JP2006519854A5 - - Google Patents
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- Publication number
- JP2006519854A5 JP2006519854A5 JP2006508652A JP2006508652A JP2006519854A5 JP 2006519854 A5 JP2006519854 A5 JP 2006519854A5 JP 2006508652 A JP2006508652 A JP 2006508652A JP 2006508652 A JP2006508652 A JP 2006508652A JP 2006519854 A5 JP2006519854 A5 JP 2006519854A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- compound
- group
- administered
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 40
- 239000011710 vitamin D Substances 0.000 claims 27
- 229940046008 vitamin d Drugs 0.000 claims 27
- 229930003316 Vitamin D Natural products 0.000 claims 25
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 25
- 235000019166 vitamin D Nutrition 0.000 claims 25
- -1 vitamin D compound Chemical class 0.000 claims 25
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000002252 acyl group Chemical group 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 208000020832 chronic kidney disease Diseases 0.000 claims 3
- 239000002552 dosage form Substances 0.000 claims 3
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 3
- 239000002694 phosphate binding agent Substances 0.000 claims 3
- ODZFJAXAEXQSKL-USTMCHFFSA-N 1,24(S)-dihydroxyvitamin D2 Chemical compound C([C@@H]([C@]1(CCC2)C)[C@H](C)/C=C/[C@@](C)(O)C(C)C)CC1\C2=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ODZFJAXAEXQSKL-USTMCHFFSA-N 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- 102000003982 Parathyroid hormone Human genes 0.000 claims 2
- 108090000445 Parathyroid hormone Proteins 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- HKXBNHCUPKIYDM-CGMHZMFXSA-N doxercalciferol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C HKXBNHCUPKIYDM-CGMHZMFXSA-N 0.000 claims 2
- 125000004991 fluoroalkenyl group Chemical group 0.000 claims 2
- 239000000199 parathyroid hormone Substances 0.000 claims 2
- 229960001319 parathyroid hormone Drugs 0.000 claims 2
- 230000003442 weekly effect Effects 0.000 claims 2
- NEETXMRNUNEBRH-GOTXBORWSA-N (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r,5s)-5,6-dimethylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CC[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C NEETXMRNUNEBRH-GOTXBORWSA-N 0.000 claims 1
- ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 claims 1
- HVAVRRBYXYEBNC-RKULPTJNSA-N 24-hydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/C(C)(O)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C HVAVRRBYXYEBNC-RKULPTJNSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 201000002980 Hyperparathyroidism Diseases 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/385,327 US20040043971A1 (en) | 1995-04-03 | 2003-03-10 | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| PCT/US2004/003059 WO2004080467A2 (en) | 2003-03-10 | 2004-02-04 | Method of treating and preventing hyperparathyroidism with vitamin d2 or d4 compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006519854A JP2006519854A (ja) | 2006-08-31 |
| JP2006519854A5 true JP2006519854A5 (cg-RX-API-DMAC7.html) | 2007-03-22 |
Family
ID=32987299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006508652A Pending JP2006519854A (ja) | 2003-03-10 | 2004-02-04 | ビタミンｄ２及びｄ４化合物により上皮小体機能亢進症を治療しかつ予防する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20040043971A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1601364A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2006519854A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1758916A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004220622A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0408198A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2517160A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004080467A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| WO2001022093A1 (en) * | 1999-09-20 | 2001-03-29 | Eli Lilly And Company | Method for monitoring treatment with a parathyroid hormone |
| CN100391464C (zh) * | 2001-12-03 | 2008-06-04 | 诺瓦西股份有限公司 | 含活性维生素d化合物的药物组合物 |
| US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| US20050020546A1 (en) * | 2003-06-11 | 2005-01-27 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| US20050148557A1 (en) * | 2003-07-29 | 2005-07-07 | Jin Tian | Use of Vitamin Ds to treat kidney disease |
| DK2792363T3 (da) * | 2003-08-26 | 2016-09-26 | Shire Biopharmaceuticals Holdings Ireland Ltd | Farmaceutisk formulering, der omfatter lanthanforbindelser |
| US7381428B2 (en) | 2003-08-26 | 2008-06-03 | Shire International Licensing B.V. | Stabilized lanthanum carbonate compositions |
| WO2005102355A1 (en) * | 2004-04-23 | 2005-11-03 | Genzyme Corporation | METHODS OF TREATING VARIOUS VITAMIN D METABOLISM CONDITIONS WITH 1α-HYDROXYVITAMIN D2 |
| US20070122477A1 (en) * | 2005-10-12 | 2007-05-31 | Cytochroma, Inc. | Methods and articles for treating 25-hydroxyvitamin D insufficiency and deficiency |
| EP1978808B1 (en) * | 2006-01-30 | 2018-08-29 | Panion & BF Biotech Inc. | Ferric citrate for reversing, preventing, delaying or stabilizing soft tissue calcification |
| PT3095447T (pt) | 2006-02-03 | 2022-01-24 | Opko Renal Llc | Tratamento da insuficiência e deficiência de vitamina d com 25-hidroxivitamina d2 e 25-hidroxivitamina d3 |
| DK2037936T3 (da) | 2006-06-21 | 2014-09-22 | Opko Renal Llc | Fremgangsmåde til behandling og forebyggelse af sekundær hyperparathyroidisme |
| EP1932807A1 (en) * | 2006-12-14 | 2008-06-18 | Novartis AG | Inorganic compounds |
| ES3047207T3 (en) * | 2007-04-25 | 2025-12-03 | Opko Renal Llc | Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease |
| KR101691876B1 (ko) | 2007-04-25 | 2017-01-02 | 사이토크로마 인코포레이티드 | 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물 |
| CA2683628C (en) * | 2007-04-25 | 2018-03-06 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
| EP2148685A4 (en) * | 2007-04-25 | 2010-07-28 | Cytochroma Inc | METHODS AND COMPOUNDS FOR THERAPY BASED ON VITAMIN D |
| AU2009214049B2 (en) * | 2008-02-13 | 2014-02-06 | Dsm Ip Assets B.V. | Combination of vitamin D and 25-hydroxyvitamin D 3 |
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| AU2009214054B2 (en) * | 2008-02-13 | 2014-12-18 | Dsm Ip Assets B.V. | Use of 25-hydroxy-vitamin D3 to affect human muscle physiology |
| ES2593356T3 (es) | 2008-04-02 | 2016-12-07 | Opko Ireland Global Holdings, Ltd. | Métodos, composiciones, usos y kits útiles para la deficiencia de la vitamina D y trastornos relacionados |
| WO2010045558A1 (en) * | 2008-10-17 | 2010-04-22 | Fresenius Medical Care Holdings, Inc. | Method of determining a phosphorus binder dosage for a dialysis patient |
| US11672809B2 (en) | 2010-03-29 | 2023-06-13 | Eirgen Pharma Ltd. | Methods and compositions for reducing parathyroid levels |
| JP5899213B2 (ja) * | 2010-08-06 | 2016-04-06 | マイカーティス エヌ．ヴェ．ＭｙＣａｒｔｉｓ ＮＶ | 腎機能不全のバイオマーカーとしてのパールカン |
| MY172886A (en) | 2012-06-29 | 2019-12-13 | Wisconsin Alumni Res Found | Use of 2-methylene-19-nor-(20s)-1?25-dihydroxyvitamin d3 to treat secondary hyperparathyroidism |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| US10369161B2 (en) | 2014-12-30 | 2019-08-06 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism |
| US9539264B2 (en) | 2014-12-30 | 2017-01-10 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics |
| KR20180123100A (ko) | 2016-03-28 | 2018-11-14 | 옵코 아일랜드 글로벌 홀딩스 리미티드 | 비타민 d 치료 방법 |
| CN106723065A (zh) * | 2017-01-12 | 2017-05-31 | 浙江格蕾斯生物科技有限公司 | 一种维生素d和硼复合营养补充剂 |
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| US5597575A (en) * | 1994-06-06 | 1997-01-28 | Breitbarth; Richard | Composition for stimulating and inducing hair growth |
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| US5559107A (en) * | 1994-10-20 | 1996-09-24 | Gates; Stephen | Regulation of immune response |
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| US5696103A (en) * | 1995-11-17 | 1997-12-09 | Syntex (U.S.A.) Inc. | Method for treating osteoporosis |
| US5691328A (en) * | 1996-02-02 | 1997-11-25 | Clarion Pharmaceuticals Inc. | Phosphoethanolamine conjugates of vitamin D compounds |
| US5716946A (en) * | 1996-02-13 | 1998-02-10 | Wisconsin Alumni Research Foundation | Multiple sclerosis treatment |
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| US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
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| US5972917A (en) * | 1998-05-29 | 1999-10-26 | Bone Care Int Inc | 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof |
| BR0113703A (pt) * | 2000-09-08 | 2003-07-22 | Wisconsin Alumni Researcg Foun | Compostos e métodos de tratamento de psorìase, leucemia, câncer do cólon, do seio ou da próstata, osteodistrofia renal, de doenças auto-imune, inflamatória e de condição de pele |
| WO2002062352A2 (en) * | 2001-02-07 | 2002-08-15 | Durect Corporation | Devices and methods for management of bone density |
| WO2002076344A1 (en) * | 2001-03-23 | 2002-10-03 | Durect Corporation | Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space |
-
2003
- 2003-03-10 US US10/385,327 patent/US20040043971A1/en not_active Abandoned
-
2004
- 2004-02-04 CN CNA2004800066681A patent/CN1758916A/zh active Pending
- 2004-02-04 JP JP2006508652A patent/JP2006519854A/ja active Pending
- 2004-02-04 WO PCT/US2004/003059 patent/WO2004080467A2/en not_active Ceased
- 2004-02-04 EP EP04708146A patent/EP1601364A2/en not_active Withdrawn
- 2004-02-04 AU AU2004220622A patent/AU2004220622A1/en not_active Abandoned
- 2004-02-04 BR BRPI0408198-6A patent/BRPI0408198A/pt not_active IP Right Cessation
- 2004-02-04 CA CA002517160A patent/CA2517160A1/en not_active Abandoned
-
2009
- 2009-05-06 US US12/436,173 patent/US20100087404A1/en not_active Abandoned
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