物。
- 約250〜約450mgのモダフィニルを含んでなる、薬剤組成物。
- 約250〜約350mgのモダフィニルを含んでなる、薬剤組成物。
- 約275〜約325mgのモダフィニルを含んでなる、請求項25の組成物。
- 約325〜約450mgのモダフィニルを含んでなる、請求項25の組成物。
- 275〜325mgのモダフィニルを含んでなる、請求項25の組成物。
- 325〜450mgのモダフィニルを含んでなる、請求項25の組成物。
- 255mgのモダフィニルを含んでなる、請求項25の組成物。
- 300mgのモダフィニルを含んでなる、請求項25の組成物。
- 340mgのモダフィニルを含んでなる、請求項25の組成物。
- 450mgのモダフィニルを含んでなる、請求項25の組成物。
- ケイ酸マグネシウムまたはタルクを含まず、約250〜約450mgのモダフィニルを含んでなる、薬剤組成物。
- デンプン、ラクトース一水和物または微晶質セルロースからそれぞれ独立して選択された1種またはそれ以上の希釈剤、アルファ化デンプンまたは架橋カルボキシメチルセルロースナトリウムからそれぞれ独立して選択された1種またはそれ以上の崩壊剤、結合剤、および滑沢剤を含んでなる、請求項35の組成物。
- 結合剤がポリビニルピロリドンであり、そして滑沢剤がステアリン酸マグネシウムである、請求項36の組成物。
- 組成物が錠剤である。請求項35の組成物。
- 錠剤重量の約90%がモダフィニルである、請求項35の組成物。
- 錠剤重量の約80%がモダフィニルである、請求項35の組成物。
- モダフィニルがR−(−)2−〔(ジフェニルメチル)スルフィニル〕アセトアミドである、請求項1の単位投薬物。
- モダフィニルがR−(−)2−〔(ジフェニルメチル)スルフィニル〕アセトアミドである、請求項25の組成物。
- モダフィニルがR−(−)2−〔(ジフェニルメチル)スルフィニル〕アセトアミドである、請求項1の単位投薬物。
- モダフィニルがR−(−)2−〔(ジフェニルメチル)スルフィニル〕アセトアミドである、請求項25の組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41039502P | 2002-09-13 | 2002-09-13 | |
US60/410,395 | 2002-09-13 | ||
US10/660,058 US20040116532A1 (en) | 2002-09-13 | 2003-09-11 | Pharmaceutical formulations of modafinil |
US10/660,058 | 2003-09-11 | ||
PCT/US2003/028651 WO2004024134A1 (en) | 2002-09-13 | 2003-09-12 | Pharmaceutical formulations of modafinil |
Publications (3)
Publication Number | Publication Date |
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JP2006522006A true JP2006522006A (ja) | 2006-09-28 |
JP2006522006A5 JP2006522006A5 (ja) | 2006-11-24 |
JP5039246B2 JP5039246B2 (ja) | 2012-10-03 |
Family
ID=32511269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2004536184A Expired - Fee Related JP5039246B2 (ja) | 2002-09-13 | 2003-09-12 | モダフィニルの医薬製剤 |
Country Status (22)
Country | Link |
---|---|
US (4) | US20040116532A1 (ja) |
EP (1) | EP1539126B1 (ja) |
JP (1) | JP5039246B2 (ja) |
KR (1) | KR101125462B1 (ja) |
CN (1) | CN100528151C (ja) |
AU (1) | AU2003267156B2 (ja) |
BR (1) | BR0314514A (ja) |
CA (1) | CA2498260C (ja) |
DK (1) | DK1539126T3 (ja) |
EA (1) | EA012964B1 (ja) |
ES (1) | ES2392580T3 (ja) |
HK (1) | HK1076734A1 (ja) |
IL (1) | IL167054A (ja) |
IS (1) | IS2871B (ja) |
MX (1) | MXPA05002827A (ja) |
NO (1) | NO333614B1 (ja) |
NZ (1) | NZ538941A (ja) |
PL (1) | PL375833A1 (ja) |
PT (1) | PT1539126E (ja) |
SI (1) | SI1539126T1 (ja) |
TW (1) | TWI335217B (ja) |
WO (1) | WO2004024134A1 (ja) |
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- 2003-09-11 US US10/660,058 patent/US20040116532A1/en not_active Abandoned
- 2003-09-12 DK DK03749630.4T patent/DK1539126T3/da active
- 2003-09-12 CN CNB03821749XA patent/CN100528151C/zh not_active Expired - Fee Related
- 2003-09-12 SI SI200332193T patent/SI1539126T1/sl unknown
- 2003-09-12 EP EP03749630A patent/EP1539126B1/en not_active Expired - Lifetime
- 2003-09-12 JP JP2004536184A patent/JP5039246B2/ja not_active Expired - Fee Related
- 2003-09-12 PT PT03749630T patent/PT1539126E/pt unknown
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Patent Citations (5)
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JP2000503310A (ja) * | 1996-01-19 | 2000-03-21 | グラクソ、グループ、リミテッド | 1日1回の投与による陰部ヘルペス治療用医薬の製造のためのバラシクロビールの使用 |
JPH09208468A (ja) * | 1996-02-02 | 1997-08-12 | Dainippon Pharmaceut Co Ltd | p−クロロ−N−(2−モルホリノエチル)ベンズアミドを含有する錠剤 |
JP2001527034A (ja) * | 1997-12-23 | 2001-12-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 1種以上の活性物質を即時的ならびに持続的に放出するための錠剤 |
WO2000037054A1 (en) * | 1998-12-18 | 2000-06-29 | Knoll Aktiengesellschaft | A pharmaceutical mixture comprising a profen |
WO2001012170A2 (en) * | 1999-08-16 | 2001-02-22 | Cephalon, Inc. | Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue |
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