JP2006517093A5 - - Google Patents
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- Publication number
- JP2006517093A5 JP2006517093A5 JP2004559278A JP2004559278A JP2006517093A5 JP 2006517093 A5 JP2006517093 A5 JP 2006517093A5 JP 2004559278 A JP2004559278 A JP 2004559278A JP 2004559278 A JP2004559278 A JP 2004559278A JP 2006517093 A5 JP2006517093 A5 JP 2006517093A5
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- marker
- expression level
- predictive marker
- predictive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003550 marker Substances 0.000 claims 28
- 238000000034 method Methods 0.000 claims 24
- 206010028980 Neoplasm Diseases 0.000 claims 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 238000002560 therapeutic procedure Methods 0.000 claims 7
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 claims 6
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 claims 6
- 230000005764 inhibitory process Effects 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 229940079156 Proteasome inhibitor Drugs 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000013610 patient sample Substances 0.000 claims 2
- -1 peptidyl aldehyde Chemical class 0.000 claims 2
- 239000003207 proteasome inhibitor Substances 0.000 claims 2
- 238000002331 protein detection Methods 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 1
- 229960001467 bortezomib Drugs 0.000 claims 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 1
- DAQAKHDKYAWHCG-RWTHQLGUSA-N lactacystin Chemical class CC(=O)N[C@H](C(O)=O)CSC(=O)[C@]1([C@@H](O)C(C)C)NC(=O)[C@H](C)[C@@H]1O DAQAKHDKYAWHCG-RWTHQLGUSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000002853 nucleic acid probe Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43151402P | 2002-12-06 | 2002-12-06 | |
| US60/431,514 | 2002-12-06 | ||
| PCT/US2003/038539 WO2004053066A2 (en) | 2002-12-06 | 2003-12-04 | Methods for the identification, assessment, and treatment of patients with proteasome inhibition therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010092346A Division JP5896593B2 (ja) | 2002-12-06 | 2010-04-13 | プロテアソーム阻害療法を用いた患者の同定、判定および治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006517093A JP2006517093A (ja) | 2006-07-20 |
| JP2006517093A5 true JP2006517093A5 (https=) | 2007-01-25 |
| JP5717937B2 JP5717937B2 (ja) | 2015-05-13 |
Family
ID=32507743
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004559278A Expired - Lifetime JP5717937B2 (ja) | 2002-12-06 | 2003-12-04 | プロテアソーム阻害療法を用いた患者の同定、判定および治療方法 |
| JP2010092346A Expired - Fee Related JP5896593B2 (ja) | 2002-12-06 | 2010-04-13 | プロテアソーム阻害療法を用いた患者の同定、判定および治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010092346A Expired - Fee Related JP5896593B2 (ja) | 2002-12-06 | 2010-04-13 | プロテアソーム阻害療法を用いた患者の同定、判定および治療方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20040156854A1 (https=) |
| EP (1) | EP1581629B1 (https=) |
| JP (2) | JP5717937B2 (https=) |
| AU (1) | AU2003298873B2 (https=) |
| CA (1) | CA2508348C (https=) |
| ES (1) | ES2542328T3 (https=) |
| MX (1) | MXPA05005923A (https=) |
| WO (1) | WO2004053066A2 (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| US20030114410A1 (en) * | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| US20090226915A1 (en) * | 2001-01-24 | 2009-09-10 | Health Discovery Corporation | Methods for Screening, Predicting and Monitoring Prostate Cancer |
| US20090215058A1 (en) * | 2001-01-24 | 2009-08-27 | Health Discovery Corporation | Methods for screening, predicting and monitoring prostate cancer |
| US20090215024A1 (en) * | 2001-01-24 | 2009-08-27 | Health Discovery Corporation | Biomarkers upregulated in prostate cancer |
| WO2004052184A2 (en) * | 2002-12-12 | 2004-06-24 | Oncotech, Inc. | Genes related to sensitivity and resistance to chemotherapeutic drug treatment |
| CA2558014A1 (en) * | 2004-03-12 | 2005-09-29 | Entremed, Inc. | Antiangiogenic agents |
| CA2567350C (en) * | 2004-05-21 | 2018-06-12 | John D. Shaughnessy | Use of gene expression profiling to predict survival in cancer patient |
| WO2006053328A2 (en) * | 2004-11-12 | 2006-05-18 | Health Discovery Corporation | Biomarkers for screening, predicting, and monitoring prostate disease |
| WO2006101535A1 (en) * | 2005-03-23 | 2006-09-28 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Inhibition of proteasome function to potentiate the proapoptotic and antitumor activity of cytokines |
| WO2006112400A1 (ja) * | 2005-04-18 | 2006-10-26 | National University Corporation Hamamatsu University School Of Medicine | 癌の転移性及び浸潤能の検査方法 |
| ES2624863T3 (es) | 2005-06-08 | 2017-07-17 | Millennium Pharmaceuticals, Inc. | Métodos para identificación, evaluación, y tratamiento de pacientes con terapia de cáncer |
| WO2007002972A2 (en) * | 2005-07-06 | 2007-01-11 | Biodevelops Pharma Entwicklung Gmbh | Use of a compound for enhancing the expression of membrane proteins on the cell surface |
| WO2007022041A2 (en) * | 2005-08-11 | 2007-02-22 | Novartis Ag | Mutations and polymorphisms of hdac3 |
| CA2623445A1 (en) * | 2005-09-21 | 2007-03-29 | Ccc Diagnostics, Llc | Comprehensive diagnostic testing procedures for personalized anticancer chemotherapy (pac) |
| CA2627129A1 (en) * | 2005-11-04 | 2007-05-18 | Merck & Co., Inc. | Methods of using saha and bortezomib for treating cancer |
| EP1958006B1 (en) * | 2005-11-10 | 2011-05-11 | Microsoft Corporation | Discover biological features using composite images |
| WO2007059111A2 (en) * | 2005-11-14 | 2007-05-24 | Entremed, Inc. | Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents |
| CN100372568C (zh) * | 2005-12-09 | 2008-03-05 | 中国科学院广州生物医药与健康研究院 | 化合物mg-132在制备治疗白血病药物中的应用 |
| US7875274B2 (en) * | 2005-12-16 | 2011-01-25 | The Board Of Trustees Of The Leland Stanford Junior University | Protein modulators of resistance to alkylating agents |
| WO2007103770A2 (en) * | 2006-03-02 | 2007-09-13 | Ppd Biomarker Discovery Sciences, Llc | Compositions and methods for analyzing renal cancer |
| CA2646065C (en) * | 2006-03-20 | 2014-01-14 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
| WO2007128884A1 (en) * | 2006-05-09 | 2007-11-15 | Oy Jurilab Ltd | Novel genes and markers in type 2 diabetes and obesity |
| CA2657213C (en) | 2006-06-19 | 2017-01-03 | Proteolix, Inc. | Peptide epoxyketones for proteasome inhibition |
| JP5725711B2 (ja) * | 2006-08-10 | 2015-05-27 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 癌治療法を有する患者の同定、評価、および治療のための方法 |
| CN101528037A (zh) * | 2006-11-03 | 2009-09-09 | 默克公司 | 使用saha和硼替佐米治疗多发性骨髓瘤的方法 |
| JP5413818B2 (ja) * | 2007-03-29 | 2014-02-12 | 国立大学法人佐賀大学 | 蛍光多重染色による蛋白定量法 |
| EP2155231B1 (en) * | 2007-04-10 | 2012-08-08 | The Johns Hopkins University | Imaging and therapy of virus-associated tumors |
| US20080317768A1 (en) * | 2007-06-21 | 2008-12-25 | Boeing Company | Bioconjugated nanoparticles |
| ES2700141T3 (es) | 2007-08-02 | 2019-02-14 | Gilead Biologics Inc | Anticuerpos inhibidores LOXL2 y usos de los mismos |
| US20110118274A1 (en) * | 2007-08-23 | 2011-05-19 | Cornell Research Foundation, Inc. | Proteasome inhibitors and their use in treating pathogen infection and cancer |
| CA2706881A1 (en) | 2007-11-30 | 2009-06-11 | Brian Z. Ring | Tle3 as a marker for chemotherapy |
| WO2009076551A2 (en) * | 2007-12-12 | 2009-06-18 | The Regents Of The University Of California | Systems and methods for predicting response of biological samples |
| WO2009148528A2 (en) * | 2008-05-30 | 2009-12-10 | Millennium Pharmaceuticals, Inc. | Assessment of chromosomal alterations to predict clinical outcome of bortezomib treatment |
| US8321144B2 (en) * | 2008-10-23 | 2012-11-27 | Microsoft Corporation | Non-contiguous regions processing |
| EP2342355A4 (en) * | 2008-10-29 | 2012-06-27 | Beaumont Hospital William | PROCESS FOR USE OF BIOMARKERS |
| JP2012514460A (ja) * | 2009-01-02 | 2012-06-28 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ アーカンソー | ボルテゾミブを用いた多発性骨髄腫患者における生存率の予測 |
| WO2010080769A2 (en) * | 2009-01-06 | 2010-07-15 | Arresto Biosciences, Inc. | Chemotherapeutic methods and compositions |
| BR112012008084A2 (pt) * | 2009-08-21 | 2019-09-24 | Gilead Biologics Inc | método terapêuticos e composições. |
| WO2011022709A1 (en) * | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vitro screening assays |
| WO2011022670A1 (en) * | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vivo screening assays |
| SG178845A1 (en) * | 2009-08-21 | 2012-04-27 | Gilead Biologics Inc | Catalytic domains from lysyl oxidase and loxl2 |
| NZ625850A (en) * | 2009-08-21 | 2015-12-24 | Gilead Biologics Inc | Methods and compositions for treatment of pulmonary fibrotic disorders |
| US8853147B2 (en) * | 2009-11-13 | 2014-10-07 | Onyx Therapeutics, Inc. | Use of peptide epoxyketones for metastasis suppression |
| WO2011085216A2 (en) | 2010-01-08 | 2011-07-14 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors for treating parkinson's disease and restless legs syndrome |
| EP2531616A4 (en) * | 2010-02-03 | 2013-07-10 | Univ Monash | DIAGNOSIS AND FORECAST ASSAY FOR BREAST CANCER |
| BR112012019693A2 (pt) | 2010-02-04 | 2017-06-20 | Gilead Biologics Inc | anticorpos que se ligam à lisil oxidase-like 2 (loxl2) e métodos de uso para eles. |
| US20130224151A1 (en) | 2010-03-31 | 2013-08-29 | United States Of America | Use of FAAH Inhibitors for Treating Abdominal, Visceral and Pelvic Pain |
| JP5740880B2 (ja) | 2010-09-15 | 2015-07-01 | 株式会社リコー | 画像形成装置、及びプログラム |
| AU2012294493B2 (en) | 2011-08-11 | 2017-02-23 | Janssen Pharmaceutica Nv | Predictors for cancer treatment |
| CN104126017A (zh) * | 2011-11-11 | 2014-10-29 | 米伦纽姆医药公司 | 对蛋白酶体抑制剂的反应的生物标记 |
| WO2013148147A1 (en) | 2012-03-26 | 2013-10-03 | The U.S.A., As Represented By The Secretary Dept. Of Health And Human Services | Dna methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms |
| WO2014078571A1 (en) * | 2012-11-14 | 2014-05-22 | The Board Of Trustees Of The University Of Arkansas | Methods of detecting 14q32 translocations |
| WO2014189843A1 (en) | 2013-05-20 | 2014-11-27 | Board Of Trustees Of The University Of Arkansas | Gep5 model for multiple myeloma |
| ES2923942T3 (es) | 2013-11-06 | 2022-10-03 | Us Health | Procedimiento para el subtipado de tipos de linfoma por medio de perfiles de expresión |
| JP6675990B2 (ja) * | 2014-05-20 | 2020-04-08 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | 多発性骨髄腫の治療方法 |
| US10607152B2 (en) * | 2015-05-26 | 2020-03-31 | Textio, Inc. | Using machine learning to predict outcomes for documents |
| US10526052B2 (en) | 2015-10-27 | 2020-01-07 | Hyundai Heavy Industries Co., Ltd. | Liquefied gas carrier |
| US20170159130A1 (en) * | 2015-12-03 | 2017-06-08 | Amit Kumar Mitra | Transcriptional classification and prediction of drug response (t-cap dr) |
| JP7075896B2 (ja) | 2016-04-20 | 2022-05-26 | アメリカ合衆国 | マントル細胞リンパ腫の評価及びそれに関連する方法 |
| CN106928370B (zh) * | 2016-09-26 | 2021-02-02 | 华东师范大学 | 一种REGγ-20S蛋白酶体抑制剂的筛选系统及其应用 |
| US11804298B2 (en) | 2017-07-17 | 2023-10-31 | Joon Kim | Cancer diagnostic apparatus and cancer diagnostic system using the same |
| KR102007664B1 (ko) * | 2017-07-17 | 2019-08-07 | 김준 | 암 진단기 및 이를 이용한 암 진단시스템 |
| WO2019040757A1 (en) * | 2017-08-23 | 2019-02-28 | The General Hospital Corporation | MULTIPLEXED PROTEOMIC AND PREDICTIVE EVALUATION OF CANDIDATE MEDICINE |
| EP3502279A1 (en) * | 2017-12-20 | 2019-06-26 | Koninklijke Philips N.V. | Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression |
| CN111770720A (zh) * | 2018-01-17 | 2020-10-13 | 奥迪思医疗公司 | 用于实时拉曼光谱法以进行癌症检测的系统和方法 |
| CN110499287B (zh) * | 2019-08-30 | 2021-07-23 | 博雅干细胞科技有限公司 | 简易制备胎盘间充质干细胞外泌体的方法 |
| US20230340604A1 (en) * | 2022-04-20 | 2023-10-26 | Morehouse School Of Medicine | Methods of treatment and diagnosis of multiple myeloma progression |
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| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
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| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
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| KR100863624B1 (ko) * | 2001-05-11 | 2008-10-15 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | Ｃｄ26을 발현하는 세포와 연관된 질환의 치료제로사용되는 항-ｃｄ26 단클론항체 |
| ES2624863T3 (es) * | 2005-06-08 | 2017-07-17 | Millennium Pharmaceuticals, Inc. | Métodos para identificación, evaluación, y tratamiento de pacientes con terapia de cáncer |
| US8067152B2 (en) * | 2006-02-27 | 2011-11-29 | The Fred Hutchinson Cancer Research Center | Liver cancer biomarkers |
-
2003
- 2003-12-04 ES ES03796633.0T patent/ES2542328T3/es not_active Expired - Lifetime
- 2003-12-04 WO PCT/US2003/038539 patent/WO2004053066A2/en not_active Ceased
- 2003-12-04 US US10/728,055 patent/US20040156854A1/en not_active Abandoned
- 2003-12-04 CA CA2508348A patent/CA2508348C/en not_active Expired - Fee Related
- 2003-12-04 AU AU2003298873A patent/AU2003298873B2/en not_active Ceased
- 2003-12-04 EP EP03796633.0A patent/EP1581629B1/en not_active Revoked
- 2003-12-04 JP JP2004559278A patent/JP5717937B2/ja not_active Expired - Lifetime
- 2003-12-04 MX MXPA05005923A patent/MXPA05005923A/es active IP Right Grant
-
2008
- 2008-12-16 US US12/316,756 patent/US20090181393A1/en not_active Abandoned
-
2010
- 2010-04-13 JP JP2010092346A patent/JP5896593B2/ja not_active Expired - Fee Related
-
2016
- 2016-03-25 US US15/080,709 patent/US20170023577A1/en not_active Abandoned
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