JP2006514990A5 - - Google Patents
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- JP2006514990A5 JP2006514990A5 JP2005508608A JP2005508608A JP2006514990A5 JP 2006514990 A5 JP2006514990 A5 JP 2006514990A5 JP 2005508608 A JP2005508608 A JP 2005508608A JP 2005508608 A JP2005508608 A JP 2005508608A JP 2006514990 A5 JP2006514990 A5 JP 2006514990A5
- Authority
- JP
- Japan
- Prior art keywords
- glucagon
- insulin
- pharmaceutical formulation
- administration
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 861
- 102000004877 Insulin Human genes 0.000 claims description 442
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- 229940125396 insulin Drugs 0.000 claims description 431
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims description 397
- 229960004666 glucagon Drugs 0.000 claims description 374
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- 239000000203 mixture Substances 0.000 claims description 85
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 64
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-
2003
- 2003-12-23 CA CA002509755A patent/CA2509755A1/en not_active Abandoned
- 2003-12-23 US US10/540,803 patent/US7314859B2/en not_active Expired - Fee Related
- 2003-12-23 NZ NZ541365A patent/NZ541365A/en unknown
- 2003-12-23 MX MXPA05006994A patent/MXPA05006994A/es unknown
- 2003-12-23 CN CNA2003801075753A patent/CN1732012A/zh active Pending
- 2003-12-23 JP JP2005508608A patent/JP2006514990A/ja active Pending
- 2003-12-23 KR KR1020057012139A patent/KR20050086948A/ko not_active Ceased
- 2003-12-23 AU AU2003303634A patent/AU2003303634B2/en not_active Ceased
- 2003-12-23 EP EP03814932A patent/EP1578437A4/en not_active Withdrawn
- 2003-12-23 WO PCT/US2003/041103 patent/WO2004060387A1/en not_active Ceased
-
2005
- 2005-07-19 NO NO20053537A patent/NO20053537L/no not_active Application Discontinuation
-
2007
- 2007-12-21 US US11/963,584 patent/US7642232B2/en not_active Expired - Fee Related
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