JP2006507285A5 - - Google Patents
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- Publication number
- JP2006507285A5 JP2006507285A5 JP2004547149A JP2004547149A JP2006507285A5 JP 2006507285 A5 JP2006507285 A5 JP 2006507285A5 JP 2004547149 A JP2004547149 A JP 2004547149A JP 2004547149 A JP2004547149 A JP 2004547149A JP 2006507285 A5 JP2006507285 A5 JP 2006507285A5
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- hydroquinone
- weight
- pharmaceutical composition
- mixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 36
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims 34
- 239000000203 mixture Substances 0.000 claims 28
- 229960004337 hydroquinone Drugs 0.000 claims 17
- 238000002156 mixing Methods 0.000 claims 13
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical class OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 12
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 claims 12
- 239000004480 active ingredient Substances 0.000 claims 11
- 239000003995 emulsifying agent Substances 0.000 claims 11
- 229960001347 fluocinolone acetonide Drugs 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 229960001727 tretinoin Drugs 0.000 claims 11
- 239000008346 aqueous phase Substances 0.000 claims 10
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 10
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 10
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 10
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 230000002209 hydrophobic effect Effects 0.000 claims 8
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical group CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 7
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims 7
- 239000002202 Polyethylene glycol Substances 0.000 claims 7
- 229940075529 glyceryl stearate Drugs 0.000 claims 7
- 229940100242 glycol stearate Drugs 0.000 claims 7
- 229920001223 polyethylene glycol Polymers 0.000 claims 7
- 150000002433 hydrophilic molecules Chemical class 0.000 claims 6
- 235000021355 Stearic acid Nutrition 0.000 claims 5
- 229960000541 cetyl alcohol Drugs 0.000 claims 5
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 5
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 5
- 229960002216 methylparaben Drugs 0.000 claims 5
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 5
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 5
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 5
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 5
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 5
- 229960003415 propylparaben Drugs 0.000 claims 5
- 239000008117 stearic acid Substances 0.000 claims 5
- 239000000839 emulsion Substances 0.000 claims 4
- 235000011187 glycerol Nutrition 0.000 claims 4
- 229960005150 glycerol Drugs 0.000 claims 4
- 239000012071 phase Substances 0.000 claims 4
- 229920000059 polyethylene glycol stearate Polymers 0.000 claims 4
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims 4
- 229940001584 sodium metabisulfite Drugs 0.000 claims 4
- 235000010262 sodium metabisulphite Nutrition 0.000 claims 4
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 3
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 3
- NWGKJDSIEKMTRX-BFWOXRRGSA-N [(2r)-2-[(3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-BFWOXRRGSA-N 0.000 claims 3
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims 3
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 3
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 238000003756 stirring Methods 0.000 claims 3
- 230000000699 topical effect Effects 0.000 claims 3
- 239000012455 biphasic mixture Substances 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- 239000007854 depigmenting agent Substances 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- 239000003410 keratolytic agent Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- -1 methyl gluces Chemical compound 0.000 claims 2
- 229960004274 stearic acid Drugs 0.000 claims 2
- 229940012831 stearyl alcohol Drugs 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 2
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 claims 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 claims 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 229960002537 betamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims 1
- 229960002842 clobetasol Drugs 0.000 claims 1
- CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 claims 1
- 229960004544 cortisone Drugs 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229940043075 fluocinolone Drugs 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 1
- 229960002751 imiquimod Drugs 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical group C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims 1
- 229960000990 monobenzone Drugs 0.000 claims 1
- 229960005205 prednisolone Drugs 0.000 claims 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 1
- 229960004618 prednisone Drugs 0.000 claims 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/280,483 US7544674B2 (en) | 2002-10-25 | 2002-10-25 | Topical skin care composition |
| PCT/US2003/033876 WO2004037201A2 (en) | 2002-10-25 | 2003-10-24 | Topical skin care composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010221381A Division JP5528973B2 (ja) | 2002-10-25 | 2010-09-30 | 局所スキンケア組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006507285A JP2006507285A (ja) | 2006-03-02 |
| JP2006507285A5 true JP2006507285A5 (enExample) | 2006-12-14 |
| JP4638234B2 JP4638234B2 (ja) | 2011-02-23 |
Family
ID=32106953
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004547149A Expired - Lifetime JP4638234B2 (ja) | 2002-10-25 | 2003-10-24 | 局所スキンケア組成物 |
| JP2010221381A Expired - Fee Related JP5528973B2 (ja) | 2002-10-25 | 2010-09-30 | 局所スキンケア組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010221381A Expired - Fee Related JP5528973B2 (ja) | 2002-10-25 | 2010-09-30 | 局所スキンケア組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (8) | US7544674B2 (enExample) |
| EP (2) | EP1562531B1 (enExample) |
| JP (2) | JP4638234B2 (enExample) |
| KR (2) | KR100852367B1 (enExample) |
| CN (1) | CN1738587B (enExample) |
| AU (1) | AU2003284353B9 (enExample) |
| BR (1) | BRPI0314882B8 (enExample) |
| CA (1) | CA2503539A1 (enExample) |
| CY (1) | CY1117292T1 (enExample) |
| DK (1) | DK1562531T3 (enExample) |
| ES (1) | ES2565317T3 (enExample) |
| HK (1) | HK1223040A1 (enExample) |
| HU (1) | HUE028549T2 (enExample) |
| MX (1) | MXPA05004404A (enExample) |
| PL (1) | PL219020B1 (enExample) |
| PT (1) | PT1562531E (enExample) |
| RU (1) | RU2350313C2 (enExample) |
| SI (1) | SI1562531T1 (enExample) |
| WO (1) | WO2004037201A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7544674B2 (en) * | 2002-10-25 | 2009-06-09 | Galderma S.A. | Topical skin care composition |
| US20060099173A1 (en) * | 2003-10-24 | 2006-05-11 | Nancy Puglia | Topical skin care composition |
| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| US8449867B2 (en) | 2004-08-31 | 2013-05-28 | Stiefel Research Australia Pty Ltd | Microemulsion and sub-micron emulsion process and compositions |
| RU2381023C2 (ru) | 2004-08-31 | 2010-02-10 | Стифель Ресёрч Австралия Пти Лтд | Способ получения микроэмульсий и субмикронных эмульсий и композиции на их основе |
| US8080560B2 (en) | 2004-12-17 | 2011-12-20 | 3M Innovative Properties Company | Immune response modifier formulations containing oleic acid and methods |
| FR2894474B1 (fr) * | 2005-12-12 | 2008-04-11 | Galderma Res & Dev | Gel depigmentant hydroalcoolique |
| FR2894482A1 (fr) * | 2005-12-14 | 2007-06-15 | Galderma Sa | Utilisation d'une composition comprenant une association d'hydroquinone,d'acetonide de fluocinolone et de tretinoine, dans le traitement d'l'hyperpigmentation de la peau suite au psoriasis ou a l'eczema |
| FR2894481A1 (fr) * | 2005-12-14 | 2007-06-15 | Galderma Sa | Utilisation d'une composition dermatologique comprenant une association d'hydroquinone, d'acetonide de fluocinolone et de tretinoine, destinee au traitement de l'hyperpigmentation des peaux non caucasiennes |
| FR2894479A1 (fr) * | 2005-12-14 | 2007-06-15 | Galderma Sa | Utilisation d'une composition a base de tretinoine, d'hydroquinone et d'acetonide de fluocinolone, en accompagnement d'un peeling chimique |
| US20070166273A1 (en) * | 2006-01-19 | 2007-07-19 | Krivulka Joseph J | Skin treatment educational kit |
| FR2900340B1 (fr) * | 2006-04-28 | 2010-07-30 | Galderma Sa | Utilisation d'une composition dermatologique comprenant une association d'hydroquinone, d'acetonide de fluocinolone et de tretinoine dans le traitement de l'hyperpigmentation de cicatrices |
| FR2901134B1 (fr) * | 2006-05-19 | 2008-10-03 | Galderma Sa | Utilisation d'une composition comprenant une association d'hydroquinone, d'acetonide de fluocinolone, et de tretinoine, destinee au traitement des signes cutanes du photovieillissement |
| CA2678733A1 (en) * | 2007-02-26 | 2008-09-04 | Galderma Research & Development | Topical composition comprising fluocinolone acetonide for use in depigmentation of the skin |
| KR100905132B1 (ko) | 2007-08-21 | 2009-06-29 | 강효신 | 젤 로션 제조 방법 |
| CN101249095B (zh) * | 2007-10-08 | 2011-08-31 | 重庆医药工业研究院有限责任公司 | 一种含脱色剂、维a酸和皮质类固醇的乳膏的制备方法 |
| PH12013500784A1 (en) | 2010-10-21 | 2019-07-17 | Cadila Healthcare Ltd | Pharmaceutical compositions comprising nano size droplets of skin whitening agents |
| US11957753B2 (en) | 2010-11-22 | 2024-04-16 | Bausch Health Ireland Limited | Pharmaceutical formulations containing corticosteroids for topical administration |
| US8809307B2 (en) | 2010-11-22 | 2014-08-19 | Dow Pharmaceutical Sciences, Inc. | Pharmaceutical formulations containing corticosteroids for topical administration |
| RU2450836C1 (ru) * | 2011-03-15 | 2012-05-20 | Закрытое акционерное общество Фармацевтическое научно-производственное предприятие "Ретиноиды" | Комбинированная мазевая композиция для уменьшения интенсивности локальной гиперпигментации кожи |
| EP3865120B1 (en) | 2013-07-19 | 2025-06-25 | Boehringer Ingelheim Vetmedica GmbH | Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition |
| JPWO2015053401A1 (ja) * | 2013-10-10 | 2017-03-09 | 淳 岡部 | クリーム状化粧料、及び、その製造方法 |
| WO2015082389A1 (en) | 2013-12-04 | 2015-06-11 | Boehringer Ingelheim Vetmedica Gmbh | Improved pharmaceutical compositions of pimobendan |
| KR101661694B1 (ko) * | 2014-07-29 | 2016-10-10 | 동아제약 주식회사 | 히드로퀴논을 포함하는 저자극성 피부 미백용 조성물 |
| AU2015371308A1 (en) | 2014-12-23 | 2017-08-03 | Intellectual Property Associates, Llc | Methods and formulations for transdermal administration |
| CN108282998B (zh) | 2015-06-18 | 2021-07-06 | 凡利亚药品北美公司 | 用于治疗银屑病的包含皮质类固醇和类视黄醇的局部组合物 |
| US11311482B2 (en) | 2017-05-12 | 2022-04-26 | Bausch Health Us, Llc | Topical compositions and methods for treating skin diseases |
| US12233073B2 (en) | 2017-06-09 | 2025-02-25 | Regents Of The University Of Minnesota | Skin care formulations and skin cancer treatment |
| EP3456314A1 (en) * | 2017-09-14 | 2019-03-20 | Tiofarma B.V. | Topical formulation comprising 17-ketolic corticosteroid |
| JP2020534285A (ja) | 2017-09-15 | 2020-11-26 | アンパサンド バイオファーマシューティカルズ インコーポレイテッドＡｍｐｅｒｓａｎｄ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 投与および処置の方法 |
| JP7262227B2 (ja) * | 2017-10-23 | 2023-04-21 | マルホ株式会社 | 被膜形成外用剤 |
| EP3586849A1 (en) * | 2018-06-29 | 2020-01-01 | Aprofol AG | Folate preparations |
| JP7623004B2 (ja) | 2018-11-02 | 2025-01-28 | ジョンソン アンド ジョンソン コンシューマー インク． | 発泡性固体クレンザー |
| CN110025493A (zh) * | 2019-03-01 | 2019-07-19 | 浙江孚诺医药股份有限公司 | 一种不含防腐剂的局部皮肤护理组合物及其制备工艺 |
| CN110559257A (zh) * | 2019-09-19 | 2019-12-13 | 湖北科益药业股份有限公司 | 一种咪喹莫特泡囊凝胶剂及其制备方法 |
| CN112022806B (zh) * | 2020-04-09 | 2022-04-15 | 广东人人康药业有限公司 | 一种油包水型的氢醌乳剂及其制备方法和其应用 |
| WO2022010129A1 (ko) * | 2020-07-08 | 2022-01-13 | 주식회사 엘지생활건강 | 하이드로퀴논 안정화 조성물 |
| KR102689535B1 (ko) * | 2020-10-29 | 2024-07-29 | 주식회사 엘지생활건강 | 히드로퀴논 또는 이의 유도체를 함유하는 안정화 조성물 |
| JP2022112595A (ja) * | 2021-01-22 | 2022-08-03 | 弘行 塚田 | ハイドロキノン含有皮膚外用剤および該ハイドロキノン含有皮膚外用剤の製造方法 |
| CN116196277A (zh) * | 2023-03-27 | 2023-06-02 | 广东人人康药业有限公司 | 一种三相复方氢醌乳液及其制备方法 |
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-
2002
- 2002-10-25 US US10/280,483 patent/US7544674B2/en not_active Expired - Lifetime
-
2003
- 2003-10-24 WO PCT/US2003/033876 patent/WO2004037201A2/en not_active Ceased
- 2003-10-24 EP EP03776536.9A patent/EP1562531B1/en not_active Expired - Lifetime
- 2003-10-24 RU RU2005115856/15A patent/RU2350313C2/ru active
- 2003-10-24 AU AU2003284353A patent/AU2003284353B9/en not_active Expired
- 2003-10-24 JP JP2004547149A patent/JP4638234B2/ja not_active Expired - Lifetime
- 2003-10-24 PL PL376715A patent/PL219020B1/pl unknown
- 2003-10-24 KR KR1020067007042A patent/KR100852367B1/ko not_active Expired - Lifetime
- 2003-10-24 MX MXPA05004404A patent/MXPA05004404A/es active IP Right Grant
- 2003-10-24 CN CN2003801075467A patent/CN1738587B/zh not_active Expired - Lifetime
- 2003-10-24 SI SI200332470T patent/SI1562531T1/sl unknown
- 2003-10-24 KR KR1020057007177A patent/KR100851789B1/ko not_active Expired - Lifetime
- 2003-10-24 HU HUE03776536A patent/HUE028549T2/en unknown
- 2003-10-24 DK DK03776536.9T patent/DK1562531T3/en active
- 2003-10-24 CA CA002503539A patent/CA2503539A1/en not_active Abandoned
- 2003-10-24 EP EP15189356.7A patent/EP3002004A1/en not_active Withdrawn
- 2003-10-24 ES ES03776536.9T patent/ES2565317T3/es not_active Expired - Lifetime
- 2003-10-24 PT PT37765369T patent/PT1562531E/pt unknown
- 2003-10-24 BR BRPI0314882A patent/BRPI0314882B8/pt not_active IP Right Cessation
-
2004
- 2004-12-15 US US11/011,176 patent/US7915243B2/en active Active
-
2007
- 2007-05-11 US US11/747,806 patent/US7939516B2/en not_active Expired - Lifetime
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2010
- 2010-01-22 US US12/691,993 patent/US20100125057A1/en not_active Abandoned
- 2010-09-30 JP JP2010221381A patent/JP5528973B2/ja not_active Expired - Fee Related
-
2011
- 2011-03-29 US US13/074,744 patent/US8247395B2/en not_active Expired - Fee Related
-
2012
- 2012-06-26 US US13/533,516 patent/US8653053B2/en not_active Expired - Lifetime
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2014
- 2014-01-09 US US14/151,438 patent/US9333172B2/en not_active Expired - Fee Related
-
2016
- 2016-03-11 US US15/067,919 patent/US20160193121A1/en not_active Abandoned
- 2016-03-18 CY CY20161100232T patent/CY1117292T1/el unknown
- 2016-09-29 HK HK16111416.5A patent/HK1223040A1/en unknown
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