JP2006512472A5 - - Google Patents
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- JP2006512472A5 JP2006512472A5 JP2005507914A JP2005507914A JP2006512472A5 JP 2006512472 A5 JP2006512472 A5 JP 2006512472A5 JP 2005507914 A JP2005507914 A JP 2005507914A JP 2005507914 A JP2005507914 A JP 2005507914A JP 2006512472 A5 JP2006512472 A5 JP 2006512472A5
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- JP
- Japan
- Prior art keywords
- nanofilm
- amphiphilic
- polymer component
- composition
- nanofilm composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920000642 polymer Polymers 0.000 claims description 376
- 239000000203 mixture Substances 0.000 claims description 344
- -1 polyethylene Chemical group 0.000 claims description 101
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 97
- 238000000034 method Methods 0.000 claims description 96
- 239000012071 phase Substances 0.000 claims description 84
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 claims description 62
- 230000035699 permeability Effects 0.000 claims description 50
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 36
- 239000000178 monomer Substances 0.000 claims description 32
- 238000001914 filtration Methods 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 25
- 239000007795 chemical reaction product Substances 0.000 claims description 21
- 230000003993 interaction Effects 0.000 claims description 20
- 150000001412 amines Chemical class 0.000 claims description 19
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 19
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 17
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- 150000002148 esters Chemical class 0.000 claims description 16
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- 229910052740 iodine Inorganic materials 0.000 claims description 15
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- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 12
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- 239000004698 Polyethylene Chemical group 0.000 claims description 11
- 229920000573 polyethylene Chemical group 0.000 claims description 11
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims description 10
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- 239000002202 Polyethylene glycol Substances 0.000 claims description 10
- 239000004642 Polyimide Substances 0.000 claims description 10
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- 239000007789 gas Substances 0.000 claims description 10
- 229920006393 polyether sulfone Polymers 0.000 claims description 10
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- 108010039918 Polylysine Proteins 0.000 claims description 8
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- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
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- 229920001567 vinyl ester resin Polymers 0.000 claims description 8
- 239000004711 α-olefin Substances 0.000 claims description 8
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 7
- 229920000936 Agarose Polymers 0.000 claims description 7
- 235000021355 Stearic acid Nutrition 0.000 claims description 7
- 150000001993 dienes Chemical class 0.000 claims description 7
- 150000002009 diols Chemical class 0.000 claims description 7
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 7
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 7
- 229920000058 polyacrylate Polymers 0.000 claims description 7
- 230000000379 polymerizing effect Effects 0.000 claims description 7
- 108091033319 polynucleotide Proteins 0.000 claims description 7
- 229920005862 polyol Polymers 0.000 claims description 7
- 150000003077 polyols Chemical class 0.000 claims description 7
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 7
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 7
- 239000011118 polyvinyl acetate Substances 0.000 claims description 7
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 7
- 239000008117 stearic acid Substances 0.000 claims description 7
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 6
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 6
- MHZGKXUYDGKKIU-UHFFFAOYSA-N Decylamine Chemical compound CCCCCCCCCCN MHZGKXUYDGKKIU-UHFFFAOYSA-N 0.000 claims description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 6
- 239000004793 Polystyrene Substances 0.000 claims description 6
- 229920001328 Polyvinylidene chloride Polymers 0.000 claims description 6
- 239000001913 cellulose Substances 0.000 claims description 6
- 229920002301 cellulose acetate Polymers 0.000 claims description 6
- 229930016911 cinnamic acid Natural products 0.000 claims description 6
- 235000013985 cinnamic acid Nutrition 0.000 claims description 6
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 6
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 6
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 6
- 229920001707 polybutylene terephthalate Polymers 0.000 claims description 6
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 6
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 6
- 229920001195 polyisoprene Polymers 0.000 claims description 6
- 102000040430 polynucleotide Human genes 0.000 claims description 6
- 239000002157 polynucleotide Substances 0.000 claims description 6
- 229920002223 polystyrene Polymers 0.000 claims description 6
- 239000005033 polyvinylidene chloride Substances 0.000 claims description 6
- JECYNCQXXKQDJN-UHFFFAOYSA-N 2-(2-methylhexan-2-yloxymethyl)oxirane Chemical compound CCCCC(C)(C)OCC1CO1 JECYNCQXXKQDJN-UHFFFAOYSA-N 0.000 claims description 5
- 229920000945 Amylopectin Polymers 0.000 claims description 5
- 229920000856 Amylose Polymers 0.000 claims description 5
- 229920002101 Chitin Polymers 0.000 claims description 5
- 229920001661 Chitosan Polymers 0.000 claims description 5
- 229920002307 Dextran Polymers 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- 229920002527 Glycogen Polymers 0.000 claims description 5
- 229930186217 Glycolipid Natural products 0.000 claims description 5
- 108090000288 Glycoproteins Proteins 0.000 claims description 5
- 102000003886 Glycoproteins Human genes 0.000 claims description 5
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 5
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 claims description 5
- 108010013639 Peptidoglycan Proteins 0.000 claims description 5
- 239000004697 Polyetherimide Substances 0.000 claims description 5
- 229920000954 Polyglycolide Polymers 0.000 claims description 5
- 108010067787 Proteoglycans Proteins 0.000 claims description 5
- 102000016611 Proteoglycans Human genes 0.000 claims description 5
- 108091034057 RNA (poly(A)) Proteins 0.000 claims description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 5
- 239000004202 carbamide Substances 0.000 claims description 5
- 150000001720 carbohydrates Chemical class 0.000 claims description 5
- 239000008103 glucose Substances 0.000 claims description 5
- 229940096919 glycogen Drugs 0.000 claims description 5
- 229920000554 ionomer Polymers 0.000 claims description 5
- 230000001404 mediated effect Effects 0.000 claims description 5
- 102000039446 nucleic acids Human genes 0.000 claims description 5
- 150000007523 nucleic acids Chemical class 0.000 claims description 5
- 229920000141 poly(maleic anhydride) Polymers 0.000 claims description 5
- 229920002401 polyacrylamide Polymers 0.000 claims description 5
- 229920001601 polyetherimide Polymers 0.000 claims description 5
- 239000004633 polyglycolic acid Substances 0.000 claims description 5
- 239000004626 polylactic acid Substances 0.000 claims description 5
- 229920000136 polysorbate Polymers 0.000 claims description 5
- 229950008882 polysorbate Drugs 0.000 claims description 5
- 108010088751 Albumins Proteins 0.000 claims description 4
- 102000009027 Albumins Human genes 0.000 claims description 4
- 150000001408 amides Chemical class 0.000 claims description 4
- 150000003949 imides Chemical class 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
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- 108010058846 Ovalbumin Proteins 0.000 claims description 3
- 238000005266 casting Methods 0.000 claims description 3
- 229940109239 creatinine Drugs 0.000 claims description 3
- 238000003618 dip coating Methods 0.000 claims description 3
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- 239000010954 inorganic particle Substances 0.000 claims description 3
- 229940092253 ovalbumin Drugs 0.000 claims description 3
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- 108010062374 Myoglobin Proteins 0.000 claims description 2
- 102000036675 Myoglobin Human genes 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 claims description 2
- 239000007863 gel particle Substances 0.000 claims description 2
- 239000001307 helium Substances 0.000 claims description 2
- 229910052734 helium Inorganic materials 0.000 claims description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 2
- 229940027941 immunoglobulin g Drugs 0.000 claims description 2
- 230000003612 virological effect Effects 0.000 claims description 2
- 125000000524 functional group Chemical group 0.000 description 148
- 241000894007 species Species 0.000 description 116
- 239000000243 solution Substances 0.000 description 115
- 238000005859 coupling reaction Methods 0.000 description 106
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 105
- 238000010168 coupling process Methods 0.000 description 101
- 230000008878 coupling Effects 0.000 description 99
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 89
- 239000011148 porous material Substances 0.000 description 89
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 73
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- 125000003118 aryl group Chemical group 0.000 description 32
- RZVGUUMNWCDIBV-UHFFFAOYSA-N diethyl propanediimidate Chemical compound CCOC(=N)CC(=N)OCC RZVGUUMNWCDIBV-UHFFFAOYSA-N 0.000 description 31
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 30
- 238000006243 chemical reaction Methods 0.000 description 30
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 28
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- 125000001424 substituent group Chemical group 0.000 description 26
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- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 description 16
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 16
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- 238000000089 atomic force micrograph Methods 0.000 description 10
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- UMRZSTCPUPJPOJ-KNVOCYPGSA-N norbornane Chemical compound C1C[C@H]2CC[C@@H]1C2 UMRZSTCPUPJPOJ-KNVOCYPGSA-N 0.000 description 10
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- 125000001931 aliphatic group Chemical group 0.000 description 9
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- 125000004432 carbon atom Chemical group C* 0.000 description 9
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- 2003-04-29 US US10/426,475 patent/US20040106741A1/en not_active Abandoned
- 2003-09-05 WO PCT/US2003/027749 patent/WO2005018013A2/en not_active Ceased
- 2003-09-05 KR KR1020057004632A patent/KR20060056266A/ko not_active Ceased
- 2003-09-05 JP JP2005507914A patent/JP2006512472A/ja active Pending
- 2003-09-05 EP EP03816729A patent/EP1573833A4/en not_active Withdrawn
- 2003-09-05 AU AU2003304453A patent/AU2003304453B2/en not_active Ceased
-
2005
- 2005-08-10 US US11/202,322 patent/US7595368B2/en not_active Expired - Fee Related
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