ES2289492T3 - Metodo para producir una forma solida de heparina. - Google Patents
Metodo para producir una forma solida de heparina. Download PDFInfo
- Publication number
- ES2289492T3 ES2289492T3 ES04717174T ES04717174T ES2289492T3 ES 2289492 T3 ES2289492 T3 ES 2289492T3 ES 04717174 T ES04717174 T ES 04717174T ES 04717174 T ES04717174 T ES 04717174T ES 2289492 T3 ES2289492 T3 ES 2289492T3
- Authority
- ES
- Spain
- Prior art keywords
- heparin
- solution
- drum dryer
- drum
- drying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920000669 heparin Polymers 0.000 title claims abstract description 94
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 89
- 239000007787 solid Substances 0.000 title claims abstract description 28
- 238000004519 manufacturing process Methods 0.000 title description 8
- 229960002897 heparin Drugs 0.000 claims abstract description 83
- 238000000034 method Methods 0.000 claims abstract description 47
- 238000001035 drying Methods 0.000 claims abstract description 29
- 239000002904 solvent Substances 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims description 10
- 239000003960 organic solvent Substances 0.000 claims description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 4
- 150000001298 alcohols Chemical class 0.000 claims description 3
- 150000007530 organic bases Chemical class 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 150000003512 tertiary amines Chemical class 0.000 claims description 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 2
- 150000001342 alkaline earth metals Chemical class 0.000 claims description 2
- -1 amine salt Chemical class 0.000 claims description 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 2
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 150000003863 ammonium salts Chemical class 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 description 38
- 239000000047 product Substances 0.000 description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 20
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 239000000356 contaminant Substances 0.000 description 6
- 238000000746 purification Methods 0.000 description 6
- 229920002683 Glycosaminoglycan Polymers 0.000 description 5
- 229920000045 Dermatan sulfate Polymers 0.000 description 4
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 4
- 229940051593 dermatan sulfate Drugs 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000010561 standard procedure Methods 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000002429 anti-coagulating effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 229940018872 dalteparin sodium Drugs 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000002036 drum drying Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012527 feed solution Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229940087051 fragmin Drugs 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229960001008 heparin sodium Drugs 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000003055 low molecular weight heparin Substances 0.000 description 1
- 229940127215 low-molecular weight heparin Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/10—Heparin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/14—Powdering or granulating by precipitation from solutions
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/10—Heparin; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45270103P | 2003-03-07 | 2003-03-07 | |
| US452701P | 2003-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2289492T3 true ES2289492T3 (es) | 2008-02-01 |
Family
ID=32962743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04717174T Expired - Lifetime ES2289492T3 (es) | 2003-03-07 | 2004-03-04 | Metodo para producir una forma solida de heparina. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6933372B2 (enExample) |
| EP (1) | EP1611161B1 (enExample) |
| JP (1) | JP2006519906A (enExample) |
| AR (1) | AR043731A1 (enExample) |
| AT (1) | ATE368057T1 (enExample) |
| CA (1) | CA2517141C (enExample) |
| CL (1) | CL2004000414A1 (enExample) |
| DE (1) | DE602004007784T2 (enExample) |
| ES (1) | ES2289492T3 (enExample) |
| MX (1) | MXPA05009498A (enExample) |
| TW (1) | TWI274761B (enExample) |
| WO (1) | WO2004078791A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| CN101575385B (zh) * | 2008-05-09 | 2011-01-12 | 青岛九龙生物医药有限公司 | 萃取法分离肝素钠中的多硫酸软骨素的方法 |
| CN101831008B (zh) * | 2009-03-11 | 2013-04-10 | 四川茂森生物科技有限公司 | 粗品肝素钠精制生产新工艺 |
| CN108508129B (zh) * | 2018-04-03 | 2020-11-27 | 青岛海洋生物医药研究院股份有限公司 | 一种肝素类药物生物效价的测定方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2034599A (en) | 1933-07-10 | 1936-03-17 | Buffalo Foundry & Machine Co | Method of drying inorganic salts and sludges |
| US2571679A (en) | 1948-07-08 | 1951-10-16 | Carlo Erba S A | Process for preparing purified heparin |
| US2797184A (en) | 1953-07-01 | 1957-06-25 | Upjohn Co | Process for the recovery of heparin |
| US2884358A (en) | 1957-04-22 | 1959-04-28 | Southern California Gland Co | Process for preparing crude heparin |
| US2954321A (en) | 1957-09-23 | 1960-09-27 | Upjohn Co | Process for preparing heparin |
| US3337409A (en) | 1963-11-20 | 1967-08-22 | Rexall Drug Chemical | Process for the recovery of heparin |
| US3330327A (en) * | 1964-03-30 | 1967-07-11 | Continental Oil Co | Drying tertiary amine oxides on extended heated surfaces at elevated temperatures |
| US3817831A (en) | 1973-01-10 | 1974-06-18 | Wilson Pharm & Chem Corp | Process for production of alkali metal salt of heparin |
| CA1136620A (en) | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Heparin fragments having selective anticoagulation activity |
| US4510135A (en) * | 1982-04-21 | 1985-04-09 | Research Corporation | Orally administered heparin |
| DE3422518A1 (de) * | 1984-06-16 | 1985-12-19 | B. Braun Melsungen Ag, 3508 Melsungen | Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen |
| DK170015B1 (da) * | 1992-03-19 | 1995-05-01 | Sudurnesja Hitaveita | Saltprodukt samt fremgangsmåde til dets fremstilling |
| US5668118A (en) * | 1992-07-24 | 1997-09-16 | Cavalier Pharmaceuticals | Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G |
| DE4310088A1 (de) | 1993-03-27 | 1994-09-29 | Hoechst Ag | Verfahren zur Herstellung und Aufarbeitung von in wäßrigem Medium löslichen N-Hydroxyalkylchitosanen |
| AU682792B2 (en) * | 1994-10-13 | 1997-10-16 | Cv Therapeutics, Inc. | Method of manufacturing non-absorbable synthetic sulfated polysaccharides |
| CA2173642C (en) * | 1995-04-10 | 1999-11-02 | James Vincent Gruber | Process for derivatizing polyglucosamines |
| TR200000086T2 (tr) | 1997-07-16 | 2000-08-21 | Akzo Nobel N.V. | Heparin üretimi için işlem. |
| CN1218058A (zh) | 1997-11-26 | 1999-06-02 | 中国林业科学研究院林产化学工业研究所 | 肝素的喷雾干燥方法 |
| US6485945B1 (en) | 1999-02-17 | 2002-11-26 | Nurture, Inc. | Polysaccharide compositions and uses thereof |
| AU3623601A (en) | 2000-02-07 | 2001-08-14 | Granate Seed Ltd | Process for extraction of beta-glucan from cereals and products obtained therefrom |
-
2004
- 2004-02-27 US US10/789,466 patent/US6933372B2/en not_active Expired - Fee Related
- 2004-03-02 CL CL200400414A patent/CL2004000414A1/es unknown
- 2004-03-04 EP EP04717174A patent/EP1611161B1/en not_active Expired - Lifetime
- 2004-03-04 ES ES04717174T patent/ES2289492T3/es not_active Expired - Lifetime
- 2004-03-04 CA CA002517141A patent/CA2517141C/en not_active Expired - Fee Related
- 2004-03-04 JP JP2006506297A patent/JP2006519906A/ja not_active Ceased
- 2004-03-04 WO PCT/IB2004/000625 patent/WO2004078791A1/en not_active Ceased
- 2004-03-04 DE DE602004007784T patent/DE602004007784T2/de not_active Expired - Lifetime
- 2004-03-04 MX MXPA05009498A patent/MXPA05009498A/es active IP Right Grant
- 2004-03-04 AT AT04717174T patent/ATE368057T1/de not_active IP Right Cessation
- 2004-03-05 TW TW093105873A patent/TWI274761B/zh not_active IP Right Cessation
- 2004-03-05 AR ARP040100707A patent/AR043731A1/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| TWI274761B (en) | 2007-03-01 |
| EP1611161B1 (en) | 2007-07-25 |
| ATE368057T1 (de) | 2007-08-15 |
| US20040176581A1 (en) | 2004-09-09 |
| DE602004007784T2 (de) | 2007-12-06 |
| EP1611161A1 (en) | 2006-01-04 |
| US6933372B2 (en) | 2005-08-23 |
| CA2517141C (en) | 2008-11-18 |
| MXPA05009498A (es) | 2005-10-18 |
| WO2004078791A1 (en) | 2004-09-16 |
| TW200502255A (en) | 2005-01-16 |
| CL2004000414A1 (es) | 2005-02-04 |
| JP2006519906A (ja) | 2006-08-31 |
| AR043731A1 (es) | 2005-08-10 |
| CA2517141A1 (en) | 2004-09-16 |
| DE602004007784D1 (de) | 2007-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6555431B2 (ja) | 保湿外用剤 | |
| CN101443364A (zh) | 由秋葵果实荚分离的果胶多糖 | |
| Haj-Ahmad et al. | Compare and contrast the effects of surfactants (Pluronic® F-127 and Cremophor® EL) and sugars (β-cyclodextrin and inulin) on properties of spray dried and crystallised lysozyme | |
| CN108264574A (zh) | 多糖的臭氧降解方法 | |
| CN107982534B (zh) | 壳聚糖/硫化铜纳米复合空心球的制备方法及其产品和应用 | |
| Niu et al. | Advances in sulfonated modification and bioactivity of polysaccharides | |
| ES2248322T3 (es) | Esteres polisacaridos de derivados n- del acido glutamico. | |
| ES2289492T3 (es) | Metodo para producir una forma solida de heparina. | |
| ES2205114T3 (es) | Fucanos con bajo peso molecular que tienen actividad anticoagulante, antitrombinica y antitrombotica. | |
| Liu et al. | Antioxidant and DNA protecting activity of carboxymethylated polysaccharides from Cortex periplocae | |
| CN102690373A (zh) | 一种胍基化壳聚糖的制法 | |
| CA2439337A1 (en) | Highly sulfated derivatives of k5 polysaccharide and their preparation | |
| CN108888775A (zh) | 一种透明质酸-甲氨蝶呤自组装纳米胶束及其制备方法 | |
| Piccirillo et al. | Photoinduced thiol‐ene chemistry applied to the synthesis of self‐assembling elastin‐inspired glycopeptides | |
| CN105294872B (zh) | 一种羧甲基化梭柄松苞菇多糖的制备方法 | |
| US20140255382A1 (en) | Solid composition containing a hypothiocyanite salt | |
| CN102675486A (zh) | 用于大量生产硒化环糊精的方法 | |
| JP2008189829A (ja) | ホスファチジルエタノールアミン結合多糖類の製造方法 | |
| CN106265807B (zh) | 一种太行菊总黄酮的提取方法 | |
| CN105949344A (zh) | 一种阳离子超支化多糖衍生物及其在增强血卟啉类光敏剂对肿瘤细胞光毒性方面的应用 | |
| JPS5813522A (ja) | 粘液溶解活性をもつ非吸収性化合物、その製法、及びそれを活性成分として含む治療用組成物 | |
| US20090239822A1 (en) | Process for the preparation of esters of diacerein with hyaluronic acid and pharmaceutical compositions containing such esters | |
| WO2014195770A1 (es) | Complejos quitina-glucano y proceso para la preparación de los mismos a partir de biomateriales ricos en quitina | |
| CN103405381B (zh) | 一种制备无定型态物质的方法 | |
| CN104623661A (zh) | 基于上转换发光技术的酞菁锌高分子脂质体的制备方法 |