JP2006516639A - 可溶性A−βに対する抗体を生成させるための能動免疫 - Google Patents
可溶性A−βに対する抗体を生成させるための能動免疫 Download PDFInfo
- Publication number
- JP2006516639A JP2006516639A JP2006503233A JP2006503233A JP2006516639A JP 2006516639 A JP2006516639 A JP 2006516639A JP 2006503233 A JP2006503233 A JP 2006503233A JP 2006503233 A JP2006503233 A JP 2006503233A JP 2006516639 A JP2006516639 A JP 2006516639A
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- Prior art keywords
- fragment
- antibody
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- disease
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44415003P | 2003-02-01 | 2003-02-01 | |
| PCT/US2004/002856 WO2004069182A2 (en) | 2003-02-01 | 2004-01-31 | Active immunization to generate antibodies to soluble a-beta |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011112789A Division JP2011201902A (ja) | 2011-05-19 | 2011-05-19 | 可溶性A−βに対する抗体を生成させるための能動免疫 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006516639A true JP2006516639A (ja) | 2006-07-06 |
| JP2006516639A5 JP2006516639A5 (enExample) | 2009-06-25 |
Family
ID=32850829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503233A Pending JP2006516639A (ja) | 2003-02-01 | 2004-01-31 | 可溶性A−βに対する抗体を生成させるための能動免疫 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20060188512A1 (enExample) |
| EP (1) | EP1594969B1 (enExample) |
| JP (1) | JP2006516639A (enExample) |
| KR (1) | KR20050118669A (enExample) |
| CN (1) | CN1745175A (enExample) |
| AU (1) | AU2004209981B2 (enExample) |
| BR (1) | BRPI0407058A (enExample) |
| CA (1) | CA2513722A1 (enExample) |
| CR (1) | CR7922A (enExample) |
| EC (1) | ECSP055939A (enExample) |
| ES (1) | ES2545765T3 (enExample) |
| HR (1) | HRP20050670A2 (enExample) |
| MX (1) | MXPA05008156A (enExample) |
| NO (1) | NO20053862L (enExample) |
| NZ (1) | NZ567324A (enExample) |
| PL (1) | PL378571A1 (enExample) |
| RU (1) | RU2390350C2 (enExample) |
| UA (1) | UA87453C2 (enExample) |
| WO (1) | WO2004069182A2 (enExample) |
| ZA (1) | ZA200505782B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017002057A (ja) * | 2007-07-26 | 2017-01-05 | ルバンス セラピュティックス インク.Revance Therapeutics,Inc. | 抗菌ペプチド、組成物及びその使用方法 |
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| US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| JP2006516639A (ja) * | 2003-02-01 | 2006-07-06 | ニユーララブ・リミテツド | 可溶性A−βに対する抗体を生成させるための能動免疫 |
| US8663650B2 (en) | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
| ES2246105B1 (es) * | 2003-05-08 | 2007-03-01 | Araclon Biotech, S.L. | Uso de anticuerpos para el tratamiento de enfermedades amiloideas. |
| PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
| US7807171B2 (en) | 2003-07-25 | 2010-10-05 | Ac Immune Sa | Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers |
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| AT500483B1 (de) * | 2004-07-13 | 2006-01-15 | Mattner Frank Dr | Set zur vorbeugung oder behandlung der alzheimer'schen erkrankung |
| AU2005294131A1 (en) * | 2004-10-05 | 2006-04-20 | Wyeth | Methods and compositions for improving recombinant protein production |
| CA2590337C (en) | 2004-12-15 | 2017-07-11 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
| WO2006066049A2 (en) | 2004-12-15 | 2006-06-22 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
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| WO2006126682A1 (ja) * | 2005-05-27 | 2006-11-30 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | アルツハイマー病の予防・治療用ワクチン |
| TW200740839A (en) * | 2005-06-17 | 2007-11-01 | Wyeth Corp | Methods of purifying Fc region containing proteins |
| AU2006318537A1 (en) * | 2005-11-22 | 2007-05-31 | The Trustees Of The University Of Pennsylvania | Antibody treatment of Alzheimer's and related diseases |
| EP1954718B1 (en) | 2005-11-30 | 2014-09-03 | AbbVie Inc. | Anti-a globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies |
| WO2007064972A2 (en) | 2005-11-30 | 2007-06-07 | Abbott Laboratories | Monoclonal antibodies against amyloid beta protein and uses thereof |
| NO345996B1 (no) | 2005-12-12 | 2021-12-13 | Ac Immune Sa | A beta 1-42-spesifikke monoklonale antistoffer med terapeutiske egenskaper. |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| CN101058608B (zh) * | 2006-04-21 | 2011-02-23 | 杜如昱 | 人类抗Aβ1-32淀粉样蛋白抗体、其纯化方法及用途 |
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| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) * | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| PT2182983E (pt) | 2007-07-27 | 2014-09-01 | Janssen Alzheimer Immunotherap | Tratamento de doenças amiloidogénicas com anticorpos anti-abeta humanizados |
| CA2704064A1 (en) * | 2007-09-13 | 2009-03-29 | University Of Zurich | Humanized antibodies against the .beta.-amyloid peptide |
| PT2238166E (pt) * | 2007-10-05 | 2014-02-11 | Genentech Inc | Utilização do anticorpo anti-amilóide beta em doenças oculares |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
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| KR20160099732A (ko) * | 2011-09-23 | 2016-08-22 | 에이씨 이뮨 에스.에이. | 백신 요법 |
| KR101755065B1 (ko) * | 2013-07-03 | 2017-07-06 | 경희대학교 산학협력단 | 에클랄바사포닌 또는 그 유도체를 포함하는 인지기능 장애 또는 집중력 장애 질환 예방 또는 치료용 약학 조성물 |
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| AU2004209981B2 (en) | 2009-02-26 |
| CN1745175A (zh) | 2006-03-08 |
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| HRP20050670A2 (en) | 2005-12-31 |
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| KR20050118669A (ko) | 2005-12-19 |
| NO20053862L (no) | 2005-10-31 |
| ES2545765T3 (es) | 2015-09-15 |
| EP1594969A2 (en) | 2005-11-16 |
| WO2004069182A3 (en) | 2005-03-03 |
| ECSP055939A (es) | 2006-04-19 |
| RU2390350C2 (ru) | 2010-05-27 |
| US20040213800A1 (en) | 2004-10-28 |
| CR7922A (es) | 2006-02-07 |
| US20080279873A1 (en) | 2008-11-13 |
| AU2004209981A1 (en) | 2004-08-19 |
| BRPI0407058A (pt) | 2006-01-17 |
| CA2513722A1 (en) | 2004-08-19 |
| ZA200505782B (en) | 2006-09-27 |
| NZ567324A (en) | 2009-08-28 |
| UA87453C2 (ru) | 2009-07-27 |
| PL378571A1 (pl) | 2006-05-02 |
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