JP2006500437A - 薬物送達 - Google Patents

薬物送達 Download PDF

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Publication number
JP2006500437A
JP2006500437A JP2004537295A JP2004537295A JP2006500437A JP 2006500437 A JP2006500437 A JP 2006500437A JP 2004537295 A JP2004537295 A JP 2004537295A JP 2004537295 A JP2004537295 A JP 2004537295A JP 2006500437 A JP2006500437 A JP 2006500437A
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JP
Japan
Prior art keywords
polyethyleneimine polymer
polyethyleneimine
polymer according
linear
halide
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Pending
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JP2004537295A
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English (en)
Japanese (ja)
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JP2006500437A5 (enExample
Inventor
アイジェオマ・ウチェグブ
アンドレアス・シャッツライン
ウォエイ・ピン・チェン
Original Assignee
ザ・ユニバーシティ・オブ・ストラスクライド
ザ・ユニヴァーシティ・コート・オブ・ザ・ユニヴァーシティ・オブ・グラスゴー
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Application filed by ザ・ユニバーシティ・オブ・ストラスクライド, ザ・ユニヴァーシティ・コート・オブ・ザ・ユニヴァーシティ・オブ・グラスゴー filed Critical ザ・ユニバーシティ・オブ・ストラスクライド
Publication of JP2006500437A publication Critical patent/JP2006500437A/ja
Publication of JP2006500437A5 publication Critical patent/JP2006500437A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • C08G73/0226—Quaternisation of polyalkylene(poly)amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2004537295A 2002-09-20 2003-09-22 薬物送達 Pending JP2006500437A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0221942.6A GB0221942D0 (en) 2002-09-20 2002-09-20 Drug delivery
PCT/GB2003/004036 WO2004026941A1 (en) 2002-09-20 2003-09-22 Drug delivery

Publications (2)

Publication Number Publication Date
JP2006500437A true JP2006500437A (ja) 2006-01-05
JP2006500437A5 JP2006500437A5 (enExample) 2006-11-02

Family

ID=9944516

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004537295A Pending JP2006500437A (ja) 2002-09-20 2003-09-22 薬物送達

Country Status (11)

Country Link
US (1) US20060148982A1 (enExample)
EP (1) EP1543063B1 (enExample)
JP (1) JP2006500437A (enExample)
AT (1) ATE426635T1 (enExample)
AU (1) AU2003267581A1 (enExample)
CA (1) CA2499681A1 (enExample)
DE (1) DE60326859D1 (enExample)
DK (1) DK1543063T3 (enExample)
GB (1) GB0221942D0 (enExample)
SI (1) SI1543063T1 (enExample)
WO (1) WO2004026941A1 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008519128A (ja) * 2004-11-03 2008-06-05 エクスプレッション・ジェネティックス・インコーポレーテッド 遺伝子送達用の生分解性架橋カチオン性マルチブロックコポリマーおよびそれを製造する方法
JP2009524719A (ja) * 2006-01-27 2009-07-02 チバ ホールディング インコーポレーテッド ポリマー状抗菌剤
JP2010513644A (ja) * 2006-12-22 2010-04-30 ビーエーエスエフ ソシエタス・ヨーロピア 移染防止剤としての疎水性に変性されたポリアルキレンイミン
JP2010533710A (ja) * 2007-07-19 2010-10-28 オールエクセル，インコーポレイティド 抗癌剤としての自己集合性の両親媒性ポリマー
JP2015535292A (ja) * 2012-11-05 2015-12-10 サーモディクス，インコーポレイテッド 疎水性生理活性物質を送達するための組成物および方法
US10213528B2 (en) 2011-05-20 2019-02-26 Surmodics, Inc. Delivery of hydrophobic active agent particles
US12226552B2 (en) 2019-09-30 2025-02-18 Surmodics, Inc. Active agent depots formed in situ

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0422877D0 (en) * 2004-10-14 2004-11-17 Univ Glasgow Bioactive polymers
WO2007084126A1 (en) 2006-01-19 2007-07-26 Allexcel, Inc. Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers
EP2500015A1 (en) * 2006-12-05 2012-09-19 Landec Corporation Delivery of drugs
US20090263346A1 (en) * 2006-12-05 2009-10-22 David Taft Systems and methods for delivery of drugs
US20090246155A1 (en) * 2006-12-05 2009-10-01 Landec Corporation Compositions and methods for personal care
US20100004124A1 (en) * 2006-12-05 2010-01-07 David Taft Systems and methods for delivery of materials for agriculture and aquaculture
US8399007B2 (en) * 2006-12-05 2013-03-19 Landec Corporation Method for formulating a controlled-release pharmaceutical formulation
US8114883B2 (en) * 2007-12-04 2012-02-14 Landec Corporation Polymer formulations for delivery of bioactive materials
FR2928373B1 (fr) 2008-03-05 2010-12-31 Centre Nat Rech Scient Polymere derive de la polyethylenimine lineaire pour le transfert de gene.
GB0903559D0 (en) 2009-03-02 2009-04-08 Univ London Pharmacy Oral delivery of hydrophilic drugs to the brain
MX342897B (es) 2009-04-28 2016-10-18 Surmodics Inc Dispositivos y metodos para suministrar agentes bioactivos.
GB0915449D0 (en) 2009-09-04 2009-10-07 Univ Robert Gordon Composition
CA2797709C (en) 2010-04-28 2018-07-31 Jason J. Locklin Photochemical cross-linkable polymers, methods of making photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers
US8721936B2 (en) 2011-04-21 2014-05-13 University Of Georgia Research Foundation, Inc. Devices and methods for forming non-spherical particles
US10213529B2 (en) 2011-05-20 2019-02-26 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
WO2013012664A2 (en) 2011-07-15 2013-01-24 The University Of Georgia Research Foundation, Inc Permanent attachment of agents to surfaces containing c-h functionality
WO2013019918A2 (en) 2011-08-04 2013-02-07 The University Of Georgia Research Foundation, Inc. Permanent attachment of ammonium and guanidine-based antimicrobials to surfaces containing-oh functionality
US9839213B2 (en) 2011-10-14 2017-12-12 The University Of Georgia Research Foundation, Inc. Photochemical cross-linkable polymers, methods of making photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers
US11246963B2 (en) 2012-11-05 2022-02-15 Surmodics, Inc. Compositions and methods for delivery of hydrophobic active agents
US10898446B2 (en) 2016-12-20 2021-01-26 Surmodics, Inc. Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01236240A (ja) * 1989-01-14 1989-09-21 Miyoshi Oil & Fat Co Ltd 新規な高分子化合物
JPH02232229A (ja) * 1989-01-20 1990-09-14 Hoechst Ag アルキル化ポリエチレンイミン誘導体
JPH07188698A (ja) * 1993-12-27 1995-07-25 Miyoshi Oil & Fat Co Ltd 両性界面活性剤
JPH0912717A (ja) * 1995-06-23 1997-01-14 Miyoshi Oil & Fat Co Ltd 抗菌剤、抗菌性樹脂及び抗菌性塗料
JPH11514024A (ja) * 1996-06-19 1999-11-30 ザ、プロクター、エンド、ギャンブル、カンパニー 変性ポリアミンから悪臭を除去する方法
JP2004520328A (ja) * 2000-12-29 2004-07-08 バイエル アクチェンゲゼルシャフト 活性物質としてポリアミンを含む医薬
JP2004522809A (ja) * 2000-09-14 2004-07-29 エクスプレッション・ジェネティックス・インコーポレーテッド 生物学的適合遺伝子送達剤としての新規カチオンリポポリマー
JP2006503933A (ja) * 2002-09-20 2006-02-02 ザ・ユニバーシティ・オブ・ストラスクライド 親水性基および疎水性基で置換された可溶化多糖類

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5879022A (ja) * 1981-11-04 1983-05-12 Bitamin Kenkyusho:Kk 第四級窒素原子を含有する新規な金属架橋高分子化合物、その製法及び該高分子化合物を有効成分とする高脂血症治療剤
US5338532A (en) * 1986-08-18 1994-08-16 The Dow Chemical Company Starburst conjugates
US5681543A (en) * 1988-02-29 1997-10-28 Shering Aktiengesellschaft Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
WO1999043752A1 (fr) * 1998-02-27 1999-09-02 Dnavec Research Inc. Compositions pour transporter des substances chargees negativement
JP3523821B2 (ja) * 2000-02-09 2004-04-26 ナノキャリア株式会社 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物
JP2004510829A (ja) * 2000-10-09 2004-04-08 バイエル　アクチェンゲゼルシャフト 核酸を細胞内に転移させるための複合体

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01236240A (ja) * 1989-01-14 1989-09-21 Miyoshi Oil & Fat Co Ltd 新規な高分子化合物
JPH02232229A (ja) * 1989-01-20 1990-09-14 Hoechst Ag アルキル化ポリエチレンイミン誘導体
JPH07188698A (ja) * 1993-12-27 1995-07-25 Miyoshi Oil & Fat Co Ltd 両性界面活性剤
JPH0912717A (ja) * 1995-06-23 1997-01-14 Miyoshi Oil & Fat Co Ltd 抗菌剤、抗菌性樹脂及び抗菌性塗料
JPH11514024A (ja) * 1996-06-19 1999-11-30 ザ、プロクター、エンド、ギャンブル、カンパニー 変性ポリアミンから悪臭を除去する方法
JP2004522809A (ja) * 2000-09-14 2004-07-29 エクスプレッション・ジェネティックス・インコーポレーテッド 生物学的適合遺伝子送達剤としての新規カチオンリポポリマー
JP2004520328A (ja) * 2000-12-29 2004-07-08 バイエル アクチェンゲゼルシャフト 活性物質としてポリアミンを含む医薬
JP2006503933A (ja) * 2002-09-20 2006-02-02 ザ・ユニバーシティ・オブ・ストラスクライド 親水性基および疎水性基で置換された可溶化多糖類

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008519128A (ja) * 2004-11-03 2008-06-05 エクスプレッション・ジェネティックス・インコーポレーテッド 遺伝子送達用の生分解性架橋カチオン性マルチブロックコポリマーおよびそれを製造する方法
JP2009524719A (ja) * 2006-01-27 2009-07-02 チバ ホールディング インコーポレーテッド ポリマー状抗菌剤
JP2010513644A (ja) * 2006-12-22 2010-04-30 ビーエーエスエフ ソシエタス・ヨーロピア 移染防止剤としての疎水性に変性されたポリアルキレンイミン
JP2010533710A (ja) * 2007-07-19 2010-10-28 オールエクセル，インコーポレイティド 抗癌剤としての自己集合性の両親媒性ポリマー
KR101470679B1 (ko) * 2007-07-19 2014-12-08 올엑셀, 인크. 항암제로서의 자기 조립형 양친매성 중합체
US10213528B2 (en) 2011-05-20 2019-02-26 Surmodics, Inc. Delivery of hydrophobic active agent particles
US11529440B2 (en) 2011-05-20 2022-12-20 Surmodics, Inc. Delivery of hydrophobic active agent particles
US12083249B2 (en) 2011-05-20 2024-09-10 Surmodics, Inc. Delivery of hydrophobic active agent particles
JP2015535292A (ja) * 2012-11-05 2015-12-10 サーモディクス，インコーポレイテッド 疎水性生理活性物質を送達するための組成物および方法
US12226552B2 (en) 2019-09-30 2025-02-18 Surmodics, Inc. Active agent depots formed in situ

Also Published As

Publication number Publication date
EP1543063A1 (en) 2005-06-22
AU2003267581A1 (en) 2004-04-08
DE60326859D1 (de) 2009-05-07
GB0221942D0 (en) 2002-10-30
CA2499681A1 (en) 2004-04-01
AU2003267581A8 (en) 2004-04-08
SI1543063T1 (sl) 2009-08-31
DK1543063T3 (da) 2009-05-18
WO2004026941A1 (en) 2004-04-01
US20060148982A1 (en) 2006-07-06
ATE426635T1 (de) 2009-04-15
EP1543063B1 (en) 2009-03-25

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