NO20050386L - Anvendelse av heteroarenkarboksamid som dopamin-D3 ligander for behandling av sykdommer i sentralnervesystemet - Google Patents

Anvendelse av heteroarenkarboksamid som dopamin-D3 ligander for behandling av sykdommer i sentralnervesystemet

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Publication number
NO20050386L
NO20050386L NO20050386A NO20050386A NO20050386L NO 20050386 L NO20050386 L NO 20050386L NO 20050386 A NO20050386 A NO 20050386A NO 20050386 A NO20050386 A NO 20050386A NO 20050386 L NO20050386 L NO 20050386L
Authority
NO
Norway
Prior art keywords
treatment
disorders
heteroarenecarboxamide
dopamine
ligands
Prior art date
Application number
NO20050386A
Other languages
English (en)
Inventor
Harald Huebner
Karin Schlotter
Peter Gmeiner
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10232020A external-priority patent/DE10232020A1/de
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of NO20050386L publication Critical patent/NO20050386L/no

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    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P25/16—Anti-Parkinson drugs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Oppfinnelsen angår neuroreseptor aktive N-[(4fenyl-l-piperazinyl)alkyl]-substituert heteroaren karboksamid med generell formel (1) og struktur-analoge 2-ferrocenyl forbindelser med generell formel (11), og anvendelse derav til behandhng av eNS-sykdommer, for eksempel schizofreni, forskjelhge former for depresjon, neurodegenerative lidelser, seksuelle dysfimksjoner, kokain-, alkohol-, opiat- og nikotinavhengighet, i tillegg til glaukom, kognitive lidelser, restless leg syndrom, hyperaktivitets- syndrom (ADHS), hyperprolaktinemi, hyperprolaktinom, bevegelseslidelser assosiert med Parkinson's sykdom, behandling av L-DOPA og neuroleptisk induserte bevegelseshdelser, for eksempel akathisia, rigor, dystoni og dyskinesi, hvori substitentene er definert i beskrivelsen.
NO20050386A 2002-07-04 2005-01-25 Anvendelse av heteroarenkarboksamid som dopamin-D3 ligander for behandling av sykdommer i sentralnervesystemet NO20050386L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10230062 2002-07-04
DE10232020A DE10232020A1 (de) 2002-07-04 2002-07-10 Neurorezeptoraktive Heteroarencarboxamide
PCT/EP2003/007060 WO2004004729A1 (de) 2002-07-04 2003-07-02 Heteroarencarboxamide zur verwendung als dopamin-d3 liganden zur behandlung von zns-erkrankungen

Publications (1)

Publication Number Publication Date
NO20050386L true NO20050386L (no) 2005-01-25

Family

ID=30116602

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050386A NO20050386L (no) 2002-07-04 2005-01-25 Anvendelse av heteroarenkarboksamid som dopamin-D3 ligander for behandling av sykdommer i sentralnervesystemet

Country Status (18)

Country Link
US (1) US20050197343A1 (no)
EP (1) EP1519726B1 (no)
JP (1) JP2005538974A (no)
KR (1) KR20050075281A (no)
CN (1) CN1665503A (no)
AT (1) ATE354367T1 (no)
AU (1) AU2003246356A1 (no)
CA (1) CA2489396A1 (no)
DE (1) DE50306588D1 (no)
DK (1) DK1519726T3 (no)
ES (1) ES2280799T3 (no)
HK (1) HK1074579A1 (no)
IL (1) IL165677A0 (no)
MX (1) MXPA05000033A (no)
NO (1) NO20050386L (no)
PL (1) PL374612A1 (no)
RU (1) RU2320656C2 (no)
WO (1) WO2004004729A1 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE521512C2 (sv) * 2001-06-25 2003-11-11 Niconovum Ab Anordning för administrering av en substans till främre delen av en individs munhåla
WO2004056363A2 (en) 2002-12-20 2004-07-08 Niconovum Ab A physically and chemically stable nicotine-containing particulate material
DE102004037445A1 (de) * 2004-08-02 2006-03-16 Schwarz Pharma Ag Carboxamide des Indolizins und seiner Aza- und Diazaderivate
DE102004054634A1 (de) * 2004-11-12 2006-05-18 Schwarz Pharma Ag Azaindolcarboxamide
DE102004063797A1 (de) * 2004-12-30 2006-07-13 Schwarz Pharma Ag Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide
WO2006072608A2 (en) * 2005-01-03 2006-07-13 Universitá Degli Studi Di Siena Aryl piperazine derivatives for the treatment of neuropsychiatric disorders
CA2646942C (en) 2006-03-16 2014-07-29 Niconovum Ab Improved snuff composition
FR2903986A1 (fr) * 2006-07-21 2008-01-25 Pierre Fabre Medicament Sa Nouveaux derives chromenes ou thiochromenes carboxamides, leur procede de preparation et leurs applications en therapeutique
AU2007354861B2 (en) * 2007-06-15 2013-03-21 The United States Of America As Represented By The Secretary, Department Of Health And Human Services 4-phenylpiperazine derivatives with functionalized linkers as dopamine D3 receptor selective ligands and methods of use
CN102264733B (zh) * 2008-10-10 2014-07-30 中国人民解放军军事医学科学院毒物药物研究所 新型多巴胺d3受体配体，其制备方法及其医药用途
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
FR2949465B1 (fr) * 2009-09-01 2011-08-12 Pf Medicament Derives chromones, leur procede de preparation et leurs applications therapeutiques
US11299476B2 (en) 2016-03-14 2022-04-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof
US11337971B2 (en) 2018-09-11 2022-05-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine D3 receptor selective antagonists/partial agonists and uses thereof
CN114409621B (zh) * 2022-02-09 2023-09-08 江苏省原子医学研究所 一种靶向多巴胺d3受体的诊疗药物及其应用

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Publication number Priority date Publication date Assignee Title
US3646048A (en) * 1970-02-02 1972-02-29 American Cyanamid Co N-(tert-aminoalkyl)-2-indenecarboxamides
US3646047A (en) * 1970-02-02 1972-02-29 American Cyanamid Co Certain benzo(b)thiophene-2-carboxamide derivatives
NL8005133A (nl) * 1980-09-12 1982-04-01 Duphar Int Res Fenylpiperazinederivaten met antiagressieve werking.
US5106849A (en) * 1988-05-24 1992-04-21 American Home Products Corporation Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders
CA1340113C (en) * 1988-05-24 1998-11-03 Magid A. Abou-Gharbia Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity
ES2027898A6 (es) * 1991-01-24 1992-06-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina.
SE9201138D0 (sv) * 1992-04-09 1992-04-09 Astra Ab Novel phthalimidoalkylpiperazines
DE4425146A1 (de) * 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen
HUP9901680A3 (en) * 1996-04-05 2000-12-28 Sod Conseils Rech Applic Use of piperazin-, piperidin- or hexahidropiridazin derivatives for the preparation of pharmaceutical compositions, new piperazin derivatives and pharmaceutical compositions containing these compounds
HUP0103987A3 (en) * 2001-09-28 2004-11-29 Richter Gedeon Vegyeszet Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates

Also Published As

Publication number Publication date
DE50306588D1 (de) 2007-04-05
KR20050075281A (ko) 2005-07-20
WO2004004729A1 (de) 2004-01-15
EP1519726B1 (de) 2007-02-21
US20050197343A1 (en) 2005-09-08
CN1665503A (zh) 2005-09-07
MXPA05000033A (es) 2005-04-08
RU2320656C2 (ru) 2008-03-27
DK1519726T3 (da) 2007-06-04
IL165677A0 (en) 2006-01-15
EP1519726A1 (de) 2005-04-06
RU2004139041A (ru) 2005-07-20
CA2489396A1 (en) 2004-01-15
PL374612A1 (en) 2005-10-31
JP2005538974A (ja) 2005-12-22
AU2003246356A1 (en) 2004-01-23
ES2280799T3 (es) 2007-09-16
ATE354367T1 (de) 2007-03-15
HK1074579A1 (en) 2005-11-18

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