JP2006512293A - ＩｇＥを調節し、細胞増殖を阻害するためのフェニル−インドール化合物 - Google Patents
ＩｇＥを調節し、細胞増殖を阻害するためのフェニル−インドール化合物 Download PDFInfo
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- JP2006512293A JP2006512293A JP2004536642A JP2004536642A JP2006512293A JP 2006512293 A JP2006512293 A JP 2006512293A JP 2004536642 A JP2004536642 A JP 2004536642A JP 2004536642 A JP2004536642 A JP 2004536642A JP 2006512293 A JP2006512293 A JP 2006512293A
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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Landscapes
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- Pulmonology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US6911462B2 (en) * | 1998-05-22 | 2005-06-28 | Avanir Pharmaceuticals | Benzimidazole compounds for regulating IgE |
| JP2004528304A (ja) * | 2001-03-12 | 2004-09-16 | アバニール・ファーマシューティカルズ | ＩｇＥを調節し、細胞増殖を阻害するためのベンゾイミダゾール化合物 |
| TW200304820A (en) * | 2002-03-25 | 2003-10-16 | Avanir Pharmaceuticals | Use of benzimidazole analogs in the treatment of cell proliferation |
| TWI276631B (en) | 2002-09-12 | 2007-03-21 | Avanir Pharmaceuticals | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation |
| WO2004024655A2 (en) * | 2002-09-12 | 2004-03-25 | Avanir Pharmaceuticals | Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation |
| AU2004263190A1 (en) * | 2003-08-08 | 2005-02-17 | Avanir Pharmaceuticals | Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases |
| US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| JP2008506702A (ja) | 2004-07-14 | 2008-03-06 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｃ型肝炎を治療するための方法 |
| WO2006019832A1 (en) | 2004-07-22 | 2006-02-23 | Ptc Therapeutics, Inc. | Thienopyridines for treating hepatitis c |
| ITMI20061368A1 (it) * | 2006-07-14 | 2008-01-15 | Acraf | Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo |
| KR20150070290A (ko) * | 2012-10-17 | 2015-06-24 | 에프. 호프만-라 로슈 아게 | Trp 채널 길항제로서의 6-아미노인돌 유도체 |
| TWI752155B (zh) | 2017-02-01 | 2022-01-11 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
| TWI674260B (zh) | 2017-02-01 | 2019-10-11 | 德商菲尼克斯製藥股份有限公司 | 芳基烴受體(AhR)調節劑化合物 |
| TW201835070A (zh) * | 2017-02-21 | 2018-10-01 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
| FI3723790T3 (fi) * | 2017-12-12 | 2024-04-19 | Kamada Ltd | Menetelmiä immuunitoleranssin indusoimiseksi ja lääkevasta-ainevasteen vähentämiseksi |
| US12173065B2 (en) * | 2018-10-18 | 2024-12-24 | Sinomab Bioscience Limited | Fusion proteins comprising extracellular domain of human CD22 |
| CN115916166A (zh) | 2020-05-08 | 2023-04-04 | 健玛保 | 针对cd3和cd20的双特异性抗体 |
| US20240034788A1 (en) * | 2020-08-20 | 2024-02-01 | The Board Of Trustees Of The Leland Stanford Junior University | Abscopal therapy for cancer |
| CN116406293A (zh) | 2020-09-10 | 2023-07-07 | 健玛保 | 用于治疗滤泡性淋巴瘤的联合疗法中的针对cd3和cd20的双特异性抗体 |
| BR112023004351A2 (pt) | 2020-09-10 | 2023-04-04 | Genmab As | Método para tratar linfoma folicular em um sujeito humano |
| CA3190349A1 (en) | 2020-09-10 | 2022-03-17 | Brian Elliott | Bispecific antibodies against cd3 and cd20 for treating chronic lymphocytic leukemia |
| CA3192251A1 (en) | 2020-09-10 | 2022-03-17 | Genmab A/S | Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma |
| CN116782933A (zh) | 2020-09-10 | 2023-09-19 | 健玛保 | 用于治疗弥漫性大b细胞淋巴瘤的联合疗法中的针对cd3和cd20的双特异性抗体 |
| AR133526A1 (es) * | 2023-08-09 | 2025-10-08 | Daewoong Pharmaceutical Co Ltd | Nuevo compuesto, y una composición farmacéutica para la prevención o el tratamiento del cáncer o tumores que comprende el mismo |
| WO2025188669A1 (en) * | 2024-03-04 | 2025-09-12 | Cardiff Oncology, Inc. | Use of plk1 inhibitor as monotherapy and in combination with cetuximab in treating ras wild-type colorectal cancer |
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| DE3224512A1 (de) | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| US4510158A (en) | 1984-03-05 | 1985-04-09 | Sterling Drug Inc. | 2-Phenylindole derivatives, their use as complement inhibitors |
| AU591495B2 (en) | 1985-05-03 | 1989-12-07 | Foxboro Company, The | Distillation cut point control |
| US4939133A (en) | 1985-10-01 | 1990-07-03 | Warner-Lambert Company | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade |
| LU86258A1 (fr) | 1986-01-21 | 1987-09-03 | Rech Dermatologiques C I R D S | Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique |
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-
2003
- 2003-09-09 WO PCT/US2003/028145 patent/WO2004024655A2/en not_active Ceased
- 2003-09-09 AU AU2003270426A patent/AU2003270426A1/en not_active Withdrawn
- 2003-09-10 TW TW092124977A patent/TW200407303A/zh unknown
- 2003-09-12 PE PE2003000932A patent/PE20050035A1/es not_active Application Discontinuation
- 2003-09-12 KR KR1020057004244A patent/KR20050051658A/ko not_active Withdrawn
- 2003-09-12 EP EP03795717A patent/EP1537079A4/en not_active Withdrawn
- 2003-09-12 PL PL03375812A patent/PL375812A1/xx not_active Application Discontinuation
- 2003-09-12 MX MXJL05000009A patent/MXJL05000009A/es not_active Application Discontinuation
- 2003-09-12 AU AU2003277152A patent/AU2003277152A1/en not_active Abandoned
- 2003-09-12 CA CA002498493A patent/CA2498493A1/en not_active Abandoned
- 2003-09-12 JP JP2004536642A patent/JP2006512293A/ja not_active Withdrawn
- 2003-09-12 CN CNA038250829A patent/CN1694868A/zh active Pending
- 2003-09-12 AR ARP030103320A patent/AR041251A1/es not_active Application Discontinuation
- 2003-09-12 RU RU2005109912/04A patent/RU2005109912A/ru not_active Application Discontinuation
- 2003-09-12 US US10/661,139 patent/US7375118B2/en not_active Expired - Fee Related
- 2003-09-12 BR BR0314223-0A patent/BR0314223A/pt not_active IP Right Cessation
- 2003-09-12 WO PCT/US2003/030959 patent/WO2004024896A2/en not_active Ceased
-
2005
- 2005-04-05 ZA ZA200502739A patent/ZA200502739B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR041251A1 (es) | 2005-05-11 |
| AU2003277152A1 (en) | 2004-04-30 |
| TW200407303A (en) | 2004-05-16 |
| PL375812A1 (en) | 2005-12-12 |
| WO2004024896A3 (en) | 2004-06-24 |
| WO2004024655A2 (en) | 2004-03-25 |
| US7375118B2 (en) | 2008-05-20 |
| KR20050051658A (ko) | 2005-06-01 |
| ZA200502739B (en) | 2005-10-13 |
| RU2005109912A (ru) | 2006-04-27 |
| CA2498493A1 (en) | 2004-03-25 |
| WO2004024896A2 (en) | 2004-03-25 |
| BR0314223A (pt) | 2005-07-26 |
| CN1694868A (zh) | 2005-11-09 |
| EP1537079A4 (en) | 2007-05-16 |
| EP1537079A2 (en) | 2005-06-08 |
| PE20050035A1 (es) | 2005-01-24 |
| MXJL05000009A (es) | 2005-06-07 |
| US20040180946A1 (en) | 2004-09-16 |
| AU2003270426A1 (en) | 2004-04-30 |
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