JP2006508720A - 抗菌性コーティングをその上に有する医用デバイス - Google Patents
抗菌性コーティングをその上に有する医用デバイス Download PDFInfo
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- JP2006508720A JP2006508720A JP2004556275A JP2004556275A JP2006508720A JP 2006508720 A JP2006508720 A JP 2006508720A JP 2004556275 A JP2004556275 A JP 2004556275A JP 2004556275 A JP2004556275 A JP 2004556275A JP 2006508720 A JP2006508720 A JP 2006508720A
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Classifications
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
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- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Eyeglasses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Paints Or Removers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43063502P | 2002-12-03 | 2002-12-03 | |
| PCT/EP2003/013598 WO2004050132A2 (en) | 2002-12-03 | 2003-12-02 | Medical devices having antimicrobial coatings thereon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006508720A true JP2006508720A (ja) | 2006-03-16 |
| JP2006508720A5 JP2006508720A5 (https=) | 2006-12-28 |
Family
ID=32469502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004556275A Pending JP2006508720A (ja) | 2002-12-03 | 2003-12-02 | 抗菌性コーティングをその上に有する医用デバイス |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8172395B2 (https=) |
| EP (1) | EP1569700B1 (https=) |
| JP (1) | JP2006508720A (https=) |
| AT (1) | ATE348640T1 (https=) |
| AU (1) | AU2003298164A1 (https=) |
| CA (1) | CA2504259A1 (https=) |
| DE (1) | DE60310611T2 (https=) |
| WO (1) | WO2004050132A2 (https=) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010513966A (ja) * | 2006-12-21 | 2010-04-30 | ノバルティス アーゲー | 生物医学的物品のコーティング方法 |
| JP2010148772A (ja) * | 2008-12-26 | 2010-07-08 | Toray Ind Inc | 医療用材料 |
| JP2011521902A (ja) * | 2008-04-21 | 2011-07-28 | シンガポール ヘルス サービシーズ ピーティーイー リミテッド | 抗菌ペプチド多量体 |
| WO2011149058A1 (ja) * | 2010-05-27 | 2011-12-01 | ナンヤン テクノロジカル ユニヴァーシティー | 眼用及び医療用の重合性組成物及びそれを重合して得られる抗菌性組成物 |
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Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| ES2423914T3 (es) | 2010-07-30 | 2013-09-25 | Novartis Ag | Lentes de hidrogel de silicona con superficies ricas en agua |
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| EP2785296B1 (en) | 2011-12-02 | 2018-06-20 | AcuFocus, Inc. | Ocular mask having selective spectral transmission |
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| US9204962B2 (en) | 2013-03-13 | 2015-12-08 | Acufocus, Inc. | In situ adjustable optical mask |
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| CN118406273B (zh) * | 2024-05-29 | 2024-11-19 | 广东安拓普聚合物科技股份有限公司 | 一种医用导管用tpu材料及其生产工艺 |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001076594A1 (en) * | 2000-04-10 | 2001-10-18 | Unisearch Limited | Antimicrobial coatings |
| JP2001527027A (ja) * | 1997-12-31 | 2001-12-25 | ハイドロマー インコーポレイテッド | 細菌接着低減及び防止用生物静力学的コーティング |
| WO2001098362A2 (en) * | 2000-06-16 | 2001-12-27 | Hercules Incorporated | Chemically-modified antimicrobial peptides, compositions and methods of production and use |
| JP2002501211A (ja) * | 1998-01-09 | 2002-01-15 | ノバルティス ファーマ アクチエンゲゼルシャフト | ポリマーのコーティング |
| WO2002079397A2 (en) * | 2001-02-16 | 2002-10-10 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Virus derived antimicrobial peptides |
| WO2002085542A1 (en) * | 2001-04-23 | 2002-10-31 | Massachusetts Institute Of Technology | Antimicrobial polymeric surfaces |
| WO2002092143A1 (en) * | 2001-05-15 | 2002-11-21 | Bausch & Lomb Incorporated | Method and composition for reducing bacterial attachment to biomaterials |
| WO2002094331A1 (en) * | 2001-05-21 | 2002-11-28 | Novartis Ag | Bottle-brush type coatings with entangled hydrophilic polymer |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1980002840A1 (en) | 1979-06-20 | 1980-12-24 | W Foley | Contact lenses with polymer bound asepticizing agents |
| US5171318A (en) * | 1987-11-09 | 1992-12-15 | Chiron Ophthalmics, Inc. | Treated corneal prosthetic device |
| US4933410A (en) * | 1989-03-29 | 1990-06-12 | Applied Immunesciences, Inc. | Covalent attachment of macromolecules on substrate surfaces |
| JPH0476518A (ja) * | 1990-07-19 | 1992-03-11 | Sangi Co Ltd | 抗菌性コンタクトレンズ |
| CA2104462A1 (en) | 1991-03-01 | 1992-09-02 | Anthony R. Booth | Oral and personal hygiene articles containing active agents bonded to the surface thereof |
| EP0537774B1 (en) | 1991-10-18 | 1998-01-07 | Kuraray Co., Ltd. | Antimicrobial polymerizable composition, the polymer and article obtained from the same |
| TW243455B (https=) | 1993-02-09 | 1995-03-21 | Ciba Geigy | |
| CN100471535C (zh) * | 1998-05-29 | 2009-03-25 | 劳伦斯A·林恩 | 路厄氏接纳器与输液的方法 |
| US6482799B1 (en) | 1999-05-25 | 2002-11-19 | The Regents Of The University Of California | Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial |
| WO2001056627A1 (en) | 2000-01-12 | 2001-08-09 | Am-Pharma B.V. | Medical device coated with antimicrobial peptides |
| US6719929B2 (en) * | 2000-02-04 | 2004-04-13 | Novartis Ag | Method for modifying a surface |
| AR027348A1 (es) | 2000-02-04 | 2003-03-26 | Novartis Ag | Proceso para recubrir una superficie |
| AU2001267488A1 (en) | 2000-05-30 | 2001-12-11 | Novartis Ag | Coated articles |
| WO2002040536A2 (en) | 2000-11-15 | 2002-05-23 | Emory University | Acylated antimicrobial peptides |
| EP1357954A1 (en) | 2001-02-09 | 2003-11-05 | Johnson & Johnson Vision Care, Inc. | Biomedical devices with antimicrobial cationic peptide coatings |
-
2003
- 2003-11-25 US US10/722,256 patent/US8172395B2/en active Active
- 2003-12-02 CA CA002504259A patent/CA2504259A1/en not_active Abandoned
- 2003-12-02 AU AU2003298164A patent/AU2003298164A1/en not_active Abandoned
- 2003-12-02 AT AT03795870T patent/ATE348640T1/de not_active IP Right Cessation
- 2003-12-02 JP JP2004556275A patent/JP2006508720A/ja active Pending
- 2003-12-02 WO PCT/EP2003/013598 patent/WO2004050132A2/en not_active Ceased
- 2003-12-02 DE DE60310611T patent/DE60310611T2/de not_active Expired - Lifetime
- 2003-12-02 EP EP03795870A patent/EP1569700B1/en not_active Expired - Lifetime
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001527027A (ja) * | 1997-12-31 | 2001-12-25 | ハイドロマー インコーポレイテッド | 細菌接着低減及び防止用生物静力学的コーティング |
| JP2002501211A (ja) * | 1998-01-09 | 2002-01-15 | ノバルティス ファーマ アクチエンゲゼルシャフト | ポリマーのコーティング |
| WO2001076594A1 (en) * | 2000-04-10 | 2001-10-18 | Unisearch Limited | Antimicrobial coatings |
| WO2001098362A2 (en) * | 2000-06-16 | 2001-12-27 | Hercules Incorporated | Chemically-modified antimicrobial peptides, compositions and methods of production and use |
| WO2002079397A2 (en) * | 2001-02-16 | 2002-10-10 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Virus derived antimicrobial peptides |
| WO2002085542A1 (en) * | 2001-04-23 | 2002-10-31 | Massachusetts Institute Of Technology | Antimicrobial polymeric surfaces |
| WO2002092143A1 (en) * | 2001-05-15 | 2002-11-21 | Bausch & Lomb Incorporated | Method and composition for reducing bacterial attachment to biomaterials |
| WO2002094331A1 (en) * | 2001-05-21 | 2002-11-28 | Novartis Ag | Bottle-brush type coatings with entangled hydrophilic polymer |
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010513966A (ja) * | 2006-12-21 | 2010-04-30 | ノバルティス アーゲー | 生物医学的物品のコーティング方法 |
| JP2015145373A (ja) * | 2008-04-21 | 2015-08-13 | シンガポール ヘルス サービシーズ ピーティーイー リミテッド | 抗菌ペプチド多量体 |
| JP2011521902A (ja) * | 2008-04-21 | 2011-07-28 | シンガポール ヘルス サービシーズ ピーティーイー リミテッド | 抗菌ペプチド多量体 |
| US9220264B2 (en) | 2008-04-21 | 2015-12-29 | Singapore Health Services Pte Ltd. | Multimeric forms of antimicrobial peptides |
| US8809262B2 (en) | 2008-04-21 | 2014-08-19 | Singapore Health Service Pte Ltd. | Multimeric forms of antimicrobial peptides |
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| US9238715B2 (en) | 2010-05-27 | 2016-01-19 | Nanyang Technological University | Polymerizable composition for ophthalmic and medical use and antimicrobial composition obtained by polymerizing the polymerizable composition |
| JP2011245053A (ja) * | 2010-05-27 | 2011-12-08 | Nanyang Technological Univ | 眼用及び医療用の重合性組成物及びそれを重合して得られる抗菌性組成物 |
| WO2011149058A1 (ja) * | 2010-05-27 | 2011-12-01 | ナンヤン テクノロジカル ユニヴァーシティー | 眼用及び医療用の重合性組成物及びそれを重合して得られる抗菌性組成物 |
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| JP2015534106A (ja) * | 2012-08-27 | 2015-11-26 | オキュラー ダイナミクス リミテッド ライアビリティ カンパニー | 親水性層を有するコンタクトレンズ |
| US12449674B2 (en) | 2012-08-27 | 2025-10-21 | Tangible Science, Inc. | Contact lens with a hydrophilic layer |
| JP2018022174A (ja) * | 2012-08-27 | 2018-02-08 | タンジブル サイエンス リミテッド ライアビリティ カンパニー | 親水性層を有するコンタクトレンズ |
| US11181754B2 (en) | 2012-08-27 | 2021-11-23 | Tangible Science, Llc | Contact lens with a hydrophilic layer |
| US11433628B2 (en) | 2013-11-15 | 2022-09-06 | Tangible Science, Inc. | Contact lens with a hydrophilic layer |
| US10330951B2 (en) | 2013-11-15 | 2019-06-25 | Tangible Science, Llc | Contact lens with a hydrophilic layer |
| US10525170B2 (en) | 2014-12-09 | 2020-01-07 | Tangible Science, Llc | Medical device coating with a biocompatible layer |
| US11260150B2 (en) | 2014-12-09 | 2022-03-01 | Tangible Science, Inc. | Medical device coating with a biocompatible layer |
| JP2015077452A (ja) * | 2014-12-25 | 2015-04-23 | ナンヤン テクノロジカル ユニヴァーシティー | 眼用及び医療用の重合性組成物及びそれを重合して得られる抗菌性組成物 |
| JP2018529123A (ja) * | 2015-09-04 | 2018-10-04 | ノバルティス アーゲー | その上に耐久性潤滑性コーティングを有するコンタクトレンズを製造するための方法 |
| JP2017094201A (ja) * | 2017-02-06 | 2017-06-01 | ナンヤン テクノロジカル ユニヴァーシティー | 眼用及び医療用の重合性組成物及びそれを重合して得られる抗菌性組成物 |
| KR20250056278A (ko) * | 2023-10-17 | 2025-04-28 | 충남대학교산학협력단 | 카르복시메틸 키토산-카테콜 접합체를 포함하는 항미생물 코팅용 조성물, 이의 제조방법, 이를 이용한 항미생물 코팅 및 이의 응용 |
| KR102921890B1 (ko) * | 2023-10-17 | 2026-02-05 | 충남대학교산학협력단 | 카르복시메틸 키토산-카테콜 접합체를 포함하는 항미생물 코팅용 조성물, 이의 제조방법, 이를 이용한 항미생물 코팅 및 이의 응용 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60310611D1 (de) | 2007-02-01 |
| US8172395B2 (en) | 2012-05-08 |
| DE60310611T2 (de) | 2007-10-25 |
| US20040135967A1 (en) | 2004-07-15 |
| WO2004050132A3 (en) | 2004-10-14 |
| AU2003298164A8 (en) | 2004-06-23 |
| WO2004050132A2 (en) | 2004-06-17 |
| CA2504259A1 (en) | 2004-06-17 |
| EP1569700A2 (en) | 2005-09-07 |
| EP1569700B1 (en) | 2006-12-20 |
| ATE348640T1 (de) | 2007-01-15 |
| AU2003298164A1 (en) | 2004-06-23 |
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