JP2006517218A5 - - Google Patents
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- Publication number
- JP2006517218A5 JP2006517218A5 JP2006502114A JP2006502114A JP2006517218A5 JP 2006517218 A5 JP2006517218 A5 JP 2006517218A5 JP 2006502114 A JP2006502114 A JP 2006502114A JP 2006502114 A JP2006502114 A JP 2006502114A JP 2006517218 A5 JP2006517218 A5 JP 2006517218A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- cycloalkyl
- alkoxy
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 nitro, hydroxy Chemical group 0.000 claims 113
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 23
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 21
- 125000005843 halogen group Chemical group 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 21
- 125000004093 cyano group Chemical group *C#N 0.000 claims 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 18
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 13
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 11
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 10
- 125000001624 naphthyl group Chemical group 0.000 claims 10
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000002541 furyl group Chemical group 0.000 claims 9
- LOTBYPQQWICYBB-UHFFFAOYSA-N methyl n-hexyl-n-[2-(hexylamino)ethyl]carbamate Chemical compound CCCCCCNCCN(C(=O)OC)CCCCCC LOTBYPQQWICYBB-UHFFFAOYSA-N 0.000 claims 9
- 239000002253 acid Substances 0.000 claims 8
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 8
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 8
- 235000010290 biphenyl Nutrition 0.000 claims 8
- 239000004305 biphenyl Substances 0.000 claims 8
- 125000000842 isoxazolyl group Chemical group 0.000 claims 8
- 125000003373 pyrazinyl group Chemical group 0.000 claims 8
- 125000004076 pyridyl group Chemical group 0.000 claims 8
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 8
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 8
- 125000001544 thienyl group Chemical group 0.000 claims 8
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 7
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 125000004419 alkynylene group Chemical group 0.000 claims 6
- 125000004604 benzisothiazolyl group Chemical group S1N=C(C2=C1C=CC=C2)* 0.000 claims 6
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims 6
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 6
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 6
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 claims 6
- 125000001070 dihydroindolyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 6
- 125000004612 furopyridinyl group Chemical group O1C(=CC2=C1C=CC=N2)* 0.000 claims 6
- 125000002883 imidazolyl group Chemical group 0.000 claims 6
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 6
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 6
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims 6
- 125000001041 indolyl group Chemical group 0.000 claims 6
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims 6
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims 6
- 125000001786 isothiazolyl group Chemical group 0.000 claims 6
- 125000002757 morpholinyl group Chemical group 0.000 claims 6
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 6
- 125000002971 oxazolyl group Chemical group 0.000 claims 6
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims 6
- 125000003226 pyrazolyl group Chemical group 0.000 claims 6
- 125000002098 pyridazinyl group Chemical group 0.000 claims 6
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 6
- 125000000168 pyrrolyl group Chemical group 0.000 claims 6
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 6
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 6
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 6
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 6
- 125000000335 thiazolyl group Chemical group 0.000 claims 6
- 125000004306 triazinyl group Chemical group 0.000 claims 6
- 125000001425 triazolyl group Chemical group 0.000 claims 6
- MHCVCKDNQYMGEX-UHFFFAOYSA-N 1,1'-biphenyl;phenoxybenzene Chemical group C1=CC=CC=C1C1=CC=CC=C1.C=1C=CC=CC=1OC1=CC=CC=C1 MHCVCKDNQYMGEX-UHFFFAOYSA-N 0.000 claims 4
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 238000007098 aminolysis reaction Methods 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- SBYWBSRSYKFDAE-UHFFFAOYSA-N (2-amino-2-oxoethyl)-benzylcarbamic acid Chemical compound NC(=O)CN(C(O)=O)CC1=CC=CC=C1 SBYWBSRSYKFDAE-UHFFFAOYSA-N 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 101000918494 Homo sapiens Fatty-acid amide hydrolase 1 Proteins 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000022873 Ocular disease Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010063897 Renal ischaemia Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- RWOYDDZAZDYZNZ-UHFFFAOYSA-N benzyl-(2-ethoxy-2-oxoethyl)carbamic acid Chemical compound CCOC(=O)CN(C(O)=O)CC1=CC=CC=C1 RWOYDDZAZDYZNZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 208000002173 dizziness Diseases 0.000 claims 1
- 239000002621 endocannabinoid Substances 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000005956 isoquinolyl group Chemical group 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 150000001475 oxazolidinediones Chemical class 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 230000003071 parasitic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0300704A FR2850377B1 (fr) | 2003-01-23 | 2003-01-23 | Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique |
| PCT/FR2004/000139 WO2004067498A2 (fr) | 2003-01-23 | 2004-01-22 | Derives d’ arylalkylcarbamates, leur preparation et leur application en therapeutique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006517218A JP2006517218A (ja) | 2006-07-20 |
| JP2006517218A5 true JP2006517218A5 (https=) | 2007-03-08 |
| JP4617292B2 JP4617292B2 (ja) | 2011-01-19 |
Family
ID=32669151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006502114A Expired - Fee Related JP4617292B2 (ja) | 2003-01-23 | 2004-01-22 | アリールアルキルカルバメート誘導体の製造およびそれらの治療用途 |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US7632850B2 (https=) |
| EP (1) | EP1590321B1 (https=) |
| JP (1) | JP4617292B2 (https=) |
| KR (1) | KR20050104352A (https=) |
| CN (2) | CN101058564B (https=) |
| AR (1) | AR042746A1 (https=) |
| AT (1) | ATE465990T1 (https=) |
| AU (1) | AU2004207657B2 (https=) |
| BR (1) | BRPI0406901A (https=) |
| CA (1) | CA2511941A1 (https=) |
| CY (1) | CY1110216T1 (https=) |
| DE (1) | DE602004026826D1 (https=) |
| DK (1) | DK1590321T3 (https=) |
| EA (1) | EA008801B1 (https=) |
| ES (1) | ES2344454T3 (https=) |
| FR (1) | FR2850377B1 (https=) |
| HR (1) | HRP20050631A2 (https=) |
| IL (1) | IL169444A (https=) |
| IS (1) | IS7916A (https=) |
| MA (1) | MA27609A1 (https=) |
| ME (1) | MEP21308A (https=) |
| MX (1) | MXPA05007848A (https=) |
| NO (1) | NO20053593L (https=) |
| NZ (1) | NZ541148A (https=) |
| PL (1) | PL378022A1 (https=) |
| PT (1) | PT1590321E (https=) |
| RS (1) | RS20050562A (https=) |
| SI (1) | SI1590321T1 (https=) |
| TN (1) | TNSN05172A1 (https=) |
| TW (1) | TWI330628B (https=) |
| UA (1) | UA86013C2 (https=) |
| WO (1) | WO2004067498A2 (https=) |
| ZA (1) | ZA200505351B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2864080B1 (fr) * | 2003-12-23 | 2006-02-03 | Sanofi Synthelabo | Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique |
| FR2865205B1 (fr) | 2004-01-16 | 2006-02-24 | Sanofi Synthelabo | Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique |
| FR2866884B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique |
| FR2866885B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique |
| FR2866886B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique |
| DE102004039326A1 (de) * | 2004-08-12 | 2006-02-16 | Abbott Gmbh & Co. Kg | Neue medizinische Verwendungen und Verfahren |
| NZ590148A (en) | 2004-12-30 | 2012-04-27 | Janssen Pharmaceutica Nv | Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase |
| US20070155707A1 (en) * | 2005-12-29 | 2007-07-05 | Kadmus Pharmaceuticals, Inc. | Ionizable inhibitors of fatty acid amide hydrolase |
| WO2008030752A2 (en) * | 2006-09-07 | 2008-03-13 | N.V. Organon | Methods for determining effective doses of fatty acid amide hydrolase inhibitors in vivo |
| US20090099240A1 (en) * | 2006-10-02 | 2009-04-16 | N.V. Organon | Methods for treating energy metabolism disorders by inhibiting fatty acid amide hydrolase activity |
| CA2674359A1 (en) * | 2006-11-20 | 2008-05-29 | N.V. Organon | Metabolically-stabilized inhibitors of fatty acid amide hydrolase |
| US8124605B2 (en) * | 2007-07-06 | 2012-02-28 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
| TW200948805A (en) * | 2008-03-07 | 2009-12-01 | Sigma Tau Ind Farmaceuti | Enol carbamate derivatives as modulators of fatty acid amide hydrolase |
| CN101537006B (zh) * | 2008-03-18 | 2012-06-06 | 中国科学院上海药物研究所 | 哒嗪酮类化合物在制备抗肿瘤药物中的用途 |
| UA108233C2 (uk) | 2010-05-03 | 2015-04-10 | Модулятори активності гідролази амідів жирних кислот | |
| US9187413B2 (en) | 2010-07-28 | 2015-11-17 | The Regents Of The University Of California | Peripherally restricted FAAH inhibitors |
| KR102079404B1 (ko) | 2011-08-19 | 2020-02-19 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 메타-치환된 비페닐 말초 제한형 faah 억제제 |
| CA2883144C (en) | 2012-08-30 | 2023-01-17 | Kinex Pharmaceuticals, Llc | N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl) acetamide as protein|tyrosine kinase modulators |
| ES2908240T3 (es) | 2014-04-07 | 2022-04-28 | Univ California | Inhibidores de la enzima amida hidrolasa de ácidos grasos (FAAH) con biodisponibilidad oral mejorada y su uso como medicamentos |
| AU2019382737A1 (en) * | 2018-11-20 | 2021-05-20 | Bayer Aktiengesellschaft | α2-adrenoceptor subtype C (alpha-2C) antagonists for the treatment of sleep apnea |
| CN118515624B (zh) * | 2024-04-29 | 2025-01-24 | 聊城金歌合成材料有限公司 | 一种含三氟甲基多取代恶唑烷-4-酮的合成方法及应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2909467A (en) * | 1958-07-09 | 1959-10-20 | Us Vitamin Pharm Corp | 3-(d-alpha-methylphenethyl)-5-methyl-1, 3-oxazolidine-2, 4-dione |
| IT649883A (https=) * | 1960-05-24 | |||
| US3742022A (en) * | 1967-05-08 | 1973-06-26 | A Verbiscar | Carbamate esters of physiologically active ph enenthylamines |
| DE3003653A1 (de) * | 1980-02-01 | 1981-08-06 | Hoechst Ag, 6000 Frankfurt | Verfahren zur herstellung von n-substituierten oxazolindionen-(2,4) |
| JP2616989B2 (ja) * | 1989-04-03 | 1997-06-04 | 株式会社トクヤマ | ２，４―オキサゾリジンジオン化合物 |
| CA2083891A1 (en) * | 1991-12-03 | 1993-06-04 | Angus Murray Macleod | Heterocyclic compounds, compositions containing them and their use in therapy |
| GB9210744D0 (en) * | 1992-05-20 | 1992-07-08 | Pfizer Ltd | Antiviral peptides |
| US6462054B1 (en) * | 2000-03-27 | 2002-10-08 | The Scripps Research Institute | Inhibitors of fatty acid amide hydrolase |
| US6562846B2 (en) * | 2001-04-27 | 2003-05-13 | Bristol-Myers Squibb Company | Bisarylimidazolyl fatty acid amide hydrolase inhibitors |
| US6949574B2 (en) * | 2002-02-08 | 2005-09-27 | Bristol-Myers Squibb Company | (Oxime)carbamoyl fatty acid amide hydrolase inhibitors |
-
2003
- 2003-01-23 FR FR0300704A patent/FR2850377B1/fr not_active Expired - Fee Related
-
2004
- 2004-01-20 TW TW093101679A patent/TWI330628B/zh not_active IP Right Cessation
- 2004-01-22 UA UAA200508210A patent/UA86013C2/ru unknown
- 2004-01-22 DK DK04704251.0T patent/DK1590321T3/da active
- 2004-01-22 BR BR0406901-3A patent/BRPI0406901A/pt not_active IP Right Cessation
- 2004-01-22 RS YUP-2005/0562A patent/RS20050562A/sr unknown
- 2004-01-22 ME MEP-213/08A patent/MEP21308A/xx unknown
- 2004-01-22 CN CN2007100840856A patent/CN101058564B/zh not_active Expired - Fee Related
- 2004-01-22 PL PL378022A patent/PL378022A1/pl not_active Application Discontinuation
- 2004-01-22 ZA ZA200505351A patent/ZA200505351B/en unknown
- 2004-01-22 DE DE602004026826T patent/DE602004026826D1/de not_active Expired - Lifetime
- 2004-01-22 KR KR1020057013551A patent/KR20050104352A/ko not_active Abandoned
- 2004-01-22 HR HR20050631A patent/HRP20050631A2/xx not_active Application Discontinuation
- 2004-01-22 CA CA002511941A patent/CA2511941A1/en not_active Abandoned
- 2004-01-22 AU AU2004207657A patent/AU2004207657B2/en not_active Ceased
- 2004-01-22 MX MXPA05007848A patent/MXPA05007848A/es active IP Right Grant
- 2004-01-22 WO PCT/FR2004/000139 patent/WO2004067498A2/fr not_active Ceased
- 2004-01-22 PT PT04704251T patent/PT1590321E/pt unknown
- 2004-01-22 SI SI200431464T patent/SI1590321T1/sl unknown
- 2004-01-22 ES ES04704251T patent/ES2344454T3/es not_active Expired - Lifetime
- 2004-01-22 EP EP04704251A patent/EP1590321B1/fr not_active Expired - Lifetime
- 2004-01-22 EA EA200500979A patent/EA008801B1/ru not_active IP Right Cessation
- 2004-01-22 NZ NZ541148A patent/NZ541148A/en not_active IP Right Cessation
- 2004-01-22 AT AT04704251T patent/ATE465990T1/de active
- 2004-01-22 JP JP2006502114A patent/JP4617292B2/ja not_active Expired - Fee Related
- 2004-01-22 AR ARP040100170A patent/AR042746A1/es unknown
- 2004-01-22 CN CNB2004800027704A patent/CN100506788C/zh not_active Expired - Fee Related
-
2005
- 2005-06-27 IS IS7916A patent/IS7916A/is unknown
- 2005-06-28 IL IL169444A patent/IL169444A/en not_active IP Right Cessation
- 2005-06-30 TN TNP2005000172A patent/TNSN05172A1/fr unknown
- 2005-07-12 MA MA28384A patent/MA27609A1/fr unknown
- 2005-07-21 US US11/186,242 patent/US7632850B2/en not_active Expired - Fee Related
- 2005-07-22 NO NO20053593A patent/NO20053593L/no not_active Application Discontinuation
-
2010
- 2010-07-20 CY CY20101100676T patent/CY1110216T1/el unknown
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