CA2513598C - Use of the cathelicidin ll-37 and derivatives thereof for wound healing - Google Patents
Use of the cathelicidin ll-37 and derivatives thereof for wound healing Download PDFInfo
- Publication number
- CA2513598C CA2513598C CA2513598A CA2513598A CA2513598C CA 2513598 C CA2513598 C CA 2513598C CA 2513598 A CA2513598 A CA 2513598A CA 2513598 A CA2513598 A CA 2513598A CA 2513598 C CA2513598 C CA 2513598C
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- Prior art keywords
- peptide
- proliferation
- cells
- hcap18
- dispersion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N5/0018—Culture media for cell or tissue culture
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Zoology (AREA)
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- Veterinary Medicine (AREA)
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- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
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- General Engineering & Computer Science (AREA)
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- Diabetes (AREA)
- Dispersion Chemistry (AREA)
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| SE0300207A SE0300207D0 (sv) | 2003-01-29 | 2003-01-29 | New use and composition |
| SE0300207-8 | 2003-01-29 | ||
| US44496403P | 2003-02-05 | 2003-02-05 | |
| US60/444,964 | 2003-02-05 | ||
| PCT/SE2004/000111 WO2004067025A1 (en) | 2003-01-29 | 2004-01-28 | Use of the cathelicidin ll-37 and derivatives thereof for wound healing |
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| CA2513598A1 CA2513598A1 (en) | 2004-08-12 |
| CA2513598C true CA2513598C (en) | 2015-04-21 |
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| SE0300207D0 (sv) * | 2003-01-29 | 2003-01-29 | Karolinska Innovations Ab | New use and composition |
| WO2004098536A2 (en) * | 2003-03-06 | 2004-11-18 | The Regents Of The University Of California | Anti-viral activity of cathelicidin peptides |
| PT3100611T (pt) | 2003-08-01 | 2018-12-14 | Stratatech Corp | Equivalentes de pele humana que expressam polipéptidos exógenos |
| WO2005013885A2 (en) | 2003-08-07 | 2005-02-17 | Healor Ltd. | Pharmaceutical compositions and methods for accelerating wound healing |
| US7776823B2 (en) * | 2003-10-21 | 2010-08-17 | The Regents Of The University Of California | Human cathelicidin antimicrobial peptides |
| SE0401942D0 (sv) * | 2004-07-28 | 2004-07-28 | Lipopeptide Ab | New antimicrobial peptide complexes |
| WO2006067402A2 (en) * | 2004-12-22 | 2006-06-29 | Lipopeptide Ab | Agents inibiting the cathelin-like protein cap18/ll-37 |
| ES2462541T3 (es) * | 2005-06-09 | 2014-05-23 | Meda Ab | Método y composición para el tratamiento de trastornos inflamatorios |
| US9044438B2 (en) | 2005-06-17 | 2015-06-02 | Yitzchak Hillman | Disease treatment via antimicrobial peptides or their inhibitors |
| US8202835B2 (en) | 2005-06-17 | 2012-06-19 | Yitzchak Hillman | Disease treatment via antimicrobial peptides or their inhibitors |
| EP2462944A3 (en) | 2005-08-29 | 2012-09-12 | HealOr Ltd. | Methods and compositions for prevention and treatment of diabetic and aged skin |
| AU2007262776A1 (en) * | 2006-06-20 | 2007-12-27 | Lipopeptide Ab | Use cathelicidin antimicrobial protein (hCAP18 ) as anticancer agent |
| US20100273748A1 (en) * | 2006-09-08 | 2010-10-28 | The Regents Of The University Of California | Antimicrobial therapy |
| EP2069377A4 (en) * | 2006-09-27 | 2009-11-11 | Univ California | METHOD AND COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES AND SKIN FUNCTIONAL DISORDERS |
| WO2008103751A2 (en) * | 2007-02-20 | 2008-08-28 | The Regents Of The University Of California | Antimicrobial and anti-inflammatory therapies and compositions |
| CN101720237A (zh) * | 2007-06-25 | 2010-06-02 | 利波佩普蒂德有限公司 | 新型医用产品 |
| JP2010533705A (ja) * | 2007-07-15 | 2010-10-28 | ヒルマン，イチャク | 抗菌ペプチドまたはその阻害剤を用いた疾病治療 |
| CN102755649A (zh) * | 2007-07-30 | 2012-10-31 | 希尔洛有限公司 | 药物组合物及相关方法 |
| US20100310514A1 (en) * | 2009-06-04 | 2010-12-09 | Chi Hin Cho | Anti-Inflammatory Bacteria |
| US20130079382A1 (en) | 2009-10-12 | 2013-03-28 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| AU2010316006B2 (en) * | 2009-11-03 | 2013-09-26 | Lipidor Ab | Composition for promoting wound healing |
| US10279007B2 (en) | 2010-11-15 | 2019-05-07 | Oxygenetix Institute, Inc. | Topical treatment method for healing wounds, disinfecting, covering and concealing the wound until healing occurs |
| WO2012150890A1 (en) * | 2011-05-02 | 2012-11-08 | Lipidor Ab | Antibacterial composition |
| AU2013235692B2 (en) * | 2012-03-20 | 2016-12-08 | Helix Biomedix Inc | Short antimicrobial lipopeptides |
| US8969290B2 (en) | 2012-06-26 | 2015-03-03 | Worcester Polytechnic Institute | Matrix scaffold with antimicrobial activity |
| EP2821077A1 (en) * | 2013-07-04 | 2015-01-07 | Praxis Biopharma Research Institute | Lipid nanoparticles for wound healing |
| CN104513293A (zh) * | 2013-09-26 | 2015-04-15 | 深圳信立泰药业股份有限公司 | 一种多肽疫苗的盐及其制备方法和含有该盐的药物制品 |
| WO2015075406A1 (en) | 2013-11-19 | 2015-05-28 | Lipopeptide Ab | New treatment of chronic ulcers |
| CN103920137B (zh) * | 2014-04-28 | 2016-03-30 | 中国药科大学 | 一种具有抗耐药性革兰阳性细菌作用的药物组合物 |
| US10138282B2 (en) * | 2014-05-27 | 2018-11-27 | Indiana University Research And Technology Corporation | Peptide antagonist of LL-37 |
| CN104984321A (zh) * | 2015-07-24 | 2015-10-21 | 中国药科大学 | 人源抗菌肽ll-37在制备治疗或预防血栓性疾病药物中的应用 |
| CN105859867A (zh) * | 2016-05-30 | 2016-08-17 | 黄石市中心医院 | 一种人源抗菌肽ll-37突变体及其应用 |
| CN106519042A (zh) * | 2016-12-29 | 2017-03-22 | 陕西慧康生物科技有限责任公司 | 人源胶原蛋白与抗菌肽的融合蛋白及其制备方法与编码基因 |
| US20190300575A1 (en) | 2018-03-29 | 2019-10-03 | Deetex, LLC | Lytic peptide biosensor and methods of making and using the same |
| CN108659102B (zh) * | 2018-04-25 | 2021-08-17 | 南方医科大学 | 具有抗菌及抗炎活性的多肽化合物 |
| ES2799098B2 (es) | 2019-06-10 | 2021-12-10 | Univ Madrid Carlos Iii | Aptameros agonistas del receptor fpr2 y usos de los mismos |
| KR102475936B1 (ko) * | 2020-10-15 | 2022-12-09 | 코스맥스 주식회사 | 펩타이드 ll-37을 발현하는 효모를 포함하는 화장료 조성물 |
| PL443243A1 (pl) * | 2022-12-22 | 2024-06-24 | Uniwersytet Warszawski | Nowe peptydy antydrobnoustrojowe |
| CN118895244B (zh) * | 2024-07-23 | 2025-06-20 | 浙江自贸区中航生物科技有限责任公司 | 一种提高nk细胞杀伤活性的多肽及其应用 |
| CN120789277A (zh) * | 2025-09-18 | 2025-10-17 | 山东大学 | 一种基于(1,3)-β-D-葡聚糖合成酶抑制剂的抗真菌药物组合物 |
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| US5861478A (en) | 1987-07-06 | 1999-01-19 | Helix Biomedix, Inc. | Lytic peptides |
| FI963066A7 (fi) | 1994-02-04 | 1996-09-30 | Lipocore Holding Ab | Lipofiiliset kantoainevalmisteet |
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-
2003
- 2003-01-29 SE SE0300207A patent/SE0300207D0/xx unknown
-
2004
- 2004-01-28 EP EP04705973.8A patent/EP1589987B1/en not_active Expired - Lifetime
- 2004-01-28 ES ES04705973.8T patent/ES2467090T3/es not_active Expired - Lifetime
- 2004-01-28 DK DK04705973.8T patent/DK1589987T3/da active
- 2004-01-28 CA CA2513598A patent/CA2513598C/en not_active Expired - Lifetime
- 2004-01-28 JP JP2006502781A patent/JP4750690B2/ja not_active Expired - Fee Related
- 2004-01-28 WO PCT/SE2004/000111 patent/WO2004067025A1/en not_active Ceased
- 2004-01-28 PT PT47059738T patent/PT1589987E/pt unknown
- 2004-01-28 US US10/543,659 patent/US7452864B2/en not_active Expired - Lifetime
- 2004-01-28 SI SI200432154T patent/SI1589987T1/sl unknown
- 2004-01-28 CN CN2004800032098A patent/CN1744913B/zh not_active Expired - Fee Related
- 2004-01-28 CN CN201010150582A patent/CN101838326A/zh active Pending
- 2004-01-28 CN CN201510400952.7A patent/CN105079784B/zh not_active Expired - Fee Related
-
2005
- 2005-07-20 ZA ZA200505830A patent/ZA200505830B/en unknown
-
2008
- 2008-09-12 US US12/232,215 patent/US8012933B2/en not_active Expired - Fee Related
-
2011
- 2011-07-28 US US13/193,131 patent/US8506994B2/en not_active Expired - Fee Related
-
2013
- 2013-07-09 US US13/938,120 patent/US8936807B2/en not_active Expired - Lifetime
-
2014
- 2014-05-15 CY CY20141100342T patent/CY1115142T1/el unknown
- 2014-12-11 US US14/567,267 patent/US9125875B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4750690B2 (ja) | 2011-08-17 |
| US8936807B2 (en) | 2015-01-20 |
| US20090088382A1 (en) | 2009-04-02 |
| EP1589987A1 (en) | 2005-11-02 |
| US9125875B2 (en) | 2015-09-08 |
| US20150094256A1 (en) | 2015-04-02 |
| CN105079784A (zh) | 2015-11-25 |
| EP1589987B1 (en) | 2014-04-23 |
| CN1744913B (zh) | 2010-05-26 |
| PT1589987E (pt) | 2014-05-28 |
| WO2004067025A1 (en) | 2004-08-12 |
| CN105079784B (zh) | 2018-05-18 |
| US7452864B2 (en) | 2008-11-18 |
| CA2513598A1 (en) | 2004-08-12 |
| CN1744913A (zh) | 2006-03-08 |
| HK1217661A1 (zh) | 2017-01-20 |
| US8012933B2 (en) | 2011-09-06 |
| ZA200505830B (en) | 2006-04-26 |
| US20070149448A1 (en) | 2007-06-28 |
| DK1589987T3 (da) | 2014-05-26 |
| US8506994B2 (en) | 2013-08-13 |
| JP2006518375A (ja) | 2006-08-10 |
| SI1589987T1 (sl) | 2014-07-31 |
| ES2467090T3 (es) | 2014-06-11 |
| US20130287839A1 (en) | 2013-10-31 |
| CY1115142T1 (el) | 2016-12-14 |
| SE0300207D0 (sv) | 2003-01-29 |
| CN101838326A (zh) | 2010-09-22 |
| US20110293707A1 (en) | 2011-12-01 |
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