CA2487867A1 - Hazard-free microencapsulation for structurally delicate agents, an application of stable aqueous-aqueous emulsion - Google Patents
Hazard-free microencapsulation for structurally delicate agents, an application of stable aqueous-aqueous emulsion Download PDFInfo
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- CA2487867A1 CA2487867A1 CA002487867A CA2487867A CA2487867A1 CA 2487867 A1 CA2487867 A1 CA 2487867A1 CA 002487867 A CA002487867 A CA 002487867A CA 2487867 A CA2487867 A CA 2487867A CA 2487867 A1 CA2487867 A1 CA 2487867A1
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- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
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- 230000029983 protein stabilization Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
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- 238000005549 size reduction Methods 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Pulmonology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38497102P | 2002-06-03 | 2002-06-03 | |
| US60/384,971 | 2002-06-03 | ||
| US41810002P | 2002-10-11 | 2002-10-11 | |
| US60/418,100 | 2002-10-11 | ||
| US10/291,327 | 2002-11-08 | ||
| US10/291,327 US6998393B2 (en) | 2000-06-23 | 2002-11-08 | Aquespheres, their preparation and uses thereof |
| PCT/CN2003/000431 WO2003101600A2 (en) | 2002-06-03 | 2003-06-03 | Hazard-free microencapsulation for structurally delicate agents, an application of stable aqueous-aqueous emulsion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2487867A1 true CA2487867A1 (en) | 2003-12-11 |
Family
ID=27404043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002487867A Abandoned CA2487867A1 (en) | 2002-06-03 | 2003-06-03 | Hazard-free microencapsulation for structurally delicate agents, an application of stable aqueous-aqueous emulsion |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6998393B2 (enExample) |
| EP (1) | EP1572341A4 (enExample) |
| JP (1) | JP2006504636A (enExample) |
| CN (1) | CN102247327A (enExample) |
| AU (1) | AU2003245804A1 (enExample) |
| CA (1) | CA2487867A1 (enExample) |
| WO (1) | WO2003101600A2 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6998393B2 (en) * | 2000-06-23 | 2006-02-14 | Biopharm Solutions, Inc. | Aquespheres, their preparation and uses thereof |
| US9186322B2 (en) * | 2002-08-02 | 2015-11-17 | Insmed Incorporated | Platinum aggregates and process for producing the same |
| US8728525B2 (en) * | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
| BRPI0404983A (pt) * | 2004-09-03 | 2006-05-02 | Nanocore Biotecnologia Ltda | composições imunogênicas |
| AU2006241145B2 (en) * | 2005-04-27 | 2011-04-28 | Baxter Healthcare S. A. | Surface-modified microparticles and methods of forming and using the same |
| US20070015689A1 (en) * | 2005-06-23 | 2007-01-18 | Alza Corporation | Complexation of metal ions with polypeptides |
| US8932633B2 (en) * | 2005-08-29 | 2015-01-13 | Biopharm Solutions Inc. | Polysaccharide microparticles containing biological agents: their preparation and applications |
| US9107824B2 (en) | 2005-11-08 | 2015-08-18 | Insmed Incorporated | Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally |
| JP2010505882A (ja) * | 2006-10-06 | 2010-02-25 | バクスター・インターナショナル・インコーポレイテッド | 表面改質微粒子を含むマイクロエンカプセルならびに、その形成および使用の方法 |
| US9475974B2 (en) * | 2007-07-17 | 2016-10-25 | Schlumberger Technology Corporation | Controlling the stability of water in water emulsions |
| US8043999B2 (en) * | 2007-07-17 | 2011-10-25 | Schlumberger Technology Corporation | Stabilizing biphasic concentrates through the addition of small amounts of high molecular weight polyelectrolytes |
| US8044000B2 (en) | 2007-07-17 | 2011-10-25 | Schlumberger Technology Corporation | Polymer delivery in well treatment applications |
| US7703527B2 (en) * | 2007-11-26 | 2010-04-27 | Schlumberger Technology Corporation | Aqueous two-phase emulsion gel systems for zone isolation |
| US7703521B2 (en) * | 2008-02-19 | 2010-04-27 | Schlumberger Technology Corporation | Polymeric microspheres as degradable fluid loss additives in oilfield applications |
| PL2169042T3 (pl) | 2008-09-30 | 2012-09-28 | Procter & Gamble | Kompozycja zawierająca mikrokapsułki |
| US7950459B2 (en) * | 2009-01-15 | 2011-05-31 | Schlumberger Technology Corporation | Using a biphasic solution as a recyclable coiled tubing cleanout fluid |
| US20100179076A1 (en) * | 2009-01-15 | 2010-07-15 | Sullivan Philip F | Filled Systems From Biphasic Fluids |
| US20100184630A1 (en) * | 2009-01-16 | 2010-07-22 | Sullivan Philip F | Breaking the rheology of a wellbore fluid by creating phase separation |
| US20100184631A1 (en) * | 2009-01-16 | 2010-07-22 | Schlumberger Technology Corporation | Provision of viscous compositions below ground |
| WO2010102066A1 (en) | 2009-03-05 | 2010-09-10 | Bend Research, Inc. | Dextran polymer powder for inhalation administration of pharmaceuticals |
| EP2411137B1 (en) | 2009-03-27 | 2016-09-07 | Bend Research, Inc. | Spray-drying process |
| JP5618307B2 (ja) * | 2009-07-09 | 2014-11-05 | 国立大学法人九州大学 | 水溶性薬物キャリア及びその製造方法 |
| US8815294B2 (en) | 2010-09-03 | 2014-08-26 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives and a carrier material |
| US9084976B2 (en) | 2010-09-03 | 2015-07-21 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
| EP2611530B1 (en) | 2010-09-03 | 2019-01-16 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
| EP2618924A1 (en) | 2010-09-24 | 2013-07-31 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
| US9060938B2 (en) | 2011-05-10 | 2015-06-23 | Bend Research, Inc. | Pharmaceutical compositions of active agents and cationic dextran polymer derivatives |
| EP2892524B1 (en) | 2012-09-04 | 2020-11-25 | Eleison Pharmaceuticals, LLC | Preventing pulmonary recurrence of cancer with lipid-complexed cisplatin |
| CN105764491A (zh) | 2013-12-09 | 2016-07-13 | 度瑞公司 | 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法 |
| CA2962540A1 (en) * | 2014-09-25 | 2016-03-31 | Manu Chaudhary | Stealth, targeted nanoparticles (stn) for oral drug delivery |
| US11364203B2 (en) | 2014-10-31 | 2022-06-21 | Bend Reserch, Inc. | Process for forming active domains dispersed in a matrix |
| CN105509836B (zh) * | 2015-12-11 | 2019-01-18 | 大连民族大学 | 一种脂质体包封体积的快速测定方法 |
| CN105571673B (zh) * | 2015-12-11 | 2019-01-18 | 大连民族大学 | 一种脂质体包封体积的测定方法 |
| US10039801B2 (en) | 2016-02-16 | 2018-08-07 | Strongbridge Ireland Limited | Pharmaceutical compositions of water soluble peptides with poor solubility in isotonic conditions and methods for their use |
| EP3484450A4 (en) | 2016-07-18 | 2020-04-01 | Tissuegen, Inc. | METHODS AND COMPOSITIONS FOR MAINTAINING THE CONFORMATION AND STRUCTURAL INTEGRITY OF BIOMOLECULES |
| EP3737415A4 (en) | 2018-01-12 | 2021-06-30 | President and Fellows of Harvard College | COMPOSITIONS AND PROCEDURES RELATED TO MACROPHAGE AND / OR MONOCYTE WITH ATTACHED PARTICLES |
| EP3979994A4 (en) * | 2019-06-07 | 2023-08-09 | President And Fellows Of Harvard College | COMPOSITIONS AND METHODS FOR ERYTHROCYTES WITH ADHERED PARTICLES |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2653255B2 (ja) * | 1990-02-13 | 1997-09-17 | 武田薬品工業株式会社 | 長期徐放型マイクロカプセル |
| US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5827707A (en) | 1995-06-07 | 1998-10-27 | Neocrin Company | Method for manufacturing minimal volume capsules containing biological materials |
| US6395302B1 (en) * | 1996-11-19 | 2002-05-28 | Octoplus B.V. | Method for the preparation of microspheres which contain colloidal systems |
| NZ506975A (en) * | 1999-01-18 | 2004-01-30 | Lg Chemical Ltd | Lipophilic microparticles containing a protein drug or antigen and formulation comprising same |
| US6805879B2 (en) * | 2000-06-23 | 2004-10-19 | Biopharm Solutions Inc. | Stable polymer aqueous/aqueous emulsion system and uses thereof |
| US6998393B2 (en) * | 2000-06-23 | 2006-02-14 | Biopharm Solutions, Inc. | Aquespheres, their preparation and uses thereof |
| SE0201599D0 (sv) * | 2002-03-21 | 2002-05-30 | Skyepharma Ab | Microparticles |
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2002
- 2002-11-08 US US10/291,327 patent/US6998393B2/en not_active Expired - Fee Related
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2003
- 2003-06-03 US US10/517,122 patent/US20060121121A1/en not_active Abandoned
- 2003-06-03 CA CA002487867A patent/CA2487867A1/en not_active Abandoned
- 2003-06-03 WO PCT/CN2003/000431 patent/WO2003101600A2/en not_active Ceased
- 2003-06-03 JP JP2004508943A patent/JP2006504636A/ja active Pending
- 2003-06-03 AU AU2003245804A patent/AU2003245804A1/en not_active Abandoned
- 2003-06-03 EP EP03737838A patent/EP1572341A4/en not_active Withdrawn
- 2003-06-03 CN CN2011101074278A patent/CN102247327A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1572341A2 (en) | 2005-09-14 |
| US20060121121A1 (en) | 2006-06-08 |
| AU2003245804A1 (en) | 2003-12-19 |
| US20030059402A1 (en) | 2003-03-27 |
| EP1572341A4 (en) | 2008-11-12 |
| AU2003245804A8 (en) | 2003-12-19 |
| JP2006504636A (ja) | 2006-02-09 |
| WO2003101600A3 (en) | 2007-12-13 |
| CN102247327A (zh) | 2011-11-23 |
| WO2003101600A2 (en) | 2003-12-11 |
| US6998393B2 (en) | 2006-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDC | Discontinued application reinstated | ||
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130218 |