JP2006508942A5 - - Google Patents
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- Publication number
- JP2006508942A5 JP2006508942A5 JP2004548591A JP2004548591A JP2006508942A5 JP 2006508942 A5 JP2006508942 A5 JP 2006508942A5 JP 2004548591 A JP2004548591 A JP 2004548591A JP 2004548591 A JP2004548591 A JP 2004548591A JP 2006508942 A5 JP2006508942 A5 JP 2006508942A5
- Authority
- JP
- Japan
- Prior art keywords
- equol
- androgen
- binding
- mammal
- enantiomeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ADFCQWZHKCXPAJ-GFCCVEGCSA-N equol Chemical compound C1=CC(O)=CC=C1[C@@H]1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-GFCCVEGCSA-N 0.000 claims 27
- 235000019126 equol Nutrition 0.000 claims 22
- ADFCQWZHKCXPAJ-UHFFFAOYSA-N indofine Natural products C1=CC(O)=CC=C1C1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-UHFFFAOYSA-N 0.000 claims 22
- 238000000034 method Methods 0.000 claims 18
- 241000124008 Mammalia Species 0.000 claims 16
- 239000003098 androgen Substances 0.000 claims 15
- 230000027455 binding Effects 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 14
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 claims 10
- ADFCQWZHKCXPAJ-LBPRGKRZSA-N (R)-Equol Chemical class C1=CC(O)=CC=C1[C@H]1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-LBPRGKRZSA-N 0.000 claims 7
- 102000001307 androgen receptors Human genes 0.000 claims 7
- 108010080146 androgen receptors Proteins 0.000 claims 7
- 229940088597 hormone Drugs 0.000 claims 6
- 239000005556 hormone Substances 0.000 claims 6
- 229940011871 estrogen Drugs 0.000 claims 5
- 239000000262 estrogen Substances 0.000 claims 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 230000004963 pathophysiological condition Effects 0.000 claims 3
- 208000002874 Acne Vulgaris Diseases 0.000 claims 2
- 201000004384 Alopecia Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000032170 Congenital Abnormalities Diseases 0.000 claims 2
- 206010017065 Foster-Kennedy Syndrome Diseases 0.000 claims 2
- 206010022489 Insulin Resistance Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010051246 Photodermatosis Diseases 0.000 claims 2
- 208000012641 Pigmentation disease Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000000323 Tourette Syndrome Diseases 0.000 claims 2
- 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 claims 2
- 206010000496 acne Diseases 0.000 claims 2
- 231100000360 alopecia Toxicity 0.000 claims 2
- 230000003712 anti-aging effect Effects 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000012875 competitive assay Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 108010038795 estrogen receptors Proteins 0.000 claims 2
- 230000001815 facial effect Effects 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 230000004132 lipogenesis Effects 0.000 claims 2
- 230000004130 lipolysis Effects 0.000 claims 2
- 230000004630 mental health Effects 0.000 claims 2
- 230000004060 metabolic process Effects 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 230000008845 photoaging Effects 0.000 claims 2
- 230000004962 physiological condition Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 210000001732 sebaceous gland Anatomy 0.000 claims 2
- 210000002374 sebum Anatomy 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 230000037075 skin appearance Effects 0.000 claims 2
- 230000003637 steroidlike Effects 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 210000001685 thyroid gland Anatomy 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- 102100038595 Estrogen receptor Human genes 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000007698 birth defect Effects 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002996 emotional effect Effects 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 102000015694 estrogen receptors Human genes 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000001991 pathophysiological effect Effects 0.000 claims 1
- 230000035479 physiological effects, processes and functions Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
- 230000002087 whitening effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42246902P | 2002-10-29 | 2002-10-29 | |
| US60/422,469 | 2002-10-29 | ||
| PCT/US2003/034441 WO2004039327A2 (en) | 2002-10-29 | 2003-10-29 | Use of equol for treating androgen mediated diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011177316A Division JP5535999B2 (ja) | 2002-10-29 | 2011-08-12 | アンドロゲンによって仲介される疾患を治療するためのエクオールの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006508942A JP2006508942A (ja) | 2006-03-16 |
| JP2006508942A5 true JP2006508942A5 (https=) | 2006-12-28 |
| JP4889944B2 JP4889944B2 (ja) | 2012-03-07 |
Family
ID=32230355
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004548591A Expired - Lifetime JP4889944B2 (ja) | 2002-10-29 | 2003-10-29 | アンドロゲンによって仲介される疾患を治療するためのエクオールの使用 |
| JP2011177316A Expired - Fee Related JP5535999B2 (ja) | 2002-10-29 | 2011-08-12 | アンドロゲンによって仲介される疾患を治療するためのエクオールの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011177316A Expired - Fee Related JP5535999B2 (ja) | 2002-10-29 | 2011-08-12 | アンドロゲンによって仲介される疾患を治療するためのエクオールの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (7) | US20060122262A1 (https=) |
| EP (1) | EP1569636B1 (https=) |
| JP (2) | JP4889944B2 (https=) |
| AU (1) | AU2003286781B2 (https=) |
| CA (1) | CA2504682A1 (https=) |
| WO (1) | WO2004039327A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8668914B2 (en) * | 2002-07-24 | 2014-03-11 | Brigham Young University | Use of equol for treating skin diseases |
| WO2004039327A2 (en) | 2002-10-29 | 2004-05-13 | Colorado State University Research Foundation | Use of equol for treating androgen mediated diseases |
| CN104643057A (zh) | 2002-07-24 | 2015-05-27 | 儿童医院医疗中心 | 含有对映体牛尿酚的组合物和产物及其用途 |
| US8580846B2 (en) | 2002-10-29 | 2013-11-12 | Brigham Young University | Use of equol for ameliorating or preventing neuropsychiatric and neurodegenerative diseases or disorders |
| TW201118175A (en) * | 2003-06-30 | 2011-06-01 | Otsuka Pharma Co Ltd | Equol-producing lactic acid bacteria-containing composition |
| CA2564399A1 (en) * | 2004-04-28 | 2005-11-17 | Brigham Young University | Use of equol for treating skin diseases |
| WO2007013547A1 (ja) * | 2005-07-29 | 2007-02-01 | Calpis Co., Ltd. | 更年期障害予防・改善剤および機能性飲食品 |
| US7528267B2 (en) | 2005-08-01 | 2009-05-05 | Girindus America, Inc. | Method for enantioselective hydrogenation of chromenes |
| NL1030571C2 (nl) * | 2005-12-01 | 2006-04-27 | Sara Lee De Nv | Geurafgiftesysteem. |
| US8680140B2 (en) * | 2006-08-02 | 2014-03-25 | University Of Southern California | Phytoestrogenic formulations for alleviation or prevention of menopausal symptoms |
| EP2063898A4 (en) * | 2006-08-18 | 2012-02-15 | Univ Brigham Young | USE OF EQUOL TO IMPROVE OR PREVENT NEUROPSYCHIATRIC AND NEURODEGENERATIVE DISEASES OR DISORDERS |
| KR20100015996A (ko) * | 2007-04-09 | 2010-02-12 | 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조 | 에쿠올류를 유효 성분으로 함유하는 미백제 |
| JP5355395B2 (ja) | 2007-06-13 | 2013-11-27 | 大塚製薬株式会社 | エクオール含有抽出物及びその製造方法、エクオール抽出方法、並びにエクオールを含む食品 |
| US8835490B2 (en) * | 2008-08-15 | 2014-09-16 | Nestec Sa | Methods for enhancing energy metabolism |
| US20110091435A1 (en) * | 2008-10-24 | 2011-04-21 | University Of Southern California | Phytoestrogenic formulations for alleviation or prevention of hair loss |
| EP2898923A3 (en) * | 2011-04-15 | 2015-10-07 | Nestec S.A. | Isoflavones for regulating sirtuin gene expression |
| EP2699095A4 (en) * | 2011-04-20 | 2015-04-15 | Nestec Sa | METHODS AND COMPOSITIONS THAT CAN BE USED TO PREVENT AND TREAT HYPERLEPTINEMIA |
| KR20160026042A (ko) * | 2014-08-29 | 2016-03-09 | (주)아모레퍼시픽 | 락토비온산을 함유하는 항스트레스용 또는 항상성 유지용 조성물 |
| JP2017531025A (ja) | 2014-10-14 | 2017-10-19 | ジャクソン，リチャード・エル | Ｓ−エクオールの無水結晶形 |
| US20210283097A1 (en) * | 2016-07-26 | 2021-09-16 | Ausio Pharmaceuticals, Llc | Methods of diagnosing and treating alzheimer's disease with s-equol |
| JP2021535187A (ja) | 2018-06-15 | 2021-12-16 | ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | Ｓ−エクオールを用いた黒色腫の処置及び予防方法 |
| AU2019285640A1 (en) | 2018-06-15 | 2021-01-21 | Board Of Regents Of The University Of Texas System | Methods of treating and preventing breast cancer with S-equol |
| EP4138921A1 (en) * | 2020-04-23 | 2023-03-01 | University Of Iowa Research Foundation | Gper proteolytic targeting chimeras |
| US20230190702A1 (en) * | 2020-05-21 | 2023-06-22 | Daicel Corporation | A composition for improving qol of a 40-year-old or older postmenopausal woman without menopausal disorder |
| US20230310367A1 (en) * | 2020-09-04 | 2023-10-05 | Daicel Corporation | Composition for enhancing nampt gene expression |
| CN116531393A (zh) * | 2023-04-03 | 2023-08-04 | 河北医科大学 | 一种预防高热惊厥发作的药物组合物 |
| JP7596493B1 (ja) * | 2023-11-24 | 2024-12-09 | 株式会社ダイセル | 男性のｑｏｌの改善のための組成物 |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4390559A (en) * | 1979-04-11 | 1983-06-28 | Z-L Limited Partnership | Isoflavones and related compounds, methods of preparing and using and antioxidant compositions containing same |
| US5468501A (en) | 1982-09-01 | 1995-11-21 | Hercon Laboratories Corporation | Article useful for administration of pharmacologically-active substances transdermally, orally or by means of implant |
| USRE34457E (en) * | 1983-12-28 | 1993-11-30 | Daicel Chemical Industries, Inc. | Separating agent |
| GB8626344D0 (en) * | 1986-11-04 | 1986-12-03 | Zyma Sa | Bicyclic compounds |
| JPH02124883A (ja) | 1988-11-04 | 1990-05-14 | Kitasato Inst:The | 抗酸化作用を有するイソフラボン誘導体およびその製造法 |
| CH679584A5 (https=) * | 1989-11-10 | 1992-03-13 | Nestle Sa | |
| TW279133B (https=) | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
| EP0656786B2 (en) * | 1992-05-19 | 2014-04-23 | Novogen Research Pty Ltd | Use of isoflavone phyto-oestrogen extracts of soy or clover |
| WO1994023716A1 (en) | 1993-04-16 | 1994-10-27 | Tufts University School Of Medicine | Method for treatment of menopausal and premenstrual symptoms |
| US5613958A (en) | 1993-05-12 | 1997-03-25 | Pp Holdings Inc. | Transdermal delivery systems for the modulated administration of drugs |
| US5320949A (en) * | 1993-10-12 | 1994-06-14 | Protein Technologies International, Inc. | Process for producing aglucone isoflavone enriched vegetable protein fiber |
| US5424331A (en) * | 1994-06-10 | 1995-06-13 | Bio-Virus Research Incorporated | Pharmaceutical compositions and dietary soybean food products for the prevention of osteoporosis |
| AU3689095A (en) | 1994-10-03 | 1996-04-26 | Schouten Industries B.V. | Food and health products |
| US5523087A (en) * | 1995-02-15 | 1996-06-04 | Bio-Virus Research Incorporated | Pharmaceutical compositions for the treatment of diabetic male sexual dysfunction |
| AUPN166195A0 (en) * | 1995-03-13 | 1995-04-06 | Norvet Research Pty Limited | Process for glucan extraction |
| FR2731706B1 (fr) * | 1995-03-14 | 1997-04-11 | Cird Galderma | Composes heterocycliques aromatiques, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
| US5554519A (en) | 1995-08-07 | 1996-09-10 | Fermalogic, Inc. | Process of preparing genistein |
| US5693018A (en) | 1995-10-11 | 1997-12-02 | Science Incorporated | Subdermal delivery device |
| US5821361A (en) * | 1996-06-11 | 1998-10-13 | Protein Technologies International, Inc. | Recovery of isoflavones from soy molasses |
| AUPO203996A0 (en) * | 1996-08-30 | 1996-09-26 | Novogen Research Pty Ltd | Therapeutic uses |
| US5726034A (en) * | 1996-09-06 | 1998-03-10 | Protein Technologies International, Inc. | Aglucone isoflavone enriched vegetable protein extract and protein material, and high genistein and daidzein content materials and process for producing the same |
| US5804234A (en) * | 1996-09-13 | 1998-09-08 | Suh; John D. | Plant protein for nutritional products and method of making same |
| US6020471A (en) * | 1996-09-13 | 2000-02-01 | Abbott Laboratories | Process for isolating phytoestrogens from plant protein |
| WO1998021946A1 (en) | 1996-11-18 | 1998-05-28 | Internutria, Inc. | Composition and treatment for persistent reproductive transition symptoms |
| US5733926A (en) * | 1996-12-13 | 1998-03-31 | Gorbach; Sherwood L. | Isoflavonoids for treatment and prevention of alzheimer dementia and reduced cognitive functions |
| AUPO427196A0 (en) * | 1996-12-19 | 1997-01-23 | University Of Sydney, The | A method for preventing or controlling cataract |
| AU7165798A (en) * | 1997-04-28 | 1998-11-24 | Anticancer, Inc. | Use of genistein and related compounds to treat certain sex hormone related conditions |
| US6146668A (en) * | 1997-04-28 | 2000-11-14 | Novogen, Inc. | Preparation of isoflavones from legumes |
| EP0979074A4 (en) * | 1997-05-01 | 2003-07-09 | Novogen Inc | TREATMENT OR PREVENTION CLIMATE ACTION SYMPTOMS AND OSTEOPOROSIS |
| US6083526A (en) * | 1997-05-22 | 2000-07-04 | Gorbach; Sherwood L. | Use of isoflavonoids in the treatment or prevention of postpartum depression |
| US6060070A (en) * | 1997-06-11 | 2000-05-09 | Gorbach; Sherwood L. | Isoflavonoids for treatment and prevention of aging skin and wrinkles |
| JP4310601B2 (ja) * | 1997-08-08 | 2009-08-12 | 大塚製薬株式会社 | イソフラボン含有組成物 |
| US6521433B1 (en) * | 1997-09-17 | 2003-02-18 | E. I. Du Pont De Nemours And Company | cDNA sequences from plants that encode activities associated with isoflavone biosynthesis |
| US5855892A (en) * | 1997-09-19 | 1999-01-05 | Potter; Susan M. | Method for decreasing LDL-cholesterol concentration and increasing HDL-cholesterol concentration in the blood to reduce the risk of atherosclerosis and vascular disease |
| US5952374A (en) * | 1997-09-29 | 1999-09-14 | Protein Technologies International, Inc. | Method for inhibiting the development of Alzheimer's disease and related dementias- and for preserving cognitive function |
| US5942539A (en) * | 1997-10-03 | 1999-08-24 | Wake Forest University | Methods of treating or preventing endometriosis with phytoestrogens |
| AUPP112497A0 (en) * | 1997-12-24 | 1998-01-22 | Novogen Research Pty Ltd | Compositions and method for protecting skin from UV induced immunosupression and skin damage |
| US5958946A (en) | 1998-01-20 | 1999-09-28 | Styczynski; Peter | Modulation of hair growth |
| US6004558A (en) * | 1998-02-25 | 1999-12-21 | Novogen, Inc. | Methods for treating cancer with legume plant extracts |
| AUPP260798A0 (en) * | 1998-03-26 | 1998-04-23 | Novogen Research Pty Ltd | Treatment of medical related conditions with isoflavone containing extracts of clover |
| US6086915A (en) | 1998-04-01 | 2000-07-11 | Bioresponse L.L.C. | Compositions and methods of adjusting steroid hormone metabolism through phytochemicals |
| WO1999061028A1 (en) | 1998-05-27 | 1999-12-02 | Gorbach Sherwood L | Isoflavonoids for treatment and prevention of migraine headaches |
| EP1041964A4 (en) | 1998-09-10 | 2003-09-03 | Avon Prod Inc | METHOD AND COMPOSITIONS FOR REDUCING DERMATOLOGICAL AGING AND FOR REDUCING CRUSHING |
| WO2000030663A1 (en) | 1998-11-25 | 2000-06-02 | Nutri Pharma Asa | Composition comprising soy protein, dietary fibres and a phytoestrogen compound and use thereof in the prevention and/or treatment of type 2 diabetes, the metabolic syndrome and associated cardiovascular diseases |
| WO2000030664A1 (en) * | 1998-11-25 | 2000-06-02 | Nutri Pharma Asa | Composition comprising soy protein, dietary fibres and a phytoestrogen compound and use thereof in the prevention and/or treatment of pulmonary diseases |
| AU1995400A (en) | 1999-01-15 | 2000-08-01 | Nutrahealth Ltd (Uk) | Modified food products and beverages, and additives for food and beverages |
| AUPP868599A0 (en) | 1999-02-15 | 1999-03-11 | Novogen Research Pty Ltd | Production of isoflavone derivatives |
| JP2002542187A (ja) * | 1999-04-16 | 2002-12-10 | アストラゼネカ・アクチエボラーグ | エストロゲン−β受容体リガンド |
| JP2002542192A (ja) | 1999-04-20 | 2002-12-10 | ボード オブ トラスティース， サザン イリノイ ユニバーシティ | イソフラボンで臨床的な疾患を処置する方法 |
| US6544566B1 (en) * | 1999-04-23 | 2003-04-08 | Protein Technologies International, Inc. | Composition containing plant sterol, soy protein and isoflavone for reducing LDL cholesterol |
| EP1173443A1 (en) | 1999-05-04 | 2002-01-23 | American Home Products Corporation | Cyclic urea and cyclic amide derivatives |
| US6159959A (en) * | 1999-05-06 | 2000-12-12 | American Home Products Corporation | Combined estrogen and antiestrogen therapy |
| US6401125B1 (en) | 1999-08-05 | 2002-06-04 | Nextpage, Inc. | System and method for maintaining state information between a web proxy server and its clients |
| US6375994B1 (en) * | 1999-08-20 | 2002-04-23 | Sun Ten Laboratories, Inc. | Preparation of fiber, L-glutamine and a soy derivative for the purpose of enhancement of isoflavone bioavailability |
| CA2416796A1 (en) * | 2000-06-14 | 2001-12-20 | Alla Shapiro | Radioprotective agents |
| AU2001271784A1 (en) | 2000-07-06 | 2002-01-21 | Wyeth | Therapy for prosthesis-related bone degeneration |
| AU2001273125A1 (en) | 2000-07-06 | 2002-01-21 | American Home Products Corporation | Combinations of bisphosphonates, estrogenic agents and optionally estrogens |
| US6455568B2 (en) * | 2000-07-06 | 2002-09-24 | Wyeth | Combination therapy for inhibiting sphincter incontinence |
| AU2001271785A1 (en) | 2000-07-06 | 2002-01-21 | American Home Products Corporation | Combinations of statins, estrogenic agents and optionally estrogens |
| WO2002011675A2 (en) | 2000-08-10 | 2002-02-14 | Zelickson M D Brian D | Organic nutrient for hair loss treatment |
| US6326366B1 (en) * | 2000-08-22 | 2001-12-04 | Protein Technologies International | Hormone replacement therapy |
| US20020143059A1 (en) | 2000-12-28 | 2002-10-03 | Sreekumar Pillai | Skin care product containing retinoids, retinoid booster and phytoestrogens in a dual compartment package |
| US6565864B2 (en) * | 2000-12-28 | 2003-05-20 | Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. | Skin care product containing retinoids and phytoestrogens in a dual compartment package |
| US20020192310A1 (en) | 2001-02-02 | 2002-12-19 | Bland Jeffrey S. | Medical composition for managing hormone balance |
| JP2004523362A (ja) * | 2001-02-02 | 2004-08-05 | コンソリデイテッド エンジニアリング カンパニー， インコーポレイテッド | 一体型金属プロセシング設備 |
| EP1234572B1 (de) * | 2001-02-26 | 2013-10-30 | Mibelle AG Cosmetics | Isoflavon-Aglykone enhaltende Hautbehandlungsmittel |
| MXPA03007609A (es) | 2001-02-27 | 2004-06-30 | Univ Michigan | Uso de inhibidores egfr naturales para evitar efectos secundarios debidos a terapia de retinoide, jabones y otros estimulos que activan el receptor del factor de crecimiento epidermico. |
| DE10121375B4 (de) | 2001-05-02 | 2014-01-16 | Beiersdorf Ag | Verwendung von Isoflavonoiden in kosmetischen oder dermatologischen Zubereitungen zur Prophylaxe vor und Behandlung von sensibler Haut |
| DE10122342A1 (de) | 2001-05-09 | 2002-11-14 | Beiersdorf Ag | Verwendung von Isoflavonen in kosmetischen oder dermatologischen Zubereitungen |
| FR2825277B1 (fr) * | 2001-05-30 | 2004-10-15 | Oreal | Composition cosmetique et/ou dermatologique et/ou pharmaceutique contenant au moins un compose ihnibiteur de l'enzime 3, b-hsd |
| US6597597B2 (en) * | 2001-11-13 | 2003-07-22 | Hewlett-Packard Company | Low temperature attaching process for MRAM components |
| US8668914B2 (en) | 2002-07-24 | 2014-03-11 | Brigham Young University | Use of equol for treating skin diseases |
| CN104643057A (zh) * | 2002-07-24 | 2015-05-27 | 儿童医院医疗中心 | 含有对映体牛尿酚的组合物和产物及其用途 |
| WO2004039327A2 (en) | 2002-10-29 | 2004-05-13 | Colorado State University Research Foundation | Use of equol for treating androgen mediated diseases |
| AU2002951271A0 (en) | 2002-09-06 | 2002-09-19 | Novogen Research Pty Ltd | Repair of dna mutagenic damage |
| EP1542654A4 (en) | 2002-09-23 | 2008-12-17 | Novogen Res Pty Ltd | TREATMENT OF PHOTOTATIOOD AND ACTINIC DETERIORATION OF THE SKIN |
| US8580846B2 (en) | 2002-10-29 | 2013-11-12 | Brigham Young University | Use of equol for ameliorating or preventing neuropsychiatric and neurodegenerative diseases or disorders |
| CA2564399A1 (en) | 2004-04-28 | 2005-11-17 | Brigham Young University | Use of equol for treating skin diseases |
| US7528267B2 (en) | 2005-08-01 | 2009-05-05 | Girindus America, Inc. | Method for enantioselective hydrogenation of chromenes |
| EP1961309A4 (en) | 2005-12-06 | 2010-01-20 | Otsuka Pharma Co Ltd | EMBRYONIC AXIS FERMENTATION PRODUCT OF SOYBEAN CONTAINING EQUOL, AND METHOD FOR PRODUCING THE SAME |
-
2003
- 2003-10-29 WO PCT/US2003/034441 patent/WO2004039327A2/en not_active Ceased
- 2003-10-29 EP EP03777994.9A patent/EP1569636B1/en not_active Expired - Lifetime
- 2003-10-29 US US10/533,045 patent/US20060122262A1/en not_active Abandoned
- 2003-10-29 JP JP2004548591A patent/JP4889944B2/ja not_active Expired - Lifetime
- 2003-10-29 CA CA002504682A patent/CA2504682A1/en not_active Abandoned
- 2003-10-29 AU AU2003286781A patent/AU2003286781B2/en not_active Expired
-
2009
- 2009-10-02 US US12/572,791 patent/US8153684B2/en not_active Expired - Fee Related
-
2011
- 2011-08-12 JP JP2011177316A patent/JP5535999B2/ja not_active Expired - Fee Related
-
2012
- 2012-04-09 US US13/442,466 patent/US8450364B2/en not_active Expired - Fee Related
-
2013
- 2013-05-28 US US13/903,748 patent/US9089547B2/en not_active Expired - Lifetime
-
2015
- 2015-07-27 US US14/810,117 patent/US9408825B2/en not_active Expired - Fee Related
-
2016
- 2016-03-09 US US15/065,344 patent/US9889116B2/en not_active Expired - Fee Related
-
2018
- 2018-01-03 US US15/861,386 patent/US10111855B2/en not_active Expired - Lifetime
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