JP2006517562A5 - - Google Patents
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- Publication number
- JP2006517562A5 JP2006517562A5 JP2006501817A JP2006501817A JP2006517562A5 JP 2006517562 A5 JP2006517562 A5 JP 2006517562A5 JP 2006501817 A JP2006501817 A JP 2006501817A JP 2006501817 A JP2006501817 A JP 2006501817A JP 2006517562 A5 JP2006517562 A5 JP 2006517562A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- compound according
- treatment
- compound
- remission
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 9
- 102000010907 Cyclooxygenase 2 Human genes 0.000 claims 8
- 108010037462 Cyclooxygenase 2 Proteins 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000001575 pathological effect Effects 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 206010037660 Pyrexia Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 229940127293 prostanoid Drugs 0.000 claims 3
- 150000003814 prostanoids Chemical class 0.000 claims 3
- 230000016160 smooth muscle contraction Effects 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000007800 oxidant agent Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 claims 2
- VXUYXOFXAQZZMF-UHFFFAOYSA-N titanium(IV) isopropoxide Chemical compound CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C VXUYXOFXAQZZMF-UHFFFAOYSA-N 0.000 claims 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical group ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims 1
- SLXXLDBGJKCVGS-HSZRJFAPSA-N 5-chloro-2-(6-methylpyridin-3-yl)-3-[4-[(r)-methylsulfinyl]phenyl]pyridine Chemical compound C1=NC(C)=CC=C1C1=NC=C(Cl)C=C1C1=CC=C([S@@](C)=O)C=C1 SLXXLDBGJKCVGS-HSZRJFAPSA-N 0.000 claims 1
- SLXXLDBGJKCVGS-QHCPKHFHSA-N 5-chloro-2-(6-methylpyridin-3-yl)-3-[4-[(s)-methylsulfinyl]phenyl]pyridine Chemical compound C1=NC(C)=CC=C1C1=NC=C(Cl)C=C1C1=CC=C([S@](C)=O)C=C1 SLXXLDBGJKCVGS-QHCPKHFHSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- YSAVZVORKRDODB-WDSKDSINSA-N diethyl tartrate Chemical compound CCOC(=O)[C@@H](O)[C@H](O)C(=O)OCC YSAVZVORKRDODB-WDSKDSINSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003462 sulfoxides Chemical class 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200300354A ES2214130B1 (es) | 2003-02-13 | 2003-02-13 | 2-3'-bipiridinas. |
| PCT/EP2004/001297 WO2004072037A1 (en) | 2003-02-13 | 2004-02-12 | 2,3'-bipyridines derivatives as selective cox-2 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006517562A JP2006517562A (ja) | 2006-07-27 |
| JP2006517562A5 true JP2006517562A5 (https=) | 2007-03-08 |
Family
ID=32865135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006501817A Pending JP2006517562A (ja) | 2003-02-13 | 2004-02-12 | 選択的ｃｏｘ−２阻害剤としての２，３’−ビピリジン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060229338A1 (https=) |
| EP (1) | EP1592666A1 (https=) |
| JP (1) | JP2006517562A (https=) |
| CN (1) | CN100408561C (https=) |
| ES (1) | ES2214130B1 (https=) |
| WO (1) | WO2004072037A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
| ES2214129B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 3-fenilfuran-2-onas. |
| MY163379A (en) * | 2010-11-15 | 2017-09-15 | Virdev Intermediates Pvt Ltd | A process for cyclooxygenase-2 selective inhibitor |
| CN103204803A (zh) * | 2012-01-13 | 2013-07-17 | 阿尔弗雷德·E·蒂芬巴赫尔有限责任两合公司 | 用于合成依托考昔的方法 |
| EP2846793A1 (en) | 2012-05-09 | 2015-03-18 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease |
| CN104788362A (zh) * | 2014-01-21 | 2015-07-22 | 济南三元化工有限公司 | 一种依托考昔或其药学上可接受的盐的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6486194B2 (en) * | 1993-06-24 | 2002-11-26 | Merck Frosst Canada, Inc. | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases |
| US6231888B1 (en) * | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
| IL127441A (en) * | 1996-07-18 | 2003-02-12 | Merck Frosst Canada Inc | Substituted pyridines, pharmaceutical compositions comprising them and their use in the preparation of anti-inflammatory medicaments or as selective cyclooxygenase-2 inhibitors |
| US6307047B1 (en) * | 1997-08-22 | 2001-10-23 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| ES2256817T3 (es) * | 1997-09-05 | 2006-07-16 | Glaxo Group Limited | Composiciones farmaceuticas que comprenden derivados de 2,3-diaril-pirazolo(1,5-b)piridazina. |
| US5994379A (en) * | 1998-02-13 | 1999-11-30 | Merck Frosst Canada, Inc. | Bisaryl COX-2 inhibiting compounds, compositions and methods of use |
| KR100295206B1 (ko) * | 1998-08-22 | 2001-07-12 | 서경배 | 디아릴벤조피란유도체및이를함유하는시클로옥시게네이즈-2저해제조성물 |
| TW587079B (en) * | 1998-09-25 | 2004-05-11 | Almirall Prodesfarma Ag | 2-phenylpyran-4-one derivatives |
| DZ3265A1 (fr) * | 1999-04-14 | 2000-10-19 | Pacific Corp | Derives de 4,5-diaryl-3(2h)-furanone comme inhibiteurs de cyclo-oxygenase-2 |
| AU5873000A (en) * | 1999-06-24 | 2001-01-31 | Pharmacia Corporation | Combination of tumors necrocis factor (tnf) antagonists and cox-2 inhibitors forthe treatment of inflammation |
| DE60006057T2 (de) * | 1999-12-03 | 2004-05-27 | Pfizer Products Inc., Groton | Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
| CA2412651A1 (en) * | 2000-05-22 | 2001-11-29 | Dr. Reddy's Laboratories Limited | Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them |
| WO2001091856A2 (en) * | 2000-06-01 | 2001-12-06 | Pharmacia Corporation | Use of cox2 inhibitors for treating skin injury from exposure to ultraviolet radiation |
| AU2001282886A1 (en) * | 2000-07-13 | 2002-01-30 | Pharmacia Corporation | Combination of a cox-2 inhibitor and a vasomodulator for treating pain and headache pain |
| JP2004505060A (ja) * | 2000-07-27 | 2004-02-19 | ファルマシア・コーポレーション | 炎症関連心臓血管障害を防止するかまたは治療するためのアルドステロンアンタゴニストおよびシクロオキシゲナーゼ−２阻害剤併用療法 |
| WO2002055502A1 (en) * | 2001-01-02 | 2002-07-18 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine derivatives useful as cyclooxygenase inhibitor |
| EP1492773B1 (en) * | 2002-04-05 | 2009-02-04 | Cadila Healthcare Ltd. | 4-(heterocyclyl)-benzenesulfoximine compounds for the treatment of inflammation |
| ES2213485B1 (es) * | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
| ES2214129B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 3-fenilfuran-2-onas. |
-
2003
- 2003-02-13 ES ES200300354A patent/ES2214130B1/es not_active Expired - Fee Related
-
2004
- 2004-02-12 WO PCT/EP2004/001297 patent/WO2004072037A1/en not_active Ceased
- 2004-02-12 JP JP2006501817A patent/JP2006517562A/ja active Pending
- 2004-02-12 CN CNB2004800098767A patent/CN100408561C/zh not_active Expired - Fee Related
- 2004-02-12 US US10/544,360 patent/US20060229338A1/en not_active Abandoned
- 2004-02-12 EP EP04710355A patent/EP1592666A1/en not_active Withdrawn
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