CN102247327A - 用于结构易变的试剂的无副作用微囊包封技术及水相-水相乳剂的应用 - Google Patents

用于结构易变的试剂的无副作用微囊包封技术及水相-水相乳剂的应用 Download PDF

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Publication number
CN102247327A
CN102247327A CN2011101074278A CN201110107427A CN102247327A CN 102247327 A CN102247327 A CN 102247327A CN 2011101074278 A CN2011101074278 A CN 2011101074278A CN 201110107427 A CN201110107427 A CN 201110107427A CN 102247327 A CN102247327 A CN 102247327A
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polysaccharide
aqueous phase
protein
polymer
emulsion
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CN2011101074278A
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Chinese (zh)
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金拓
朱桦
朱家浩
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
CN2011101074278A 2002-06-03 2003-06-03 用于结构易变的试剂的无副作用微囊包封技术及水相-水相乳剂的应用 Pending CN102247327A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US38497102P 2002-06-03 2002-06-03
US60/384,971 2002-06-03
US41810002P 2002-10-11 2002-10-11
US60/418,100 2002-10-11
US10/291,327 2002-11-08
US10/291,327 US6998393B2 (en) 2000-06-23 2002-11-08 Aquespheres, their preparation and uses thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA038128578A Division CN101115468A (zh) 2002-06-03 2003-06-03 用于结构易变的试剂的无副作用微囊包封技术及水相-水相乳剂的应用

Publications (1)

Publication Number Publication Date
CN102247327A true CN102247327A (zh) 2011-11-23

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CN2011101074278A Pending CN102247327A (zh) 2002-06-03 2003-06-03 用于结构易变的试剂的无副作用微囊包封技术及水相-水相乳剂的应用

Country Status (7)

Country Link
US (2) US6998393B2 (enExample)
EP (1) EP1572341A4 (enExample)
JP (1) JP2006504636A (enExample)
CN (1) CN102247327A (enExample)
AU (1) AU2003245804A1 (enExample)
CA (1) CA2487867A1 (enExample)
WO (1) WO2003101600A2 (enExample)

Cited By (2)

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CN105509836A (zh) * 2015-12-11 2016-04-20 大连民族大学 一种脂质体包封体积的快速测定方法
CN105571673A (zh) * 2015-12-11 2016-05-11 大连民族大学 一种脂质体包封体积的测定方法

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US9186322B2 (en) * 2002-08-02 2015-11-17 Insmed Incorporated Platinum aggregates and process for producing the same
US8728525B2 (en) * 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
BRPI0404983A (pt) * 2004-09-03 2006-05-02 Nanocore Biotecnologia Ltda composições imunogênicas
AU2006241145B2 (en) * 2005-04-27 2011-04-28 Baxter Healthcare S. A. Surface-modified microparticles and methods of forming and using the same
US20070015689A1 (en) * 2005-06-23 2007-01-18 Alza Corporation Complexation of metal ions with polypeptides
US8932633B2 (en) * 2005-08-29 2015-01-13 Biopharm Solutions Inc. Polysaccharide microparticles containing biological agents: their preparation and applications
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
JP2010505882A (ja) * 2006-10-06 2010-02-25 バクスター・インターナショナル・インコーポレイテッド 表面改質微粒子を含むマイクロエンカプセルならびに、その形成および使用の方法
US9475974B2 (en) * 2007-07-17 2016-10-25 Schlumberger Technology Corporation Controlling the stability of water in water emulsions
US8043999B2 (en) * 2007-07-17 2011-10-25 Schlumberger Technology Corporation Stabilizing biphasic concentrates through the addition of small amounts of high molecular weight polyelectrolytes
US8044000B2 (en) 2007-07-17 2011-10-25 Schlumberger Technology Corporation Polymer delivery in well treatment applications
US7703527B2 (en) * 2007-11-26 2010-04-27 Schlumberger Technology Corporation Aqueous two-phase emulsion gel systems for zone isolation
US7703521B2 (en) * 2008-02-19 2010-04-27 Schlumberger Technology Corporation Polymeric microspheres as degradable fluid loss additives in oilfield applications
PL2169042T3 (pl) 2008-09-30 2012-09-28 Procter & Gamble Kompozycja zawierająca mikrokapsułki
US7950459B2 (en) * 2009-01-15 2011-05-31 Schlumberger Technology Corporation Using a biphasic solution as a recyclable coiled tubing cleanout fluid
US20100179076A1 (en) * 2009-01-15 2010-07-15 Sullivan Philip F Filled Systems From Biphasic Fluids
US20100184630A1 (en) * 2009-01-16 2010-07-22 Sullivan Philip F Breaking the rheology of a wellbore fluid by creating phase separation
US20100184631A1 (en) * 2009-01-16 2010-07-22 Schlumberger Technology Corporation Provision of viscous compositions below ground
WO2010102066A1 (en) 2009-03-05 2010-09-10 Bend Research, Inc. Dextran polymer powder for inhalation administration of pharmaceuticals
EP2411137B1 (en) 2009-03-27 2016-09-07 Bend Research, Inc. Spray-drying process
JP5618307B2 (ja) * 2009-07-09 2014-11-05 国立大学法人九州大学 水溶性薬物キャリア及びその製造方法
US8815294B2 (en) 2010-09-03 2014-08-26 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives and a carrier material
US9084976B2 (en) 2010-09-03 2015-07-21 Bend Research, Inc. Spray-drying apparatus and methods of using the same
EP2611530B1 (en) 2010-09-03 2019-01-16 Bend Research, Inc. Spray-drying apparatus and methods of using the same
EP2618924A1 (en) 2010-09-24 2013-07-31 Bend Research, Inc. High-temperature spray drying process and apparatus
US9060938B2 (en) 2011-05-10 2015-06-23 Bend Research, Inc. Pharmaceutical compositions of active agents and cationic dextran polymer derivatives
EP2892524B1 (en) 2012-09-04 2020-11-25 Eleison Pharmaceuticals, LLC Preventing pulmonary recurrence of cancer with lipid-complexed cisplatin
CN105764491A (zh) 2013-12-09 2016-07-13 度瑞公司 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法
CA2962540A1 (en) * 2014-09-25 2016-03-31 Manu Chaudhary Stealth, targeted nanoparticles (stn) for oral drug delivery
US11364203B2 (en) 2014-10-31 2022-06-21 Bend Reserch, Inc. Process for forming active domains dispersed in a matrix
US10039801B2 (en) 2016-02-16 2018-08-07 Strongbridge Ireland Limited Pharmaceutical compositions of water soluble peptides with poor solubility in isotonic conditions and methods for their use
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105509836A (zh) * 2015-12-11 2016-04-20 大连民族大学 一种脂质体包封体积的快速测定方法
CN105571673A (zh) * 2015-12-11 2016-05-11 大连民族大学 一种脂质体包封体积的测定方法
CN105509836B (zh) * 2015-12-11 2019-01-18 大连民族大学 一种脂质体包封体积的快速测定方法
CN105571673B (zh) * 2015-12-11 2019-01-18 大连民族大学 一种脂质体包封体积的测定方法

Also Published As

Publication number Publication date
EP1572341A2 (en) 2005-09-14
US20060121121A1 (en) 2006-06-08
AU2003245804A1 (en) 2003-12-19
US20030059402A1 (en) 2003-03-27
CA2487867A1 (en) 2003-12-11
EP1572341A4 (en) 2008-11-12
AU2003245804A8 (en) 2003-12-19
JP2006504636A (ja) 2006-02-09
WO2003101600A3 (en) 2007-12-13
WO2003101600A2 (en) 2003-12-11
US6998393B2 (en) 2006-02-14

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Application publication date: 20111123