JP2005538974A5 - - Google Patents
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- Publication number
- JP2005538974A5 JP2005538974A5 JP2004518667A JP2004518667A JP2005538974A5 JP 2005538974 A5 JP2005538974 A5 JP 2005538974A5 JP 2004518667 A JP2004518667 A JP 2004518667A JP 2004518667 A JP2004518667 A JP 2004518667A JP 2005538974 A5 JP2005538974 A5 JP 2005538974A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cyano
- hydrogen
- halogen
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 43
- 229910052739 hydrogen Inorganic materials 0.000 claims 40
- 239000001257 hydrogen Substances 0.000 claims 40
- 229910052736 halogen Chemical group 0.000 claims 39
- -1 4- (2-methoxyphenyl) piperazin-1-yl Chemical group 0.000 claims 37
- 150000002367 halogens Chemical group 0.000 claims 37
- 125000004093 cyano group Chemical group *C#N 0.000 claims 31
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 30
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 21
- 125000003118 aryl group Chemical group 0.000 claims 20
- 125000003342 alkenyl group Chemical group 0.000 claims 18
- 125000000304 alkynyl group Chemical group 0.000 claims 18
- 125000002252 acyl group Chemical group 0.000 claims 17
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 11
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 10
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 10
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 10
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 10
- 229910052794 bromium Inorganic materials 0.000 claims 10
- 229910052801 chlorine Inorganic materials 0.000 claims 10
- 239000000460 chlorine Substances 0.000 claims 10
- 229910052731 fluorine Inorganic materials 0.000 claims 10
- 239000011737 fluorine Substances 0.000 claims 10
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 10
- 208000016285 Movement disease Diseases 0.000 claims 8
- 208000018737 Parkinson disease Diseases 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 208000011580 syndromic disease Diseases 0.000 claims 6
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 5
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 5
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 206010003591 Ataxia Diseases 0.000 claims 4
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 4
- 230000003111 delayed effect Effects 0.000 claims 4
- 206010013663 drug dependence Diseases 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 101710155073 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase Proteins 0.000 claims 2
- 208000007848 Alcoholism Diseases 0.000 claims 2
- 208000022497 Cocaine-Related disease Diseases 0.000 claims 2
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010057852 Nicotine dependence Diseases 0.000 claims 2
- 239000008896 Opium Substances 0.000 claims 2
- 208000004224 Opium Dependence Diseases 0.000 claims 2
- 208000005793 Restless legs syndrome Diseases 0.000 claims 2
- 201000001880 Sexual dysfunction Diseases 0.000 claims 2
- 208000025569 Tobacco Use disease Diseases 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 229960003920 cocaine Drugs 0.000 claims 2
- 201000006145 cocaine dependence Diseases 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000002651 drug therapy Methods 0.000 claims 2
- 208000013403 hyperactivity Diseases 0.000 claims 2
- 208000031424 hyperprolactinemia Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 229960001027 opium Drugs 0.000 claims 2
- 230000035935 pregnancy Effects 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 231100000872 sexual dysfunction Toxicity 0.000 claims 2
- 230000002269 spontaneous effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000002123 temporal effect Effects 0.000 claims 1
- 0 CC(C)(CC(C)(C)N(CC1)CCN1c1ccccc1)CNC(c1c(*)c(cccc2)c2[n]1)=O Chemical compound CC(C)(CC(C)(C)N(CC1)CCN1c1ccccc1)CNC(c1c(*)c(cccc2)c2[n]1)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10230062 | 2002-07-04 | ||
| DE10232020A DE10232020A1 (de) | 2002-07-04 | 2002-07-10 | Neurorezeptoraktive Heteroarencarboxamide |
| PCT/EP2003/007060 WO2004004729A1 (de) | 2002-07-04 | 2003-07-02 | Heteroarencarboxamide zur verwendung als dopamin-d3 liganden zur behandlung von zns-erkrankungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005538974A JP2005538974A (ja) | 2005-12-22 |
| JP2005538974A5 true JP2005538974A5 (https=) | 2006-04-20 |
Family
ID=30116602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004518667A Pending JP2005538974A (ja) | 2002-07-04 | 2003-07-02 | 中枢神経系の病気を治療するドーパミン−ｄ３リガンドとして使用するためのヘテロアレーンカルボキサミド |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20050197343A1 (https=) |
| EP (1) | EP1519726B1 (https=) |
| JP (1) | JP2005538974A (https=) |
| KR (1) | KR20050075281A (https=) |
| CN (1) | CN1665503A (https=) |
| AT (1) | ATE354367T1 (https=) |
| AU (1) | AU2003246356A1 (https=) |
| CA (1) | CA2489396A1 (https=) |
| DE (1) | DE50306588D1 (https=) |
| DK (1) | DK1519726T3 (https=) |
| ES (1) | ES2280799T3 (https=) |
| IL (1) | IL165677A0 (https=) |
| MX (1) | MXPA05000033A (https=) |
| NO (1) | NO20050386L (https=) |
| PL (1) | PL374612A1 (https=) |
| RU (1) | RU2320656C2 (https=) |
| WO (1) | WO2004004729A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE521512C2 (sv) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| ES2285233T3 (es) | 2002-12-20 | 2007-11-16 | Niconovum Ab | Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable. |
| DE102004037445A1 (de) * | 2004-08-02 | 2006-03-16 | Schwarz Pharma Ag | Carboxamide des Indolizins und seiner Aza- und Diazaderivate |
| DE102004054634A1 (de) * | 2004-11-12 | 2006-05-18 | Schwarz Pharma Ag | Azaindolcarboxamide |
| DE102004063797A1 (de) * | 2004-12-30 | 2006-07-13 | Schwarz Pharma Ag | Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide |
| CA2593266A1 (en) * | 2005-01-03 | 2006-07-13 | Universita Degli Studi Di Siena | Aryl piperazine derivatives for the treatment of neuropsychiatric disorders |
| US9402809B2 (en) | 2006-03-16 | 2016-08-02 | Niconovum Usa, Inc. | Snuff composition |
| FR2903986A1 (fr) * | 2006-07-21 | 2008-01-25 | Pierre Fabre Medicament Sa | Nouveaux derives chromenes ou thiochromenes carboxamides, leur procede de preparation et leurs applications en therapeutique |
| WO2008153573A1 (en) * | 2007-06-15 | 2008-12-18 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | 4-phenylpiperazine derivatives with functionalized linkers as dopamine d3 receptor selective ligands and methods of use |
| US9227944B2 (en) | 2008-10-10 | 2016-01-05 | Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China | Dopamine D3 receptor ligands and preparation and medical uses of the same |
| JP5701213B2 (ja) * | 2008-10-10 | 2015-04-15 | インスティチュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー．エル．エー．チャイナ | 新規なドーパミンｄ３受容体リガンド、その調製及び使用 |
| FR2949465B1 (fr) * | 2009-09-01 | 2011-08-12 | Pf Medicament | Derives chromones, leur procede de preparation et leurs applications therapeutiques |
| US11299476B2 (en) | 2016-03-14 | 2022-04-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof |
| SI3429993T1 (sl) | 2016-03-14 | 2021-09-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health, Office Of Technology Transfer | Selektivni antagonisti/delni agonisti dopaminskega receptorja D3; postopki izdelave; in uporaba le-teh |
| EP3849963A1 (en) | 2018-09-11 | 2021-07-21 | The United States of America, as Represented By the Secretary, Department of Health and Human Services | Dopamine d3 receptor selective antagonists/partial agonists and uses thereof |
| CN114409621B (zh) * | 2022-02-09 | 2023-09-08 | 江苏省原子医学研究所 | 一种靶向多巴胺d3受体的诊疗药物及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3646048A (en) * | 1970-02-02 | 1972-02-29 | American Cyanamid Co | N-(tert-aminoalkyl)-2-indenecarboxamides |
| US3646047A (en) * | 1970-02-02 | 1972-02-29 | American Cyanamid Co | Certain benzo(b)thiophene-2-carboxamide derivatives |
| NL8005133A (nl) * | 1980-09-12 | 1982-04-01 | Duphar Int Res | Fenylpiperazinederivaten met antiagressieve werking. |
| IL90279A (en) * | 1988-05-24 | 1995-03-30 | American Home Prod | Piperazinyl carboxamide derivatives, their preparation and pharmaceutical com¦ositions containing them |
| US5106849A (en) * | 1988-05-24 | 1992-04-21 | American Home Products Corporation | Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders |
| ES2027898A6 (es) * | 1991-01-24 | 1992-06-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina. |
| SE9201138D0 (sv) * | 1992-04-09 | 1992-04-09 | Astra Ab | Novel phthalimidoalkylpiperazines |
| DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
| EP0891344B1 (fr) * | 1996-04-05 | 2002-12-18 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Antagonistes du recepteur alpha-1 adrenergique |
| HUP0103987A3 (en) * | 2001-09-28 | 2004-11-29 | Richter Gedeon Vegyeszet | Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates |
-
2003
- 2003-07-02 AT AT03762588T patent/ATE354367T1/de not_active IP Right Cessation
- 2003-07-02 EP EP03762588A patent/EP1519726B1/de not_active Expired - Lifetime
- 2003-07-02 CA CA002489396A patent/CA2489396A1/en not_active Abandoned
- 2003-07-02 KR KR1020047021525A patent/KR20050075281A/ko not_active Withdrawn
- 2003-07-02 MX MXPA05000033A patent/MXPA05000033A/es not_active Application Discontinuation
- 2003-07-02 WO PCT/EP2003/007060 patent/WO2004004729A1/de not_active Ceased
- 2003-07-02 RU RU2004139041/04A patent/RU2320656C2/ru not_active IP Right Cessation
- 2003-07-02 ES ES03762588T patent/ES2280799T3/es not_active Expired - Lifetime
- 2003-07-02 US US10/519,487 patent/US20050197343A1/en not_active Abandoned
- 2003-07-02 AU AU2003246356A patent/AU2003246356A1/en not_active Abandoned
- 2003-07-02 PL PL03374612A patent/PL374612A1/xx unknown
- 2003-07-02 DK DK03762588T patent/DK1519726T3/da active
- 2003-07-02 CN CN03815742XA patent/CN1665503A/zh active Pending
- 2003-07-02 JP JP2004518667A patent/JP2005538974A/ja active Pending
- 2003-07-02 DE DE50306588T patent/DE50306588D1/de not_active Expired - Fee Related
-
2004
- 2004-12-02 IL IL16567704A patent/IL165677A0/xx unknown
-
2005
- 2005-01-25 NO NO20050386A patent/NO20050386L/no not_active Application Discontinuation
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