JP2006511476A - 新規トリアジン化合物の組成物および方法 - Google Patents
新規トリアジン化合物の組成物および方法 Download PDFInfo
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- JP2006511476A JP2006511476A JP2004538153A JP2004538153A JP2006511476A JP 2006511476 A JP2006511476 A JP 2006511476A JP 2004538153 A JP2004538153 A JP 2004538153A JP 2004538153 A JP2004538153 A JP 2004538153A JP 2006511476 A JP2006511476 A JP 2006511476A
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- Prior art keywords
- methoxy
- fluoro
- triazine
- methyl
- phenyl
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- 238000000034 method Methods 0.000 title claims abstract description 163
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- -1 3-chloro-4-propoxy-phenyl Chemical group 0.000 claims description 248
- 230000000694 effects Effects 0.000 claims description 191
- 125000004432 carbon atom Chemical group C* 0.000 claims description 122
- 210000004027 cell Anatomy 0.000 claims description 94
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- 230000014509 gene expression Effects 0.000 claims description 76
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 72
- 201000010099 disease Diseases 0.000 claims description 72
- 125000000217 alkyl group Chemical group 0.000 claims description 69
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 62
- 229910052760 oxygen Inorganic materials 0.000 claims description 51
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 50
- 238000002493 microarray Methods 0.000 claims description 50
- 150000003839 salts Chemical class 0.000 claims description 38
- 239000003814 drug Substances 0.000 claims description 37
- 206010061218 Inflammation Diseases 0.000 claims description 36
- 230000004054 inflammatory process Effects 0.000 claims description 36
- 108010031186 Glycoside Hydrolases Proteins 0.000 claims description 35
- 102000005744 Glycoside Hydrolases Human genes 0.000 claims description 34
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- 125000003118 aryl group Chemical group 0.000 claims description 30
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 23
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- 108090000695 Cytokines Proteins 0.000 claims description 22
- 229910052744 lithium Inorganic materials 0.000 claims description 22
- 229910052749 magnesium Inorganic materials 0.000 claims description 22
- 229910052757 nitrogen Inorganic materials 0.000 claims description 22
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 21
- 229910052791 calcium Inorganic materials 0.000 claims description 21
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 19
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- 241000282414 Homo sapiens Species 0.000 claims description 15
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- 150000003527 tetrahydropyrans Chemical group 0.000 claims description 15
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 14
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 10
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- JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 claims description 4
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- SFBXELJTEBYSGU-UHFFFAOYSA-N 4-[[4-(cycloheptylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]amino]-2-fluorophenol Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(O)=CC=2)=N1 SFBXELJTEBYSGU-UHFFFAOYSA-N 0.000 claims 6
- PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 claims 4
- UXECJAJBAWUAMQ-UHFFFAOYSA-N 1h-triazine-2,4,6-triamine Chemical compound NN1NC(N)=CC(N)=N1 UXECJAJBAWUAMQ-UHFFFAOYSA-N 0.000 claims 4
- NERDOBLWHCNQPO-UHFFFAOYSA-N 2-[[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]pyrrolidine-1-carboxamide Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2N(CCC2)C(N)=O)=NC(NC2CCCCCC2)=N1 NERDOBLWHCNQPO-UHFFFAOYSA-N 0.000 claims 4
- MAVLTASOAMRKNW-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-(1-methylpiperidin-4-yl)oxy-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(OC2CCN(C)CC2)=N1 MAVLTASOAMRKNW-UHFFFAOYSA-N 0.000 claims 4
- MIALDMZIYGRJAR-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-n-(oxolan-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2OCCC2)=NC(NC2CCCCCC2)=N1 MIALDMZIYGRJAR-UHFFFAOYSA-N 0.000 claims 4
- UKJONFYGAQQFFP-UHFFFAOYSA-N 2-n-cycloheptyl-6-[(1-ethylpyrrolidin-2-yl)methoxy]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1COC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 UKJONFYGAQQFFP-UHFFFAOYSA-N 0.000 claims 4
- OFNSSSIQKGHKSA-UHFFFAOYSA-N 4-[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]piperidine-1-carboxamide Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCN(CC2)C(N)=O)=NC(NC2CCCCCC2)=N1 OFNSSSIQKGHKSA-UHFFFAOYSA-N 0.000 claims 4
- DVUGRZGYABJWJQ-UHFFFAOYSA-N 4-[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]piperidine-1-carboxylic acid Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCN(CC2)C(O)=O)=NC(NC2CCCCCC2)=N1 DVUGRZGYABJWJQ-UHFFFAOYSA-N 0.000 claims 4
- NHEHPBICMWVHEP-UHFFFAOYSA-N 4-[[4-(cycloheptylamino)-6-(piperidin-4-ylamino)-1,3,5-triazin-2-yl]amino]-2-fluorophenol Chemical compound C1=C(F)C(O)=CC=C1NC1=NC(NC2CCNCC2)=NC(NC2CCCCCC2)=N1 NHEHPBICMWVHEP-UHFFFAOYSA-N 0.000 claims 4
- UOQSDNUEBGNYNR-UHFFFAOYSA-N 4-n-cycloheptyl-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-6-(3-fluoro-4-methoxyphenoxy)-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(OC=2C=C(F)C(OC)=CC=2)=N1 UOQSDNUEBGNYNR-UHFFFAOYSA-N 0.000 claims 4
- HAJZKYNSFBZXIH-UHFFFAOYSA-N 6-(3-chloro-4-methoxyphenoxy)-4-n-cycloheptyl-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(OC=2C=C(Cl)C(OC)=CC=2)=N1 HAJZKYNSFBZXIH-UHFFFAOYSA-N 0.000 claims 4
- INQAKYAKDADPCL-UHFFFAOYSA-N 6-(3-chloro-4-methoxyphenoxy)-4-n-cycloheptyl-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(Cl)C(OC)=CC=C1OC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 INQAKYAKDADPCL-UHFFFAOYSA-N 0.000 claims 4
- OGCITAJBXWNTHX-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-4-n-(oxolan-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2OCCC2)=NC(NCC2CCCCC2)=N1 OGCITAJBXWNTHX-UHFFFAOYSA-N 0.000 claims 4
- QGBYUXISHNKLKF-UHFFFAOYSA-N 6-n-[(3-aminocyclopentyl)methyl]-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CC(N)CC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 QGBYUXISHNKLKF-UHFFFAOYSA-N 0.000 claims 4
- QJSPREZYSFKEAB-UHFFFAOYSA-N 6-n-cycloheptyl-2-n-(3-fluoro-4-methoxyphenyl)-4-n-(1-hydroxypiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCN(O)CC2)=NC(NC2CCCCCC2)=N1 QJSPREZYSFKEAB-UHFFFAOYSA-N 0.000 claims 4
- MRVOVQYFZZSOJG-UHFFFAOYSA-N 6-n-cycloheptyl-2-n-(3-fluoro-4-methoxyphenyl)-4-n-(oxan-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCOCC2)=NC(NC2CCCCCC2)=N1 MRVOVQYFZZSOJG-UHFFFAOYSA-N 0.000 claims 4
- UUAKJAGPKPJOAB-UHFFFAOYSA-N [4-(cyclohexylmethylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl] pyrrolidine-2-carboxylate Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(OC(=O)C2NCCC2)=N1 UUAKJAGPKPJOAB-UHFFFAOYSA-N 0.000 claims 4
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical class OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 claims 4
- OBHSRZSNIUZYBK-UHFFFAOYSA-N 2-[[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]pyrrolidine-1-carboxylic acid Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2N(CCC2)C(O)=O)=NC(NC2CCCCCC2)=N1 OBHSRZSNIUZYBK-UHFFFAOYSA-N 0.000 claims 3
- ILASVAWGXSKSIW-UHFFFAOYSA-N (3-bromo-4-methoxyphenyl)-[4-(cycloheptylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]cyanamide Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(N(C#N)C=2C=C(Br)C(OC)=CC=2)=N1 ILASVAWGXSKSIW-UHFFFAOYSA-N 0.000 claims 2
- OIEGDGYSNFTEKW-UHFFFAOYSA-N (3-chloro-4-methoxyphenyl)-[4-(cycloheptylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]cyanamide Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(N(C#N)C=2C=C(Cl)C(OC)=CC=2)=N1 OIEGDGYSNFTEKW-UHFFFAOYSA-N 0.000 claims 2
- BPOKJCZVLUYOBN-UHFFFAOYSA-M 1-[2-[[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]-1-ethylpyrrolidin-1-ium-1-yl]ethanone;chloride Chemical compound [Cl-].CC[N+]1(C(C)=O)CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 BPOKJCZVLUYOBN-UHFFFAOYSA-M 0.000 claims 2
- AJXHQFPLRJYGSD-UHFFFAOYSA-N 1-[2-[[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]pyrrolidin-1-yl]-3-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propan-1-one Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2N(CCC2)C(=O)CCOCCOCCOCCOCCO)=NC(NC2CCCCCC2)=N1 AJXHQFPLRJYGSD-UHFFFAOYSA-N 0.000 claims 2
- RXGJKTPLWALZGL-UHFFFAOYSA-N 1-[2-[[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]pyrrolidin-1-yl]-3-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]propan-1-one Chemical compound COCCOCCOCCOCCOCCC(=O)N1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 RXGJKTPLWALZGL-UHFFFAOYSA-N 0.000 claims 2
- FAAXXIHMMOIJCT-UHFFFAOYSA-N 1-[2-[[[4-(cyclohexylmethylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]pyrrolidin-1-yl]-3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]propan-1-one Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2N(CCC2)C(=O)CCOCCOCCOCCO)=NC(NCC2CCCCC2)=N1 FAAXXIHMMOIJCT-UHFFFAOYSA-N 0.000 claims 2
- SCYQGPGPGITXPY-UHFFFAOYSA-N 1-[2-[[[4-(cyclohexylmethylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]pyrrolidin-1-yl]-3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]propan-1-one Chemical compound COCCOCCOCCOCCC(=O)N1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 SCYQGPGPGITXPY-UHFFFAOYSA-N 0.000 claims 2
- RVKUABSFQMTDEA-UHFFFAOYSA-N 1-[2-[[[4-(cyclohexylmethylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]pyrrolidin-1-yl]ethanone Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2N(CCC2)C(C)=O)=NC(NCC2CCCCC2)=N1 RVKUABSFQMTDEA-UHFFFAOYSA-N 0.000 claims 2
- UJVIGJWVJLOARE-UHFFFAOYSA-N 1-[4-(cyclohexylmethylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]imidazolidine-2,4-dione Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(N2C(NC(=O)C2)=O)=N1 UJVIGJWVJLOARE-UHFFFAOYSA-N 0.000 claims 2
- YXSVWSONPGRBRZ-UHFFFAOYSA-N 1-[4-(cyclohexylmethylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]pyrrolidine-2,5-dione Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(N2C(CCC2=O)=O)=N1 YXSVWSONPGRBRZ-UHFFFAOYSA-N 0.000 claims 2
- PMAZZZYPWHBOIK-UHFFFAOYSA-N 1-[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]pentan-2-one Chemical compound N=1C(NC=2C=C(F)C(OC)=CC=2)=NC(CC(=O)CCC)=NC=1NCC1CCCN1CC PMAZZZYPWHBOIK-UHFFFAOYSA-N 0.000 claims 2
- MXJBGKABENLLJQ-UHFFFAOYSA-N 1-[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]propan-2-one Chemical compound CCN1CCCC1CNC1=NC(CC(C)=O)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 MXJBGKABENLLJQ-UHFFFAOYSA-N 0.000 claims 2
- TZXPFHFSXKZOPH-UHFFFAOYSA-N 1-[4-[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]-4h-pyridin-1-yl]ethanone Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2C=CN(C=C2)C(C)=O)=NC(NC2CCCCCC2)=N1 TZXPFHFSXKZOPH-UHFFFAOYSA-N 0.000 claims 2
- JAUVIZFZOGESOG-UHFFFAOYSA-N 1-[4-[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]piperidin-1-yl]-3-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]propan-1-one Chemical compound C1CN(C(=O)CCOCCOCCOCCOCCOC)CCC1NC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 JAUVIZFZOGESOG-UHFFFAOYSA-N 0.000 claims 2
- CYAFAWWOQGLXTH-UHFFFAOYSA-N 1-[4-[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]piperidin-1-yl]ethanone Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCN(CC2)C(C)=O)=NC(NC2CCCCCC2)=N1 CYAFAWWOQGLXTH-UHFFFAOYSA-N 0.000 claims 2
- QGFMYZFSXZKVAS-UHFFFAOYSA-N 1-[4-[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]piperidin-1-yl]hexan-2-one Chemical compound C1CN(CC(=O)CCCC)CCC1NC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 QGFMYZFSXZKVAS-UHFFFAOYSA-N 0.000 claims 2
- XRAFCAKPEVRHQN-UHFFFAOYSA-N 1-[4-[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]piperidin-1-yl]pentan-2-one Chemical compound C1CN(CC(=O)CCC)CCC1NC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 XRAFCAKPEVRHQN-UHFFFAOYSA-N 0.000 claims 2
- FTMSBPSUURYXOP-UHFFFAOYSA-N 1-[4-[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]piperidin-1-yl]propan-2-one Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCN(CC(C)=O)CC2)=NC(NC2CCCCCC2)=N1 FTMSBPSUURYXOP-UHFFFAOYSA-N 0.000 claims 2
- COPNOAFUAGAXDM-UHFFFAOYSA-N 1-[4-[[4-(cycloheptylamino)-6-(3-fluoro-n-methoxyanilino)-1,3,5-triazin-2-yl]amino]piperidin-1-yl]pentan-1-one Chemical compound C1CN(C(=O)CCCC)CCC1NC1=NC(NC2CCCCCC2)=NC(N(OC)C=2C=C(F)C=CC=2)=N1 COPNOAFUAGAXDM-UHFFFAOYSA-N 0.000 claims 2
- IGBDLHUKXWEQEV-UHFFFAOYSA-N 1-o-tert-butyl 2-o-[4-(cyclohexylmethylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl] pyrrolidine-1,2-dicarboxylate Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(OC(=O)C2N(CCC2)C(=O)OC(C)(C)C)=N1 IGBDLHUKXWEQEV-UHFFFAOYSA-N 0.000 claims 2
- XNMGWHSWJDKWDE-UHFFFAOYSA-N 2-(3-chloro-4-methoxyphenoxy)-4-cycloheptyloxy-6-(1-methylpiperidin-4-yl)oxy-1,3,5-triazine Chemical compound C1=C(Cl)C(OC)=CC=C1OC1=NC(OC2CCN(C)CC2)=NC(OC2CCCCCC2)=N1 XNMGWHSWJDKWDE-UHFFFAOYSA-N 0.000 claims 2
- YTLCVZRLQRLYAY-UHFFFAOYSA-N 2-(cyclohexylmethylamino)-6-(3-fluoro-4-methoxyanilino)-1h-1,3,5-triazin-4-one Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(O)=NC(NCC2CCCCC2)=N1 YTLCVZRLQRLYAY-UHFFFAOYSA-N 0.000 claims 2
- HSTZLMLIXXWIAB-UHFFFAOYSA-N 2-(cyclohexylmethylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1h-1,3,5-triazin-4-one Chemical compound CCN1CCCC1CNC1=NC(O)=NC(NCC2CCCCC2)=N1 HSTZLMLIXXWIAB-UHFFFAOYSA-N 0.000 claims 2
- DGOWHWSRKCXXMX-UHFFFAOYSA-N 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl propanoate Chemical compound CCC(=O)OCCOCCOCCOCCO DGOWHWSRKCXXMX-UHFFFAOYSA-N 0.000 claims 2
- QXQATHOBVKNGEC-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[4-[[4-(3-chloro-4-methoxyanilino)-6-(cycloheptylamino)-1,3,5-triazin-2-yl]amino]-1-methylpiperidin-1-ium-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CC[N+](C)(CCOCCOCCOCCOCCOCCO)CC2)=NC(NC2CCCCCC2)=N1 QXQATHOBVKNGEC-UHFFFAOYSA-N 0.000 claims 2
- BGZLWFGRQVCQJN-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[4-[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]-1-methylpiperidin-1-ium-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CC[N+](C)(CCOCCOCCOCCOCCOCCO)CC2)=NC(NC2CCCCCC2)=N1 BGZLWFGRQVCQJN-UHFFFAOYSA-N 0.000 claims 2
- LAJVCBWVBQASOM-UHFFFAOYSA-N 2-[2-[2-[2-[4-[[4-(cycloheptylamino)-6-[methyl-(1-methylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl]amino]-2-fluorophenoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound N=1C(NC2CCCCCC2)=NC(NC=2C=C(F)C(OCCOCCOCCOCCO)=CC=2)=NC=1N(C)C1CCN(C)CC1 LAJVCBWVBQASOM-UHFFFAOYSA-N 0.000 claims 2
- ZLOHQEULKBSXKB-UHFFFAOYSA-N 2-[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]-5,6,7,7a-tetrahydro-1h-pyrrolo[1,2-c]imidazol-3-one Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N2C(N3CCCC3C2)=O)=N1 ZLOHQEULKBSXKB-UHFFFAOYSA-N 0.000 claims 2
- JNFJSHXRLNMKAB-UHFFFAOYSA-N 2-[4-(cyclohexylmethylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]-5,6,7,7a-tetrahydro-3h-pyrrolo[1,2-c]imidazol-1-one Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(N2C(C3CCCN3C2)=O)=N1 JNFJSHXRLNMKAB-UHFFFAOYSA-N 0.000 claims 2
- VGROONFUACUHNU-UHFFFAOYSA-N 2-[4-(cyclohexylmethylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]guanidine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(NC(N)=N)=N1 VGROONFUACUHNU-UHFFFAOYSA-N 0.000 claims 2
- FFTZUFJFGSXUNZ-UHFFFAOYSA-N 2-[[4-(3-chloro-4-methoxyanilino)-6-(cycloheptylamino)-1,3,5-triazin-2-yl]-methylamino]cyclohexan-1-ol Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2C(CCCC2)O)=N1 FFTZUFJFGSXUNZ-UHFFFAOYSA-N 0.000 claims 2
- JYKFISBKOOWORN-UHFFFAOYSA-N 2-[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]cyclopentan-1-ol Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2C(CCC2)O)=NC(NC2CCCCCC2)=N1 JYKFISBKOOWORN-UHFFFAOYSA-N 0.000 claims 2
- OSLSJTVWFQJKIB-UHFFFAOYSA-N 2-[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]-2-(4-hydroxyphenyl)acetic acid Chemical compound CCN1CCCC1CNC1=NC(NC(C(O)=O)C=2C=CC(O)=CC=2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 OSLSJTVWFQJKIB-UHFFFAOYSA-N 0.000 claims 2
- QTZWIWKKGWUBSV-UHFFFAOYSA-N 2-[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]-2-phenylacetic acid Chemical compound CCN1CCCC1CNC1=NC(NC(C(O)=O)C=2C=CC=CC=2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 QTZWIWKKGWUBSV-UHFFFAOYSA-N 0.000 claims 2
- CLURIRMADIKECQ-UHFFFAOYSA-N 2-[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]-2-phenylethanol Chemical compound CCN1CCCC1CNC1=NC(NC(CO)C=2C=CC=CC=2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 CLURIRMADIKECQ-UHFFFAOYSA-N 0.000 claims 2
- XDCGAAQOIOQHNW-UHFFFAOYSA-N 2-[[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]cyclopentan-1-ol Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2C(CCC2)O)=NC(NC2CCCCCC2)=N1 XDCGAAQOIOQHNW-UHFFFAOYSA-N 0.000 claims 2
- FIZAMVOLZXKJJH-UHFFFAOYSA-N 2-[[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]pyrrolidine-1-carbaldehyde Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2N(CCC2)C=O)=NC(NC2CCCCCC2)=N1 FIZAMVOLZXKJJH-UHFFFAOYSA-N 0.000 claims 2
- BUIWACWOOIGQQN-UHFFFAOYSA-N 2-[[[4-(cyclohexylmethylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]cyclopentan-1-one Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2C(CCC2)=O)=NC(NCC2CCCCC2)=N1 BUIWACWOOIGQQN-UHFFFAOYSA-N 0.000 claims 2
- PICQRPRQCYGTFX-UHFFFAOYSA-N 2-[[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]cyclohexan-1-ol Chemical compound CCN1CCCC1CNC1=NC(NCC2C(CCCC2)O)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 PICQRPRQCYGTFX-UHFFFAOYSA-N 0.000 claims 2
- RZAABPKICPSXIU-UHFFFAOYSA-N 2-[[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]cyclopentan-1-ol Chemical compound CCN1CCCC1CNC1=NC(NCC2C(CCC2)O)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 RZAABPKICPSXIU-UHFFFAOYSA-N 0.000 claims 2
- SYTZDVLVFLUNJI-UHFFFAOYSA-N 2-bromo-4-[[4-(cycloheptylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]amino]phenol Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(Br)C(O)=CC=2)=N1 SYTZDVLVFLUNJI-UHFFFAOYSA-N 0.000 claims 2
- TZEKQOZAYHTXOS-UHFFFAOYSA-N 2-chloro-4-[[4-(cycloheptylamino)-6-(piperidin-4-ylamino)-1,3,5-triazin-2-yl]amino]phenol Chemical compound C1=C(Cl)C(O)=CC=C1NC1=NC(NC2CCNCC2)=NC(NC2CCCCCC2)=N1 TZEKQOZAYHTXOS-UHFFFAOYSA-N 0.000 claims 2
- BDYLTRKJWISFDS-UHFFFAOYSA-N 2-cycloheptyloxy-4-(3-fluoro-4-methoxyphenoxy)-6-(1-methylpiperidin-4-yl)oxy-1,3,5-triazine Chemical compound C1=C(F)C(OC)=CC=C1OC1=NC(OC2CCN(C)CC2)=NC(OC2CCCCCC2)=N1 BDYLTRKJWISFDS-UHFFFAOYSA-N 0.000 claims 2
- FNPKWMVRRSZKBP-UHFFFAOYSA-N 2-cycloheptyloxy-4-[(1-ethylpyrrolidin-2-yl)methoxy]-6-(3-fluoro-4-methoxyphenoxy)-1,3,5-triazine Chemical compound CCN1CCCC1COC1=NC(OC2CCCCCC2)=NC(OC=2C=C(F)C(OC)=CC=2)=N1 FNPKWMVRRSZKBP-UHFFFAOYSA-N 0.000 claims 2
- BAUUABAGXILYLE-UHFFFAOYSA-N 2-hydroxy-1h-triazine Chemical compound ON1NC=CC=N1 BAUUABAGXILYLE-UHFFFAOYSA-N 0.000 claims 2
- WSNZKSTZNPFREW-UHFFFAOYSA-N 2-n-(1-azabicyclo[2.2.1]heptan-3-yl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2C3CCN(C3)C2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 WSNZKSTZNPFREW-UHFFFAOYSA-N 0.000 claims 2
- LKVAFHYLGARWAV-UHFFFAOYSA-N 2-n-(1-azabicyclo[2.2.2]octan-3-yl)-6-n-(cyclohexylmethyl)-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(NC2C3CCN(CC3)C2)=N1 LKVAFHYLGARWAV-UHFFFAOYSA-N 0.000 claims 2
- JQZCSUNDZNMWTN-UHFFFAOYSA-N 2-n-(1-azabicyclo[2.2.2]octan-3-yl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2C3CCN(CC3)C2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 JQZCSUNDZNMWTN-UHFFFAOYSA-N 0.000 claims 2
- XQYULNPVJNKGCG-UHFFFAOYSA-N 2-n-(2-aminocyclohexyl)-6-n-(3-chloro-4-methoxyphenyl)-4-n-cycloheptyl-2-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2C(CCCC2)N)=N1 XQYULNPVJNKGCG-UHFFFAOYSA-N 0.000 claims 2
- JFUPWGCVEIUUEE-UHFFFAOYSA-N 2-n-(3-aminocyclohexyl)-6-n-(3-chloro-4-methoxyphenyl)-4-n-cycloheptyl-2-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CC(N)CCC2)=N1 JFUPWGCVEIUUEE-UHFFFAOYSA-N 0.000 claims 2
- QGJKYQOJCDVVTF-UHFFFAOYSA-N 2-n-(3-bicyclo[2.2.1]heptanyl)-6-n-(cyclohexylmethyl)-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(NC2C3CCC(C3)C2)=N1 QGJKYQOJCDVVTF-UHFFFAOYSA-N 0.000 claims 2
- LRNDVQRPTAFJSP-UHFFFAOYSA-N 2-n-(3-bicyclo[2.2.1]heptanyl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2C3CCC(C3)C2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 LRNDVQRPTAFJSP-UHFFFAOYSA-N 0.000 claims 2
- ZLFAKQYZIZYHOU-UHFFFAOYSA-N 2-n-(3-bromo-4-methoxyphenyl)-6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(Br)C(OC)=CC=2)=N1 ZLFAKQYZIZYHOU-UHFFFAOYSA-N 0.000 claims 2
- CVGMKNGTTFDZRJ-UHFFFAOYSA-N 2-n-(3-chloro-4-cyclopropyloxyphenyl)-6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(Cl)C(OC3CC3)=CC=2)=N1 CVGMKNGTTFDZRJ-UHFFFAOYSA-N 0.000 claims 2
- HCVYHSXOMHXCSZ-UHFFFAOYSA-N 2-n-(3-chloro-4-methoxyphenyl)-6-(cycloheptylideneamino)-4-n-methyl-4-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(N=C2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 HCVYHSXOMHXCSZ-UHFFFAOYSA-N 0.000 claims 2
- GNWQBKOELBUIHO-UHFFFAOYSA-N 2-n-(3-chloro-4-methoxyphenyl)-6-cycloheptyloxy-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(Cl)C(OC)=CC=2)=NC(OC2CCCCCC2)=N1 GNWQBKOELBUIHO-UHFFFAOYSA-N 0.000 claims 2
- KWOYSNFVJIGNOE-UHFFFAOYSA-N 2-n-(3-chloro-4-methoxyphenyl)-6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(Cl)C(OC)=CC=2)=N1 KWOYSNFVJIGNOE-UHFFFAOYSA-N 0.000 claims 2
- BJHGSYVNKYROKJ-UHFFFAOYSA-N 2-n-(3-chloro-4-methoxyphenyl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(imidazol-1-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCN2C=NC=C2)=NC(NC=2C=C(Cl)C(OC)=CC=2)=N1 BJHGSYVNKYROKJ-UHFFFAOYSA-N 0.000 claims 2
- FMWFLNNDGZZORL-UHFFFAOYSA-N 2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-2-n-ethyl-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(NCC2N(CCC2)CC)=NC(NC2CCCCCC2)=NC=1N(CC)C1=CC=C(OC)C(Cl)=C1 FMWFLNNDGZZORL-UHFFFAOYSA-N 0.000 claims 2
- QQRIRVBQGJLUIP-UHFFFAOYSA-N 2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-4-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCN(C)CC2)=NC(NC2CCCCCC2)=N1 QQRIRVBQGJLUIP-UHFFFAOYSA-N 0.000 claims 2
- FYVMLJIYJXDRAR-UHFFFAOYSA-N 2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-4-n-(1-methylsulfonylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCN(CC2)S(C)(=O)=O)=NC(NC2CCCCCC2)=N1 FYVMLJIYJXDRAR-UHFFFAOYSA-N 0.000 claims 2
- UJKHYNLDWADPBA-UHFFFAOYSA-N 2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-4-n-(3-methylcyclohexyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CC(C)CCC2)=NC(NC2CCCCCC2)=N1 UJKHYNLDWADPBA-UHFFFAOYSA-N 0.000 claims 2
- DADJKKLMFFAHQU-UHFFFAOYSA-N 2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-4-n-(4-methylsulfanylcyclohexyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCC(CC2)SC)=NC(NC2CCCCCC2)=N1 DADJKKLMFFAHQU-UHFFFAOYSA-N 0.000 claims 2
- OEBCHBRKIOZHAL-UHFFFAOYSA-N 2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-4-n-(4-methylsulfonylcyclohexyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCC(CC2)S(C)(=O)=O)=NC(NC2CCCCCC2)=N1 OEBCHBRKIOZHAL-UHFFFAOYSA-N 0.000 claims 2
- DNEOVUUKKCSOQR-UHFFFAOYSA-N 2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-4-n-[1-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]-1-methylpiperidin-1-ium-4-yl]-1,3,5-triazine-2,4,6-triamine Chemical compound C1C[N+](CCOCCOCCOCCOCCOCCOC)(C)CCC1NC1=NC(NC2CCCCCC2)=NC(NC=2C=C(Cl)C(OC)=CC=2)=N1 DNEOVUUKKCSOQR-UHFFFAOYSA-N 0.000 claims 2
- CMLCDGQHBGOCAP-UHFFFAOYSA-N 2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-4-n-[4-(dimethylamino)cyclohexyl]-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCC(CC2)N(C)C)=NC(NC2CCCCCC2)=N1 CMLCDGQHBGOCAP-UHFFFAOYSA-N 0.000 claims 2
- AFMVQLPNIGCEKA-UHFFFAOYSA-N 2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-4-n-piperidin-1-yl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(NN2CCCCC2)=N1 AFMVQLPNIGCEKA-UHFFFAOYSA-N 0.000 claims 2
- QJEOMZBTQHQGOT-UHFFFAOYSA-N 2-n-(3-chloro-4-methylphenyl)-6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(Cl)C(C)=CC=2)=N1 QJEOMZBTQHQGOT-UHFFFAOYSA-N 0.000 claims 2
- SVRGIOHPAOYMFI-UHFFFAOYSA-N 2-n-(3-chloro-4-propan-2-yloxyphenyl)-2-n-cycloheptyl-4-n-methyl-4-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC(C)C)=CC=C1N(C=1N=C(N=C(N)N=1)N(C)C1CCN(C)CC1)C1CCCCCC1 SVRGIOHPAOYMFI-UHFFFAOYSA-N 0.000 claims 2
- WLLSYYDXRKATGW-UHFFFAOYSA-N 2-n-(3-fluoro-4-methoxyphenyl)-4-n-heptan-2-yl-6-n-(2-methylcyclohexyl)-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(NC=2C=C(F)C(OC)=CC=2)=NC(NC(C)CCCCC)=NC=1NC1CCCCC1C WLLSYYDXRKATGW-UHFFFAOYSA-N 0.000 claims 2
- FERNXSVJXKIRRM-UHFFFAOYSA-N 2-n-(4-amino-3-chlorophenyl)-6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(Cl)C(N)=CC=2)=N1 FERNXSVJXKIRRM-UHFFFAOYSA-N 0.000 claims 2
- LYPGIWIHDILGBC-UHFFFAOYSA-N 2-n-(4-amino-3-fluorophenyl)-6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(N)=CC=2)=N1 LYPGIWIHDILGBC-UHFFFAOYSA-N 0.000 claims 2
- ZJFXNBCZJHMFOE-UHFFFAOYSA-N 2-n-(4-aminocyclohexyl)-4-n-cycloheptyl-6-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCC(N)CC2)=N1 ZJFXNBCZJHMFOE-UHFFFAOYSA-N 0.000 claims 2
- CDOCYIOFJODDEP-UHFFFAOYSA-N 2-n-(4-methoxycyclohexyl)-4-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical compound CNC1=NC(N)=NC(NC2CCC(CC2)OC)=N1 CDOCYIOFJODDEP-UHFFFAOYSA-N 0.000 claims 2
- ZZRLEWMHJHFTSW-UHFFFAOYSA-N 2-n-(azepan-1-yl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NN2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 ZZRLEWMHJHFTSW-UHFFFAOYSA-N 0.000 claims 2
- NSJDREYLKOVEOY-UHFFFAOYSA-N 2-n-(azepan-2-yl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2NCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 NSJDREYLKOVEOY-UHFFFAOYSA-N 0.000 claims 2
- PSFHJQALEGOFIB-UHFFFAOYSA-N 2-n-(azepan-3-yl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CNCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 PSFHJQALEGOFIB-UHFFFAOYSA-N 0.000 claims 2
- FYVPLQNGGGDZMY-UHFFFAOYSA-N 2-n-(azepan-4-yl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCNCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 FYVPLQNGGGDZMY-UHFFFAOYSA-N 0.000 claims 2
- CJIRBQPTNWVDPL-UHFFFAOYSA-N 2-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-6-(1,3-oxazol-5-ylmethoxy)-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(OCC=2OC=NC=2)=N1 CJIRBQPTNWVDPL-UHFFFAOYSA-N 0.000 claims 2
- PGYLLHBCHKTZML-UHFFFAOYSA-N 2-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-6-(thiophen-2-ylmethoxy)-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(OCC=2SC=CC=2)=N1 PGYLLHBCHKTZML-UHFFFAOYSA-N 0.000 claims 2
- NWKXQFZWICYOTB-UHFFFAOYSA-N 2-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-6-phenylmethoxy-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(OCC=2C=CC=CC=2)=N1 NWKXQFZWICYOTB-UHFFFAOYSA-N 0.000 claims 2
- IAENZSAGPZKKQJ-UHFFFAOYSA-N 2-n-[(1-ethylpyrrolidin-2-yl)methyl]-6-(3-fluoro-4-methoxyphenoxy)-4-n-(piperidin-4-ylmethyl)-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCNCC2)=NC(OC=2C=C(F)C(OC)=CC=2)=N1 IAENZSAGPZKKQJ-UHFFFAOYSA-N 0.000 claims 2
- WXJWKBMQXJMSPY-UHFFFAOYSA-N 2-n-[(2-aminopyrimidin-4-yl)methyl]-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2N=C(N)N=CC=2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 WXJWKBMQXJMSPY-UHFFFAOYSA-N 0.000 claims 2
- OCCCZCDWYGMAGA-UHFFFAOYSA-N 2-n-[(3-bromo-4-methoxyphenyl)methyl]-4-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2C=C(Br)C(OC)=CC=2)=NC(NC2CCCCCC2)=N1 OCCCZCDWYGMAGA-UHFFFAOYSA-N 0.000 claims 2
- NXNZAPHRKPUVJA-UHFFFAOYSA-N 2-n-[(3-chloro-4-methoxyphenyl)methyl]-4-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2C=C(Cl)C(OC)=CC=2)=NC(NC2CCCCCC2)=N1 NXNZAPHRKPUVJA-UHFFFAOYSA-N 0.000 claims 2
- ANGLWWRPULECPY-UHFFFAOYSA-N 2-n-benzyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2C=CC=CC=2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 ANGLWWRPULECPY-UHFFFAOYSA-N 0.000 claims 2
- TWCAJQZJHVTVGD-UHFFFAOYSA-N 2-n-cyclohept-2-en-1-yl-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CN(C=1N=C(NC=2C=C(F)C(OC)=CC=2)N=C(N)N=1)C1C=CCCCC1 TWCAJQZJHVTVGD-UHFFFAOYSA-N 0.000 claims 2
- RZXJIBLETYAHHE-UHFFFAOYSA-N 2-n-cyclohept-3-en-1-yl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CC=CCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 RZXJIBLETYAHHE-UHFFFAOYSA-N 0.000 claims 2
- LYSAJFLZXIXMDP-UHFFFAOYSA-N 2-n-cycloheptyl-2-n-ethyl-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-6-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(NCC2N(CCC2)CC)=NC(NC=2C=C(F)C(OC)=CC=2)=NC=1N(CC)C1CCCCCC1 LYSAJFLZXIXMDP-UHFFFAOYSA-N 0.000 claims 2
- MQWIVJPIWQLEIQ-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-(thiophen-2-ylmethoxy)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(OCC=2SC=CC=2)=N1 MQWIVJPIWQLEIQ-UHFFFAOYSA-N 0.000 claims 2
- RPOKVGXHFAUBRR-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-[(1-methylpyrrol-2-yl)methoxy]-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(OCC=2N(C=CC=2)C)=N1 RPOKVGXHFAUBRR-UHFFFAOYSA-N 0.000 claims 2
- YJULSCNAIOPBAC-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-indol-1-yl-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N2C3=CC=CC=C3C=C2)=N1 YJULSCNAIOPBAC-UHFFFAOYSA-N 0.000 claims 2
- HLMJVJSMMDPYDZ-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-n-(1h-imidazol-5-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC=2N=CNC=2)=NC(NC2CCCCCC2)=N1 HLMJVJSMMDPYDZ-UHFFFAOYSA-N 0.000 claims 2
- NNZANKQSIIFNPX-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-n-(furan-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC=2OC=CC=2)=NC(NC2CCCCCC2)=N1 NNZANKQSIIFNPX-UHFFFAOYSA-N 0.000 claims 2
- PFBJLJBBJSAWTC-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-n-(pyridin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC=2N=CC=CC=2)=NC(NC2CCCCCC2)=N1 PFBJLJBBJSAWTC-UHFFFAOYSA-N 0.000 claims 2
- YGWUFXXJKCSLBE-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-n-(pyridin-3-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC=2C=NC=CC=2)=NC(NC2CCCCCC2)=N1 YGWUFXXJKCSLBE-UHFFFAOYSA-N 0.000 claims 2
- TYYOLSQEWHPURH-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-n-(pyrrolidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2NCCC2)=NC(NC2CCCCCC2)=N1 TYYOLSQEWHPURH-UHFFFAOYSA-N 0.000 claims 2
- HZRAXBHRDLWTQS-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-n-(thiophen-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC=2SC=CC=2)=NC(NC2CCCCCC2)=N1 HZRAXBHRDLWTQS-UHFFFAOYSA-N 0.000 claims 2
- ICHWZSGRTLZPNR-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-n-[(1-methylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2N(CCC2)C)=NC(NC2CCCCCC2)=N1 ICHWZSGRTLZPNR-UHFFFAOYSA-N 0.000 claims 2
- UJNRQONEELBTBT-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-n-[(2-methylcyclopentyl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2C(CCC2)C)=NC(NC2CCCCCC2)=N1 UJNRQONEELBTBT-UHFFFAOYSA-N 0.000 claims 2
- ASHPYRXQWDEIAH-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-n-[[1-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxymethyl]pyrrolidin-2-yl]methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound COCCOCCOCCOCCOCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 ASHPYRXQWDEIAH-UHFFFAOYSA-N 0.000 claims 2
- KAACABJIUDJDDJ-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-n-methyl-2-n-(oxan-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(N(C2CCOCC2)C2CCCCCC2)=NC(NC)=NC=1NC1=CC=C(OC)C(F)=C1 KAACABJIUDJDDJ-UHFFFAOYSA-N 0.000 claims 2
- BOBRWXSTBRMMCY-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-6-piperidin-4-yloxy-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(OC2CCNCC2)=N1 BOBRWXSTBRMMCY-UHFFFAOYSA-N 0.000 claims 2
- SJBJPADDUAUGNI-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(4-cyclopropyloxy-3-fluorophenyl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC3CC3)=CC=2)=N1 SJBJPADDUAUGNI-UHFFFAOYSA-N 0.000 claims 2
- WDWGGHOSQNUNGQ-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(4-ethoxy-3-fluorophenyl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OCC)=CC=C1NC1=NC(NCC2N(CCC2)CC)=NC(NC2CCCCCC2)=N1 WDWGGHOSQNUNGQ-UHFFFAOYSA-N 0.000 claims 2
- TTWQNCBBBUGSKT-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-(4-ethoxy-3-iodophenyl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(I)C(OCC)=CC=C1NC1=NC(NCC2N(CCC2)CC)=NC(NC2CCCCCC2)=N1 TTWQNCBBBUGSKT-UHFFFAOYSA-N 0.000 claims 2
- QZROKJJWPFRMJA-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-6-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(N(C)C2CCCCCC2)=N1 QZROKJJWPFRMJA-UHFFFAOYSA-N 0.000 claims 2
- MVMKAMHWRLPMKG-UHFFFAOYSA-N 2-n-cycloheptyl-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-6-n-(3-fluoro-4-methoxyphenyl)-2-n-propyl-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(NCC2N(CCC2)CC)=NC(NC=2C=C(F)C(OC)=CC=2)=NC=1N(CCC)C1CCCCCC1 MVMKAMHWRLPMKG-UHFFFAOYSA-N 0.000 claims 2
- FIBHMKSYLKQYTI-UHFFFAOYSA-N 2-n-cycloheptyl-6-(2,3-dihydroindol-1-yl)-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N2C3=CC=CC=C3CC2)=N1 FIBHMKSYLKQYTI-UHFFFAOYSA-N 0.000 claims 2
- YLBUCEQOJIMNPS-UHFFFAOYSA-N 2-n-cycloheptyl-6-n-(2,3-dihydro-1h-indol-2-ylmethyl)-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2NC3=CC=CC=C3C2)=NC(NC2CCCCCC2)=N1 YLBUCEQOJIMNPS-UHFFFAOYSA-N 0.000 claims 2
- QSDIYQLLJVLNAE-UHFFFAOYSA-M 2-n-cycloheptyl-6-n-[(1-ethyl-1-methylpyrrolidin-1-ium-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine;iodide Chemical compound [I-].CC[N+]1(C)CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 QSDIYQLLJVLNAE-UHFFFAOYSA-M 0.000 claims 2
- XEUOUSMZFLAJEG-UHFFFAOYSA-N 2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-1-ium-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine;bromide Chemical compound [Br-].CC[NH+]1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 XEUOUSMZFLAJEG-UHFFFAOYSA-N 0.000 claims 2
- PPAWTEBFYHPNCU-UHFFFAOYSA-N 2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine;hydrochloride Chemical compound [Cl-].CC[NH+]1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 PPAWTEBFYHPNCU-UHFFFAOYSA-N 0.000 claims 2
- IHXLDVHOENBEDU-UHFFFAOYSA-N 2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-propoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OCCC)=CC=C1NC1=NC(NCC2N(CCC2)CC)=NC(NC2CCCCCC2)=N1 IHXLDVHOENBEDU-UHFFFAOYSA-N 0.000 claims 2
- YIBSFEWEFULHPN-UHFFFAOYSA-N 2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-iodo-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(I)C(OC)=CC=2)=N1 YIBSFEWEFULHPN-UHFFFAOYSA-N 0.000 claims 2
- ZVCQOYLLMWEYDF-UHFFFAOYSA-N 2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-iodo-4-propoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(I)C(OCCC)=CC=C1NC1=NC(NCC2N(CCC2)CC)=NC(NC2CCCCCC2)=N1 ZVCQOYLLMWEYDF-UHFFFAOYSA-N 0.000 claims 2
- YNLUFCUBTUSQKO-UHFFFAOYSA-N 2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(4-fluoro-5-methoxypyridin-2-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2N=CC(OC)=C(F)C=2)=N1 YNLUFCUBTUSQKO-UHFFFAOYSA-N 0.000 claims 2
- SDTWLZCUVJOPHP-UHFFFAOYSA-N 2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(5-fluoro-6-methoxypyridin-3-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=NC=2)=N1 SDTWLZCUVJOPHP-UHFFFAOYSA-N 0.000 claims 2
- RWQWXQZYSNGFPG-UHFFFAOYSA-N 2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-[3-fluoro-4-(methoxymethoxy)phenyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OCOC)=CC=2)=N1 RWQWXQZYSNGFPG-UHFFFAOYSA-N 0.000 claims 2
- FUTOBMKPWKKJBI-UHFFFAOYSA-N 2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-[3-fluoro-4-[2-[2-[2-(3-methoxypropoxy)ethoxy]ethoxy]ethoxy]phenyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OCCOCCOCCOCCCOC)=CC=2)=N1 FUTOBMKPWKKJBI-UHFFFAOYSA-N 0.000 claims 2
- YERLZIXHXISDKP-UHFFFAOYSA-N 2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-[4-(trifluoromethoxy)-3-(trifluoromethyl)phenyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(C(OC(F)(F)F)=CC=2)C(F)(F)F)=N1 YERLZIXHXISDKP-UHFFFAOYSA-N 0.000 claims 2
- GKAFASLBVYAZED-UHFFFAOYSA-N 2-n-cycloheptyl-6-n-[(2-ethylcyclopentyl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCC1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 GKAFASLBVYAZED-UHFFFAOYSA-N 0.000 claims 2
- MUOKKBLWSFDWLN-UHFFFAOYSA-N 2-n-cyclopent-2-en-1-yl-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CN(C=1N=C(NC=2C=C(F)C(OC)=CC=2)N=C(N)N=1)C1C=CCC1 MUOKKBLWSFDWLN-UHFFFAOYSA-N 0.000 claims 2
- KTTNUZHOERZAMX-UHFFFAOYSA-N 3-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]propanoic acid Chemical compound COCCOCCOCCOCCOCCC(O)=O KTTNUZHOERZAMX-UHFFFAOYSA-N 0.000 claims 2
- VVJXPGXAUQQPLQ-UHFFFAOYSA-N 3-[2-[2-[2-[4-[[4-(cycloheptylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]amino]-2-fluorophenoxy]ethoxy]ethoxy]ethoxy]propan-1-ol Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OCCOCCOCCOCCCO)=CC=2)=N1 VVJXPGXAUQQPLQ-UHFFFAOYSA-N 0.000 claims 2
- MTHYEKGQBMMTII-UHFFFAOYSA-N 3-[4-(cyclohexylmethylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]-1,3-thiazolidine-2,5-dione Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(N2C(SC(=O)C2)=O)=N1 MTHYEKGQBMMTII-UHFFFAOYSA-N 0.000 claims 2
- IDZYSMRMCGNRHL-UHFFFAOYSA-N 3-[[4-(3-chloro-4-methoxyanilino)-6-(cycloheptylamino)-1,3,5-triazin-2-yl]-methylamino]cyclohexan-1-ol Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CC(O)CCC2)=N1 IDZYSMRMCGNRHL-UHFFFAOYSA-N 0.000 claims 2
- ZGASHPXLKFIALD-UHFFFAOYSA-N 3-[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]-methylamino]cyclohexan-1-ol Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CC(O)CCC2)=N1 ZGASHPXLKFIALD-UHFFFAOYSA-N 0.000 claims 2
- JTGMAPABKSRMOF-UHFFFAOYSA-N 3-[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]azepan-2-one Chemical compound CCN1CCCC1CNC1=NC(NC2C(NCCCC2)=O)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 JTGMAPABKSRMOF-UHFFFAOYSA-N 0.000 claims 2
- QOYQBTZBHBHFDC-UHFFFAOYSA-N 3-[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]piperidin-2-one Chemical compound CCN1CCCC1CNC1=NC(NC2C(NCCC2)=O)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 QOYQBTZBHBHFDC-UHFFFAOYSA-N 0.000 claims 2
- LEWQVOPAQBHHHK-UHFFFAOYSA-N 3-[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]pyrrolidin-2-one Chemical compound CCN1CCCC1CNC1=NC(NC2C(NCC2)=O)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 LEWQVOPAQBHHHK-UHFFFAOYSA-N 0.000 claims 2
- CBTMSZODDAVINZ-UHFFFAOYSA-N 3-[[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]cyclopentan-1-ol Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CC(O)CC2)=NC(NC2CCCCCC2)=N1 CBTMSZODDAVINZ-UHFFFAOYSA-N 0.000 claims 2
- SPMRQLCFQRBANJ-UHFFFAOYSA-N 3-[[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]cyclohexan-1-ol Chemical compound CCN1CCCC1CNC1=NC(NCC2CC(O)CCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 SPMRQLCFQRBANJ-UHFFFAOYSA-N 0.000 claims 2
- HZWFAJNWUIAHON-UHFFFAOYSA-N 3-[[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]cyclopentan-1-ol Chemical compound CCN1CCCC1CNC1=NC(NCC2CC(O)CC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 HZWFAJNWUIAHON-UHFFFAOYSA-N 0.000 claims 2
- PRJHZGLUMILXHA-UHFFFAOYSA-N 4-[[4-(3-chloro-4-methoxyanilino)-6-(cycloheptylamino)-1,3,5-triazin-2-yl]-methylamino]cyclohexan-1-ol Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCC(O)CC2)=N1 PRJHZGLUMILXHA-UHFFFAOYSA-N 0.000 claims 2
- HXSCUZXYCDVRKW-UHFFFAOYSA-N 4-[[4-(3-chloro-4-methoxyanilino)-6-(cycloheptylamino)-1,3,5-triazin-2-yl]amino]cyclohexane-1-thiol Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCC(S)CC2)=NC(NC2CCCCCC2)=N1 HXSCUZXYCDVRKW-UHFFFAOYSA-N 0.000 claims 2
- BMTHEFSLPKJPCG-UHFFFAOYSA-N 4-[[4-(cycloheptylamino)-6-(hydroxymethylamino)-1,3,5-triazin-2-yl]amino]-2-fluorophenol Chemical compound N=1C(NC=2C=C(F)C(O)=CC=2)=NC(NCO)=NC=1NC1CCCCCC1 BMTHEFSLPKJPCG-UHFFFAOYSA-N 0.000 claims 2
- FFNJRKAEZZPQND-UHFFFAOYSA-N 4-[[4-(cycloheptylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]amino]-2-(trifluoromethyl)phenol Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(C(O)=CC=2)C(F)(F)F)=N1 FFNJRKAEZZPQND-UHFFFAOYSA-N 0.000 claims 2
- DKSMFQLMRROYPW-UHFFFAOYSA-N 4-[[4-(cycloheptylamino)-6-[[1-[(4-methoxyphenyl)methyl]piperidin-4-yl]amino]-1,3,5-triazin-2-yl]amino]-2-fluorophenol Chemical compound C1=CC(OC)=CC=C1CN1CCC(NC=2N=C(NC=3C=C(F)C(O)=CC=3)N=C(NC3CCCCCC3)N=2)CC1 DKSMFQLMRROYPW-UHFFFAOYSA-N 0.000 claims 2
- BZIAOCPFZJTSIW-UHFFFAOYSA-N 4-[[4-(cycloheptylamino)-6-[methyl(piperidin-4-yl)amino]-1,3,5-triazin-2-yl]amino]-2-fluorophenol Chemical compound N=1C(NC2CCCCCC2)=NC(NC=2C=C(F)C(O)=CC=2)=NC=1N(C)C1CCNCC1 BZIAOCPFZJTSIW-UHFFFAOYSA-N 0.000 claims 2
- LNFXMGRFHXFLFU-UHFFFAOYSA-N 4-[[4-(cycloheptylamino)-6-[methyl-(1-methylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl]amino]-2-fluorophenol Chemical compound N=1C(NC2CCCCCC2)=NC(NC=2C=C(F)C(O)=CC=2)=NC=1N(C)C1CCN(C)CC1 LNFXMGRFHXFLFU-UHFFFAOYSA-N 0.000 claims 2
- YGNLMHIRLCRTNK-UHFFFAOYSA-N 4-[[4-(cyclohexylmethylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]amino]-2,6-difluorophenol Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(O)=C(F)C=2)=N1 YGNLMHIRLCRTNK-UHFFFAOYSA-N 0.000 claims 2
- YEGXQDWVETUUAR-UHFFFAOYSA-N 4-[[4-(cyclohexylmethylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]amino]-2-fluorobenzenethiol Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(S)=CC=2)=N1 YEGXQDWVETUUAR-UHFFFAOYSA-N 0.000 claims 2
- LEHDOHMTQMZWSD-UHFFFAOYSA-N 4-[[4-(cyclohexylmethylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]amino]-2-fluorophenol Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(O)=CC=2)=N1 LEHDOHMTQMZWSD-UHFFFAOYSA-N 0.000 claims 2
- NDYIHVCANGAFAH-UHFFFAOYSA-N 4-[[4-(cyclopropylamino)-6-(piperidin-4-ylamino)-1,3,5-triazin-2-yl]amino]-2-fluorophenol Chemical compound C1=C(F)C(O)=CC=C1NC1=NC(NC2CC2)=NC(NC2CCNCC2)=N1 NDYIHVCANGAFAH-UHFFFAOYSA-N 0.000 claims 2
- NIMDAKBLQCUYLJ-UHFFFAOYSA-N 4-[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]oxymethyl]cyclohexan-1-ol Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(OCC2CCC(O)CC2)=N1 NIMDAKBLQCUYLJ-UHFFFAOYSA-N 0.000 claims 2
- DRPXCTQVIKFZSS-UHFFFAOYSA-N 4-[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]oxymethyl]phenol Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(OCC=2C=CC(O)=CC=2)=N1 DRPXCTQVIKFZSS-UHFFFAOYSA-N 0.000 claims 2
- WVPKSHIAEFRLRI-UHFFFAOYSA-N 4-[[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]cyclohexan-1-ol Chemical compound CCN1CCCC1CNC1=NC(NCC2CCC(O)CC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 WVPKSHIAEFRLRI-UHFFFAOYSA-N 0.000 claims 2
- QRXPHPXEWHTIJP-UHFFFAOYSA-N 4-cycloheptyloxy-6-[(1-ethylpyrrolidin-2-yl)methoxy]-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazin-2-amine Chemical compound CCN1CCCC1COC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(OC2CCCCCC2)=N1 QRXPHPXEWHTIJP-UHFFFAOYSA-N 0.000 claims 2
- IJEUKYVVBWJFKC-UHFFFAOYSA-N 4-cycloheptyloxy-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1h-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(N)(OC2CCCCCC2)N1 IJEUKYVVBWJFKC-UHFFFAOYSA-N 0.000 claims 2
- FDCPKOSIBITIHW-UHFFFAOYSA-N 4-cycloheptyloxy-n-(3-fluoro-4-methoxyphenyl)-6-(1-methylpiperidin-4-yl)oxy-1,3,5-triazin-2-amine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(OC2CCN(C)CC2)=NC(OC2CCCCCC2)=N1 FDCPKOSIBITIHW-UHFFFAOYSA-N 0.000 claims 2
- FZXLMVCHXPBWIT-UHFFFAOYSA-N 4-cycloheptyloxy-n-(3-fluoro-4-methoxyphenyl)-6-piperidin-4-yloxy-1,3,5-triazin-2-amine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(OC2CCNCC2)=NC(OC2CCCCCC2)=N1 FZXLMVCHXPBWIT-UHFFFAOYSA-N 0.000 claims 2
- VIBOUKMMNLKPII-UHFFFAOYSA-N 4-cycloheptyloxy-n-[(1-ethylpyrrolidin-2-yl)methyl]-6-(3-fluoro-4-methoxyphenoxy)-1,3,5-triazin-2-amine Chemical compound CCN1CCCC1CNC1=NC(OC2CCCCCC2)=NC(OC=2C=C(F)C(OC)=CC=2)=N1 VIBOUKMMNLKPII-UHFFFAOYSA-N 0.000 claims 2
- OQTQOBKQGWGWHG-UHFFFAOYSA-N 4-cyclohexyloxy-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1h-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(N)(OC2CCCCC2)N1 OQTQOBKQGWGWHG-UHFFFAOYSA-N 0.000 claims 2
- YRBXXBOHWOEPEY-UHFFFAOYSA-N 4-cyclopentyloxy-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1h-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(N)(OC2CCCC2)N1 YRBXXBOHWOEPEY-UHFFFAOYSA-N 0.000 claims 2
- ANXUVFDVTSAAKG-UHFFFAOYSA-N 4-cyclopropyloxy-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1h-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(N)(OC2CC2)N1 ANXUVFDVTSAAKG-UHFFFAOYSA-N 0.000 claims 2
- VYNOPYYOCRUQHR-UHFFFAOYSA-N 4-n-(1-azabicyclo[2.2.2]octan-3-yl)-2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2C3CCN(CC3)C2)=NC(NC2CCCCCC2)=N1 VYNOPYYOCRUQHR-UHFFFAOYSA-N 0.000 claims 2
- PRMOAIKOLMPKMP-UHFFFAOYSA-N 4-n-(2-aminocyclohexyl)-6-n-cycloheptyl-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2C(CCCC2)N)=NC(NC2CCCCCC2)=N1 PRMOAIKOLMPKMP-UHFFFAOYSA-N 0.000 claims 2
- QXNMDZVSPACUAT-UHFFFAOYSA-N 4-n-(2-cyclohexylpropan-2-yl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(NC(C)(C)C2CCCCC2)=N1 QXNMDZVSPACUAT-UHFFFAOYSA-N 0.000 claims 2
- IVPOKWVNQIMMEP-UHFFFAOYSA-N 4-n-(3-bicyclo[2.2.1]heptanyl)-2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2C3CCC(C3)C2)=NC(NC2CCCCCC2)=N1 IVPOKWVNQIMMEP-UHFFFAOYSA-N 0.000 claims 2
- FOKRBQJESKPBCZ-UHFFFAOYSA-N 4-n-(3-bicyclo[2.2.2]octanyl)-2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2C3CCC(CC3)C2)=NC(NC2CCCCCC2)=N1 FOKRBQJESKPBCZ-UHFFFAOYSA-N 0.000 claims 2
- WMDZXWAKSCVWGM-UHFFFAOYSA-N 4-n-(3-bromo-4-ethoxyphenyl)-2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Br)C(OCC)=CC=C1NC1=NC(NCC2N(CCC2)CC)=NC(NC2CCCCCC2)=N1 WMDZXWAKSCVWGM-UHFFFAOYSA-N 0.000 claims 2
- NRJJPNMZTDXJHD-UHFFFAOYSA-N 4-n-(3-bromo-4-methoxyphenyl)-2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(Br)C(OC)=CC=2)=N1 NRJJPNMZTDXJHD-UHFFFAOYSA-N 0.000 claims 2
- RDHMHPOZNFQAEZ-UHFFFAOYSA-N 4-n-(3-bromo-4-propoxyphenyl)-2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Br)C(OCCC)=CC=C1NC1=NC(NCC2N(CCC2)CC)=NC(NC2CCCCCC2)=N1 RDHMHPOZNFQAEZ-UHFFFAOYSA-N 0.000 claims 2
- GLONBRSBQHNMJB-UHFFFAOYSA-N 4-n-(3-chloro-4-ethoxyphenyl)-2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OCC)=CC=C1NC1=NC(NCC2N(CCC2)CC)=NC(NC2CCCCCC2)=N1 GLONBRSBQHNMJB-UHFFFAOYSA-N 0.000 claims 2
- BPQYNDDSICREPX-UHFFFAOYSA-N 4-n-(3-chloro-4-ethoxyphenyl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(2-methylphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OCC)=CC=C1NC1=NC(NCC2N(CCC2)CC)=NC(NC=2C(=CC=CC=2)C)=N1 BPQYNDDSICREPX-UHFFFAOYSA-N 0.000 claims 2
- CSCIISLBPMRTJQ-UHFFFAOYSA-N 4-n-(3-chloro-4-methoxyphenyl)-2-n-cycloheptyl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(N)=NC(NC2CCCCCC2)=N1 CSCIISLBPMRTJQ-UHFFFAOYSA-N 0.000 claims 2
- QUMPYUCGJAOGID-UHFFFAOYSA-N 4-n-(3-chloro-4-methoxyphenyl)-2-n-cycloheptyl-6-(1-methylpiperidin-4-yl)oxy-1,3,5-triazine-2,4-diamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(OC2CCN(C)CC2)=N1 QUMPYUCGJAOGID-UHFFFAOYSA-N 0.000 claims 2
- XWLHXDOQBJIRGD-UHFFFAOYSA-N 4-n-(3-chloro-4-methoxyphenyl)-2-n-cycloheptyl-6-[(1-ethylpyrrolidin-2-yl)methoxy]-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1COC1=NC(NC2CCCCCC2)=NC(NC=2C=C(Cl)C(OC)=CC=2)=N1 XWLHXDOQBJIRGD-UHFFFAOYSA-N 0.000 claims 2
- XNWYTIDNBGJCDB-UHFFFAOYSA-N 4-n-(3-chloro-4-methoxyphenyl)-2-n-cycloheptyl-6-n-(methoxymethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(NC=2C=C(Cl)C(OC)=CC=2)=NC(NCOC)=NC=1NC1CCCCCC1 XNWYTIDNBGJCDB-UHFFFAOYSA-N 0.000 claims 2
- YDQLTEWYXRYKCC-UHFFFAOYSA-N 4-n-(3-chloro-4-methoxyphenyl)-2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-1-ium-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine;chloride Chemical compound [Cl-].CC[NH+]1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(Cl)C(OC)=CC=2)=N1 YDQLTEWYXRYKCC-UHFFFAOYSA-N 0.000 claims 2
- QTFUASHXTQVXCD-UHFFFAOYSA-N 4-n-(3-chloro-4-methoxyphenyl)-2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(Cl)C(OC)=CC=2)=N1 QTFUASHXTQVXCD-UHFFFAOYSA-N 0.000 claims 2
- DZIPFBCIELXFSF-UHFFFAOYSA-N 4-n-(3-chloro-4-methoxyphenyl)-2-n-cycloheptyl-6-piperidin-4-yloxy-1,3,5-triazine-2,4-diamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(OC2CCNCC2)=N1 DZIPFBCIELXFSF-UHFFFAOYSA-N 0.000 claims 2
- VRSCKZIVFZXLPQ-UHFFFAOYSA-N 4-n-(3-chloro-4-methoxyphenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-6-n-propyl-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(N(C)C2CCN(C)CC2)=NC(NCCC)=NC=1NC1=CC=C(OC)C(Cl)=C1 VRSCKZIVFZXLPQ-UHFFFAOYSA-N 0.000 claims 2
- FYXYHKKWIDXKTH-UHFFFAOYSA-N 4-n-(3-chloro-4-methoxyphenyl)-6-cycloheptyloxy-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(OC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 FYXYHKKWIDXKTH-UHFFFAOYSA-N 0.000 claims 2
- BIVJEKPOVNTJOP-UHFFFAOYSA-N 4-n-(3-chloro-4-methoxyphenyl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(1,3-oxazol-5-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2OC=NC=2)=NC(NC=2C=C(Cl)C(OC)=CC=2)=N1 BIVJEKPOVNTJOP-UHFFFAOYSA-N 0.000 claims 2
- CNBXNQJLVGUAPZ-UHFFFAOYSA-N 4-n-(3-chloro-4-methoxyphenyl)-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(thiophen-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2SC=CC=2)=NC(NC=2C=C(Cl)C(OC)=CC=2)=N1 CNBXNQJLVGUAPZ-UHFFFAOYSA-N 0.000 claims 2
- RPOVDKPEYKDSIL-UHFFFAOYSA-N 4-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-2-n,4-n-dimethyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1N(C)C1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 RPOVDKPEYKDSIL-UHFFFAOYSA-N 0.000 claims 2
- SEDQWSKDRWWLMA-UHFFFAOYSA-N 4-n-(3-chloro-4-propoxyphenyl)-2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OCCC)=CC=C1NC1=NC(NCC2N(CCC2)CC)=NC(NC2CCCCCC2)=N1 SEDQWSKDRWWLMA-UHFFFAOYSA-N 0.000 claims 2
- WNKQXQNPBHSGQZ-UHFFFAOYSA-N 4-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-6-n-propyl-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(N(C)C2CCN(C)CC2)=NC(NCCC)=NC=1NC1=CC=C(OC)C(F)=C1 WNKQXQNPBHSGQZ-UHFFFAOYSA-N 0.000 claims 2
- JSKDNZVRPFFUCR-UHFFFAOYSA-N 4-n-(4-aminocyclohexyl)-2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCC(N)CC2)=NC(NC2CCCCCC2)=N1 JSKDNZVRPFFUCR-UHFFFAOYSA-N 0.000 claims 2
- GAAWRWJZQJPYRJ-UHFFFAOYSA-N 4-n-(4-aminocyclohexyl)-6-n-cycloheptyl-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCC(N)CC2)=NC(NC2CCCCCC2)=N1 GAAWRWJZQJPYRJ-UHFFFAOYSA-N 0.000 claims 2
- KCTFPKFRTIWEBS-UHFFFAOYSA-N 4-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(N)=NC(NCC2CCCCC2)=N1 KCTFPKFRTIWEBS-UHFFFAOYSA-N 0.000 claims 2
- VQJSRHLSGPRDCM-UHFFFAOYSA-N 4-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-6-(1-methylpyrrolidin-2-yl)oxy-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(OC2N(CCC2)C)=N1 VQJSRHLSGPRDCM-UHFFFAOYSA-N 0.000 claims 2
- LLJXVSHALNCJCM-UHFFFAOYSA-N 4-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-6-(pyrrolidin-2-ylmethoxy)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(OCC2NCCC2)=N1 LLJXVSHALNCJCM-UHFFFAOYSA-N 0.000 claims 2
- UPVVZQNPOVRPMF-UHFFFAOYSA-N 4-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-6-(thiophen-2-ylmethoxy)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(OCC=2SC=CC=2)=N1 UPVVZQNPOVRPMF-UHFFFAOYSA-N 0.000 claims 2
- KCJQIVIZSPSUFJ-UHFFFAOYSA-N 4-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-6-[(1-methylpyrrol-2-yl)methoxy]-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(OCC=2N(C=CC=2)C)=N1 KCJQIVIZSPSUFJ-UHFFFAOYSA-N 0.000 claims 2
- QASGITAGQWDYQD-UHFFFAOYSA-N 4-n-(cyclohexylmethyl)-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-6-(3-fluoro-4-methoxyphenoxy)-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(OC=2C=C(F)C(OC)=CC=2)=N1 QASGITAGQWDYQD-UHFFFAOYSA-N 0.000 claims 2
- HRNHBLCUSDZBRN-UHFFFAOYSA-N 4-n-(cyclohexylmethyl)-6-[(1-ethylpyrrolidin-2-yl)methoxy]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1COC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 HRNHBLCUSDZBRN-UHFFFAOYSA-N 0.000 claims 2
- TYOHRHXHGSQKJJ-UHFFFAOYSA-N 4-n-(cyclohexylmethyl)-6-[2-(dimethylamino)ethoxy]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(OCCN(C)C)=N1 TYOHRHXHGSQKJJ-UHFFFAOYSA-N 0.000 claims 2
- ICVIWEOZEYDIDN-UHFFFAOYSA-N 4-n-(cyclohexylmethyl)-6-n-[2-(dimethylamino)ethyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCCN(C)C)=NC(NCC2CCCCC2)=N1 ICVIWEOZEYDIDN-UHFFFAOYSA-N 0.000 claims 2
- XUDCZAGLQMWYEW-UHFFFAOYSA-N 4-n-[(1-benzylpyrrolidin-2-yl)methyl]-6-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2N(CCC2)CC=2C=CC=CC=2)=NC(NCC2CCCCC2)=N1 XUDCZAGLQMWYEW-UHFFFAOYSA-N 0.000 claims 2
- IPMQWYJGITXISS-UHFFFAOYSA-N 4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-6-n-(oxan-4-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCOCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 IPMQWYJGITXISS-UHFFFAOYSA-N 0.000 claims 2
- JEHUYUCFVNVMIT-UHFFFAOYSA-N 4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-6-n-(thian-4-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCSCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 JEHUYUCFVNVMIT-UHFFFAOYSA-N 0.000 claims 2
- MFOKOUNMKLNTCM-UHFFFAOYSA-N 4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-6-n-[(2-methylcyclohexyl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2C(CCCC2)C)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 MFOKOUNMKLNTCM-UHFFFAOYSA-N 0.000 claims 2
- VRTBLPZPZCZKQN-UHFFFAOYSA-N 4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-6-n-[(4-methylcyclohexyl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCC(C)CC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 VRTBLPZPZCZKQN-UHFFFAOYSA-N 0.000 claims 2
- CVMRVVMOEFDCLW-UHFFFAOYSA-N 4-n-[4-(aminomethyl)cyclohexyl]-2-n-(3-chloro-4-methoxyphenyl)-6-n-cycloheptyl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCC(CN)CC2)=NC(NC2CCCCCC2)=N1 CVMRVVMOEFDCLW-UHFFFAOYSA-N 0.000 claims 2
- CUGFBFQFERGGOS-UHFFFAOYSA-N 4-n-[4-(aminomethyl)cyclohexyl]-6-n-cycloheptyl-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCC(CN)CC2)=NC(NC2CCCCCC2)=N1 CUGFBFQFERGGOS-UHFFFAOYSA-N 0.000 claims 2
- HVXBEBHJPQAROM-UHFFFAOYSA-N 4-n-cyclohept-2-en-1-yl-6-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2C=CCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 HVXBEBHJPQAROM-UHFFFAOYSA-N 0.000 claims 2
- XVTJVNIVFQECIR-UHFFFAOYSA-N 4-n-cyclohept-3-en-1-yl-6-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CC=CCCC2)=NC(N(C)C2CCN(C)CC2)=N1 XVTJVNIVFQECIR-UHFFFAOYSA-N 0.000 claims 2
- YZIWUOKXNWCZTB-UHFFFAOYSA-N 4-n-cyclohept-4-en-1-yl-6-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCC=CCC2)=NC(N(C)C2CCN(C)CC2)=N1 YZIWUOKXNWCZTB-UHFFFAOYSA-N 0.000 claims 2
- YCZTXHVCUFVCLL-UHFFFAOYSA-N 4-n-cycloheptyl-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-6-(3-iodo-4-methoxyphenoxy)-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(OC=2C=C(I)C(OC)=CC=2)=N1 YCZTXHVCUFVCLL-UHFFFAOYSA-N 0.000 claims 2
- QBONCYGYWVXXDI-UHFFFAOYSA-N 4-n-cycloheptyl-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-6-n-[2-(3-fluoro-4-methoxyphenyl)ethyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCCC=2C=C(F)C(OC)=CC=2)=NC(NC2CCCCCC2)=N1 QBONCYGYWVXXDI-UHFFFAOYSA-N 0.000 claims 2
- XOJVGYKCJUADEK-UHFFFAOYSA-N 4-n-cycloheptyl-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-6-n-[2-(3-iodo-4-methoxyphenyl)ethyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCCC=2C=C(I)C(OC)=CC=2)=NC(NC2CCCCCC2)=N1 XOJVGYKCJUADEK-UHFFFAOYSA-N 0.000 claims 2
- PYZVORYHWRBFAU-UHFFFAOYSA-N 4-n-cycloheptyl-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-6-n-[4-(trifluoromethoxy)-3-(trifluoromethyl)phenyl]-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(NC2CCCCCC2)=NC(NC=2C=C(C(OC(F)(F)F)=CC=2)C(F)(F)F)=NC=1N(C)C1CCN(C)CC1 PYZVORYHWRBFAU-UHFFFAOYSA-N 0.000 claims 2
- PIGIRLZEIDORAK-UHFFFAOYSA-N 4-n-cycloheptyl-6-(3-fluoro-4-methoxyphenoxy)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1OC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 PIGIRLZEIDORAK-UHFFFAOYSA-N 0.000 claims 2
- QMAQJQDRFLGVHP-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine;hydron;chloride Chemical compound Cl.C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 QMAQJQDRFLGVHP-UHFFFAOYSA-N 0.000 claims 2
- LSOSODMFNOAIQW-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-2-n-(4-methylcyclohexyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCC(C)CC2)=N1 LSOSODMFNOAIQW-UHFFFAOYSA-N 0.000 claims 2
- GNAOLJWZDVXYKI-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-2-n-(4-methylpiperazin-1-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)N2CCN(C)CC2)=N1 GNAOLJWZDVXYKI-UHFFFAOYSA-N 0.000 claims 2
- FYIIOQAMYDAPRQ-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-2-n-(oxan-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCOCC2)=N1 FYIIOQAMYDAPRQ-UHFFFAOYSA-N 0.000 claims 2
- OXFVUZZVRNRYQB-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-2-n-piperidin-4-yl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCNCC2)=N1 OXFVUZZVRNRYQB-UHFFFAOYSA-N 0.000 claims 2
- UNCMGAGDUDUZQV-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-2-n-pyridin-4-yl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C=2C=CN=CC=2)=N1 UNCMGAGDUDUZQV-UHFFFAOYSA-N 0.000 claims 2
- ZCVVDHPHIHIDMI-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-(3-fluoro-4-propan-2-yloxyphenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC(C)C)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 ZCVVDHPHIHIDMI-UHFFFAOYSA-N 0.000 claims 2
- AEUUYZBCJJHUPX-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-(3-fluoro-4-propoxyphenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OCCC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 AEUUYZBCJJHUPX-UHFFFAOYSA-N 0.000 claims 2
- SKDKDSLWNIULMU-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-(3-iodo-4-methoxyphenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(I)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 SKDKDSLWNIULMU-UHFFFAOYSA-N 0.000 claims 2
- YIUOUFZMDJJISN-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-(4-ethyl-3-fluorophenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(CC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 YIUOUFZMDJJISN-UHFFFAOYSA-N 0.000 claims 2
- WVINNDOZBKDCIW-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-(4-fluoro-5-methoxypyridin-2-yl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CN=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 WVINNDOZBKDCIW-UHFFFAOYSA-N 0.000 claims 2
- DXFQOJAPPKXIPT-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-(4-methoxy-3-nitrophenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C([N+]([O-])=O)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 DXFQOJAPPKXIPT-UHFFFAOYSA-N 0.000 claims 2
- SIJZZMOCNIGREO-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-(5-fluoro-6-methoxypyridin-3-yl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=NC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 SIJZZMOCNIGREO-UHFFFAOYSA-N 0.000 claims 2
- ZCGQFGQBQJNWJJ-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-[(3-fluoro-4-methoxyphenyl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2C=C(F)C(OC)=CC=2)=NC(NC2CCCCCC2)=N1 ZCGQFGQBQJNWJJ-UHFFFAOYSA-N 0.000 claims 2
- PLTRYGXUNDCPJM-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-[(3-iodo-4-methoxyphenyl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2C=C(I)C(OC)=CC=2)=NC(NC2CCCCCC2)=N1 PLTRYGXUNDCPJM-UHFFFAOYSA-N 0.000 claims 2
- ZKVGZXGAYKRZKS-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-[(3-fluoro-4-methoxyphenyl)methyl]-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1CNC1=NC(NC2CCN(C)CC2)=NC(NC2CCCCCC2)=N1 ZKVGZXGAYKRZKS-UHFFFAOYSA-N 0.000 claims 2
- OKQLOHWAHIWZKV-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-[(3-fluoro-4-methoxyphenyl)methyl]-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1CNC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 OKQLOHWAHIWZKV-UHFFFAOYSA-N 0.000 claims 2
- JUPACFVQERGKOH-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-[(3-fluoro-4-methoxyphenyl)methyl]-2-n-methyl-2-n-piperidin-4-yl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1CNC1=NC(NC2CCCCCC2)=NC(N(C)C2CCNCC2)=N1 JUPACFVQERGKOH-UHFFFAOYSA-N 0.000 claims 2
- NUUIXFLHILFAFW-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-[2-(3-fluoro-4-methoxyphenyl)ethyl]-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1CCNC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 NUUIXFLHILFAFW-UHFFFAOYSA-N 0.000 claims 2
- PVTGSELSODMGIQ-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-[3-fluoro-4-(methoxymethoxy)phenyl]-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical group C1=C(F)C(OCOC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 PVTGSELSODMGIQ-UHFFFAOYSA-N 0.000 claims 2
- YQDYWMHRCSNBND-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-[3-fluoro-4-(methylamino)phenyl]-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(NC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 YQDYWMHRCSNBND-UHFFFAOYSA-N 0.000 claims 2
- FGNMTVUPJPZCLX-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-[3-fluoro-4-(trifluoromethyl)phenyl]-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(NC2CCCCCC2)=NC(NC=2C=C(F)C(=CC=2)C(F)(F)F)=NC=1N(C)C1CCN(C)CC1 FGNMTVUPJPZCLX-UHFFFAOYSA-N 0.000 claims 2
- HFTPWGOEAZFFQJ-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-[4-(dimethylamino)-3-fluorophenyl]-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(N(C)C)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 HFTPWGOEAZFFQJ-UHFFFAOYSA-N 0.000 claims 2
- GSYGLEGWPFJKCK-UHFFFAOYSA-N 4-n-cycloheptyl-6-n-[4-methoxy-3-(trifluoromethyl)phenyl]-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(C(F)(F)F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 GSYGLEGWPFJKCK-UHFFFAOYSA-N 0.000 claims 2
- FQNZKWHWHZLCTJ-UHFFFAOYSA-N 5-[[4-(cycloheptylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]amino]-2-hydroxybenzoic acid Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(C(O)=CC=2)C(O)=O)=N1 FQNZKWHWHZLCTJ-UHFFFAOYSA-N 0.000 claims 2
- NPJBJNXNFXEINQ-UHFFFAOYSA-N 5-[[4-(cycloheptylamino)-6-[methyl-(1-methylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl]amino]-2-methoxybenzonitrile Chemical compound C1=C(C#N)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 NPJBJNXNFXEINQ-UHFFFAOYSA-N 0.000 claims 2
- GYQMFRCFUBAFQX-UHFFFAOYSA-N 5-[[4-(cyclohexylmethylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]amino]-2-methoxybenzoic acid Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(C(OC)=CC=2)C(O)=O)=N1 GYQMFRCFUBAFQX-UHFFFAOYSA-N 0.000 claims 2
- MQNUPHQBKBOFIE-UHFFFAOYSA-N 5-[[4-(cyclohexylmethylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]amino]-2-methoxybenzonitrile Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(C(OC)=CC=2)C#N)=N1 MQNUPHQBKBOFIE-UHFFFAOYSA-N 0.000 claims 2
- VNPOKTPUTKDQMV-UHFFFAOYSA-N 5-[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(2-methylpentylamino)-1,3,5-triazin-2-yl]amino]-2-methoxybenzenesulfonic acid Chemical compound N=1C(NC=2C=C(C(OC)=CC=2)S(O)(=O)=O)=NC(NCC(C)CCC)=NC=1NCC1CCCN1CC VNPOKTPUTKDQMV-UHFFFAOYSA-N 0.000 claims 2
- RMTBBGIBGAVZFU-UHFFFAOYSA-N 5-[[[4-(3-chloro-4-hydroxyanilino)-6-(cycloheptylamino)-1,3,5-triazin-2-yl]amino]methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=C(Cl)C(O)=CC=C1NC1=NC(NCC2C(NC(=O)S2)=O)=NC(NC2CCCCCC2)=N1 RMTBBGIBGAVZFU-UHFFFAOYSA-N 0.000 claims 2
- FFSRFZFPZMUOCA-UHFFFAOYSA-N 5-[[[4-(3-chloro-4-hydroxyanilino)-6-(cyclohexylmethylamino)-1,3,5-triazin-2-yl]amino]methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=C(Cl)C(O)=CC=C1NC1=NC(NCC2C(NC(=O)S2)=O)=NC(NCC2CCCCC2)=N1 FFSRFZFPZMUOCA-UHFFFAOYSA-N 0.000 claims 2
- YQESFOTUBOGCEH-UHFFFAOYSA-N 5-[[[4-(3-chloro-4-methoxyanilino)-6-(cycloheptylamino)-1,3,5-triazin-2-yl]amino]methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NCC2C(NC(=O)S2)=O)=NC(NC2CCCCCC2)=N1 YQESFOTUBOGCEH-UHFFFAOYSA-N 0.000 claims 2
- JGZRWCBQOLKISD-UHFFFAOYSA-N 5-[[[4-(3-chloro-4-methoxyanilino)-6-(cyclohexylmethylamino)-1,3,5-triazin-2-yl]amino]methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NCC2C(NC(=O)S2)=O)=NC(NCC2CCCCC2)=N1 JGZRWCBQOLKISD-UHFFFAOYSA-N 0.000 claims 2
- DUNDGRSRQBGYDU-UHFFFAOYSA-N 5-[[[4-(3-fluoro-4-methoxyanilino)-6-[methyl-(1-methylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl]amino]methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2C(NC(=O)S2)=O)=NC(N(C)C2CCN(C)CC2)=N1 DUNDGRSRQBGYDU-UHFFFAOYSA-N 0.000 claims 2
- HFCRSXFPRUXCON-UHFFFAOYSA-N 5-[[[4-(cycloheptylamino)-6-(3-fluoro-4-hydroxyanilino)-1,3,5-triazin-2-yl]amino]methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=C(F)C(O)=CC=C1NC1=NC(NCC2C(NC(=O)S2)=O)=NC(NC2CCCCCC2)=N1 HFCRSXFPRUXCON-UHFFFAOYSA-N 0.000 claims 2
- AIIWJXBMHPJYBQ-UHFFFAOYSA-N 5-[[[4-(cyclohexylmethylamino)-6-(3-fluoro-4-hydroxyanilino)-1,3,5-triazin-2-yl]amino]methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=C(F)C(O)=CC=C1NC1=NC(NCC2C(NC(=O)S2)=O)=NC(NCC2CCCCC2)=N1 AIIWJXBMHPJYBQ-UHFFFAOYSA-N 0.000 claims 2
- IUZOXUTVNVMRJB-UHFFFAOYSA-N 5-[[[4-(cyclohexylmethylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2C(NC(=O)S2)=O)=NC(NCC2CCCCC2)=N1 IUZOXUTVNVMRJB-UHFFFAOYSA-N 0.000 claims 2
- PGCTYXKPBFFZNA-UHFFFAOYSA-N 5-[[[4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]-1,3-thiazolidine-2,4-dione Chemical compound CCN1CCCC1CNC1=NC(NCC2C(NC(=O)S2)=O)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 PGCTYXKPBFFZNA-UHFFFAOYSA-N 0.000 claims 2
- VAPPUVWPSFBRPG-UHFFFAOYSA-N 6-(1,3,5,6,7,7a-hexahydropyrrolo[1,2-c]imidazol-2-yl)-4-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(N2CN3CCCC3C2)=N1 VAPPUVWPSFBRPG-UHFFFAOYSA-N 0.000 claims 2
- VKEBCYOUBYMFKR-UHFFFAOYSA-N 6-(2-amino-1-phenylethoxy)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(OC(CN)C=2C=CC=CC=2)=N1 VKEBCYOUBYMFKR-UHFFFAOYSA-N 0.000 claims 2
- ZAYDHMLGRPHNNP-UHFFFAOYSA-N 6-(3,4,6,7,8,8a-hexahydro-1h-pyrrolo[1,2-a]pyrazin-2-yl)-4-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(N2CC3CCCN3CC2)=N1 ZAYDHMLGRPHNNP-UHFFFAOYSA-N 0.000 claims 2
- LBODWWVKTLGGCO-UHFFFAOYSA-N 6-(3-bicyclo[2.2.1]heptanyloxy)-4-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(OC2C3CCC(C3)C2)=NC(N(C)C2CCN(C)CC2)=N1 LBODWWVKTLGGCO-UHFFFAOYSA-N 0.000 claims 2
- CHTRMAQTGPNORK-UHFFFAOYSA-N 6-(3-bromo-4-methoxyphenoxy)-4-n-cycloheptyl-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(OC=2C=C(Br)C(OC)=CC=2)=N1 CHTRMAQTGPNORK-UHFFFAOYSA-N 0.000 claims 2
- CQQCPJRBFIRAAS-UHFFFAOYSA-N 6-(4-amino-2-fluorophenoxy)-4-n-(cyclohexylmethyl)-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(OC=2C(=CC(N)=CC=2)F)=N1 CQQCPJRBFIRAAS-UHFFFAOYSA-N 0.000 claims 2
- DUYJGTWTKACIIQ-UHFFFAOYSA-N 6-(4-amino-3-fluorophenoxy)-4-n-(cyclohexylmethyl)-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(OC=2C=C(F)C(N)=CC=2)=N1 DUYJGTWTKACIIQ-UHFFFAOYSA-N 0.000 claims 2
- QHZZLQSNUSOYEH-UHFFFAOYSA-N 6-(furan-2-ylmethoxy)-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC(N)=NC(OCC=2OC=CC=2)=N1 QHZZLQSNUSOYEH-UHFFFAOYSA-N 0.000 claims 2
- JTUXIZHZSJNQAE-UHFFFAOYSA-N 6-[3-chloro-4-(methylamino)phenoxy]-4-n-cycloheptyl-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(Cl)C(NC)=CC=C1OC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 JTUXIZHZSJNQAE-UHFFFAOYSA-N 0.000 claims 2
- MUQYPFDJBMNVCP-UHFFFAOYSA-N 6-cycloheptyloxy-4-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4-diamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(OC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 MUQYPFDJBMNVCP-UHFFFAOYSA-N 0.000 claims 2
- NASOUHASJMOBMT-UHFFFAOYSA-N 6-cycloheptyloxy-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4-diamine Chemical compound CCN1CCCC1CNC1=NC(NC=2C=C(F)C(OC)=CC=2)=NC(OC2CCCCCC2)=N1 NASOUHASJMOBMT-UHFFFAOYSA-N 0.000 claims 2
- VZBQMGLSHRXSMU-UHFFFAOYSA-N 6-n-(3-chloro-4-ethoxyphenyl)-4-n-cycloheptyl-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OCC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 VZBQMGLSHRXSMU-UHFFFAOYSA-N 0.000 claims 2
- PAGDSFCNYWSGOX-UHFFFAOYSA-N 6-n-(3-chloro-4-methoxyphenyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-4-n-(thiepan-3-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CSCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 PAGDSFCNYWSGOX-UHFFFAOYSA-N 0.000 claims 2
- MZIACKFBAJRMAA-UHFFFAOYSA-N 6-n-(3-chloro-4-methoxyphenyl)-4-n-cyclohept-2-en-1-yl-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2C=CCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 MZIACKFBAJRMAA-UHFFFAOYSA-N 0.000 claims 2
- JSIHHPDYZBVFNJ-UHFFFAOYSA-N 6-n-(3-chloro-4-methoxyphenyl)-4-n-cycloheptyl-2-n-(1-ethylpiperidin-4-yl)-2-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical compound C1CN(CC)CCC1N(C)C1=NC(NC2CCCCCC2)=NC(NC=2C=C(Cl)C(OC)=CC=2)=N1 JSIHHPDYZBVFNJ-UHFFFAOYSA-N 0.000 claims 2
- YLEKPALSEXZKLQ-UHFFFAOYSA-N 6-n-(3-chloro-4-methoxyphenyl)-4-n-cycloheptyl-2-n-[3-(dimethylamino)propyl]-2-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)CCCN(C)C)=N1 YLEKPALSEXZKLQ-UHFFFAOYSA-N 0.000 claims 2
- TWWWNDXJBUSRHB-UHFFFAOYSA-N 6-n-(3-chloro-4-methoxyphenyl)-4-n-cycloheptyl-2-n-methyl-2-n-pyridin-4-yl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C=2C=CN=CC=2)=N1 TWWWNDXJBUSRHB-UHFFFAOYSA-N 0.000 claims 2
- RNHRLSLZWFAPQP-UHFFFAOYSA-N 6-n-(4-amino-3-chlorophenyl)-4-n-cycloheptyl-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(NC2CCCCCC2)=NC(NC=2C=C(Cl)C(N)=CC=2)=NC=1N(C)C1CCN(C)CC1 RNHRLSLZWFAPQP-UHFFFAOYSA-N 0.000 claims 2
- GHSWJDUMMABKKA-UHFFFAOYSA-N 6-n-(4-amino-3-fluorophenyl)-4-n-cycloheptyl-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(NC2CCCCCC2)=NC(NC=2C=C(F)C(N)=CC=2)=NC=1N(C)C1CCN(C)CC1 GHSWJDUMMABKKA-UHFFFAOYSA-N 0.000 claims 2
- BUSDKCCWNWCVII-UHFFFAOYSA-N 6-n-(cycloheptylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 BUSDKCCWNWCVII-UHFFFAOYSA-N 0.000 claims 2
- NIDSSHRVIIXDST-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-4-n-(pyrrolidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1N(C)C1=NC(NCC2NCCC2)=NC(NCC2CCCCC2)=N1 NIDSSHRVIIXDST-UHFFFAOYSA-N 0.000 claims 2
- JGNDOXDQLCWEOV-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-4-n-(imidazol-1-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(NCN2C=NC=C2)=N1 JGNDOXDQLCWEOV-UHFFFAOYSA-N 0.000 claims 2
- VRBWGCXQTLQZTH-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-4-n-(pyrrolidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2NCCC2)=NC(NCC2CCCCC2)=N1 VRBWGCXQTLQZTH-UHFFFAOYSA-N 0.000 claims 2
- JQAXECLTFLDJMB-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-4-n-(thiolan-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2SCCC2)=NC(NCC2CCCCC2)=N1 JQAXECLTFLDJMB-UHFFFAOYSA-N 0.000 claims 2
- VXFHVCWLNIQQIU-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-4-n-[(1-methylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2N(CCC2)C)=NC(NCC2CCCCC2)=N1 VXFHVCWLNIQQIU-UHFFFAOYSA-N 0.000 claims 2
- WYNUNJANMMCQMT-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-4-n-[[1-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl]pyrrolidin-2-yl]methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound COCCOCCOCCOCCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 WYNUNJANMMCQMT-UHFFFAOYSA-N 0.000 claims 2
- VZMLTGXBBYZOEJ-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-2-n-(4-cyclopropyloxy-3-fluorophenyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC3CC3)=CC=2)=N1 VZMLTGXBBYZOEJ-UHFFFAOYSA-N 0.000 claims 2
- YKBZCUJJPCFCGZ-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-2-n-(4-ethyl-3-fluorophenyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(CC)=CC=2)=N1 YKBZCUJJPCFCGZ-UHFFFAOYSA-N 0.000 claims 2
- YGZWFNZLYNMWBR-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CN(C)C1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 YGZWFNZLYNMWBR-UHFFFAOYSA-N 0.000 claims 2
- TUIJJEARJNBVQB-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-2-n-[4-(dimethylamino)-3-fluorophenyl]-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(N(C)C)=CC=2)=N1 TUIJJEARJNBVQB-UHFFFAOYSA-N 0.000 claims 2
- BJIVZMBJRMPTFY-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-(2,3-dihydro-1h-indol-2-ylmethyl)-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2NC3=CC=CC=C3C2)=NC(NCC2CCCCC2)=N1 BJIVZMBJRMPTFY-UHFFFAOYSA-N 0.000 claims 2
- ROMJBJIDQNZKMO-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-(3-fluoro-4-methoxyphenyl)-2-n-(1-methylpyrrolidin-2-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(NC2N(CCC2)C)=N1 ROMJBJIDQNZKMO-UHFFFAOYSA-N 0.000 claims 2
- RBFYEINNPIDEDO-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-(3-fluoro-4-methoxyphenyl)-2-n-(furan-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(NCC=2OC=CC=2)=N1 RBFYEINNPIDEDO-UHFFFAOYSA-N 0.000 claims 2
- VIYALCSDBKCQMI-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-(3-fluoro-4-methoxyphenyl)-2-n-(thiophen-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(NCC=2SC=CC=2)=N1 VIYALCSDBKCQMI-UHFFFAOYSA-N 0.000 claims 2
- QMWCBYVWTLBIPZ-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-(4-ethoxy-3-fluorophenyl)-2-n-(1h-pyrrol-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OCC)=CC=C1NC1=NC(NCC2CCCCC2)=NC(NCC=2NC=CC=2)=N1 QMWCBYVWTLBIPZ-UHFFFAOYSA-N 0.000 claims 2
- PFFPIPCLECPIFF-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpiperidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 PFFPIPCLECPIFF-UHFFFAOYSA-N 0.000 claims 2
- JZCXMKFUARHRTK-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine;2,2,2-trifluoroacetic acid Chemical compound [O-]C(=O)C(F)(F)F.CC[NH+]1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 JZCXMKFUARHRTK-UHFFFAOYSA-N 0.000 claims 2
- MYTGMFLPNRMOQY-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-2-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(N(C)C=2C=C(F)C(OC)=CC=2)=N1 MYTGMFLPNRMOQY-UHFFFAOYSA-N 0.000 claims 2
- JXZJPXOOJRWWEH-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methylphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(C)=CC=2)=N1 JXZJPXOOJRWWEH-UHFFFAOYSA-N 0.000 claims 2
- IINBPOYOGUINLV-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methylsulfanylphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(SC)=CC=2)=N1 IINBPOYOGUINLV-UHFFFAOYSA-N 0.000 claims 2
- LQONCUJVVFXMIS-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-propan-2-yloxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC(C)C)=CC=2)=N1 LQONCUJVVFXMIS-UHFFFAOYSA-N 0.000 claims 2
- WOQHUBBFUJZJME-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(4-fluoro-5-methoxypyridin-2-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2N=CC(OC)=C(F)C=2)=N1 WOQHUBBFUJZJME-UHFFFAOYSA-N 0.000 claims 2
- XJHNGRPYERROSZ-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(4-methoxy-3-nitrophenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(C(OC)=CC=2)[N+]([O-])=O)=N1 XJHNGRPYERROSZ-UHFFFAOYSA-N 0.000 claims 2
- WKJSLRYPVJBIJJ-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(5-fluoro-6-methoxypyridin-3-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC)=NC=2)=N1 WKJSLRYPVJBIJJ-UHFFFAOYSA-N 0.000 claims 2
- ZVUIRHNVZVKEAO-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(8-fluoro-3,4-dihydro-2h-chromen-6-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C3CCCOC3=C(F)C=2)=N1 ZVUIRHNVZVKEAO-UHFFFAOYSA-N 0.000 claims 2
- PJJGAVLTSYDBKE-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-[(3-fluoro-4-methoxyphenyl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NCC=2C=C(F)C(OC)=CC=2)=N1 PJJGAVLTSYDBKE-UHFFFAOYSA-N 0.000 claims 2
- ZODOYZCGYQZBFL-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-[3-fluoro-4-(methoxymethoxy)phenyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OCOC)=CC=2)=N1 ZODOYZCGYQZBFL-UHFFFAOYSA-N 0.000 claims 2
- FTRLVQUHPZUEAT-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-[3-fluoro-4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OCCOCCOCCOC)=CC=2)=N1 FTRLVQUHPZUEAT-UHFFFAOYSA-N 0.000 claims 2
- QETBMKXEOKLSHJ-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-3-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1N(CC)CCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 QETBMKXEOKLSHJ-UHFFFAOYSA-N 0.000 claims 2
- SEMMDBIMUNRDCU-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(2-ethylcyclopentyl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCC1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 SEMMDBIMUNRDCU-UHFFFAOYSA-N 0.000 claims 2
- XJNIMFCBYAYTMM-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(2-ethylpyrazolidin-1-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCN1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 XJNIMFCBYAYTMM-UHFFFAOYSA-N 0.000 claims 2
- IZBYANPDCNGMRH-UHFFFAOYSA-N 6-n-(cyclohexylmethyl)-4-n-[(3-ethyl-1,3-oxazolidin-4-yl)methyl]-2-n-[4-(trifluoromethoxy)-3-(trifluoromethyl)phenyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1COCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(C(OC(F)(F)F)=CC=2)C(F)(F)F)=N1 IZBYANPDCNGMRH-UHFFFAOYSA-N 0.000 claims 2
- LUYQIAJUJBDRJD-UHFFFAOYSA-N 6-n-(cyclopentylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 LUYQIAJUJBDRJD-UHFFFAOYSA-N 0.000 claims 2
- XXEDSJKFIPYRDX-UHFFFAOYSA-N 6-n-(cyclopropylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 XXEDSJKFIPYRDX-UHFFFAOYSA-N 0.000 claims 2
- LGXYKFKEBIDJBM-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-4-n-(imidazol-1-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCN2C=NC=C2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 LGXYKFKEBIDJBM-UHFFFAOYSA-N 0.000 claims 2
- PBYOBSNBVFSYDE-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-4-n-(thiomorpholin-4-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCN2CCSCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 PBYOBSNBVFSYDE-UHFFFAOYSA-N 0.000 claims 2
- IRFOWSZGMOGTJW-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-(1-methylazepan-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCN(C)CCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 IRFOWSZGMOGTJW-UHFFFAOYSA-N 0.000 claims 2
- MFESEONRJLMVIA-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-(furan-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2OC=CC=2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 MFESEONRJLMVIA-UHFFFAOYSA-N 0.000 claims 2
- QJGIYJLOAPDUFS-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-(oxan-3-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2COCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 QJGIYJLOAPDUFS-UHFFFAOYSA-N 0.000 claims 2
- NJJHCSPDPQZXMO-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-(oxepan-2-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2OCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 NJJHCSPDPQZXMO-UHFFFAOYSA-N 0.000 claims 2
- UEDNNCLCAZIZPH-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-(oxepan-3-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2COCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 UEDNNCLCAZIZPH-UHFFFAOYSA-N 0.000 claims 2
- NPVJOGCTWVQFTL-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-(oxolan-3-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2COCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 NPVJOGCTWVQFTL-UHFFFAOYSA-N 0.000 claims 2
- ZIGWSOOSATYFHA-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-(pyrimidin-4-ylmethyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2N=CN=CC=2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 ZIGWSOOSATYFHA-UHFFFAOYSA-N 0.000 claims 2
- ZBIWAPVLURMWDS-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-(thiepan-2-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2SCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 ZBIWAPVLURMWDS-UHFFFAOYSA-N 0.000 claims 2
- YGYQYGBJTTXJJX-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-(thiepan-3-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CSCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 YGYQYGBJTTXJJX-UHFFFAOYSA-N 0.000 claims 2
- UYBYIFKXNQANTQ-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-(thiepan-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CCSCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 UYBYIFKXNQANTQ-UHFFFAOYSA-N 0.000 claims 2
- RERXHVZNGGTDPC-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-[(4-fluorophenyl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2C=CC(F)=CC=2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 RERXHVZNGGTDPC-UHFFFAOYSA-N 0.000 claims 2
- QLGQBYRCRNWDQN-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-[(4-methoxyphenyl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2C=CC(OC)=CC=2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 QLGQBYRCRNWDQN-UHFFFAOYSA-N 0.000 claims 2
- GJQPTZHIEAITRT-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-[(4-methylphenyl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2C=CC(C)=CC=2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 GJQPTZHIEAITRT-UHFFFAOYSA-N 0.000 claims 2
- VLSXTYUPTIRAII-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-[(4-nitrophenyl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC=2C=CC(=CC=2)[N+]([O-])=O)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 VLSXTYUPTIRAII-UHFFFAOYSA-N 0.000 claims 2
- FYSKCBIHALYXIH-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-heptan-4-yl-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(NC=2C=C(F)C(OC)=CC=2)=NC(NC(CCC)CCC)=NC=1NCC1CCCN1CC FYSKCBIHALYXIH-UHFFFAOYSA-N 0.000 claims 2
- MJRPMHCEKYZKKA-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-piperidin-1-yl-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NN2CCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 MJRPMHCEKYZKKA-UHFFFAOYSA-N 0.000 claims 2
- VPUUGMJLXMSZMD-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-pyrrolidin-1-yl-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NN2CCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 VPUUGMJLXMSZMD-UHFFFAOYSA-N 0.000 claims 2
- GGACMHHACOPSSB-UHFFFAOYSA-N 6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-2-n-pyrrolidin-3-yl-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NC2CNCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 GGACMHHACOPSSB-UHFFFAOYSA-N 0.000 claims 2
- SHHRNVHIUKHVEY-UHFFFAOYSA-N 6-n-[(2-aminocyclopentyl)methyl]-2-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NCC2C(CCC2)N)=NC(NC2CCCCCC2)=N1 SHHRNVHIUKHVEY-UHFFFAOYSA-N 0.000 claims 2
- KUCCPEDQLTWWPN-UHFFFAOYSA-N 6-n-[(2-aminocyclopentyl)methyl]-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2C(CCC2)N)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 KUCCPEDQLTWWPN-UHFFFAOYSA-N 0.000 claims 2
- DSDNAWQNTWWETL-UHFFFAOYSA-N 6-n-[(3-aminocyclohexyl)methyl]-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CC(N)CCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 DSDNAWQNTWWETL-UHFFFAOYSA-N 0.000 claims 2
- APHUIEBUVRLWRA-UHFFFAOYSA-N 6-n-[(4-aminocyclohexyl)methyl]-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCC2CCC(N)CC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 APHUIEBUVRLWRA-UHFFFAOYSA-N 0.000 claims 2
- CVJBVHLRLSALPA-UHFFFAOYSA-N 6-n-[2-(3-bromo-4-methoxyphenyl)ethyl]-4-n-cycloheptyl-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCCC=2C=C(Br)C(OC)=CC=2)=NC(NC2CCCCCC2)=N1 CVJBVHLRLSALPA-UHFFFAOYSA-N 0.000 claims 2
- GCDYZJWASFESDW-UHFFFAOYSA-N 6-n-[2-(3-chloro-4-methoxyphenyl)ethyl]-4-n-cycloheptyl-2-n-[(1-ethylpyrrolidin-2-yl)methyl]-1,3,5-triazine-2,4,6-triamine Chemical compound CCN1CCCC1CNC1=NC(NCCC=2C=C(Cl)C(OC)=CC=2)=NC(NC2CCCCCC2)=N1 GCDYZJWASFESDW-UHFFFAOYSA-N 0.000 claims 2
- KKCLMOFSWIQROX-UHFFFAOYSA-N 6-n-[2-(3-chloro-4-methoxyphenyl)ethyl]-4-n-cycloheptyl-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OC)=CC=C1CCNC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 KKCLMOFSWIQROX-UHFFFAOYSA-N 0.000 claims 2
- IJSSWSFXFLIXLS-UHFFFAOYSA-N 6-n-[3-chloro-4-(dimethylamino)phenyl]-4-n-cycloheptyl-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(N(C)C)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 IJSSWSFXFLIXLS-UHFFFAOYSA-N 0.000 claims 2
- FSMSRVWQYMJJQH-UHFFFAOYSA-N 6-n-[3-chloro-4-(methoxymethoxy)phenyl]-4-n-cycloheptyl-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OCOC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 FSMSRVWQYMJJQH-UHFFFAOYSA-N 0.000 claims 2
- DWFYRCGFQGBPTK-UHFFFAOYSA-N 6-n-[3-chloro-4-(methylsulfanylmethoxy)phenyl]-4-n-cycloheptyl-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(Cl)C(OCSC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 DWFYRCGFQGBPTK-UHFFFAOYSA-N 0.000 claims 2
- OJFMPCXCCXLYFN-UHFFFAOYSA-N 6-n-cycloheptyl-2-n-(3-fluoro-4-methoxyphenyl)-2-n,4-n-dimethyl-4-n-pyridin-4-yl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1N(C)C1=NC(NC2CCCCCC2)=NC(N(C)C=2C=CN=CC=2)=N1 OJFMPCXCCXLYFN-UHFFFAOYSA-N 0.000 claims 2
- UBZOXFQUNZJRSR-UHFFFAOYSA-N 6-n-cycloheptyl-2-n-(3-fluoro-4-methoxyphenyl)-4-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCN(C)CC2)=NC(NC2CCCCCC2)=N1 UBZOXFQUNZJRSR-UHFFFAOYSA-N 0.000 claims 2
- PZIWSQUIHFRGEC-UHFFFAOYSA-N 6-n-cycloheptyl-2-n-(3-fluoro-4-methoxyphenyl)-4-n-(1-methylsulfonylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCN(CC2)S(C)(=O)=O)=NC(NC2CCCCCC2)=N1 PZIWSQUIHFRGEC-UHFFFAOYSA-N 0.000 claims 2
- IBPPTNLHESLOND-UHFFFAOYSA-N 6-n-cycloheptyl-2-n-(3-fluoro-4-methoxyphenyl)-4-n-(3-methylcyclohexyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CC(C)CCC2)=NC(NC2CCCCCC2)=N1 IBPPTNLHESLOND-UHFFFAOYSA-N 0.000 claims 2
- QXQKRMOGFPEJHM-UHFFFAOYSA-N 6-n-cycloheptyl-2-n-(3-fluoro-4-methoxyphenyl)-4-n-(4-methylsulfonylcyclohexyl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCC(CC2)S(C)(=O)=O)=NC(NC2CCCCCC2)=N1 QXQKRMOGFPEJHM-UHFFFAOYSA-N 0.000 claims 2
- MWLRMHRVGNBILC-UHFFFAOYSA-N 6-n-cycloheptyl-2-n-(3-fluoro-4-methoxyphenyl)-4-n-piperidin-4-yl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCNCC2)=NC(NC2CCCCCC2)=N1 MWLRMHRVGNBILC-UHFFFAOYSA-N 0.000 claims 2
- XJPYAIAAGNKMAL-UHFFFAOYSA-N 6-n-cycloheptyl-2-n-(3-fluoro-4-methoxyphenyl)-4-n-pyridin-4-yl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(NC=2C=CN=CC=2)=N1 XJPYAIAAGNKMAL-UHFFFAOYSA-N 0.000 claims 2
- BOOOMOCMDLEIEF-UHFFFAOYSA-N 6-n-cycloheptyl-2-n-cyclohexyl-4-n-(3-fluoro-4-methoxyphenyl)-2-n,4-n-dimethyl-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1N(C)C1=NC(NC2CCCCCC2)=NC(N(C)C2CCCCC2)=N1 BOOOMOCMDLEIEF-UHFFFAOYSA-N 0.000 claims 2
- JXGKGDUKGIEQNL-UHFFFAOYSA-N 6-n-cycloheptyl-2-n-ethyl-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound N=1C(NCC2N(CCC2)CC)=NC(NC2CCCCCC2)=NC=1N(CC)C1=CC=C(OC)C(F)=C1 JXGKGDUKGIEQNL-UHFFFAOYSA-N 0.000 claims 2
- MUBCOININFDXPG-UHFFFAOYSA-N 6-n-cycloheptyl-4-n-(3-fluoro-4-methoxycyclohexyl)-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1C(F)C(OC)CCC1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 MUBCOININFDXPG-UHFFFAOYSA-N 0.000 claims 2
- BBXAVAGGEVTBGQ-UHFFFAOYSA-N 6-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-2-n,4-n-dimethyl-2-n-(1-methylpiperidin-3-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1N(C)C1=NC(NC2CCCCCC2)=NC(N(C)C2CN(C)CCC2)=N1 BBXAVAGGEVTBGQ-UHFFFAOYSA-N 0.000 claims 2
- QDKJTAZMKWYBIK-UHFFFAOYSA-N 6-n-cycloheptyl-4-n-(3-fluoro-4-methoxyphenyl)-2-n,4-n-dimethyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound C1=C(F)C(OC)=CC=C1N(C)C1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(C)CC2)=N1 QDKJTAZMKWYBIK-UHFFFAOYSA-N 0.000 claims 2
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- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 claims 2
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- YFMHLEBDOCSDHT-UHFFFAOYSA-N [2-[[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]-1-ethylpyrrolidin-1-ium-1-yl]methyl dihydrogen phosphate;chloride Chemical compound [Cl-].OP(=O)(O)OC[N+]1(CC)CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 YFMHLEBDOCSDHT-UHFFFAOYSA-N 0.000 claims 2
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- OOEKUOXVXPYRLS-UHFFFAOYSA-N [4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]carbamic acid Chemical compound CCN1CCCC1CNC1=NC(NC(O)=O)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 OOEKUOXVXPYRLS-UHFFFAOYSA-N 0.000 claims 2
- STNMJAGXAHUKAT-UHFFFAOYSA-N [4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]cyanamide Chemical compound CCN1CCCC1CNC1=NC(NC#N)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 STNMJAGXAHUKAT-UHFFFAOYSA-N 0.000 claims 2
- YYVDYCWXVSQOSK-UHFFFAOYSA-N [4-[(1-ethylpyrrolidin-2-yl)methylamino]-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]urea Chemical compound CCN1CCCC1CNC1=NC(NC(N)=O)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 YYVDYCWXVSQOSK-UHFFFAOYSA-N 0.000 claims 2
- LAGOAJYKJRDVTK-UHFFFAOYSA-N [4-[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]-methylamino]piperidin-1-yl]methyl dihydrogen phosphate Chemical compound C1=C(F)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CCN(COP(O)(O)=O)CC2)=N1 LAGOAJYKJRDVTK-UHFFFAOYSA-N 0.000 claims 2
- FDOZPJTTZKFFTO-UHFFFAOYSA-N [4-[[4-(cycloheptylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]amino]-2-fluorophenyl] 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]propanoate Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC(=O)CCOCCOCCOCCO)=CC=2)=N1 FDOZPJTTZKFFTO-UHFFFAOYSA-N 0.000 claims 2
- GJKDCWDFLQTAOX-UHFFFAOYSA-N [4-[[4-(cycloheptylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]amino]-2-fluorophenyl] 3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]propanoate Chemical compound CCN1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC(=O)CCOCCOCCOCCOC)=CC=2)=N1 GJKDCWDFLQTAOX-UHFFFAOYSA-N 0.000 claims 2
- LBBPGKQPXBEBFJ-UHFFFAOYSA-N [4-[[4-(cycloheptylamino)-6-[methyl-(1-methylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl]amino]-2-fluorophenyl] 3-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoate Chemical compound N=1C(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC(=O)CCOCCOCCOCCOCCO)=CC=2)=NC=1N(C)C1CCN(C)CC1 LBBPGKQPXBEBFJ-UHFFFAOYSA-N 0.000 claims 2
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- RGCTYRIFQKSQNF-UHFFFAOYSA-N [4-[[4-(cyclohexylmethylamino)-6-[(1-ethylpyrrolidin-2-yl)methylamino]-1,3,5-triazin-2-yl]amino]-2-fluorophenyl] acetate Chemical compound CCN1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC(C)=O)=CC=2)=N1 RGCTYRIFQKSQNF-UHFFFAOYSA-N 0.000 claims 2
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- HBBGNLNKQDJZAR-UHFFFAOYSA-N but-2-enedioic acid;6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound OC(=O)C=CC([O-])=O.CC[NH+]1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 HBBGNLNKQDJZAR-UHFFFAOYSA-N 0.000 claims 2
- HFMYPIGJSNIOKJ-UHFFFAOYSA-N butanedioic acid;2-n-cycloheptyl-6-n-[(1-ethylpyrrolidin-2-yl)methyl]-4-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound OC(=O)CCC([O-])=O.CC[NH+]1CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 HFMYPIGJSNIOKJ-UHFFFAOYSA-N 0.000 claims 2
- FSVCCECOICUWGB-UHFFFAOYSA-N butanedioic acid;6-n-(3-chloro-4-methoxyphenyl)-4-n-cycloheptyl-2-n-methyl-2-n-(1-methylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine Chemical compound OC(=O)CCC([O-])=O.C1=C(Cl)C(OC)=CC=C1NC1=NC(NC2CCCCCC2)=NC(N(C)C2CC[NH+](C)CC2)=N1 FSVCCECOICUWGB-UHFFFAOYSA-N 0.000 claims 2
- VOTXZOGYXITDOH-UHFFFAOYSA-N butanedioic acid;6-n-(cyclohexylmethyl)-4-n-[(1-ethylpyrrolidin-2-yl)methyl]-2-n-(3-fluoro-4-methoxyphenyl)-1,3,5-triazine-2,4,6-triamine Chemical compound OC(=O)CCC([O-])=O.CC[NH+]1CCCC1CNC1=NC(NCC2CCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 VOTXZOGYXITDOH-UHFFFAOYSA-N 0.000 claims 2
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- UBGATSMTZGWBJI-UHFFFAOYSA-M dibenzyl [2-[[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]-1-ethylpyrrolidin-1-ium-1-yl]methyl phosphate;chloride Chemical compound [Cl-].C1CCC(CNC=2N=C(NC=3C=C(F)C(OC)=CC=3)N=C(NC3CCCCCC3)N=2)[N+]1(CC)COP(=O)(OCC=1C=CC=CC=1)OCC1=CC=CC=C1 UBGATSMTZGWBJI-UHFFFAOYSA-M 0.000 claims 2
- WYPWUUQJRVVGPC-UHFFFAOYSA-M ditert-butyl [2-[[[4-(cycloheptylamino)-6-(3-fluoro-4-methoxyanilino)-1,3,5-triazin-2-yl]amino]methyl]-1-ethylpyrrolidin-1-ium-1-yl]methyl phosphate;chloride Chemical compound [Cl-].CC(C)(C)OP(=O)(OC(C)(C)C)OC[N+]1(CC)CCCC1CNC1=NC(NC2CCCCCC2)=NC(NC=2C=C(F)C(OC)=CC=2)=N1 WYPWUUQJRVVGPC-UHFFFAOYSA-M 0.000 claims 2
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| PCT/US2003/009356 WO2004026844A1 (en) | 2002-09-23 | 2003-03-26 | Methods and compositions of novel triazine compounds |
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| EP (1) | EP1560817A4 (https=) |
| JP (2) | JP2006511476A (https=) |
| AU (1) | AU2003231975A1 (https=) |
| BR (1) | BR0314670A (https=) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2006188533A (ja) * | 2002-09-23 | 2006-07-20 | Reddy Us Therapeutics Inc | 新規トリアジン化合物の組成物および方法 |
| JP2013540778A (ja) * | 2010-10-27 | 2013-11-07 | ウォルター アンド エリザ ホール インスティテュート オブ メディカル リサーチ | 新規抗がん剤 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2006188533A (ja) * | 2002-09-23 | 2006-07-20 | Reddy Us Therapeutics Inc | 新規トリアジン化合物の組成物および方法 |
| JP2013540778A (ja) * | 2010-10-27 | 2013-11-07 | ウォルター アンド エリザ ホール インスティテュート オブ メディカル リサーチ | 新規抗がん剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20070043051A1 (en) | 2007-02-22 |
| AU2003231975A1 (en) | 2004-04-08 |
| EP1560817A4 (en) | 2011-05-11 |
| CA2499964A1 (en) | 2004-04-01 |
| US7173032B2 (en) | 2007-02-06 |
| WO2004026844A1 (en) | 2004-04-01 |
| US20040077648A1 (en) | 2004-04-22 |
| EP1560817A1 (en) | 2005-08-10 |
| US20070099874A1 (en) | 2007-05-03 |
| RU2005108351A (ru) | 2006-02-27 |
| US7332489B2 (en) | 2008-02-19 |
| JP2006188533A (ja) | 2006-07-20 |
| WO2004026844A9 (en) | 2004-11-11 |
| BR0314670A (pt) | 2005-08-09 |
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