JP2006501246A - 神経変性疾患の治療において有用なアナバセイン誘導体 - Google Patents

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Publication number

JP2006501246A

JP2006501246A JP2004531954A JP2004531954A JP2006501246A JP 2006501246 A JP2006501246 A JP 2006501246A JP 2004531954 A JP2004531954 A JP 2004531954A JP 2004531954 A JP2004531954 A JP 2004531954A JP 2006501246 A JP2006501246 A JP 2006501246A

Authority

JP

Japan

Prior art keywords

bipyridinyl

tetrahydro

ylmethylene

carbon atoms

alkyl

Prior art date

2002-08-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 208000015122 neurodegenerative disease Diseases 0.000 title claims description 13
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• 230000004770 neurodegeneration Effects 0.000 title description 9
• 150000001875 compounds Chemical class 0.000 claims abstract description 148
• 239000000126 substance Substances 0.000 claims abstract description 10
• -1 cyano, hydroxyl Chemical group 0.000 claims description 844
• VEKIYFGCEAJDDT-UHFFFAOYSA-N 2-pyridin-3-ylpyridine Chemical group N1=CC=CC=C1C1=CC=CN=C1 VEKIYFGCEAJDDT-UHFFFAOYSA-N 0.000 claims description 771
• 125000004432 carbon atom Chemical group C* 0.000 claims description 406
• 125000000217 alkyl group Chemical group 0.000 claims description 157
• 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 144
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• 229910052736 halogen Inorganic materials 0.000 claims description 117
• 150000002367 halogens Chemical class 0.000 claims description 113
• 238000000034 method Methods 0.000 claims description 112
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 83
• 125000004043 oxo group Chemical group O=* 0.000 claims description 82
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 78
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 76
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 68
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 66
• 125000004663 dialkyl amino group Chemical group 0.000 claims description 62
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 58
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• 125000003118 aryl group Chemical group 0.000 claims description 57
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• 229920006395 saturated elastomer Polymers 0.000 claims description 33
• UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical compound CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 claims description 32
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• 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 7
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• VFWZSSRYGCTVFB-UHFFFAOYSA-N phenyl-[5-[(6-pyridin-3-yl-3,4-dihydro-2h-pyridin-5-ylidene)methyl]-1-benzofuran-2-yl]methanone Chemical compound C=1C=CC=CC=1C(=O)C(OC1=CC=2)=CC1=CC=2C=C1CCCN=C1C1=CC=CN=C1 VFWZSSRYGCTVFB-UHFFFAOYSA-N 0.000 claims description 7
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