JP2006519906A5 - - Google Patents

Info

Publication number

JP2006519906A5

JP2006519906A5 JP2006506297A JP2006506297A JP2006519906A5 JP 2006519906 A5 JP2006519906 A5 JP 2006519906A5 JP 2006506297 A JP2006506297 A JP 2006506297A JP 2006506297 A JP2006506297 A JP 2006506297A JP 2006519906 A5 JP2006519906 A5 JP 2006519906A5

Authority

JP

Japan

Prior art keywords

heparin

drum dryer

salt

solid form

solvent

Prior art date

2004-03-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
• Discuss

• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 17
• 229920000669 heparin Polymers 0.000 claims description 17
• 229960002897 heparin Drugs 0.000 claims description 15
• 238000000034 method Methods 0.000 claims description 14
• 239000007787 solid Substances 0.000 claims description 5
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
• 239000003960 organic solvent Substances 0.000 claims description 4
• 239000002904 solvent Substances 0.000 claims description 3
• ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims description 2
• 229960001008 heparin sodium Drugs 0.000 claims description 2
• 239000012046 mixed solvent Substances 0.000 claims description 2
• -1 tertiary amine salt Chemical class 0.000 claims description 2
• 150000003839 salts Chemical class 0.000 claims 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
• 125000003158 alcohol group Chemical group 0.000 claims 1
• 229910052783 alkali metal Inorganic materials 0.000 claims 1
• 150000001340 alkali metals Chemical class 0.000 claims 1
• 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
• 150000001342 alkaline earth metals Chemical class 0.000 claims 1
• 150000003863 ammonium salts Chemical class 0.000 claims 1
• 238000001035 drying Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 150000007530 organic bases Chemical class 0.000 claims 1
• 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
• 150000003242 quaternary ammonium salts Chemical class 0.000 claims 1
• 150000003512 tertiary amines Chemical class 0.000 claims 1
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
• BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
• 229960000686 benzalkonium chloride Drugs 0.000 description 1
• BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1