JP2006519810A5 - - Google Patents
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- Publication number
- JP2006519810A5 JP2006519810A5 JP2006504641A JP2006504641A JP2006519810A5 JP 2006519810 A5 JP2006519810 A5 JP 2006519810A5 JP 2006504641 A JP2006504641 A JP 2006504641A JP 2006504641 A JP2006504641 A JP 2006504641A JP 2006519810 A5 JP2006519810 A5 JP 2006519810A5
- Authority
- JP
- Japan
- Prior art keywords
- phenoxy
- methyl
- carboran
- compound
- phthalonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 34
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 34
- 150000001875 compounds Chemical class 0.000 claims 23
- 239000011701 zinc Substances 0.000 claims 22
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 21
- 229910052725 zinc Inorganic materials 0.000 claims 21
- 229920006391 phthalonitrile polymer Polymers 0.000 claims 14
- 239000007983 Tris buffer Substances 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 5
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 229910052796 boron Inorganic materials 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000006994 Precancerous Conditions Diseases 0.000 claims 2
- CFNUZRMHHJZBOM-UHFFFAOYSA-N [B]1C2[B][B]C1[B][B][B][B][B][B][B]2 Chemical compound [B]1C2[B][B]C1[B][B][B][B][B][B][B]2 CFNUZRMHHJZBOM-UHFFFAOYSA-N 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 238000002428 photodynamic therapy Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- IFPMZBBHBZQTOV-UHFFFAOYSA-N 1,3,5-trinitro-2-(2,4,6-trinitrophenyl)-4-[2,4,6-trinitro-3-(2,4,6-trinitrophenyl)phenyl]benzene Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C(C=2C(=C(C=3C(=CC(=CC=3[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O)C(=CC=2[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O)=C1[N+]([O-])=O IFPMZBBHBZQTOV-UHFFFAOYSA-N 0.000 claims 1
- GBMHRAHIGHKROS-UHFFFAOYSA-N 1-sulfanylpyrrolidine-2,5-dione Chemical compound SN1C(=O)CCC1=O GBMHRAHIGHKROS-UHFFFAOYSA-N 0.000 claims 1
- GUYGJCNTCOUHBK-UHFFFAOYSA-N 3-[3,5-bis(bromomethyl)phenoxy]benzene-1,2-dicarbonitrile Chemical compound BrCC1=CC(CBr)=CC(OC=2C(=C(C#N)C=CC=2)C#N)=C1 GUYGJCNTCOUHBK-UHFFFAOYSA-N 0.000 claims 1
- UUIMTYIFGOBYKF-UHFFFAOYSA-N 3-[4-(bromomethyl)phenoxy]benzene-1,2-dicarbonitrile Chemical compound C1=CC(CBr)=CC=C1OC1=CC=CC(C#N)=C1C#N UUIMTYIFGOBYKF-UHFFFAOYSA-N 0.000 claims 1
- AAWGDBBRKJFKMG-UHFFFAOYSA-N 3-[4-(methylsulfonylmethyl)phenoxy]benzene-1,2-dicarbonitrile Chemical compound C1=CC(CS(=O)(=O)C)=CC=C1OC1=CC=CC(C#N)=C1C#N AAWGDBBRKJFKMG-UHFFFAOYSA-N 0.000 claims 1
- DHFCZMUHZPTUOW-UHFFFAOYSA-N 4-[3,5-bis(bromomethyl)phenoxy]benzene-1,2-dicarbonitrile Chemical compound BrCC1=CC(CBr)=CC(OC=2C=C(C(C#N)=CC=2)C#N)=C1 DHFCZMUHZPTUOW-UHFFFAOYSA-N 0.000 claims 1
- OZZBAKGLJQNXRK-UHFFFAOYSA-N 4-[4-(bromomethyl)phenoxy]benzene-1,2-dicarbonitrile Chemical compound C1=CC(CBr)=CC=C1OC1=CC=C(C#N)C(C#N)=C1 OZZBAKGLJQNXRK-UHFFFAOYSA-N 0.000 claims 1
- NGTAGGACDPIXKN-UHFFFAOYSA-N 4-[4-(methylsulfonylmethyl)phenoxy]benzene-1,2-dicarbonitrile Chemical compound C1=CC(CS(=O)(=O)C)=CC=C1OC1=CC=C(C#N)C(C#N)=C1 NGTAGGACDPIXKN-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- TVBISCWBJBKUDP-UHFFFAOYSA-N borate Chemical compound [O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-] TVBISCWBJBKUDP-UHFFFAOYSA-N 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 125000005948 methanesulfonyloxy group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical class N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 claims 1
- XQZYPMVTSDWCCE-UHFFFAOYSA-N phthalonitrile Chemical compound N#CC1=CC=CC=C1C#N XQZYPMVTSDWCCE-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000005424 tosyloxy group Chemical group S(=O)(=O)(C1=CC=C(C)C=C1)O* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITFI2003A00063 | 2003-03-11 | ||
| IT000063A ITFI20030063A1 (it) | 2003-03-11 | 2003-03-11 | Metallo ftalocianine boronate, loro preparazione, composizioni |
| PCT/EP2004/002505 WO2004081014A1 (en) | 2003-03-11 | 2004-03-11 | Boronated metal-phthalocyanines, process for their preparation, pharmaceutical compositions comprising them and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006519810A JP2006519810A (ja) | 2006-08-31 |
| JP2006519810A5 true JP2006519810A5 (enExample) | 2007-05-31 |
| JP4968673B2 JP4968673B2 (ja) | 2012-07-04 |
Family
ID=32983184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006504641A Expired - Fee Related JP4968673B2 (ja) | 2003-03-11 | 2004-03-11 | ホウ素化金属フタロシアニン、その調製方法、これを有する薬学的組成物及びその使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7842682B2 (enExample) |
| EP (1) | EP1603918B1 (enExample) |
| JP (1) | JP4968673B2 (enExample) |
| CN (1) | CN100374442C (enExample) |
| AT (1) | ATE402936T1 (enExample) |
| AU (1) | AU2004220406B2 (enExample) |
| CA (1) | CA2518934C (enExample) |
| DE (1) | DE602004015428D1 (enExample) |
| DK (1) | DK1603918T3 (enExample) |
| ES (1) | ES2311147T3 (enExample) |
| IL (1) | IL170761A (enExample) |
| IT (1) | ITFI20030063A1 (enExample) |
| PL (1) | PL1603918T3 (enExample) |
| WO (1) | WO2004081014A1 (enExample) |
| ZA (1) | ZA200507975B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7910755B2 (en) * | 2004-09-29 | 2011-03-22 | Harbor Biosciences, Inc. | Stem cell expansion and uses |
| WO2007098968A1 (en) * | 2006-03-03 | 2007-09-07 | Universität Bremen | Triggered release of liposome contents |
| US8287839B2 (en) | 2006-12-04 | 2012-10-16 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
| CN102284059A (zh) * | 2011-08-23 | 2011-12-21 | 福州大学 | 一种光敏剂及其制备方法和应用 |
| US10723694B2 (en) | 2018-10-02 | 2020-07-28 | Kuwait University | Propargyl-functionalized macrocyclic compounds |
| CN113968878B (zh) * | 2021-11-10 | 2023-07-07 | 中国科学院宁波材料技术与工程研究所 | 超支化硼酸改性的酞腈单体及其制备方法与应用 |
| CN116731315B (zh) * | 2022-03-04 | 2024-06-21 | 中国科学院化学研究所 | 一种含硼邻苯二甲腈树脂及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3730950A (en) * | 1972-02-01 | 1973-05-01 | Singer Co | Polyurethane copolymers derived from the carborane-silicon phthalocyanine monomer |
| JPH08225751A (ja) * | 1994-10-26 | 1996-09-03 | Nippon Shokubai Co Ltd | 新規フタロシアニン化合物、その製造方法およびそれらを用いた光記録媒体 |
| IT1294325B1 (it) * | 1997-08-14 | 1999-03-24 | Molteni L E C Dei Fratelli Ali | Zinco-ftalocianine e relativi coniugati, preparazione e uso nella terapia fotodinamica e come diagnostici |
-
2003
- 2003-03-11 IT IT000063A patent/ITFI20030063A1/it unknown
-
2004
- 2004-03-11 US US10/548,793 patent/US7842682B2/en not_active Expired - Fee Related
- 2004-03-11 WO PCT/EP2004/002505 patent/WO2004081014A1/en not_active Ceased
- 2004-03-11 CA CA2518934A patent/CA2518934C/en not_active Expired - Fee Related
- 2004-03-11 JP JP2006504641A patent/JP4968673B2/ja not_active Expired - Fee Related
- 2004-03-11 ES ES04719429T patent/ES2311147T3/es not_active Expired - Lifetime
- 2004-03-11 AT AT04719429T patent/ATE402936T1/de active
- 2004-03-11 DE DE602004015428T patent/DE602004015428D1/de not_active Expired - Lifetime
- 2004-03-11 DK DK04719429T patent/DK1603918T3/da active
- 2004-03-11 AU AU2004220406A patent/AU2004220406B2/en not_active Ceased
- 2004-03-11 CN CNB2004800065335A patent/CN100374442C/zh not_active Expired - Fee Related
- 2004-03-11 PL PL04719429T patent/PL1603918T3/pl unknown
- 2004-03-11 EP EP04719429A patent/EP1603918B1/en not_active Expired - Lifetime
-
2005
- 2005-09-08 IL IL170761A patent/IL170761A/en not_active IP Right Cessation
- 2005-10-03 ZA ZA200507975A patent/ZA200507975B/en unknown