CN1665503A - 杂芳烃甲酰胺作为多巴胺－d3配体用于治疗中枢神经系统疾病的用途 - Google Patents

杂芳烃甲酰胺作为多巴胺－d3配体用于治疗中枢神经系统疾病的用途 Download PDF

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Publication number
CN1665503A
CN1665503A CN03815742XA CN03815742A CN1665503A CN 1665503 A CN1665503 A CN 1665503A CN 03815742X A CN03815742X A CN 03815742XA CN 03815742 A CN03815742 A CN 03815742A CN 1665503 A CN1665503 A CN 1665503A
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alkyl
group
hydrogen
halogen
alkynyl
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Chinese (zh)
Inventor
P·格梅纳
H·许布纳
K·施罗特尔
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UCB Pharma GmbH
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Schwarz Pharma AG
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Priority claimed from DE10232020A external-priority patent/DE10232020A1/de
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
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    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
CN03815742XA 2002-07-04 2003-07-02 杂芳烃甲酰胺作为多巴胺－d3配体用于治疗中枢神经系统疾病的用途 Pending CN1665503A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10230062.3 2002-07-04
DE10230062 2002-07-04
DE10232020.9 2002-07-10
DE10232020A DE10232020A1 (de) 2002-07-04 2002-07-10 Neurorezeptoraktive Heteroarencarboxamide

Publications (1)

Publication Number Publication Date
CN1665503A true CN1665503A (zh) 2005-09-07

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ID=30116602

Family Applications (1)

Application Number Title Priority Date Filing Date
CN03815742XA Pending CN1665503A (zh) 2002-07-04 2003-07-02 杂芳烃甲酰胺作为多巴胺－d3配体用于治疗中枢神经系统疾病的用途

Country Status (17)

Country Link
US (1) US20050197343A1 (https=)
EP (1) EP1519726B1 (https=)
JP (1) JP2005538974A (https=)
KR (1) KR20050075281A (https=)
CN (1) CN1665503A (https=)
AT (1) ATE354367T1 (https=)
AU (1) AU2003246356A1 (https=)
CA (1) CA2489396A1 (https=)
DE (1) DE50306588D1 (https=)
DK (1) DK1519726T3 (https=)
ES (1) ES2280799T3 (https=)
IL (1) IL165677A0 (https=)
MX (1) MXPA05000033A (https=)
NO (1) NO20050386L (https=)
PL (1) PL374612A1 (https=)
RU (1) RU2320656C2 (https=)
WO (1) WO2004004729A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010040274A1 (zh) * 2008-10-10 2010-04-15 中国人民解放军军事医学科学院毒物药物研究所 新型多巴胺d3受体配体，其制备方法及其医药用途
CN114409621A (zh) * 2022-02-09 2022-04-29 江苏省原子医学研究所 一种靶向多巴胺d3受体的诊疗药物及其应用

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE521512C2 (sv) * 2001-06-25 2003-11-11 Niconovum Ab Anordning för administrering av en substans till främre delen av en individs munhåla
ES2285233T3 (es) 2002-12-20 2007-11-16 Niconovum Ab Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable.
DE102004037445A1 (de) * 2004-08-02 2006-03-16 Schwarz Pharma Ag Carboxamide des Indolizins und seiner Aza- und Diazaderivate
DE102004054634A1 (de) * 2004-11-12 2006-05-18 Schwarz Pharma Ag Azaindolcarboxamide
DE102004063797A1 (de) * 2004-12-30 2006-07-13 Schwarz Pharma Ag Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide
CA2593266A1 (en) * 2005-01-03 2006-07-13 Universita Degli Studi Di Siena Aryl piperazine derivatives for the treatment of neuropsychiatric disorders
US9402809B2 (en) 2006-03-16 2016-08-02 Niconovum Usa, Inc. Snuff composition
FR2903986A1 (fr) * 2006-07-21 2008-01-25 Pierre Fabre Medicament Sa Nouveaux derives chromenes ou thiochromenes carboxamides, leur procede de preparation et leurs applications en therapeutique
WO2008153573A1 (en) * 2007-06-15 2008-12-18 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 4-phenylpiperazine derivatives with functionalized linkers as dopamine d3 receptor selective ligands and methods of use
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
FR2949465B1 (fr) * 2009-09-01 2011-08-12 Pf Medicament Derives chromones, leur procede de preparation et leurs applications therapeutiques
US11299476B2 (en) 2016-03-14 2022-04-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof
SI3429993T1 (sl) 2016-03-14 2021-09-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health, Office Of Technology Transfer Selektivni antagonisti/delni agonisti dopaminskega receptorja D3; postopki izdelave; in uporaba le-teh
EP3849963A1 (en) 2018-09-11 2021-07-21 The United States of America, as Represented By the Secretary, Department of Health and Human Services Dopamine d3 receptor selective antagonists/partial agonists and uses thereof

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US3646047A (en) * 1970-02-02 1972-02-29 American Cyanamid Co Certain benzo(b)thiophene-2-carboxamide derivatives
NL8005133A (nl) * 1980-09-12 1982-04-01 Duphar Int Res Fenylpiperazinederivaten met antiagressieve werking.
IL90279A (en) * 1988-05-24 1995-03-30 American Home Prod Piperazinyl carboxamide derivatives, their preparation and pharmaceutical com¦ositions containing them
US5106849A (en) * 1988-05-24 1992-04-21 American Home Products Corporation Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders
ES2027898A6 (es) * 1991-01-24 1992-06-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina.
SE9201138D0 (sv) * 1992-04-09 1992-04-09 Astra Ab Novel phthalimidoalkylpiperazines
DE4425146A1 (de) * 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen
EP0891344B1 (fr) * 1996-04-05 2002-12-18 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Antagonistes du recepteur alpha-1 adrenergique
HUP0103987A3 (en) * 2001-09-28 2004-11-29 Richter Gedeon Vegyeszet Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010040274A1 (zh) * 2008-10-10 2010-04-15 中国人民解放军军事医学科学院毒物药物研究所 新型多巴胺d3受体配体，其制备方法及其医药用途
CN102264733B (zh) * 2008-10-10 2014-07-30 中国人民解放军军事医学科学院毒物药物研究所 新型多巴胺d3受体配体，其制备方法及其医药用途
CN114409621A (zh) * 2022-02-09 2022-04-29 江苏省原子医学研究所 一种靶向多巴胺d3受体的诊疗药物及其应用
CN114409621B (zh) * 2022-02-09 2023-09-08 江苏省原子医学研究所 一种靶向多巴胺d3受体的诊疗药物及其应用

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KR20050075281A (ko) 2005-07-20
AU2003246356A1 (en) 2004-01-23
US20050197343A1 (en) 2005-09-08
WO2004004729A1 (de) 2004-01-15
MXPA05000033A (es) 2005-04-08
ES2280799T3 (es) 2007-09-16
ATE354367T1 (de) 2007-03-15
RU2320656C2 (ru) 2008-03-27
PL374612A1 (en) 2005-10-31
EP1519726B1 (de) 2007-02-21
EP1519726A1 (de) 2005-04-06
CA2489396A1 (en) 2004-01-15
NO20050386L (no) 2005-01-25
JP2005538974A (ja) 2005-12-22
IL165677A0 (en) 2006-01-15
RU2004139041A (ru) 2005-07-20
DK1519726T3 (da) 2007-06-04
HK1074579A1 (en) 2005-11-18
DE50306588D1 (de) 2007-04-05

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