ES2055019T3 - Metodo para la conversion fotoquimica de compuestos de taquisterol en compuestos de previtamina d y de compuestos de trans-vitamina d en compuestos de cis-vitamina d. - Google Patents
Metodo para la conversion fotoquimica de compuestos de taquisterol en compuestos de previtamina d y de compuestos de trans-vitamina d en compuestos de cis-vitamina d.Info
- Publication number
- ES2055019T3 ES2055019T3 ES89202959T ES89202959T ES2055019T3 ES 2055019 T3 ES2055019 T3 ES 2055019T3 ES 89202959 T ES89202959 T ES 89202959T ES 89202959 T ES89202959 T ES 89202959T ES 2055019 T3 ES2055019 T3 ES 2055019T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- vitamin
- compound
- cis
- trans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006243 chemical reaction Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- XQFJZHAVTPYDIQ-LETJEVNCSA-N (1s)-3-[(e)-2-[(1r,3ar,7ar)-1-[(e,2r,5r)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-1,2,3,3a,6,7-hexahydroinden-4-yl]ethenyl]-4-methylcyclohex-3-en-1-ol Chemical class C=1([C@@H]2CC[C@@H]([C@]2(CCC=1)C)[C@H](C)/C=C/[C@H](C)C(C)C)\C=C\C1=C(C)CC[C@H](O)C1 XQFJZHAVTPYDIQ-LETJEVNCSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 3
- 229940088594 vitamin Drugs 0.000 title 2
- 239000011782 vitamin Substances 0.000 title 2
- 229920000642 polymer Polymers 0.000 abstract 5
- 239000003504 photosensitizing agent Substances 0.000 abstract 4
- 239000011710 vitamin D Substances 0.000 abstract 4
- 229940046008 vitamin d Drugs 0.000 abstract 4
- 125000003277 amino group Chemical group 0.000 abstract 3
- 239000004721 Polyphenylene oxide Substances 0.000 abstract 2
- 229920000570 polyether Polymers 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- -1 tachysterol compound Chemical class 0.000 abstract 2
- 206010073306 Exposure to radiation Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229920001400 block copolymer Polymers 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- YUGCAAVRZWBXEQ-WHTXLNIXSA-N previtamin D3 Chemical class C=1([C@@H]2CC[C@@H]([C@]2(CCC=1)C)[C@H](C)CCCC(C)C)\C=C/C1=C(C)CC[C@H](O)C1 YUGCAAVRZWBXEQ-WHTXLNIXSA-N 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- BUNBVCKYYMRTNS-UHFFFAOYSA-N tachysterol Natural products C=1CCC2(C)C(C(C)CCC(C)C(C)C)CCC2C=1C=CC1=C(C)CCC(O)C1 BUNBVCKYYMRTNS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/337—Polymers modified by chemical after-treatment with organic compounds containing other elements
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyethers (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
DICHAS CONVERSIONES SE REALIZAN BAJO LA INFLUENCIA DE RADIACION POR EXPOSICION DEL COMPUESTO DE TAQUISTEROL Y EL DE TRANS-VITAMINA, RESPECTIVAMENTE DISUELTOS EN UN DISOLVENTE APROPIADO EN PRESENCIA DE UN FOTOSINTETIZADOR POLIMERICO QUE CONSISTE EN UNA CADENA DE POLIMERO (EJE. CENTRAL) QUE COMPRENDE UN ENLACE COVALENTEMENTE SINTETIZADO APROPIADO PARA LA CONVERSION FOTOQUIMICA, PARA ILUMINAR CON UNA LONGITUD DE ONDA DE APROX. 300 A 1.000NM, Y PARA SU AISLAMIENTO DEL COMPUESTO DE PREVITAMINA D Y DE CIS-VITAMINA D RESPECTIVAMENTE PARA LOS CUALES UN FOTOSINTETIZADOR ES USADO EN LA CADENA DE POLIMERO, LA CUAL HA SIDO SELECCIONADA DEL GRUPO QUE CONSISTE EN UNA CADENA POLIETER, UNA CADENA DE POLIMERO QUE CONTIENE GRUPOS AMINO Y UNA CADENA DE BLOQUES DE COPOLIMERO QUE COMPRENDE SEGMENTOS DE POLIETER Y/O SEGMENTOS DE POLIMERO QUE CONTIENEN GRUPOS AMINAS, DE MANERA QUE EL FOTOSINTETIZADOR POLIMERICO DISUELVE EN EL SISTEMA DISOLVENTE DURANTE LA EXPOSICION A LA RADIACION PERO CUALQUIERA SE PRECIPITAEN FRIO DESDE LA SOLUCION Y PUEDE SER SEPARADO, O EN CASO DE QUE DICHA CADENA DE POLIMERO COMPRENDA GRUPOS AMINAS PUEDE SER PROTONADOS CON UNA SUSTANCIA ACIDA APROPIADA Y ELIMINADOS EN UN TRATAMIENTO POSTERIOR. LA INVENCION TAMBIEN TRATA UN FOTOSINTETIZADOR PARA SER USADO EN DICHO METODO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8803040 | 1988-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2055019T3 true ES2055019T3 (es) | 1994-08-16 |
Family
ID=19853363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89202959T Expired - Lifetime ES2055019T3 (es) | 1988-12-12 | 1989-11-22 | Metodo para la conversion fotoquimica de compuestos de taquisterol en compuestos de previtamina d y de compuestos de trans-vitamina d en compuestos de cis-vitamina d. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5035783A (es) |
| EP (1) | EP0373687B1 (es) |
| JP (1) | JPH02202870A (es) |
| AT (1) | ATE90075T1 (es) |
| AU (1) | AU622958B2 (es) |
| CA (1) | CA2004816A1 (es) |
| DE (1) | DE68906866T2 (es) |
| DK (1) | DK615789A (es) |
| ES (1) | ES2055019T3 (es) |
| IL (1) | IL92635A0 (es) |
| ZA (1) | ZA899375B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0454204B1 (en) * | 1990-04-27 | 1995-06-28 | Duphar International Research B.V | Method for the photochemical isomeration of organic compounds under the influence of a photosensitizer |
| US5543016A (en) * | 1991-07-12 | 1996-08-06 | Inrad | Photoconversion of steroids in microreactors |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US5972917A (en) * | 1998-05-29 | 1999-10-26 | Bone Care Int Inc | 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof |
| ATE246172T1 (de) | 1998-05-29 | 2003-08-15 | Bone Care Int Inc | Verfahren zur herstellung von hydroxy-25-ene vitamin d verbindungen |
| WO2000053578A1 (en) * | 1999-03-11 | 2000-09-14 | Kuraray Co., Ltd. | Vitamin d derivatives and process for the preparation thereof |
| WO2004046097A1 (en) * | 2002-11-18 | 2004-06-03 | Teva Pharmaceutical Industries Ltd. | A crystallization method for purification of calcipotriene |
| US7094775B2 (en) | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
| US20190116791A1 (en) * | 2016-03-15 | 2019-04-25 | Fmc Corporation | Use of safeners with ppo inhibitor herbicides |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4609444A (en) * | 1982-11-16 | 1986-09-02 | Solarchem Corporation | Photochemical reactions for commercial synthesis |
| US4517125A (en) * | 1983-02-03 | 1985-05-14 | Chugai Seiyaku Kabushiki Kaisha | Novel vitamin D3 derivatives and process for producing the same |
| US4551214A (en) * | 1983-07-01 | 1985-11-05 | Hoffmann-La Roche Inc. | Photochemical preparation of previtamin D |
| US4686023A (en) * | 1985-11-26 | 1987-08-11 | Solarchem Research, Division Of Brolor Investments, Ltd. | Sensitized photochemical preparation of vitamin D |
| DK353487A (da) * | 1986-07-09 | 1988-01-10 | Solarchem Res | Polymere fotokatalysatorer |
| US4849076A (en) * | 1987-10-13 | 1989-07-18 | Neckers Douglas C | Continuous oxidation method |
-
1989
- 1989-11-22 ES ES89202959T patent/ES2055019T3/es not_active Expired - Lifetime
- 1989-11-22 DE DE8989202959T patent/DE68906866T2/de not_active Expired - Fee Related
- 1989-11-22 EP EP89202959A patent/EP0373687B1/en not_active Expired - Lifetime
- 1989-11-22 AT AT89202959T patent/ATE90075T1/de active
- 1989-12-07 DK DK615789A patent/DK615789A/da not_active Application Discontinuation
- 1989-12-07 US US07/447,509 patent/US5035783A/en not_active Expired - Fee Related
- 1989-12-07 ZA ZA899375A patent/ZA899375B/xx unknown
- 1989-12-07 CA CA002004816A patent/CA2004816A1/en not_active Abandoned
- 1989-12-09 JP JP1320423A patent/JPH02202870A/ja active Pending
- 1989-12-11 IL IL92635A patent/IL92635A0/xx not_active IP Right Cessation
- 1989-12-11 AU AU46155/89A patent/AU622958B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0373687B1 (en) | 1993-06-02 |
| DK615789D0 (da) | 1989-12-07 |
| AU622958B2 (en) | 1992-04-30 |
| DE68906866T2 (de) | 1993-09-09 |
| AU4615589A (en) | 1990-06-14 |
| JPH02202870A (ja) | 1990-08-10 |
| US5035783A (en) | 1991-07-30 |
| EP0373687A1 (en) | 1990-06-20 |
| IL92635A0 (en) | 1990-08-31 |
| DE68906866D1 (de) | 1993-07-08 |
| ATE90075T1 (de) | 1993-06-15 |
| ZA899375B (en) | 1990-08-29 |
| DK615789A (da) | 1990-06-13 |
| CA2004816A1 (en) | 1990-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Grant refused |
Effective date: 19920729 |
|
| FG2A | Definitive protection |
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