JP2006516278A5 - - Google Patents
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- Publication number
- JP2006516278A5 JP2006516278A5 JP2006500733A JP2006500733A JP2006516278A5 JP 2006516278 A5 JP2006516278 A5 JP 2006516278A5 JP 2006500733 A JP2006500733 A JP 2006500733A JP 2006500733 A JP2006500733 A JP 2006500733A JP 2006516278 A5 JP2006516278 A5 JP 2006516278A5
- Authority
- JP
- Japan
- Prior art keywords
- sphingolipid
- phytosphingosine
- food
- lysosphingomyelin
- sphinganine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003408 sphingolipids Chemical class 0.000 claims description 14
- 235000013305 food Nutrition 0.000 claims description 13
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 claims description 11
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 claims description 11
- 229940033329 phytosphingosine Drugs 0.000 claims description 11
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 claims description 8
- OKTWQKXBJUBAKS-WQADZSDSSA-N 2-[[(e,2r,3s)-2-amino-3-hydroxyoctadec-4-enoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC\C=C\[C@H](O)[C@H](N)COP(O)(=O)OCC[N+](C)(C)C OKTWQKXBJUBAKS-WQADZSDSSA-N 0.000 claims description 8
- OTKJDMGTUTTYMP-UHFFFAOYSA-N dihydrosphingosine Natural products CCCCCCCCCCCCCCCC(O)C(N)CO OTKJDMGTUTTYMP-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- OTKJDMGTUTTYMP-ZWKOTPCHSA-N sphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO OTKJDMGTUTTYMP-ZWKOTPCHSA-N 0.000 claims description 8
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 claims description 8
- 239000002243 precursor Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 4
- 244000005709 gut microbiome Species 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1022443A NL1022443C2 (nl) | 2003-01-20 | 2003-01-20 | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
| PCT/NL2004/000046 WO2004064819A1 (en) | 2003-01-20 | 2004-01-20 | Sphingolipids for improvement of the composition of the intestinal flora |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006516278A JP2006516278A (ja) | 2006-06-29 |
| JP2006516278A5 true JP2006516278A5 (https=) | 2007-03-01 |
Family
ID=32768715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500733A Pending JP2006516278A (ja) | 2003-01-20 | 2004-01-20 | 腸内細菌叢の組成の改善のためのスフィンゴ脂質 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8703172B2 (https=) |
| EP (1) | EP1585509B1 (https=) |
| JP (1) | JP2006516278A (https=) |
| AT (1) | ATE409030T1 (https=) |
| DE (1) | DE602004016727D1 (https=) |
| NL (1) | NL1022443C2 (https=) |
| WO (1) | WO2004064819A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20010688A1 (it) | 2001-11-21 | 2003-05-21 | Univ Roma | Composti immunoregolatori. |
| EP1585508B1 (en) | 2003-01-20 | 2009-04-01 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Use of sphingolipids for reducing plasma cholesterol and triacylglycerol levels |
| NL1022443C2 (nl) | 2003-01-20 | 2004-07-22 | Tno | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
| US20050196461A1 (en) * | 2004-01-14 | 2005-09-08 | Udell Ronald G. | Ceramide formulations suitable for oral administration |
| JP2005281257A (ja) * | 2004-03-30 | 2005-10-13 | Snow Brand Milk Prod Co Ltd | 美肌剤 |
| US7906488B2 (en) | 2004-11-30 | 2011-03-15 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Sphingolipids in treatment and prevention of steatosis and of steatosis or of hepatotoxicity and its sequelae |
| US8025552B2 (en) * | 2004-12-30 | 2011-09-27 | The United States Of America As Represented By The Secretary Of Agriculture | Artificial diets for honey bees |
| GB0513431D0 (en) * | 2005-06-30 | 2005-08-10 | Kherion Technology Ltd | Prophylactic compositions and uses |
| US20090162482A1 (en) * | 2007-12-21 | 2009-06-25 | S.A.F.E. Research & Development, Llc | Nutritional Compositions for Bees |
| AR077520A1 (es) * | 2007-12-21 | 2011-09-07 | Nutricia Nv | Uso de esfingomielina y carbohidratos no digeribles para mejorar la microbiota intestinal |
| JP6675752B2 (ja) * | 2016-02-23 | 2020-04-01 | 国立大学法人佐賀大学 | 腸内Ｂｌａｕｔｉａ ｃｏｃｃｏｉｄｅｓ増殖刺激剤 |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3622666A (en) * | 1968-03-04 | 1971-11-23 | Stanley Drug Products Inc | Methods for treating bacterial infections with phrenosin |
| FR2492259A1 (fr) | 1980-10-21 | 1982-04-23 | Idinvex Sa | Formulation d'heparine |
| JPS61152632A (ja) | 1984-12-26 | 1986-07-11 | Dai Ichi Seiyaku Co Ltd | 抗動脈硬化剤 |
| JPS6344842A (ja) | 1986-08-12 | 1988-02-25 | Kao Corp | 油中水中油型乳化油脂組成物 |
| IT1235162B (it) | 1988-12-02 | 1992-06-22 | Fidia Farmaceutici | Derivati di lisosfingolipidi |
| US5190876A (en) | 1988-12-27 | 1993-03-02 | Emory University | Method of modifying cellular differentiation and function and compositions therefor |
| BR9106744A (pt) | 1990-08-13 | 1993-07-20 | Univ Duke | Processo para induzir diferenciacao celular,preparacao farmaceutica,composicao e uso de um composto |
| US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
| US5232837A (en) | 1991-08-05 | 1993-08-03 | Emory University | Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination |
| US5374616A (en) | 1991-10-18 | 1994-12-20 | Georgetown University | Compositions containing sphingosylphosphorylcholine and the use thereof as a cellular growth factor |
| JPH05320048A (ja) | 1992-05-19 | 1993-12-03 | Shiseido Co Ltd | 抗酸化剤 |
| US6190894B1 (en) | 1993-03-19 | 2001-02-20 | The Regents Of The University Of California | Method and compositions for disrupting the epithelial barrier function |
| US5478860A (en) | 1993-06-04 | 1995-12-26 | Inex Pharmaceuticals Corp. | Stable microemulsions for hydrophobic compound delivery |
| US5830853A (en) | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
| US6773719B2 (en) | 1994-03-04 | 2004-08-10 | Esperion Luv Development, Inc. | Liposomal compositions, and methods of using liposomal compositions to treat dislipidemias |
| US20020182250A1 (en) | 1995-09-06 | 2002-12-05 | Goro Hori | Lipid metabolism improving agent |
| DE69607854T2 (de) | 1995-09-29 | 2000-08-17 | Georgetown University, Washington | Sphingosylphosphorylcholin als wirkstoff zur wundheilung |
| DE19602108A1 (de) | 1996-01-22 | 1997-07-24 | Beiersdorf Ag | Gegen Bakterien, Parasiten, Protozoen, Mycota und Viren wirksame Substanzen |
| EP0888458A4 (en) | 1996-02-20 | 2004-05-06 | Sloan Kettering Institutefor C | COMBINATION OF PKC INHIBITORS AND THERAPEUTIC AGENTS FOR TREATING CANCER |
| WO1997036996A2 (en) * | 1996-03-28 | 1997-10-09 | Gist-Brocades B.V. | Process for the preparation of a granular microbial biomass and isolation of valuable compounds therefrom |
| JP3495740B2 (ja) | 1997-04-10 | 2004-02-09 | 麒麟麦酒株式会社 | α−グリコシルセラミドを含有するＮＫＴ細胞活性化剤 |
| US6800661B1 (en) | 1997-04-15 | 2004-10-05 | Board Of Trustees Of The University Of Illinois | Spisulosine compounds |
| BR9804872A (pt) | 1997-05-02 | 1999-08-24 | Gist Brocades Bv | Composi-{es antimicrobianas para uso tÄpico |
| US5989803A (en) | 1997-09-05 | 1999-11-23 | The Trustees Of Columbia University In The City Of New York | Method for treating a subject suffering from a condition associated with an extracellular zinc sphingomyelinase |
| ATE332888T1 (de) * | 1997-09-11 | 2006-08-15 | Takara Bio Inc | Sphingosinderivate und medizinische zubereitung |
| DE69943314D1 (de) | 1998-02-12 | 2011-05-12 | Kapil N Bhalla | Sphingolipid-derivate und verfahren zu deren verwendung |
| JP3581010B2 (ja) | 1998-03-18 | 2004-10-27 | 雪印乳業株式会社 | 脂質の消化吸収機能改善剤 |
| CA2329124A1 (en) | 1998-05-26 | 1999-12-02 | Office Of The Dean Of Research And Graduate Education | Sphingosine kinase, cloning, expression and methods of use |
| AU776785B2 (en) | 1999-02-24 | 2004-09-23 | Johns Hopkins University, The | Compositions and methods for modulating serum cholesterol |
| JP3544493B2 (ja) | 1999-06-10 | 2004-07-21 | 雪印乳業株式会社 | 乳幼児用栄養組成物 |
| KR100341793B1 (ko) | 1999-07-02 | 2002-06-24 | 권 영 근 | 스핑고신 1-포스페이트를 유효성분으로 포함하는 혈관신생 촉진제 |
| WO2001003739A1 (fr) | 1999-07-12 | 2001-01-18 | Ono Pharmaceutical Co., Ltd. | Inhibiteurs de fibrose contenant comme ingredient actif l'agoniste du recepteur de sphingosine-1-phosphate ou la sphingosine-1-phosphate |
| JP2001213858A (ja) | 1999-11-24 | 2001-08-07 | Sagami Chem Res Center | スフィンゴシン誘導体 |
| JP2001158736A (ja) | 1999-11-30 | 2001-06-12 | Snow Brand Milk Prod Co Ltd | 骨関節疾患の予防及び改善剤 |
| JP2001158735A (ja) | 1999-11-30 | 2001-06-12 | Snow Brand Milk Prod Co Ltd | 歯周病の予防及び改善剤 |
| JP2003523336A (ja) | 2000-02-18 | 2003-08-05 | メルク エンド カムパニー インコーポレーテッド | 糖尿病及び脂質障害のためのアリールオキシ酢酸 |
| AU2001255199A1 (en) | 2000-03-28 | 2001-10-08 | The Liposome Company, Inc. | Ceramide derivatives and method of use |
| JP2002068998A (ja) | 2000-08-29 | 2002-03-08 | Meiji Milk Prod Co Ltd | 経腸栄養および静脈栄養に伴う脂肪肝発生予防組成物 |
| WO2002034062A1 (en) | 2000-10-27 | 2002-05-02 | Nv Marc Boone | Method for obtaining products enriched in phospho- and sphingolipids |
| US6949247B2 (en) | 2000-12-28 | 2005-09-27 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Stable skin care compositions containing a retinoid and a retinoid booster system |
| FR2820037B1 (fr) * | 2001-01-29 | 2005-12-09 | Dermaconcept Jmc | Composition dermatologique a usage veterinaire comprenant une base sphingoide |
| JP2002226394A (ja) | 2001-02-01 | 2002-08-14 | Meiji Milk Prod Co Ltd | 脂質代謝改善組成物 |
| CN102319266B (zh) | 2001-06-18 | 2014-12-17 | 海王星技术&生物资源有限公司 | 用于预防和/或治疗心血管疾病、关节炎、皮肤癌、糖尿病、经前综合症和透皮转运的磷虾和/或海产提取物 |
| DK1417211T3 (da) | 2001-07-27 | 2007-10-08 | Neptune Technologies & Bioress | Naturlige phospholipider af marin oprindelse, der indeholder flavonoider og polyumættede phospholipider, og deres anvendelse |
| EP1291340B1 (en) | 2001-09-05 | 2006-03-15 | Charmzone Co., Ltd | Phytosphingosine derivatives with antitumor activity |
| US20030109044A1 (en) | 2001-10-16 | 2003-06-12 | Millennium Pharmaceuticals, Inc. | Methods of using 279, a human G protein-coupled protein receptor |
| JP4035759B2 (ja) | 2001-11-06 | 2008-01-23 | 独立行政法人産業技術総合研究所 | アミノアルコールリン酸化合物、製造方法、及びその利用方法 |
| JP2003155231A (ja) * | 2001-11-20 | 2003-05-27 | Kikkoman Corp | 医薬及び抗アレルギー剤 |
| JP2003252765A (ja) | 2002-02-28 | 2003-09-10 | Snow Brand Milk Prod Co Ltd | 腸管運動機能不全性疾患の治療剤 |
| DE10217555A1 (de) | 2002-04-19 | 2004-02-19 | Degussa Bioactives Deutschland Gmbh | Physiologisch verträgliche, Phospholipid-haltige, stabile und harte Matrix |
| JP2006507223A (ja) | 2002-05-17 | 2006-03-02 | エスペリオン セラピューティクス，インコーポレイテッド | 脂質代謝異常疾患の治療方法 |
| JP2005535717A (ja) | 2002-08-14 | 2005-11-24 | キム，テユン | フィトスフィンゴシン誘導体を含むアポトーシス誘導用組成物 |
| NL1022443C2 (nl) | 2003-01-20 | 2004-07-22 | Tno | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
| EP1585508B1 (en) | 2003-01-20 | 2009-04-01 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Use of sphingolipids for reducing plasma cholesterol and triacylglycerol levels |
| GB0301395D0 (en) | 2003-01-21 | 2003-02-19 | Univ Aston | Inflammatory disorder treatment |
| US20040171522A1 (en) | 2003-02-27 | 2004-09-02 | Yaron Ilan | Regulation of immune responses by manipulation of intermediary metabolite levels |
| US9717754B2 (en) | 2003-02-27 | 2017-08-01 | Enzo Therapeutics, Inc. | Glucocerebroside treatment of disease |
| AU2004233873B2 (en) | 2003-04-25 | 2010-11-18 | The Penn State Research Foundation | Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds |
| US8282773B2 (en) | 2007-12-14 | 2012-10-09 | Andritz Inc. | Method and system to enhance fiber development by addition of treatment agent during mechanical pulping |
-
2003
- 2003-01-20 NL NL1022443A patent/NL1022443C2/nl not_active IP Right Cessation
-
2004
- 2004-01-20 AT AT04703547T patent/ATE409030T1/de not_active IP Right Cessation
- 2004-01-20 EP EP04703547A patent/EP1585509B1/en not_active Revoked
- 2004-01-20 DE DE602004016727T patent/DE602004016727D1/de not_active Expired - Lifetime
- 2004-01-20 JP JP2006500733A patent/JP2006516278A/ja active Pending
- 2004-01-20 US US10/542,838 patent/US8703172B2/en not_active Expired - Fee Related
- 2004-01-20 WO PCT/NL2004/000046 patent/WO2004064819A1/en not_active Ceased
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