JP2006512283A5 - - Google Patents
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- Publication number
- JP2006512283A5 JP2006512283A5 JP2004506365A JP2004506365A JP2006512283A5 JP 2006512283 A5 JP2006512283 A5 JP 2006512283A5 JP 2004506365 A JP2004506365 A JP 2004506365A JP 2004506365 A JP2004506365 A JP 2004506365A JP 2006512283 A5 JP2006512283 A5 JP 2006512283A5
- Authority
- JP
- Japan
- Prior art keywords
- medium
- rhsa
- anion exchange
- separation medium
- μmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 12
- 238000000926 separation method Methods 0.000 claims 11
- 238000005349 anion exchange Methods 0.000 claims 10
- 239000003446 ligand Substances 0.000 claims 7
- 102000008100 Human Serum Albumin Human genes 0.000 claims 5
- 108091006905 Human Serum Albumin Proteins 0.000 claims 5
- 239000013541 low molecular weight contaminant Substances 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 239000000356 contaminant Substances 0.000 claims 1
- 239000007857 degradation product Substances 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0201518A SE526227C2 (sv) | 2002-05-15 | 2002-05-15 | Metod för rening av rekombinant humant serumalbumin |
| PCT/SE2003/000792 WO2003097693A1 (en) | 2002-05-15 | 2003-05-15 | Method, use and kit for separating albumin from contaminants in a liquid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006512283A JP2006512283A (ja) | 2006-04-13 |
| JP2006512283A5 true JP2006512283A5 (enExample) | 2006-06-29 |
| JP4559216B2 JP4559216B2 (ja) | 2010-10-06 |
Family
ID=20287916
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004506364A Pending JP2006502098A (ja) | 2002-05-15 | 2003-05-09 | アルブミン精製法 |
| JP2004506365A Expired - Fee Related JP4559216B2 (ja) | 2002-05-15 | 2003-05-15 | 液体中の夾雑物からアルブミンを分離する方法、使用及びキット |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004506364A Pending JP2006502098A (ja) | 2002-05-15 | 2003-05-09 | アルブミン精製法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7423124B2 (enExample) |
| EP (2) | EP1504031B1 (enExample) |
| JP (2) | JP2006502098A (enExample) |
| CN (1) | CN100463921C (enExample) |
| AT (1) | ATE335006T1 (enExample) |
| AU (2) | AU2003228193B2 (enExample) |
| BR (2) | BRPI0309992B1 (enExample) |
| CA (2) | CA2483612A1 (enExample) |
| DE (1) | DE60307262T2 (enExample) |
| ES (1) | ES2268362T3 (enExample) |
| IL (1) | IL164844A (enExample) |
| SE (1) | SE526227C2 (enExample) |
| WO (2) | WO2003097692A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8802146B2 (en) * | 1998-11-06 | 2014-08-12 | Neomend, Inc. | Systems, methods, and compositions for prevention of tissue adhesion |
| KR100921594B1 (ko) * | 2003-01-28 | 2009-10-14 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 시아노 안트라닐아미드 살충제 |
| CA2514981A1 (en) * | 2003-03-12 | 2004-09-23 | Fresenius Kabi Deutschland Gmbh | Use of recombinant albumin in dialysis after liver failure |
| PT1745078E (pt) * | 2004-04-23 | 2009-09-17 | Conjuchem Biotechnologies Inc | Método para a purificação de conjugados de albumina |
| CN1854155B (zh) * | 2005-04-29 | 2010-11-17 | 华北制药集团新药研究开发有限责任公司 | 一种纯化rHSA的方法 |
| AR067536A1 (es) * | 2007-07-17 | 2009-10-14 | Hoffmann La Roche | Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea |
| AR067537A1 (es) * | 2007-07-17 | 2009-10-14 | Hoffmann La Roche | Purificacion de polipeptidos pegilados |
| JP4452324B2 (ja) * | 2008-03-31 | 2010-04-21 | 積水メディカル株式会社 | 精製血清アルブミン及び免疫学的測定方法 |
| US8753868B2 (en) * | 2008-08-04 | 2014-06-17 | General Electric Company | Method and system for selective isolation of target biological molecules in a general purpose system |
| CN101768206B (zh) * | 2008-12-31 | 2013-05-15 | 华北制药集团新药研究开发有限责任公司 | 一种重组人血清白蛋白的纯化方法及其应用 |
| SG173469A1 (en) | 2009-02-20 | 2011-09-29 | Ventria Bioscience | Cell culture media containing combinations of proteins |
| MY161534A (en) | 2010-05-25 | 2017-04-28 | Genentech Inc | Methods of purifying polypeptides |
| CN102127164B (zh) | 2010-12-20 | 2013-01-30 | 武汉禾元生物科技有限公司 | 一种从水稻种子中提取重组人血清白蛋白的方法 |
| CN102532254B (zh) * | 2010-12-24 | 2015-06-24 | 武汉禾元生物科技股份有限公司 | 一种从水稻种子中分离纯化重组人血清白蛋白的方法 |
| CN104812491B (zh) * | 2012-03-08 | 2018-06-19 | 生物辐射实验室股份有限公司 | 阴离子交换-疏水性混合模式 |
| CN103880947B (zh) | 2012-12-21 | 2016-01-13 | 武汉禾元生物科技股份有限公司 | 一种分离纯化高纯度重组人血清白蛋白的层析方法 |
| CN103923211A (zh) * | 2014-05-08 | 2014-07-16 | 齐智 | 一种医药级重组人血清白蛋白的纯化方法 |
| KR20240013282A (ko) * | 2015-06-10 | 2024-01-30 | 이뮤너티바이오, 인크. | 암을 치료하기 위한 변형된 nk-92 세포 |
| CN106117347A (zh) * | 2015-12-09 | 2016-11-16 | 烟台大学 | 一种疏水层析制备高纯度藻红蛋白的方法 |
| CN106117326A (zh) * | 2015-12-09 | 2016-11-16 | 烟台大学 | 一种离心法结合阴离子交换层析介质制备藻红蛋白的方法 |
| CN106146631A (zh) * | 2015-12-09 | 2016-11-23 | 烟台大学 | 一种离心技术结合疏水层析介质制备藻红蛋白的方法 |
| CN120334439A (zh) | 2019-09-24 | 2025-07-18 | 里珍纳龙药品有限公司 | 用于色谱介质的使用和再生的系统及方法 |
| US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
| US12161777B2 (en) | 2020-07-02 | 2024-12-10 | Davol Inc. | Flowable hemostatic suspension |
| CN114885608A (zh) | 2020-12-08 | 2022-08-09 | 通化安睿特生物制药股份有限公司 | 纯化重组蛋白的方法 |
| CN116744984A (zh) | 2020-12-28 | 2023-09-12 | 达沃有限公司 | 包含蛋白质和多官能化改性的基于聚乙二醇的交联剂的反应性干粉状止血材料 |
| CN113461804A (zh) * | 2021-08-09 | 2021-10-01 | 山东健通生物科技有限公司 | 减少重组人血白蛋白发酵过程中色素的方法 |
| CN113880908B (zh) * | 2021-08-25 | 2024-05-14 | 北京伟德杰生物科技有限公司 | 纯化重组人血清白蛋白的融合蛋白的方法 |
| CN113735962B (zh) * | 2021-08-27 | 2023-11-10 | 常熟纳微生物科技有限公司 | 一种从猪血中纯化重组人血清白蛋白的方法及应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093612A (en) | 1975-08-04 | 1978-06-06 | Research Corporation | Selective removal of albumin from blood fluids and compositions therefore |
| FR2403098A1 (fr) | 1977-09-19 | 1979-04-13 | Merieux Inst | Nouveau materiau capable de fixer de facon reversible des macromolecules biologiques, sa preparation et son application |
| US5849874A (en) * | 1991-07-12 | 1998-12-15 | Gist-Brocades, N.V. | Process for the purification of serum albumin |
| EP0933083A1 (en) * | 1991-07-12 | 1999-08-04 | Dsm N.V. | Process for the purification of serum albumin |
| US5440018A (en) * | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
| US5521287A (en) * | 1992-05-20 | 1996-05-28 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
| JPH07102148B2 (ja) * | 1992-05-20 | 1995-11-08 | 株式会社ミドリ十字 | 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物 |
| CA2116385A1 (en) | 1993-02-25 | 1994-08-26 | Akinori Sumi | Human serum albumin and process for producing the same |
| DK0658569T3 (da) | 1993-12-17 | 2005-02-07 | Mitsubishi Pharma Corp | Fremgangsmåde til affarvning af humant serumalbumin |
| CA2157219C (en) | 1994-08-31 | 2010-10-05 | Munehiro Noda | Process for purifying recombinant human serum albumin |
| JP3840674B2 (ja) * | 1994-08-31 | 2006-11-01 | 三菱ウェルファーマ株式会社 | 遺伝子操作に由来するヒト血清アルブミンの精製方法 |
| GB9902000D0 (en) * | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| SE0002688D0 (sv) | 2000-07-17 | 2000-07-17 | Amersham Pharm Biotech Ab | Adsorption method and ligands |
| JP4798832B2 (ja) * | 2000-10-24 | 2011-10-19 | 一般財団法人化学及血清療法研究所 | ヒト血清アルブミン多量体の除去方法 |
-
2002
- 2002-05-15 SE SE0201518A patent/SE526227C2/sv not_active IP Right Cessation
-
2003
- 2003-05-09 DE DE60307262T patent/DE60307262T2/de not_active Expired - Lifetime
- 2003-05-09 AU AU2003228193A patent/AU2003228193B2/en not_active Ceased
- 2003-05-09 EP EP03725953A patent/EP1504031B1/en not_active Expired - Lifetime
- 2003-05-09 JP JP2004506364A patent/JP2006502098A/ja active Pending
- 2003-05-09 BR BRPI0309992-0A patent/BRPI0309992B1/pt active IP Right Grant
- 2003-05-09 US US10/514,536 patent/US7423124B2/en not_active Expired - Lifetime
- 2003-05-09 AT AT03725953T patent/ATE335006T1/de not_active IP Right Cessation
- 2003-05-09 CA CA002483612A patent/CA2483612A1/en not_active Abandoned
- 2003-05-09 ES ES03725953T patent/ES2268362T3/es not_active Expired - Lifetime
- 2003-05-09 BR BRPI0309992A patent/BRPI0309992B8/pt active IP Right Grant
- 2003-05-09 CN CNB031235026A patent/CN100463921C/zh not_active Expired - Fee Related
- 2003-05-09 WO PCT/SE2003/000766 patent/WO2003097692A1/en not_active Ceased
- 2003-05-15 AU AU2003232704A patent/AU2003232704A1/en not_active Abandoned
- 2003-05-15 EP EP03752962A patent/EP1504032A1/en not_active Withdrawn
- 2003-05-15 CA CA002483616A patent/CA2483616A1/en not_active Abandoned
- 2003-05-15 WO PCT/SE2003/000792 patent/WO2003097693A1/en not_active Ceased
- 2003-05-15 US US10/514,544 patent/US7351801B2/en not_active Expired - Fee Related
- 2003-05-15 JP JP2004506365A patent/JP4559216B2/ja not_active Expired - Fee Related
-
2004
- 2004-10-26 IL IL164844A patent/IL164844A/en not_active IP Right Cessation
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