JP2006518375A5 - - Google Patents

Info

Publication number

JP2006518375A5

JP2006518375A5 JP2006502781A JP2006502781A JP2006518375A5 JP 2006518375 A5 JP2006518375 A5 JP 2006518375A5 JP 2006502781 A JP2006502781 A JP 2006502781A JP 2006502781 A JP2006502781 A JP 2006502781A JP 2006518375 A5 JP2006518375 A5 JP 2006518375A5

Authority

JP

Japan

Prior art keywords

seq

peptide

epithelial

sequence

stromal cells

Prior art date

2004-01-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 19
• 210000002919 epithelial cell Anatomy 0.000 claims 9
• 210000002536 stromal cell Anatomy 0.000 claims 9
• 150000001413 amino acids Chemical class 0.000 claims 8
• 239000008194 pharmaceutical composition Substances 0.000 claims 8
• 150000002632 lipids Chemical class 0.000 claims 7
• 239000003814 drug Substances 0.000 claims 6
• 230000035755 proliferation Effects 0.000 claims 5
• 150000003839 salts Chemical class 0.000 claims 5
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 4
• 238000000338 in vitro Methods 0.000 claims 4
• 210000004898 n-terminal fragment Anatomy 0.000 claims 4
• 206010052428 Wound Diseases 0.000 claims 3
• 208000027418 Wounds and injury Diseases 0.000 claims 3
• 210000004027 cell Anatomy 0.000 claims 3
• 230000004663 cell proliferation Effects 0.000 claims 3
• 239000001963 growth medium Substances 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 208000025865 Ulcer Diseases 0.000 claims 2
• 239000007640 basal medium Substances 0.000 claims 2
• 239000002299 complementary DNA Substances 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 230000002068 genetic effect Effects 0.000 claims 2
• 230000002101 lytic effect Effects 0.000 claims 2
• 150000003904 phospholipids Chemical group 0.000 claims 2
• 230000008929 regeneration Effects 0.000 claims 2
• 238000011069 regeneration method Methods 0.000 claims 2
• 150000003408 sphingolipids Chemical class 0.000 claims 2
• 238000001890 transfection Methods 0.000 claims 2
• 238000012250 transgenic expression Methods 0.000 claims 2
• 231100000397 ulcer Toxicity 0.000 claims 2
• QZXMUPATKGLZAP-DXLAUQRQSA-N [(2S)-1-hexadecanoyloxy-3-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxypropan-2-yl] (9Z,12Z)-octadeca-9,12-dienoate Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](OC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)O[C@@H]1CO[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 QZXMUPATKGLZAP-DXLAUQRQSA-N 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• 239000007864 aqueous solution Substances 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 210000004748 cultured cell Anatomy 0.000 claims 1
• 230000003013 cytotoxicity Effects 0.000 claims 1
• 231100000135 cytotoxicity Toxicity 0.000 claims 1
• 230000002708 enhancing effect Effects 0.000 claims 1
• 210000000981 epithelium Anatomy 0.000 claims 1
• 230000035876 healing Effects 0.000 claims 1
• 230000036074 healthy skin Effects 0.000 claims 1
• 230000008938 immune dysregulation Effects 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 208000014674 injury Diseases 0.000 claims 1
• 239000002609 medium Substances 0.000 claims 1
• 230000003818 metabolic dysfunction Effects 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 238000002054 transplantation Methods 0.000 claims 1
• 230000008733 trauma Effects 0.000 claims 1
• 201000002282 venous insufficiency Diseases 0.000 claims 1
• 230000029663 wound healing Effects 0.000 claims 1