JP2006517561A5 - - Google Patents
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- Publication number
- JP2006517561A5 JP2006517561A5 JP2006501816A JP2006501816A JP2006517561A5 JP 2006517561 A5 JP2006517561 A5 JP 2006517561A5 JP 2006501816 A JP2006501816 A JP 2006501816A JP 2006501816 A JP2006501816 A JP 2006501816A JP 2006517561 A5 JP2006517561 A5 JP 2006517561A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- disease
- formula
- treatment
- pathological condition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 102000010907 Cyclooxygenase 2 Human genes 0.000 claims 8
- 108010037462 Cyclooxygenase 2 Proteins 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000001575 pathological effect Effects 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 230000005764 inhibitory process Effects 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 206010037660 Pyrexia Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 229940127293 prostanoid Drugs 0.000 claims 3
- 150000003814 prostanoids Chemical class 0.000 claims 3
- 230000016160 smooth muscle contraction Effects 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- RAECDKKKKNJXTF-OAQYLSRUSA-N 3-[4-[(r)-methylsulfinyl]phenyl]-4-phenyl-2h-furan-5-one Chemical compound C1=CC([S@](=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RAECDKKKKNJXTF-OAQYLSRUSA-N 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- 239000007800 oxidant agent Substances 0.000 claims 2
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 claims 2
- VXUYXOFXAQZZMF-UHFFFAOYSA-N titanium(IV) isopropoxide Chemical compound CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C VXUYXOFXAQZZMF-UHFFFAOYSA-N 0.000 claims 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical group ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- YSAVZVORKRDODB-WDSKDSINSA-N diethyl tartrate Chemical compound CCOC(=O)[C@@H](O)[C@H](O)C(=O)OCC YSAVZVORKRDODB-WDSKDSINSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200300353A ES2214129B1 (es) | 2003-02-13 | 2003-02-13 | 3-fenilfuran-2-onas. |
| PCT/EP2004/001296 WO2004072057A1 (en) | 2003-02-13 | 2004-02-12 | 3-phenylfuran-2-one derivatives as cox-2 inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006517561A JP2006517561A (ja) | 2006-07-27 |
| JP2006517561A5 true JP2006517561A5 (https=) | 2007-03-15 |
Family
ID=32865134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006501816A Pending JP2006517561A (ja) | 2003-02-13 | 2004-02-12 | Ｃｏｘ−２阻害剤としての３−フェニルフラン−２−オン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060189684A1 (https=) |
| EP (1) | EP1592678A1 (https=) |
| JP (1) | JP2006517561A (https=) |
| CN (1) | CN100349884C (https=) |
| ES (1) | ES2214129B1 (https=) |
| WO (1) | WO2004072057A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2213485B1 (es) * | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
| ES2214130B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 2-3'-bipiridinas. |
| JP5666087B2 (ja) * | 2005-04-06 | 2015-02-12 | アダマス・ファーマシューティカルズ・インコーポレーテッド | Ｃｎｓ関連疾患の治療のための方法及び組成物 |
| EP2846793A1 (en) | 2012-05-09 | 2015-03-18 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease |
| CA3119728A1 (en) * | 2018-11-21 | 2020-05-28 | Tremeau Pharmaceuticals, Inc. | Purified forms of rofecoxib, methods of manufacture and use |
| US10945992B1 (en) | 2019-11-13 | 2021-03-16 | Tremeau Pharmaceuticals, Inc. | Dosage forms of rofecoxib and related methods |
| US11161833B1 (en) | 2021-04-09 | 2021-11-02 | Tremeau Pharmaceuticals, Inc. | Deuterated etoricoxib, methods of manufacture, and use thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6486194B2 (en) * | 1993-06-24 | 2002-11-26 | Merck Frosst Canada, Inc. | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases |
| US6231888B1 (en) * | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
| JP2000510444A (ja) * | 1996-03-29 | 2000-08-15 | メルク フロスト カナダ アンド カンパニー | シクロオキシゲナーゼ抑制剤としてのビスアリールシクロブテン誘導体 |
| CN1140267C (zh) * | 1996-05-17 | 2004-03-03 | 麦克公司 | 治疗环加氧酶-2介导的疾病的每天一次的组合物 |
| US6307047B1 (en) * | 1997-08-22 | 2001-10-23 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| ES2256817T3 (es) * | 1997-09-05 | 2006-07-16 | Glaxo Group Limited | Composiciones farmaceuticas que comprenden derivados de 2,3-diaril-pirazolo(1,5-b)piridazina. |
| US5994379A (en) * | 1998-02-13 | 1999-11-30 | Merck Frosst Canada, Inc. | Bisaryl COX-2 inhibiting compounds, compositions and methods of use |
| EP1085845A2 (en) * | 1998-06-08 | 2001-03-28 | Advanced Medicine, Inc. | Multibinding inhibitors of cyclooxygenase-2 |
| KR100295206B1 (ko) * | 1998-08-22 | 2001-07-12 | 서경배 | 디아릴벤조피란유도체및이를함유하는시클로옥시게네이즈-2저해제조성물 |
| TW587079B (en) * | 1998-09-25 | 2004-05-11 | Almirall Prodesfarma Ag | 2-phenylpyran-4-one derivatives |
| DZ3265A1 (fr) * | 1999-04-14 | 2000-10-19 | Pacific Corp | Derives de 4,5-diaryl-3(2h)-furanone comme inhibiteurs de cyclo-oxygenase-2 |
| DE60006057T2 (de) * | 1999-12-03 | 2004-05-27 | Pfizer Products Inc., Groton | Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
| CA2412651A1 (en) * | 2000-05-22 | 2001-11-29 | Dr. Reddy's Laboratories Limited | Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them |
| ES2213485B1 (es) * | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
| ES2214130B1 (es) * | 2003-02-13 | 2005-12-01 | Almirall Prodesfarma, S.A. | 2-3'-bipiridinas. |
-
2003
- 2003-02-13 ES ES200300353A patent/ES2214129B1/es not_active Expired - Fee Related
-
2004
- 2004-02-12 WO PCT/EP2004/001296 patent/WO2004072057A1/en not_active Ceased
- 2004-02-12 JP JP2006501816A patent/JP2006517561A/ja active Pending
- 2004-02-12 US US10/544,359 patent/US20060189684A1/en not_active Abandoned
- 2004-02-12 CN CNB2004800096102A patent/CN100349884C/zh not_active Expired - Fee Related
- 2004-02-12 EP EP04710354A patent/EP1592678A1/en not_active Withdrawn
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