JP2006514063A5 - - Google Patents

Info

Publication number

JP2006514063A5

JP2006514063A5 JP2004566119A JP2004566119A JP2006514063A5 JP 2006514063 A5 JP2006514063 A5 JP 2006514063A5 JP 2004566119 A JP2004566119 A JP 2004566119A JP 2004566119 A JP2004566119 A JP 2004566119A JP 2006514063 A5 JP2006514063 A5 JP 2006514063A5

Authority

JP

Japan

Prior art keywords

alkyl

bile acid

reuptake inhibitor

group

disease

Prior art date

2003-12-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 22
• 239000003112 inhibitor Substances 0.000 claims 15
• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical group C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 11
• 239000003613 bile acid Substances 0.000 claims 11
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 10
• 150000001875 compounds Chemical class 0.000 claims 10
• 208000024827 Alzheimer disease Diseases 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 5
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
• 238000011282 treatment Methods 0.000 claims 5
• 230000002265 prevention Effects 0.000 claims 4
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
• 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 2
• 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 2
• 229940127328 Cholesterol Synthesis Inhibitors Drugs 0.000 claims 2
• 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 239000008280 blood Substances 0.000 claims 2
• 210000004369 blood Anatomy 0.000 claims 2
• 235000012000 cholesterol Nutrition 0.000 claims 2
• 125000000600 disaccharide group Chemical group 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 125000001483 monosaccharide substituent group Chemical group 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims 2
• 125000006239 protecting group Chemical group 0.000 claims 2
• 125000004076 pyridyl group Chemical group 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 150000004044 tetrasaccharides Chemical group 0.000 claims 2
• 150000004043 trisaccharides Chemical group 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 125000004414 alkyl thio group Chemical group 0.000 claims 1
• 229910052794 bromium Inorganic materials 0.000 claims 1
• 229910052801 chlorine Inorganic materials 0.000 claims 1
• 229910052731 fluorine Inorganic materials 0.000 claims 1
• 125000001153 fluoro group Chemical group F* 0.000 claims 1
• 229910052736 halogen Chemical group 0.000 claims 1
• 150000002367 halogens Chemical group 0.000 claims 1
• 125000001072 heteroaryl group Chemical group 0.000 claims 1
• 229910052740 iodine Inorganic materials 0.000 claims 1
• 230000000149 penetrating effect Effects 0.000 claims 1
• 239000008177 pharmaceutical agent Substances 0.000 claims 1
• 238000011321 prophylaxis Methods 0.000 claims 1