JP2006512891A - 糸状菌における機能性抗体の生産 - Google Patents

糸状菌における機能性抗体の生産 Download PDF

Info

Publication number
JP2006512891A
JP2006512891A JP2003586327A JP2003586327A JP2006512891A JP 2006512891 A JP2006512891 A JP 2006512891A JP 2003586327 A JP2003586327 A JP 2003586327A JP 2003586327 A JP2003586327 A JP 2003586327A JP 2006512891 A JP2006512891 A JP 2006512891A
Authority
JP
Japan
Prior art keywords
nucleic acid
monoclonal antibody
immunoglobulin
fusion
glucoamylase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003586327A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006512891A5 (fr
Inventor
パワー、スコット・ディー
ワン、ホアミン
ワード、マイケル
Original Assignee
ジェネンコー・インターナショナル・インク
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29255585&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2006512891(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ジェネンコー・インターナショナル・インク filed Critical ジェネンコー・インターナショナル・インク
Publication of JP2006512891A publication Critical patent/JP2006512891A/ja
Publication of JP2006512891A5 publication Critical patent/JP2006512891A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2003586327A 2002-04-18 2003-04-17 糸状菌における機能性抗体の生産 Pending JP2006512891A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37388902P 2002-04-18 2002-04-18
US41154002P 2002-09-18 2002-09-18
US41153702P 2002-09-18 2002-09-18
US45213403P 2003-03-04 2003-03-04
PCT/US2003/012246 WO2003089614A2 (fr) 2002-04-18 2003-04-17 Production d'anticorps fonctionnels dans des champignons filamenteux

Publications (2)

Publication Number Publication Date
JP2006512891A true JP2006512891A (ja) 2006-04-20
JP2006512891A5 JP2006512891A5 (fr) 2006-06-08

Family

ID=29255585

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003586327A Pending JP2006512891A (ja) 2002-04-18 2003-04-17 糸状菌における機能性抗体の生産

Country Status (6)

Country Link
US (2) US20040018573A1 (fr)
EP (1) EP1495055B1 (fr)
JP (1) JP2006512891A (fr)
AU (1) AU2003222664A1 (fr)
DK (1) DK1495055T3 (fr)
WO (1) WO2003089614A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009060804A (ja) * 2007-09-04 2009-03-26 National Research Inst Of Brewing ピヒア属酵母において異種タンパク質を高分泌させる方法
JP2010183885A (ja) * 2009-02-13 2010-08-26 Kobe Univ タンパク質の製造方法およびそれに用いる発現ベクター
KR20200066340A (ko) 2017-10-10 2020-06-09 아지노모토 가부시키가이샤 단백질의 제조 방법
WO2021251383A1 (fr) 2020-06-11 2021-12-16 味の素株式会社 Procédé de production d'une protéine

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1495055T3 (da) * 2002-04-18 2013-11-11 Genencor Int Produktion af funktionelle antistoffer i filamentøse svampe
US7208585B2 (en) * 2002-09-18 2007-04-24 Genencor International, Inc. Protein purification
WO2004026891A2 (fr) * 2002-09-18 2004-04-01 Genencor International, Inc. Purification de proteines
WO2005012531A2 (fr) * 2003-08-01 2005-02-10 Genentech, Inc. Polypeptides de liaison avec sequences de diversite restreinte
RS50516B (sr) * 2003-11-05 2010-05-07 Ares Trading S.A. Prečišćavanje il-18 vezujućeg proteina
WO2005070962A1 (fr) * 2004-01-21 2005-08-04 Novozymes A/S Production d'un anticorps monoclonal dans un champignon heterocaryon ou dans une cellule hote fongique
DK1941025T3 (da) * 2005-10-17 2011-09-26 Novozymes As Brug af svampemutanter til ekspression af antistoffer
US20080026376A1 (en) 2006-07-11 2008-01-31 Huaming Wang KEX2 cleavage regions of recombinant fusion proteins
US8198046B2 (en) 2006-07-11 2012-06-12 Danisco Us Inc. KEX2 cleavage regions of recombinant fusion proteins
BRPI0714870A2 (pt) 2006-07-21 2013-05-28 Novozymes Inc mÉtodo para produzir um polipeptÍdeo secretado tendo atividade biolàgica, proteÍna de fusço isolada, polinucleotÍdeo isolado, construÇço de proteÍna de fusço, vetor de expressço, cÉlula hospedeira féngica, mÉtodos para degradar ou conventer um material celulàsico e para produzir uma substÂncia
US20100062491A1 (en) * 2007-01-05 2010-03-11 Novozymes A/S Overexpression of the Chaperone BIP in a Heterokaryon
EP2129685B1 (fr) * 2007-03-21 2013-11-20 Danisco US Inc. Surexpression de foldases et de chaperones améliorant la production de protéines
HUE029635T2 (en) 2007-09-26 2017-03-28 Chugai Pharmaceutical Co Ltd A method for modifying an isoelectric point of an antibody by amino acid substitution in CDR
SG193868A1 (en) 2007-09-26 2013-10-30 Chugai Pharmaceutical Co Ltd Modified antibody constant region
US20100273215A1 (en) * 2007-12-21 2010-10-28 Anna Cornelia Hendrika Van Hautum Secretion Yield of a Protein of Interest by in vivo Proteolytic Processing of a Multimeric Precursor
EP2282769A4 (fr) 2008-04-29 2012-04-25 Abbott Lab Immunoglobulines à double domaine variable et utilisations
JP5723769B2 (ja) 2008-06-03 2015-05-27 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリン及びその使用
EP2297209A4 (fr) 2008-06-03 2012-08-01 Abbott Lab Immunoglobulines à deux domaines variables et leurs utilisations
EP2321422A4 (fr) 2008-07-08 2013-06-19 Abbvie Inc Immunoglobulines à double domaine variable de prostaglandine e2 et leurs utilisations
EP2427488A1 (fr) * 2009-05-07 2012-03-14 Novozymes Biopharma DK A/S Procédé pour limiter la glycosylation à liaison o des anticorps
US9403898B2 (en) 2009-05-07 2016-08-02 Novozymes Biopharma Dk A/S Method for purifying albumin
US10385367B2 (en) * 2009-06-01 2019-08-20 Ginkgo Bioworks, Inc. Methods and molecules for yield improvement involving metabolic engineering
SG178602A1 (en) 2009-09-01 2012-04-27 Abbott Lab Dual variable domain immunoglobulins and uses thereof
WO2011047262A2 (fr) 2009-10-15 2011-04-21 Abbott Laboratories Immunoglobulines à deux domaines variables et utilisations afférentes
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
JP2013537415A (ja) 2010-08-03 2013-10-03 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリンおよびその使用
CA2809433A1 (fr) 2010-08-26 2012-03-01 Abbvie Inc. Immunoglobulines a deux domaines variables et leurs utilisations
PT2663579T (pt) 2011-01-14 2017-07-28 Univ California Terapêutica de anticorpos contra a proteína r0r-1 e métodos para sua utilização
US9120870B2 (en) 2011-12-30 2015-09-01 Abbvie Inc. Dual specific binding proteins directed against IL-13 and IL-17
CN104245919B (zh) 2012-01-05 2017-07-14 诺华股份有限公司 蛋白酶缺陷丝状真菌细胞及其使用方法
KR101505157B1 (ko) 2012-05-08 2015-03-24 주식회사 종근당 항―ＥｒｂＢ２ 항체 변이체
DK2852610T3 (en) 2012-05-23 2018-09-03 Glykos Finland Oy PRODUCTION OF FUCOSYLED GLYCOPROTEIN
BR112015009961B1 (pt) 2012-11-01 2020-10-20 Abbvie Inc. proteína de ligação capaz de se ligar a dll4 e vegf, bem como composição que a compreende como composição que a compreende
US20160024204A1 (en) * 2013-03-15 2016-01-28 Bristol-Myers Squibb Company Methods for producing antibodies
WO2014144280A2 (fr) 2013-03-15 2014-09-18 Abbvie Inc. Protéines de liaison spécifiques à domaines variables doubles dirigées contre il -1β et/ou il -17
CA2916905A1 (fr) 2013-07-10 2015-01-15 Novartis Ag Cellules fongiques filamenteuses deficientes en plusieurs proteases et procedes d'utilisation de celles-ci
EP3172333B1 (fr) 2014-07-21 2020-05-13 Glykos Finland Oy Production de glycoprotéines avec des n-glycanes de type mammifères dans des champignons filamenteux
WO2016094881A2 (fr) 2014-12-11 2016-06-16 Abbvie Inc. Protéines de liaison à lrp-8
KR101515535B1 (ko) 2015-01-28 2015-05-06 주식회사 종근당 항―ＥｒｂＢ２ 항체 변이체
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
EP3398965A4 (fr) 2015-12-28 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Procédé pour favoriser l'efficacité de purification d'un polypeptide contenant une région fc
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
CN107674900B (zh) * 2017-06-12 2021-05-14 诺利如一（安阳）生物科技有限公司 一种采用串联膜浓缩大豆肽的工艺方法
CA3093729A1 (fr) 2018-03-15 2019-09-19 Chugai Seiyaku Kabushiki Kaisha Anticorps diriges contre le virus de la dengue presentant une reactivite croisee au virus zika et procedes d'utilisation
EP3947442A2 (fr) 2019-03-28 2022-02-09 Danisco US Inc. Anticorps modifiés
US20230203191A1 (en) 2020-03-30 2023-06-29 Danisco Us Inc Engineered antibodies
WO2023225459A2 (fr) 2022-05-14 2023-11-23 Novozymes A/S Compositions et procédés de prévention, de traitement, de suppression et/ou d'élimination d'infestations et d'infections phytopathogènes
WO2024015953A1 (fr) 2022-07-15 2024-01-18 Danisco Us Inc. Procédés de production d'anticorps monoclonaux

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3009104C2 (de) 1980-03-10 1990-10-04 Odenwald-Chemie GmbH, 6901 Schönau Verwendung eines Epoxydharzes zur Herstellung von feuerhemmenden Schichten oder Überzügen und Verfahren zur Herstellung derselben
CA1338400C (fr) 1983-08-31 1996-06-18 David H. Gelfand Cellulases fongiques recombinantes
US20020061560A1 (en) * 1985-08-29 2002-05-23 Genencor, Inc. DNA sequences, vectors, and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi
US5679543A (en) * 1985-08-29 1997-10-21 Genencor International, Inc. DNA sequences, vectors and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi
US5364770A (en) 1985-08-29 1994-11-15 Genencor International Inc. Heterologous polypeptides expressed in aspergillus
DE3650202T3 (de) 1985-08-29 2004-06-03 Genencor International, Inc., South San Francisco Expression von heterologen Polypeptiden in filamentösen Pilzen, Verfahren zu deren Herstellung und Vektoren zu deren Herstellung.
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5610034A (en) * 1987-04-29 1997-03-11 Alko Group Ltd. Immunoglobulin production by trichoderma
US5218093A (en) 1989-03-01 1993-06-08 Allelix Biopharmaceuticals, Inc. EGF variants and pharmaceutical use thereof
GB9215540D0 (en) * 1992-07-22 1992-09-02 Celltech Ltd Protein expression system
US6838254B1 (en) * 1993-04-29 2005-01-04 Conopco, Inc. Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae
US5643745A (en) * 1994-02-03 1997-07-01 University Of Hawaii Heterologous dimeric proteins produced in heterokaryons
US5683899A (en) * 1994-02-03 1997-11-04 University Of Hawaii Methods and compositions for combinatorial-based discovery of new multimeric molecules
US6300114B1 (en) * 1994-07-29 2001-10-09 Rohm Enzyme Finland Oy Sequences of xylanase and xylanase expression vectors
CN1231588C (zh) * 1996-01-19 2005-12-14 诺沃奇梅兹生物技术有限公司 丝状真菌的形态突变体
US6140113A (en) * 1996-03-28 2000-10-31 The Johns Hopkins University Polynucleotides encoding molecular complexes which modify immune responses
US6265204B1 (en) * 1997-01-17 2001-07-24 Genencor International, Inc. DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi
GB9703406D0 (en) * 1997-02-19 1997-04-09 Chiron Spa Expression of heterologous proteins
US5994511A (en) * 1997-07-02 1999-11-30 Genentech, Inc. Anti-IgE antibodies and methods of improving polypeptides
US6232112B1 (en) * 1997-11-24 2001-05-15 Flinders Technologies Pty Ltd Of Flinders University Reagents and methods for diversification of DNA
ZA9811162B (en) * 1997-12-12 2000-06-07 Genentech Inc Treatment with anti-ERBB2 antibodies.
HUP0100813A3 (en) * 1998-02-25 2003-08-28 Lexigen Pharmaceuticals Corp L Enhancing the circulating half-life of antibody-based fusion proteins
AU1219000A (en) 1998-10-22 2000-05-08 Regents Of The University Of California, The Functionally assembled antigen-specific intact recombinant antibody and a methodfor production thereof
US6767701B1 (en) * 1998-10-26 2004-07-27 Novozymes A/S Methods of constructing and screening a DNA library of interest in filamentous fungal cells
CA2329074A1 (fr) * 1998-10-30 2000-05-11 Thomas Jefferson University Production de proteines et de peptides biomedicaux dans des plantes au moyen de vecteurs viraux de vegetaux
US7094571B2 (en) * 2000-10-27 2006-08-22 The Board Of Regents Of The University Of Texas System Combinatorial protein library screening by periplasmic expression
US7083945B1 (en) * 2000-10-27 2006-08-01 The Board Of Regents Of The University Of Texas System Isolation of binding proteins with high affinity to ligands
DE60138927D1 (de) * 2000-11-07 2009-07-16 Zymogenetics Inc Menschlicher rezeptor für tumor necrosis factor
CN1306272C (zh) * 2000-11-17 2007-03-21 罗切斯特大学 筛选编码抗原特异性免疫球蛋白分子或其抗原特异性片段的方法
ATE542545T1 (de) * 2001-05-24 2012-02-15 Zymogenetics Inc Taci-immunoglobulin-fusionsproteine
DK1495055T3 (da) * 2002-04-18 2013-11-11 Genencor Int Produktion af funktionelle antistoffer i filamentøse svampe
US7611866B2 (en) * 2002-07-15 2009-11-03 Board Of Regents, The University Of Texas System Selection of bacterial inner-membrane anchor polypeptides
EP2301966A1 (fr) * 2002-12-16 2011-03-30 Genentech, Inc. Variantes de l'immunoglobuline et leurs utilisations
EP1588166A4 (fr) * 2003-01-09 2007-06-27 Macrogenics Inc Systeme vectoriel a double expression servant a exprimer des anticorps dans des cellules bacteriennes et mammiferes
US20060024782A1 (en) * 2004-01-21 2006-02-02 Novozymes A/S Production of a monoclonal antibody in a heterokaryon filamentous fungus or in a filamentous fungal host cell
WO2005103074A2 (fr) * 2004-03-18 2005-11-03 Board Of Regents, The University Of Texas System Criblage de bibliotheque de proteines combinatoire par expression periplasmique
CA2671264C (fr) * 2006-11-30 2015-11-24 Research Development Foundation Bibliotheques d'immunoglobulines ameliorees
US8629245B2 (en) * 2007-05-01 2014-01-14 Research Development Foundation Immunoglobulin Fc libraries

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009060804A (ja) * 2007-09-04 2009-03-26 National Research Inst Of Brewing ピヒア属酵母において異種タンパク質を高分泌させる方法
JP2010183885A (ja) * 2009-02-13 2010-08-26 Kobe Univ タンパク質の製造方法およびそれに用いる発現ベクター
KR20200066340A (ko) 2017-10-10 2020-06-09 아지노모토 가부시키가이샤 단백질의 제조 방법
US11746342B2 (en) 2017-10-10 2023-09-05 Ajinomoto Co., Inc. Method for manufacturing protein
WO2021251383A1 (fr) 2020-06-11 2021-12-16 味の素株式会社 Procédé de production d'une protéine
KR20230023751A (ko) 2020-06-11 2023-02-17 아지노모토 가부시키가이샤 단백질의 제조법

Also Published As

Publication number Publication date
DK1495055T3 (da) 2013-11-11
WO2003089614A3 (fr) 2004-02-26
AU2003222664A1 (en) 2003-11-03
AU2003222664A8 (en) 2003-11-03
EP1495055A2 (fr) 2005-01-12
EP1495055B1 (fr) 2013-08-14
US20050158825A1 (en) 2005-07-21
EP1495055A4 (fr) 2007-08-01
WO2003089614A2 (fr) 2003-10-30
US20040018573A1 (en) 2004-01-29
US7977067B2 (en) 2011-07-12

Similar Documents

Publication Publication Date Title
EP1495055B1 (fr) Production d'anticorps fonctionnels dans des champignons filamenteux
EP2542575B1 (fr) Expression d'anticorps monoclonaux dans tetrahymena
Ward et al. Characterization of humanized antibodies secreted by Aspergillus niger
JP6840908B1 (ja) エフェクター機能が除去されたＩｇＧ１ Ｆｃ変異体
US20190169309A1 (en) Removal of cancer cells by circulating virus-specific cytotoxic t-cells using cancer cell targeted mhc class 1 compromising multi-function proteins
US20180291103A1 (en) Single domain antibody and derivative proteins thereof against programmed death-ligand (pdl1)
JP2007535913A (ja) ヘテロカリオン菌類又は菌類宿主細胞におけるモノクローナル抗体の生成
US20150344586A1 (en) Disulfide-Linked Multivalent MHC Class I Comprising Multi-function Proteins
CN110229235A (zh) 利用包含mhc i类的复合物通过循环中的病毒特异性细胞毒性t细胞清除靶细胞
US8518667B2 (en) KEX2 cleavage regions of recombinant fusion proteins
JP2008538926A (ja) 切断可能なリンカーを有する一本鎖抗体
KR20170021375A (ko) 항체 발현을 위한 골수성 백혈병 기원의 인간 세포의 용도
CN113906052A (zh) 一种抗ceacam5的单克隆抗体及其制备方法和用途
US8198046B2 (en) KEX2 cleavage regions of recombinant fusion proteins
JP2021514625A (ja) 抗ｍｕｃ１抗体およびｉｌ−１５を含む融合タンパク質構築物
CN116249718A (zh) 结合至钙网蛋白的多功能性分子及其用途
AU2021297923A1 (en) Antibodies and methods for treating claudin-associated diseases
EP3019601B1 (fr) Procédés de production de protéines thérapeutiques sialylées
US20240166750A1 (en) GLYCOENGINEERED Fc VARIANT POLYPEPTIDES WITH ENHANCED EFFECTOR FUNCTION
CN118451105A (zh) 新型抗-il-36r抗体
Jung Engineering of aglycosylated antibody Fc for effector functions

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under section 19 (pct)

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20060412

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060412

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090113

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090406

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090413

A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090713

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090811