JP2006504636A - 構造的に脆弱な薬剤のための無障害のマイクロカプセル化、及び安定水性−水性乳剤の応用 - Google Patents

構造的に脆弱な薬剤のための無障害のマイクロカプセル化、及び安定水性−水性乳剤の応用 Download PDF

Info

Publication number
JP2006504636A
JP2006504636A JP2004508943A JP2004508943A JP2006504636A JP 2006504636 A JP2006504636 A JP 2006504636A JP 2004508943 A JP2004508943 A JP 2004508943A JP 2004508943 A JP2004508943 A JP 2004508943A JP 2006504636 A JP2006504636 A JP 2006504636A
Authority
JP
Japan
Prior art keywords
aqueous
protein
polysaccharide
composition
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004508943A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006504636A5 (enExample
Inventor
ジン，ツオ
ツー，ファ
ツー，ジャハオ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2006504636A publication Critical patent/JP2006504636A/ja
Publication of JP2006504636A5 publication Critical patent/JP2006504636A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
JP2004508943A 2002-06-03 2003-06-03 構造的に脆弱な薬剤のための無障害のマイクロカプセル化、及び安定水性−水性乳剤の応用 Pending JP2006504636A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38497102P 2002-06-03 2002-06-03
US41810002P 2002-10-11 2002-10-11
US10/291,327 US6998393B2 (en) 2000-06-23 2002-11-08 Aquespheres, their preparation and uses thereof
PCT/CN2003/000431 WO2003101600A2 (en) 2002-06-03 2003-06-03 Hazard-free microencapsulation for structurally delicate agents, an application of stable aqueous-aqueous emulsion

Publications (2)

Publication Number Publication Date
JP2006504636A true JP2006504636A (ja) 2006-02-09
JP2006504636A5 JP2006504636A5 (enExample) 2006-07-20

Family

ID=27404043

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004508943A Pending JP2006504636A (ja) 2002-06-03 2003-06-03 構造的に脆弱な薬剤のための無障害のマイクロカプセル化、及び安定水性−水性乳剤の応用

Country Status (7)

Country Link
US (2) US6998393B2 (enExample)
EP (1) EP1572341A4 (enExample)
JP (1) JP2006504636A (enExample)
CN (1) CN102247327A (enExample)
AU (1) AU2003245804A1 (enExample)
CA (1) CA2487867A1 (enExample)
WO (1) WO2003101600A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011004552A1 (ja) * 2009-07-09 2011-01-13 国立大学法人九州大学 水溶性薬物キャリア及びその製造方法

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998393B2 (en) * 2000-06-23 2006-02-14 Biopharm Solutions, Inc. Aquespheres, their preparation and uses thereof
US9186322B2 (en) * 2002-08-02 2015-11-17 Insmed Incorporated Platinum aggregates and process for producing the same
US8728525B2 (en) * 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
BRPI0404983A (pt) * 2004-09-03 2006-05-02 Nanocore Biotecnologia Ltda composições imunogênicas
AU2006241145B2 (en) * 2005-04-27 2011-04-28 Baxter Healthcare S. A. Surface-modified microparticles and methods of forming and using the same
US20070015689A1 (en) * 2005-06-23 2007-01-18 Alza Corporation Complexation of metal ions with polypeptides
US8932633B2 (en) * 2005-08-29 2015-01-13 Biopharm Solutions Inc. Polysaccharide microparticles containing biological agents: their preparation and applications
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
JP2010505882A (ja) * 2006-10-06 2010-02-25 バクスター・インターナショナル・インコーポレイテッド 表面改質微粒子を含むマイクロエンカプセルならびに、その形成および使用の方法
US9475974B2 (en) * 2007-07-17 2016-10-25 Schlumberger Technology Corporation Controlling the stability of water in water emulsions
US8043999B2 (en) * 2007-07-17 2011-10-25 Schlumberger Technology Corporation Stabilizing biphasic concentrates through the addition of small amounts of high molecular weight polyelectrolytes
US8044000B2 (en) 2007-07-17 2011-10-25 Schlumberger Technology Corporation Polymer delivery in well treatment applications
US7703527B2 (en) * 2007-11-26 2010-04-27 Schlumberger Technology Corporation Aqueous two-phase emulsion gel systems for zone isolation
US7703521B2 (en) * 2008-02-19 2010-04-27 Schlumberger Technology Corporation Polymeric microspheres as degradable fluid loss additives in oilfield applications
PL2169042T3 (pl) 2008-09-30 2012-09-28 Procter & Gamble Kompozycja zawierająca mikrokapsułki
US7950459B2 (en) * 2009-01-15 2011-05-31 Schlumberger Technology Corporation Using a biphasic solution as a recyclable coiled tubing cleanout fluid
US20100179076A1 (en) * 2009-01-15 2010-07-15 Sullivan Philip F Filled Systems From Biphasic Fluids
US20100184630A1 (en) * 2009-01-16 2010-07-22 Sullivan Philip F Breaking the rheology of a wellbore fluid by creating phase separation
US20100184631A1 (en) * 2009-01-16 2010-07-22 Schlumberger Technology Corporation Provision of viscous compositions below ground
WO2010102066A1 (en) 2009-03-05 2010-09-10 Bend Research, Inc. Dextran polymer powder for inhalation administration of pharmaceuticals
EP2411137B1 (en) 2009-03-27 2016-09-07 Bend Research, Inc. Spray-drying process
US8815294B2 (en) 2010-09-03 2014-08-26 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives and a carrier material
US9084976B2 (en) 2010-09-03 2015-07-21 Bend Research, Inc. Spray-drying apparatus and methods of using the same
EP2611530B1 (en) 2010-09-03 2019-01-16 Bend Research, Inc. Spray-drying apparatus and methods of using the same
EP2618924A1 (en) 2010-09-24 2013-07-31 Bend Research, Inc. High-temperature spray drying process and apparatus
US9060938B2 (en) 2011-05-10 2015-06-23 Bend Research, Inc. Pharmaceutical compositions of active agents and cationic dextran polymer derivatives
EP2892524B1 (en) 2012-09-04 2020-11-25 Eleison Pharmaceuticals, LLC Preventing pulmonary recurrence of cancer with lipid-complexed cisplatin
CN105764491A (zh) 2013-12-09 2016-07-13 度瑞公司 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法
CA2962540A1 (en) * 2014-09-25 2016-03-31 Manu Chaudhary Stealth, targeted nanoparticles (stn) for oral drug delivery
US11364203B2 (en) 2014-10-31 2022-06-21 Bend Reserch, Inc. Process for forming active domains dispersed in a matrix
CN105509836B (zh) * 2015-12-11 2019-01-18 大连民族大学 一种脂质体包封体积的快速测定方法
CN105571673B (zh) * 2015-12-11 2019-01-18 大连民族大学 一种脂质体包封体积的测定方法
US10039801B2 (en) 2016-02-16 2018-08-07 Strongbridge Ireland Limited Pharmaceutical compositions of water soluble peptides with poor solubility in isotonic conditions and methods for their use
EP3484450A4 (en) 2016-07-18 2020-04-01 Tissuegen, Inc. METHODS AND COMPOSITIONS FOR MAINTAINING THE CONFORMATION AND STRUCTURAL INTEGRITY OF BIOMOLECULES
EP3737415A4 (en) 2018-01-12 2021-06-30 President and Fellows of Harvard College COMPOSITIONS AND PROCEDURES RELATED TO MACROPHAGE AND / OR MONOCYTE WITH ATTACHED PARTICLES
EP3979994A4 (en) * 2019-06-07 2023-08-09 President And Fellows Of Harvard College COMPOSITIONS AND METHODS FOR ERYTHROCYTES WITH ADHERED PARTICLES

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055461A1 (en) * 2000-06-23 2002-05-09 Tuo Jin Stable polymer aqueous/aqueous emulsion system and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2653255B2 (ja) * 1990-02-13 1997-09-17 武田薬品工業株式会社 長期徐放型マイクロカプセル
US5716644A (en) 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5827707A (en) 1995-06-07 1998-10-27 Neocrin Company Method for manufacturing minimal volume capsules containing biological materials
US6395302B1 (en) * 1996-11-19 2002-05-28 Octoplus B.V. Method for the preparation of microspheres which contain colloidal systems
NZ506975A (en) * 1999-01-18 2004-01-30 Lg Chemical Ltd Lipophilic microparticles containing a protein drug or antigen and formulation comprising same
US6998393B2 (en) * 2000-06-23 2006-02-14 Biopharm Solutions, Inc. Aquespheres, their preparation and uses thereof
SE0201599D0 (sv) * 2002-03-21 2002-05-30 Skyepharma Ab Microparticles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055461A1 (en) * 2000-06-23 2002-05-09 Tuo Jin Stable polymer aqueous/aqueous emulsion system and uses thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011004552A1 (ja) * 2009-07-09 2011-01-13 国立大学法人九州大学 水溶性薬物キャリア及びその製造方法
US8568745B2 (en) 2009-07-09 2013-10-29 Kyushu University, National University Corporation Water-soluble drug carrier and process for producing the same

Also Published As

Publication number Publication date
EP1572341A2 (en) 2005-09-14
US20060121121A1 (en) 2006-06-08
AU2003245804A1 (en) 2003-12-19
US20030059402A1 (en) 2003-03-27
CA2487867A1 (en) 2003-12-11
EP1572341A4 (en) 2008-11-12
AU2003245804A8 (en) 2003-12-19
WO2003101600A3 (en) 2007-12-13
CN102247327A (zh) 2011-11-23
WO2003101600A2 (en) 2003-12-11
US6998393B2 (en) 2006-02-14

Similar Documents

Publication Publication Date Title
JP2006504636A (ja) 構造的に脆弱な薬剤のための無障害のマイクロカプセル化、及び安定水性−水性乳剤の応用
ES2283394T3 (es) Kit para implantacion que contiene una fase de soporte y un disolvente.
ES2292634T3 (es) Procedimiento de transicion de fase inducida para la produccion de microparticulas que contienen agentes hidrofilos activos.
US6692770B2 (en) Starch microparticles
CN101249077A (zh) 一种可降解聚合物多孔微球的制备方法及其用途
IL163218A (en) Polymer-based preparations for prolonged release of the hormone FSH
US7087246B2 (en) Controlled release preparation of insulin and its method
CN105616385A (zh) 磷脂蛋白质微粒复合微球及其制备方法
US8932633B2 (en) Polysaccharide microparticles containing biological agents: their preparation and applications
US7105181B2 (en) Microparticles
KR101354521B1 (ko) Ｐｅｇｔ／ｐｂｔ 블럭 공중합체를 기본으로 하는 인터페론의 방출 제어형 조성물
Yuan et al. Preparation of dextran glassy particles through freezing-induced phase separation
Saez et al. Microspheres as delivery systems for the controlled release of peptides and proteins
Yeo et al. Characterization of reservoir-type microcapsules made by the solvent exchange method
KR100342746B1 (ko) 인슐린의 방출제어제제 및 그 방법
JP2004513914A (ja) 非経口的投与可能な微粒子
TW201714610A (zh) 蛋白質或肽傳遞用的可溶性微針
KR102744052B1 (ko) 리라글루티드 함유 plga 미립구의 제조방법, 이에 따라 제조된 서방출성 미립구, 및 이를 포함하는 주사제용 조성물
Babu et al. Materials for Pharmaceutical Dosage Forms: Aspects of Controlled Release Drug Delivery and Molecular Pharmaceutics
CN101115468A (zh) 用于结构易变的试剂的无副作用微囊包封技术及水相-水相乳剂的应用
Yuan et al. Microencapsulation of protein‐loaded polysaccharide particles within poly (D, L‐lactic‐co‐glycolic acid) microspheres using S/O/W: characterization and release studies
Jin et al. Granulation Approaches in Biotech Industry
WO2002039986A1 (en) Process for producing microparticles
TW200307713A (en) Stable polymer aqueous/aqueous emulsion: material, preparation, and application thereof

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060530

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060530

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100105

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100402

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100427

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100427

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100526

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100601

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110531

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110930