JP2006508036A5 - - Google Patents
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- Publication number
- JP2006508036A5 JP2006508036A5 JP2004512756A JP2004512756A JP2006508036A5 JP 2006508036 A5 JP2006508036 A5 JP 2006508036A5 JP 2004512756 A JP2004512756 A JP 2004512756A JP 2004512756 A JP2004512756 A JP 2004512756A JP 2006508036 A5 JP2006508036 A5 JP 2006508036A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- independently selected
- haloalkyl
- alkyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45371102P | 2002-06-12 | 2002-06-12 | |
| US60/453,711 | 2002-06-12 | ||
| PCT/US2003/018660 WO2003105853A1 (en) | 2002-06-12 | 2003-06-11 | 1-aryl-4-substituted piperazines derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006508036A JP2006508036A (ja) | 2006-03-09 |
| JP2006508036A5 true JP2006508036A5 (cg-RX-API-DMAC7.html) | 2006-08-03 |
| JP4723242B2 JP4723242B2 (ja) | 2011-07-13 |
Family
ID=29736828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004512756A Expired - Lifetime JP4723242B2 (ja) | 2002-06-12 | 2003-06-11 | 炎症および免疫障害治療用ｃｃｒ１アンタゴニストとして使用するための１−アリール−４−置換ピペラジン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7157464B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1531822B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4723242B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101255356B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1867336B (cg-RX-API-DMAC7.html) |
| AT (1) | ATE438401T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003236500B9 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2488202C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60328690D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1531822T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2329356T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA04012393A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003105853A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (66)
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| SI1906965T1 (sl) * | 2005-06-22 | 2015-09-30 | Chemocentryx, Inc. | Azaindolne spojine in postopki uporabe |
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| EP2563787B1 (en) | 2010-04-30 | 2014-11-26 | Boehringer Ingelheim International GmbH | Azaindazole amide compounds as ccr1 receptor antagonists |
| JP5684406B2 (ja) | 2010-12-23 | 2015-03-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１受容体アンタゴニストとしてのピラゾロピペリジン化合物 |
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| US8741892B2 (en) | 2011-12-05 | 2014-06-03 | Boehringer Ingelheim International Gmbh | Compounds |
| US8642774B2 (en) | 2011-12-08 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Compounds |
| US8846948B2 (en) | 2011-12-13 | 2014-09-30 | Boehringer Ingelheim International Gmbh | Compounds |
| US8796467B2 (en) | 2011-12-13 | 2014-08-05 | Boehringer Ingelheim International Gmbh | Compounds |
| US8716277B2 (en) | 2011-12-14 | 2014-05-06 | Boehringer Ingelheim International Gmbh | Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity |
| US8883789B2 (en) | 2011-12-14 | 2014-11-11 | Boehringer Ingelheim International Gmbh | Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors |
| US8937176B2 (en) | 2011-12-14 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Compounds |
| US8889677B2 (en) | 2012-01-17 | 2014-11-18 | Boehringer Ingellheim International GmbH | Substituted triazoles useful as mGlu5 receptor modulators |
| KR102295416B1 (ko) | 2013-07-22 | 2021-08-30 | 이도르시아 파마슈티컬스 리미티드 | 1-(피페라진-1-일)-2-([1,2,4]트리아졸-1-일)-에타논 유도체 |
| AR099789A1 (es) | 2014-03-24 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| SI3245203T1 (sl) | 2015-01-15 | 2019-03-29 | Idorsia Pharmaceuticals Ltd | Derivati hiroksialkil-piperazina kot modulatorji receptorja CXCR3 |
| SG11201811023UA (en) * | 2016-06-23 | 2019-01-30 | St Jude Childrens Res Hospital | Small molecule modulators of pantothenate kinases |
| IL275658B2 (en) | 2017-12-27 | 2024-04-01 | St Jude Childrens Res Hospital Inc | Small molecule modulators of pantothenate kinases |
| WO2019133632A1 (en) | 2017-12-27 | 2019-07-04 | St. Jude Children's Research Hospital | Methods of treating disorders associated with castor |
| CN114206338B (zh) | 2019-07-10 | 2025-12-12 | 凯莫森特里克斯股份有限公司 | 作为pd-l1抑制剂的二氢化茚类 |
| WO2021039961A1 (ja) * | 2019-08-30 | 2021-03-04 | 大日本住友製薬株式会社 | 縮環ピラゾール誘導体 |
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2003
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- 2003-06-11 AT AT03737057T patent/ATE438401T1/de active
- 2003-06-11 JP JP2004512756A patent/JP4723242B2/ja not_active Expired - Lifetime
- 2003-06-11 ES ES03737057T patent/ES2329356T3/es not_active Expired - Lifetime
- 2003-06-11 CN CN038193027A patent/CN1867336B/zh not_active Expired - Fee Related
- 2003-06-11 DE DE60328690T patent/DE60328690D1/de not_active Expired - Lifetime
- 2003-06-11 DK DK03737057T patent/DK1531822T3/da active
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- 2003-06-11 MX MXPA04012393A patent/MXPA04012393A/es active IP Right Grant
- 2003-06-11 WO PCT/US2003/018660 patent/WO2003105853A1/en not_active Ceased
- 2003-06-11 KR KR1020047020177A patent/KR101255356B1/ko not_active Expired - Fee Related
- 2003-06-11 US US10/460,752 patent/US7157464B2/en not_active Expired - Lifetime
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2006
- 2006-07-21 US US11/491,540 patent/US7449576B1/en not_active Expired - Lifetime