MXPA05009498A - Metodo para producir una forma solida de heparina. - Google Patents

Metodo para producir una forma solida de heparina.

Info

Publication number
MXPA05009498A
MXPA05009498A MXPA05009498A MXPA05009498A MXPA05009498A MX PA05009498 A MXPA05009498 A MX PA05009498A MX PA05009498 A MXPA05009498 A MX PA05009498A MX PA05009498 A MXPA05009498 A MX PA05009498A MX PA05009498 A MXPA05009498 A MX PA05009498A
Authority
MX
Mexico
Prior art keywords
heparin
solid form
produce
solvents
solvent
Prior art date
Application number
MXPA05009498A
Other languages
English (en)
Inventor
Jay Lee Jett
Original Assignee
Pfizer Health Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Health Ab filed Critical Pfizer Health Ab
Publication of MXPA05009498A publication Critical patent/MXPA05009498A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/10—Heparin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/10—Heparin; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La presente invencion proporciona un metodo nuevo para tratar una disolucion que contiene heparina; sales de heparina o complejos de heparina en un disolvente o una mezcla de disolventes para obtener una forma solida de productos de heparina, caracterizado por el uso de un secador de tambor a presion atmosferica o a vacio y a una temperatura de secado adecuada.
MXPA05009498A 2003-03-07 2004-03-04 Metodo para producir una forma solida de heparina. MXPA05009498A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45270103P 2003-03-07 2003-03-07
PCT/IB2004/000625 WO2004078791A1 (en) 2003-03-07 2004-03-04 Method to produce a solid form of heparin

Publications (1)

Publication Number Publication Date
MXPA05009498A true MXPA05009498A (es) 2005-10-18

Family

ID=32962743

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05009498A MXPA05009498A (es) 2003-03-07 2004-03-04 Metodo para producir una forma solida de heparina.

Country Status (12)

Country Link
US (1) US6933372B2 (es)
EP (1) EP1611161B1 (es)
JP (1) JP2006519906A (es)
AR (1) AR043731A1 (es)
AT (1) ATE368057T1 (es)
CA (1) CA2517141C (es)
CL (1) CL2004000414A1 (es)
DE (1) DE602004007784T2 (es)
ES (1) ES2289492T3 (es)
MX (1) MXPA05009498A (es)
TW (1) TWI274761B (es)
WO (1) WO2004078791A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
CN101575385B (zh) * 2008-05-09 2011-01-12 青岛九龙生物医药有限公司 萃取法分离肝素钠中的多硫酸软骨素的方法
CN101831008B (zh) * 2009-03-11 2013-04-10 四川茂森生物科技有限公司 粗品肝素钠精制生产新工艺
CN108508129B (zh) * 2018-04-03 2020-11-27 青岛海洋生物医药研究院股份有限公司 一种肝素类药物生物效价的测定方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2034599A (en) * 1933-07-10 1936-03-17 Buffalo Foundry & Machine Co Method of drying inorganic salts and sludges
US2571679A (en) * 1948-07-08 1951-10-16 Carlo Erba S A Process for preparing purified heparin
US2797184A (en) * 1953-07-01 1957-06-25 Upjohn Co Process for the recovery of heparin
US2884358A (en) * 1957-04-22 1959-04-28 Southern California Gland Co Process for preparing crude heparin
US2954321A (en) * 1957-09-23 1960-09-27 Upjohn Co Process for preparing heparin
US3337409A (en) * 1963-11-20 1967-08-22 Rexall Drug Chemical Process for the recovery of heparin
US3330327A (en) * 1964-03-30 1967-07-11 Continental Oil Co Drying tertiary amine oxides on extended heated surfaces at elevated temperatures
US3817831A (en) * 1973-01-10 1974-06-18 Wilson Pharm & Chem Corp Process for production of alkali metal salt of heparin
CA1136620A (en) 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
US4510135A (en) * 1982-04-21 1985-04-09 Research Corporation Orally administered heparin
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
DK170015B1 (da) * 1992-03-19 1995-05-01 Sudurnesja Hitaveita Saltprodukt samt fremgangsmåde til dets fremstilling
US5668118A (en) 1992-07-24 1997-09-16 Cavalier Pharmaceuticals Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G
DE4310088A1 (de) * 1993-03-27 1994-09-29 Hoechst Ag Verfahren zur Herstellung und Aufarbeitung von in wäßrigem Medium löslichen N-Hydroxyalkylchitosanen
AU682792B2 (en) 1994-10-13 1997-10-16 Cv Therapeutics, Inc. Method of manufacturing non-absorbable synthetic sulfated polysaccharides
ATE212041T1 (de) 1995-04-10 2002-02-15 Amerchol Corp Verfahren zur derivatisierung von polyglukosaminen
ATE315588T1 (de) * 1997-07-16 2006-02-15 Akzo Nobel Nv Verfahren zur herstellung von heparin
CN1218058A (zh) 1997-11-26 1999-06-02 中国林业科学研究院林产化学工业研究所 肝素的喷雾干燥方法
US6485945B1 (en) * 1999-02-17 2002-11-26 Nurture, Inc. Polysaccharide compositions and uses thereof
US7138519B2 (en) 2000-02-07 2006-11-21 Grante Seed Limited Process for extraction of β-glucan from cereals and products obtained therefrom

Also Published As

Publication number Publication date
US6933372B2 (en) 2005-08-23
AR043731A1 (es) 2005-08-10
ATE368057T1 (de) 2007-08-15
JP2006519906A (ja) 2006-08-31
CA2517141C (en) 2008-11-18
CL2004000414A1 (es) 2005-02-04
TW200502255A (en) 2005-01-16
EP1611161A1 (en) 2006-01-04
WO2004078791A1 (en) 2004-09-16
DE602004007784D1 (de) 2007-09-06
DE602004007784T2 (de) 2007-12-06
EP1611161B1 (en) 2007-07-25
CA2517141A1 (en) 2004-09-16
US20040176581A1 (en) 2004-09-09
ES2289492T3 (es) 2008-02-01
TWI274761B (en) 2007-03-01

Similar Documents

Publication Publication Date Title
DE602004025237D1 (de) Abgabeverfahren für leichtflüchtigen stoff
EA201070610A1 (ru) Способы получения и применения вспомогательного газа
UY24286A1 (es) Nuevo proceso para la producción de una sal ácida calcica amorfa
MY153731A (en) Recovery of higher alcohols from dilute aqueous solutions
AU6023701A (en) Device for spray-drying solvent-containing compositions
WO2008010781A3 (en) An industrially viable method for the production of polycarbynes; polymeric precursors to diamond and diamond like ceramics
IL165217A (en) Pesticidal pyridinecarboxamide derivatives, process for their preparation, pesticidal compositions comprising them and use thereof in the preparation of pesticidal compositions
TW200502255A (en) New method to produce a solid form of heparin
FR2801316B1 (fr) Procede de sechage des bacteries
DK1289629T3 (da) Mikrofiltrering under anvendelse af aktivt kul
NO20022619L (no) Fremgangsmåte ved formulding
NO20010266D0 (no) Sykliske forbindelser som kan anvendes ved behandling av dyslipidemi, aterosklerose og diabetes, farmasöytiske preparater og fremstillingsfremgangsmåte
HUP0300065A2 (en) Material processing by repeated solvent expansion-contraction
ATE416193T1 (de) Verfahren zur herstellung von eisensuccinylcasein und acetylaspartat-eisen-casein-komplexen und deren anwendung in pharmazeutischen mischungen
TW200708539A (en) Process for producing cellulose acylate film, cellulose acylate film, optically-compensatory film, polarizing palte and liquid-crystal display device
NO20013021L (no) Fremgangsmåte for fremstilling av mono- eller diorganoboraner
AU2003233064A1 (en) Process for the preparation of the amorphous form of atorvastatin calcium salt
TR200403039T1 (tr) Seramik parçalarının süslenmesi için yöntem ve donatım ile buradan elde edilen ürünler
DE50207212D1 (de) Verfahren zur herstellung von 2-pyrrolidon
DK1194297T3 (da) Coatingfremgangsmåde og produkter opnået ved fremgangsmåden
SE0300724D0 (sv) Impregneringsförfarande
IL156640A (en) Process for preparing arylethanoldiamines from imidazooxazoles, starting material and intermediate used in the process
JP2006519906A5 (es)
IT1219823B (it) Procedimento per la produzione di prodotti alimentari compressi disidratati
JPS51123777A (en) An apparatus for removing organic solvents from air containing organic solvent vapor

Legal Events

Date Code Title Description
FG Grant or registration