JP2006517093A5 - - Google Patents
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- Publication number
- JP2006517093A5 JP2006517093A5 JP2004559278A JP2004559278A JP2006517093A5 JP 2006517093 A5 JP2006517093 A5 JP 2006517093A5 JP 2004559278 A JP2004559278 A JP 2004559278A JP 2004559278 A JP2004559278 A JP 2004559278A JP 2006517093 A5 JP2006517093 A5 JP 2006517093A5
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- marker
- expression level
- predictive marker
- predictive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003550 marker Substances 0.000 claims 28
- 238000000034 method Methods 0.000 claims 24
- 206010028980 Neoplasm Diseases 0.000 claims 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 238000002560 therapeutic procedure Methods 0.000 claims 7
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 claims 6
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 claims 6
- 230000005764 inhibitory process Effects 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 229940079156 Proteasome inhibitor Drugs 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000013610 patient sample Substances 0.000 claims 2
- -1 peptidyl aldehyde Chemical class 0.000 claims 2
- 239000003207 proteasome inhibitor Substances 0.000 claims 2
- 238000002331 protein detection Methods 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 1
- 229960001467 bortezomib Drugs 0.000 claims 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 1
- DAQAKHDKYAWHCG-RWTHQLGUSA-N lactacystin Chemical class CC(=O)N[C@H](C(O)=O)CSC(=O)[C@]1([C@@H](O)C(C)C)NC(=O)[C@H](C)[C@@H]1O DAQAKHDKYAWHCG-RWTHQLGUSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000002853 nucleic acid probe Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43151402P | 2002-12-06 | 2002-12-06 | |
| US60/431,514 | 2002-12-06 | ||
| PCT/US2003/038539 WO2004053066A2 (en) | 2002-12-06 | 2003-12-04 | Methods for the identification, assessment, and treatment of patients with proteasome inhibition therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010092346A Division JP5896593B2 (ja) | 2002-12-06 | 2010-04-13 | プロテアソーム阻害療法を用いた患者の同定、判定および治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006517093A JP2006517093A (ja) | 2006-07-20 |
| JP2006517093A5 true JP2006517093A5 (https=) | 2007-01-25 |
| JP5717937B2 JP5717937B2 (ja) | 2015-05-13 |
Family
ID=32507743
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004559278A Expired - Lifetime JP5717937B2 (ja) | 2002-12-06 | 2003-12-04 | プロテアソーム阻害療法を用いた患者の同定、判定および治療方法 |
| JP2010092346A Expired - Fee Related JP5896593B2 (ja) | 2002-12-06 | 2010-04-13 | プロテアソーム阻害療法を用いた患者の同定、判定および治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010092346A Expired - Fee Related JP5896593B2 (ja) | 2002-12-06 | 2010-04-13 | プロテアソーム阻害療法を用いた患者の同定、判定および治療方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20040156854A1 (https=) |
| EP (1) | EP1581629B1 (https=) |
| JP (2) | JP5717937B2 (https=) |
| AU (1) | AU2003298873B2 (https=) |
| CA (1) | CA2508348C (https=) |
| ES (1) | ES2542328T3 (https=) |
| MX (1) | MXPA05005923A (https=) |
| WO (1) | WO2004053066A2 (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080050836A1 (en) * | 1998-05-01 | 2008-02-28 | Isabelle Guyon | Biomarkers for screening, predicting, and monitoring benign prostate hyperplasia |
| US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| US20090226915A1 (en) * | 2001-01-24 | 2009-09-10 | Health Discovery Corporation | Methods for Screening, Predicting and Monitoring Prostate Cancer |
| US20090215024A1 (en) * | 2001-01-24 | 2009-08-27 | Health Discovery Corporation | Biomarkers upregulated in prostate cancer |
| US20090215058A1 (en) * | 2001-01-24 | 2009-08-27 | Health Discovery Corporation | Methods for screening, predicting and monitoring prostate cancer |
| AU2003300899A1 (en) * | 2002-12-12 | 2004-06-30 | Oncotech, Inc. | Genes related to sensitivity and resistance to chemotherapeutic drug treatment |
| US7498322B2 (en) * | 2004-03-12 | 2009-03-03 | Entremed, Inc. | Antiangiogenic agents |
| DK2537942T3 (en) | 2004-05-21 | 2015-12-14 | Trustees Of The University Of Arkansas System Board Of | Use of genudtryksprofilering to predict survival in cancer patients |
| WO2006053328A2 (en) * | 2004-11-12 | 2006-05-18 | Health Discovery Corporation | Biomarkers for screening, predicting, and monitoring prostate disease |
| WO2006101535A1 (en) * | 2005-03-23 | 2006-09-28 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Inhibition of proteasome function to potentiate the proapoptotic and antitumor activity of cytokines |
| WO2006112400A1 (ja) * | 2005-04-18 | 2006-10-26 | National University Corporation Hamamatsu University School Of Medicine | 癌の転移性及び浸潤能の検査方法 |
| CA2611728A1 (en) | 2005-06-08 | 2006-12-14 | Millennium Pharmaceuticals, Inc. | Methods for the identification, assessment, and treatment of patients with cancer therapy |
| EP1912664A2 (en) * | 2005-07-06 | 2008-04-23 | Biodevelops Pharma Entwicklung GmbH | Use of a compound for enhancing the expression of membrane proteins on the cell surface |
| WO2007022041A2 (en) * | 2005-08-11 | 2007-02-22 | Novartis Ag | Mutations and polymorphisms of hdac3 |
| WO2007035842A2 (en) * | 2005-09-21 | 2007-03-29 | Ccc Diagnostics, Llc | Comprehensive diagnostic testing procedures for personalized anticancer chemotherapy (pac) |
| CA2636596A1 (en) * | 2005-11-04 | 2007-05-18 | James Pluda | Method of treating cancers with saha and pemetrexed |
| JP2009516172A (ja) * | 2005-11-10 | 2009-04-16 | ロゼッタ インファーマティックス エルエルシー | 合成画像を使用した生物学的特徴の発見 |
| US20070185069A1 (en) * | 2005-11-14 | 2007-08-09 | Plum Stacy M | Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents |
| CN100372568C (zh) * | 2005-12-09 | 2008-03-05 | 中国科学院广州生物医药与健康研究院 | 化合物mg-132在制备治疗白血病药物中的应用 |
| US7875274B2 (en) * | 2005-12-16 | 2011-01-25 | The Board Of Trustees Of The Leland Stanford Junior University | Protein modulators of resistance to alkylating agents |
| WO2007103770A2 (en) * | 2006-03-02 | 2007-09-13 | Ppd Biomarker Discovery Sciences, Llc | Compositions and methods for analyzing renal cancer |
| WO2007109312A2 (en) * | 2006-03-20 | 2007-09-27 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
| EP2021502A4 (en) * | 2006-05-09 | 2010-08-25 | Mas Metabolic Analytical Servi | GENES AND ATYPICAL MARKERS IN TYPE 2 DIABETES AND OBESITY |
| RU2450016C2 (ru) | 2006-06-19 | 2012-05-10 | Протеоликс, Инк. | Пептидные эпоксикетоны для ингибирования протеасомы |
| EP2046973A4 (en) * | 2006-08-10 | 2010-04-07 | Millennium Pharm Inc | IDENTIFICATION, ASSESSMENT AND TREATMENT OF CANCER THERAPY PATIENTS |
| CN101528037A (zh) * | 2006-11-03 | 2009-09-09 | 默克公司 | 使用saha和硼替佐米治疗多发性骨髓瘤的方法 |
| JP5413818B2 (ja) * | 2007-03-29 | 2014-02-12 | 国立大学法人佐賀大学 | 蛍光多重染色による蛋白定量法 |
| WO2008124197A1 (en) * | 2007-04-10 | 2008-10-16 | The Johns Hopkins University | Imaging and therapy of virus-associated tumors |
| US20080317768A1 (en) * | 2007-06-21 | 2008-12-25 | Boeing Company | Bioconjugated nanoparticles |
| CA2693310C (en) | 2007-08-02 | 2018-11-27 | Arresto Biosciences, Inc. | Lox and loxl2 inhibitors, antibodies and uses thereof |
| US20110118274A1 (en) * | 2007-08-23 | 2011-05-19 | Cornell Research Foundation, Inc. | Proteasome inhibitors and their use in treating pathogen infection and cancer |
| GB2460769C (en) | 2007-11-30 | 2011-09-07 | Applied Genomics Inc | TLE3 as a marker for chemotherapy |
| WO2009076551A2 (en) * | 2007-12-12 | 2009-06-18 | The Regents Of The University Of California | Systems and methods for predicting response of biological samples |
| WO2009148528A2 (en) * | 2008-05-30 | 2009-12-10 | Millennium Pharmaceuticals, Inc. | Assessment of chromosomal alterations to predict clinical outcome of bortezomib treatment |
| US8321144B2 (en) * | 2008-10-23 | 2012-11-27 | Microsoft Corporation | Non-contiguous regions processing |
| EP2722400A3 (en) * | 2008-10-29 | 2014-07-09 | William Beaumont Hospital | Methods of using biomarkers |
| JP2012514460A (ja) * | 2009-01-02 | 2012-06-28 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ アーカンソー | ボルテゾミブを用いた多発性骨髄腫患者における生存率の予測 |
| WO2010080769A2 (en) | 2009-01-06 | 2010-07-15 | Arresto Biosciences, Inc. | Chemotherapeutic methods and compositions |
| WO2011022670A1 (en) * | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vivo screening assays |
| WO2011022709A1 (en) * | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vitro screening assays |
| AU2010283997B2 (en) * | 2009-08-21 | 2015-04-09 | Gilead Biologics, Inc. | Methods and compositions for treatment of pulmonary fibrotic disorders |
| CN102711821A (zh) * | 2009-08-21 | 2012-10-03 | 吉联亚生物科技有限公司 | 治疗方法和组合物 |
| EP2467396A4 (en) * | 2009-08-21 | 2012-12-26 | Gilead Biologics Inc | CATALYTIC DOMAINS FROM LYSYL OXIDASE AND LOXL2 |
| JP5919196B2 (ja) * | 2009-11-13 | 2016-05-18 | オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 転移抑制のためのペプチドエポキシケトンの使用 |
| WO2011085216A2 (en) | 2010-01-08 | 2011-07-14 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors for treating parkinson's disease and restless legs syndrome |
| EP2531616A4 (en) * | 2010-02-03 | 2013-07-10 | Univ Monash | DIAGNOSIS AND FORECAST ASSAY FOR BREAST CANCER |
| US8680246B2 (en) | 2010-02-04 | 2014-03-25 | Gilead Biologics, Inc. | Antibodies that bind to lysyl oxidase-like 2 (LOXL2) |
| WO2011123719A2 (en) | 2010-03-31 | 2011-10-06 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors for treating abdominal, visceral and pelvic pain |
| JP5740880B2 (ja) | 2010-09-15 | 2015-07-01 | 株式会社リコー | 画像形成装置、及びプログラム |
| MX357429B (es) | 2011-08-11 | 2018-07-09 | Janssen Pharmaceutica Nv | Predictores para el tratamiento del cáncer. |
| CA2855368A1 (en) | 2011-11-11 | 2013-05-16 | Millennium Pharmaceuticals, Inc. | Biomarkers of response to proteasome inhibitors |
| US9428813B2 (en) | 2012-03-26 | 2016-08-30 | The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services | DNA methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms |
| WO2014078571A1 (en) * | 2012-11-14 | 2014-05-22 | The Board Of Trustees Of The University Of Arkansas | Methods of detecting 14q32 translocations |
| WO2014189843A1 (en) | 2013-05-20 | 2014-11-27 | Board Of Trustees Of The University Of Arkansas | Gep5 model for multiple myeloma |
| US10607717B2 (en) | 2013-11-06 | 2020-03-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for subtyping lymphoma types by means of expression profiling |
| US20170166974A1 (en) * | 2014-05-20 | 2017-06-15 | Erasmus University Medical Center Rotterdam | Method for the treatment of multiple myeloma |
| US10607152B2 (en) | 2015-05-26 | 2020-03-31 | Textio, Inc. | Using machine learning to predict outcomes for documents |
| US20170159130A1 (en) * | 2015-12-03 | 2017-06-08 | Amit Kumar Mitra | Transcriptional classification and prediction of drug response (t-cap dr) |
| USRE50076E1 (en) | 2015-12-30 | 2024-08-13 | Hyundai Heavy Industries Co., Ltd. | Liquefied gas carrier |
| JP7075896B2 (ja) | 2016-04-20 | 2022-05-26 | アメリカ合衆国 | マントル細胞リンパ腫の評価及びそれに関連する方法 |
| CN106928370B (zh) * | 2016-09-26 | 2021-02-02 | 华东师范大学 | 一种REGγ-20S蛋白酶体抑制剂的筛选系统及其应用 |
| US11804298B2 (en) | 2017-07-17 | 2023-10-31 | Joon Kim | Cancer diagnostic apparatus and cancer diagnostic system using the same |
| KR102007664B1 (ko) * | 2017-07-17 | 2019-08-07 | 김준 | 암 진단기 및 이를 이용한 암 진단시스템 |
| US11899022B2 (en) | 2017-08-23 | 2024-02-13 | The General Hospital Corporation | Multiplexed proteomics and predictive drug candidate assessment |
| EP3502279A1 (en) * | 2017-12-20 | 2019-06-26 | Koninklijke Philips N.V. | Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression |
| JP7257009B2 (ja) * | 2018-01-17 | 2023-04-13 | オーディーエス メディカル インコーポレイテッド | がん検出を目的としたリアルタイムラマン分光法のためのシステムおよび方法 |
| CN110499287B (zh) * | 2019-08-30 | 2021-07-23 | 博雅干细胞科技有限公司 | 简易制备胎盘间充质干细胞外泌体的方法 |
| US20230340604A1 (en) * | 2022-04-20 | 2023-10-26 | Morehouse School Of Medicine | Methods of treatment and diagnosis of multiple myeloma progression |
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| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
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| JPS63501765A (ja) | 1985-11-01 | 1988-07-21 | インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド | 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途 |
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| US8067152B2 (en) * | 2006-02-27 | 2011-11-29 | The Fred Hutchinson Cancer Research Center | Liver cancer biomarkers |
-
2003
- 2003-12-04 ES ES03796633.0T patent/ES2542328T3/es not_active Expired - Lifetime
- 2003-12-04 JP JP2004559278A patent/JP5717937B2/ja not_active Expired - Lifetime
- 2003-12-04 MX MXPA05005923A patent/MXPA05005923A/es active IP Right Grant
- 2003-12-04 US US10/728,055 patent/US20040156854A1/en not_active Abandoned
- 2003-12-04 CA CA2508348A patent/CA2508348C/en not_active Expired - Fee Related
- 2003-12-04 EP EP03796633.0A patent/EP1581629B1/en not_active Revoked
- 2003-12-04 WO PCT/US2003/038539 patent/WO2004053066A2/en not_active Ceased
- 2003-12-04 AU AU2003298873A patent/AU2003298873B2/en not_active Ceased
-
2008
- 2008-12-16 US US12/316,756 patent/US20090181393A1/en not_active Abandoned
-
2010
- 2010-04-13 JP JP2010092346A patent/JP5896593B2/ja not_active Expired - Fee Related
-
2016
- 2016-03-25 US US15/080,709 patent/US20170023577A1/en not_active Abandoned
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