JP2006500392A5 - - Google Patents
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- JP2006500392A5 JP2006500392A5 JP2004534616A JP2004534616A JP2006500392A5 JP 2006500392 A5 JP2006500392 A5 JP 2006500392A5 JP 2004534616 A JP2004534616 A JP 2004534616A JP 2004534616 A JP2004534616 A JP 2004534616A JP 2006500392 A5 JP2006500392 A5 JP 2006500392A5
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- 150000001875 compounds Chemical class 0.000 claims description 51
- 230000000295 complement effect Effects 0.000 claims description 34
- 208000006673 asthma Diseases 0.000 claims description 29
- 230000002757 inflammatory effect Effects 0.000 claims description 16
- 102000005962 receptors Human genes 0.000 claims description 12
- 108020003175 receptors Proteins 0.000 claims description 12
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- 238000006243 chemical reaction Methods 0.000 claims description 5
- 210000004072 lung Anatomy 0.000 claims description 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 3
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- 239000000427 antigen Substances 0.000 claims description 2
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- 239000000048 adrenergic agonist Substances 0.000 claims 5
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 5
- 208000037883 airway inflammation Diseases 0.000 claims 5
- 102000016966 beta-2 Adrenergic Receptors Human genes 0.000 claims 5
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 claims 5
- 229940124125 5 Lipoxygenase inhibitor Drugs 0.000 claims 3
- XGUFMAUYGBDFJS-UHFFFAOYSA-N 6'-formyl-2,3,4'-trihydroxy-4,4,7,8a-tetramethylspiro[2,3,4a,5,6,7-hexahydro-1h-naphthalene-8,2'-3h-1-benzofuran]-7'-carboxylic acid Chemical compound C1C(C(=CC(C=O)=C2C(O)=O)O)=C2OC21C1(C)CC(O)C(O)C(C)(C)C1CCC2C XGUFMAUYGBDFJS-UHFFFAOYSA-N 0.000 claims 3
- 229940082333 CD23 antagonist Drugs 0.000 claims 3
- 102100022002 CD59 glycoprotein Human genes 0.000 claims 3
- 108010053085 Complement Factor H Proteins 0.000 claims 3
- 102000016550 Complement Factor H Human genes 0.000 claims 3
- 102000003712 Complement factor B Human genes 0.000 claims 3
- 108090000056 Complement factor B Proteins 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 3
- 108090000695 Cytokines Proteins 0.000 claims 3
- 229940124056 Histamine H1 receptor antagonist Drugs 0.000 claims 3
- 229940119155 Histamine release inhibitor Drugs 0.000 claims 3
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims 3
- 102000003816 Interleukin-13 Human genes 0.000 claims 3
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- 102100026061 Mannan-binding lectin serine protease 1 Human genes 0.000 claims 3
- 101710117390 Mannan-binding lectin serine protease 1 Proteins 0.000 claims 3
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- 101710117460 Mannan-binding lectin serine protease 2 Proteins 0.000 claims 3
- 102100026553 Mannose-binding protein C Human genes 0.000 claims 3
- 101710110798 Mannose-binding protein C Proteins 0.000 claims 3
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 3
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- 239000003112 inhibitor Substances 0.000 claims 3
- 239000003199 leukotriene receptor blocking agent Substances 0.000 claims 3
- MQQNFDZXWVTQEH-UHFFFAOYSA-N nafamostat Chemical compound C1=CC(N=C(N)N)=CC=C1C(=O)OC1=CC=C(C=C(C=C2)C(N)=N)C2=C1 MQQNFDZXWVTQEH-UHFFFAOYSA-N 0.000 claims 3
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- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 2
- 230000001387 anti-histamine Effects 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 2
- 208000009079 Bronchial Spasm Diseases 0.000 claims 1
- 102000016574 Complement C3-C5 Convertases Human genes 0.000 claims 1
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- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
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- JJGZGELTZPACID-OTLJHNKQSA-N chloropeptin II Chemical compound N([C@@H]1CC=2C3=CC=C(C=C3NC=2)C=2C=C3C=C(C=2O)OC2=CC=C(C=C2)C[C@H](N(C([C@@H](C=2C=C(Cl)C(O)=C(Cl)C=2)NC(=O)[C@@H]3NC(=O)[C@@H](C=2C=C(Cl)C(O)=C(Cl)C=2)NC1=O)=O)C)C(=O)N[C@@H](C(O)=O)C=1C=CC(O)=CC=1)C(=O)C(=O)C1=CC(Cl)=C(O)C(Cl)=C1 JJGZGELTZPACID-OTLJHNKQSA-N 0.000 claims 1
- 230000024203 complement activation Effects 0.000 claims 1
- 108010029904 complestatin Proteins 0.000 claims 1
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- JJGZGELTZPACID-UHFFFAOYSA-N isocomplestatin Natural products O=C1NC(C=2C=C(Cl)C(O)=C(Cl)C=2)C(=O)NC2C(=O)NC(C=3C=C(Cl)C(O)=C(Cl)C=3)C(=O)N(C)C(C(=O)NC(C(O)=O)C=3C=CC(O)=CC=3)CC(C=C3)=CC=C3OC(C=3O)=CC2=CC=3C(C=C2NC=3)=CC=C2C=3CC1NC(=O)C(=O)C1=CC(Cl)=C(O)C(Cl)=C1 JJGZGELTZPACID-UHFFFAOYSA-N 0.000 claims 1
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- 239000000304 virulence factor Substances 0.000 claims 1
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- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 16
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- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 2
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- 102000005741 Metalloproteases Human genes 0.000 description 2
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- 102000006734 Beta-Globulins Human genes 0.000 description 1
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- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 108010028773 Complement C5 Proteins 0.000 description 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 1
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- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
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- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 238000007805 zymography Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40857102P | 2002-09-06 | 2002-09-06 | |
| US46918903P | 2003-05-09 | 2003-05-09 | |
| PCT/US2003/027808 WO2004022096A1 (en) | 2002-09-06 | 2003-09-05 | Method of treatment of asthma using antibodies to complement component c5 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010028219A Division JP5137983B2 (ja) | 2002-09-06 | 2010-02-10 | 補体成分ｃ５に対する抗体を使用する喘息の処置の方法 |
| JP2010157203A Division JP2010215674A (ja) | 2002-09-06 | 2010-07-09 | 補体成分ｃ５に対する抗体を使用する喘息の処置の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006500392A JP2006500392A (ja) | 2006-01-05 |
| JP2006500392A5 true JP2006500392A5 (https=) | 2006-10-19 |
| JP4601426B2 JP4601426B2 (ja) | 2010-12-22 |
Family
ID=31981600
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004534616A Expired - Fee Related JP4601426B2 (ja) | 2002-09-06 | 2003-09-05 | 補体成分ｃ５に対する抗体を使用する喘息の処置の方法 |
| JP2010028219A Expired - Fee Related JP5137983B2 (ja) | 2002-09-06 | 2010-02-10 | 補体成分ｃ５に対する抗体を使用する喘息の処置の方法 |
| JP2010157203A Withdrawn JP2010215674A (ja) | 2002-09-06 | 2010-07-09 | 補体成分ｃ５に対する抗体を使用する喘息の処置の方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010028219A Expired - Fee Related JP5137983B2 (ja) | 2002-09-06 | 2010-02-10 | 補体成分ｃ５に対する抗体を使用する喘息の処置の方法 |
| JP2010157203A Withdrawn JP2010215674A (ja) | 2002-09-06 | 2010-07-09 | 補体成分ｃ５に対する抗体を使用する喘息の処置の方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040115194A1 (https=) |
| EP (1) | EP1545611B1 (https=) |
| JP (3) | JP4601426B2 (https=) |
| AU (2) | AU2003270330B2 (https=) |
| CA (1) | CA2496834C (https=) |
| ES (1) | ES2614274T3 (https=) |
| NZ (1) | NZ538384A (https=) |
| WO (1) | WO2004022096A1 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6969601B2 (en) | 1997-04-03 | 2005-11-29 | Jensenius Jens Chr | MASP-2, a complement-fixing enzyme, and uses for it |
| US9028822B2 (en) | 2002-06-28 | 2015-05-12 | Domantis Limited | Antagonists against TNFR1 and methods of use therefor |
| US20050271660A1 (en) * | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
| US9415102B2 (en) | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
| JP4601426B2 (ja) * | 2002-09-06 | 2010-12-22 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 補体成分ｃ５に対する抗体を使用する喘息の処置の方法 |
| HUE024996T2 (en) | 2003-05-12 | 2016-01-28 | Helion Biotech Aps | Anti-MASP-2 antibodies |
| PL1713503T3 (pl) | 2004-02-10 | 2014-02-28 | Univ Colorado Regents | Hamowanie czynnika B, alternatywny szlak dopełniacza i związane z tym sposoby |
| BRPI0506629A (pt) | 2004-02-10 | 2007-05-02 | Univ Colorado | inibição do fator b, a via alternativa do sistema complemento e métodos relacionados |
| US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US8840893B2 (en) | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US20090215717A1 (en) * | 2004-08-05 | 2009-08-27 | Ivax Drug Research Institute Ltd. | Sulfated oligosaccharides |
| EP1824886B1 (en) | 2004-11-17 | 2010-12-22 | Amgen Inc. | Fully human monoclonal antibodies to il-13 |
| GB0521621D0 (en) * | 2005-10-24 | 2005-11-30 | Domantis Ltd | Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases |
| GB0507577D0 (en) * | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| WO2006128006A1 (en) | 2005-05-26 | 2006-11-30 | The Regents Of The University Of Colorado | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
| PL2061501T3 (pl) * | 2006-09-08 | 2016-01-29 | Volution Immuno Pharmaceuticals Sa | Sposób leczenia zaburzeń oddechowych |
| GB2445920A (en) * | 2007-01-25 | 2008-07-30 | Mucokinetica Ltd | Amidino compounds for treatment of respiratory disease |
| HUE026001T2 (en) | 2007-02-05 | 2016-04-28 | Apellis Pharmaceuticals Inc | Compstatin analogues for use in the treatment of the inflammatory condition of the respiratory system |
| CN101668773B (zh) | 2007-03-14 | 2016-08-31 | 亚力史制药公司 | 人工程化抗b因子抗体 |
| CA2688433A1 (en) | 2007-06-06 | 2008-12-11 | Domantis Limited | Methods for selecting protease resistant polypeptides |
| GB0724331D0 (en) | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
| CA2742802C (en) | 2008-11-10 | 2019-11-26 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
| GB0904214D0 (en) * | 2009-03-11 | 2009-04-22 | Ucb Pharma Sa | Biological products |
| WO2011003098A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| DK2488203T3 (en) | 2009-10-16 | 2017-03-13 | Omeros Corp | METHODS OF TREATING DISSEMINATED INTRAVASCULAR COAGULATION BY INHIBITION OF MASP-2 DEPENDENT COMPLEMENT ACTIVATION |
| CN101839910A (zh) * | 2010-05-07 | 2010-09-22 | 刘东旭 | 自发性免疫性疾病特异性抗体和相关的自发性免疫性疾病诊断试剂盒 |
| EP2608809B1 (en) | 2010-08-27 | 2019-05-22 | Gilead Biologics, Inc. | Antibodies to matrix metalloproteinase 9 |
| EP2468295A1 (en) | 2010-12-21 | 2012-06-27 | Affiris AG | Vaccines based on peptides of the complement protein C5a |
| HK1204926A1 (en) | 2012-02-29 | 2015-12-11 | 吉联亚生物科技有限公司 | Antibodies to matrix metalloproteinase 9 |
| WO2013130078A1 (en) * | 2012-02-29 | 2013-09-06 | Gilead Biologics, Inc. | Antibodies to matrix metalloproteinase 9 |
| US9803005B2 (en) | 2012-05-24 | 2017-10-31 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| EP3722320A3 (en) | 2012-10-25 | 2020-12-30 | Bioverativ USA Inc. | Anti-complement c1s antibodies and uses thereof |
| DK2914291T3 (da) | 2012-11-02 | 2022-05-16 | Bioverativ Usa Inc | Anti-komplement-c1s-antistoffer og anvendelser deraf |
| SI3011345T1 (sl) | 2013-08-07 | 2017-12-29 | Alexion Pharmaceuticals, Inc. | Biomarkerski proteini za atipični hemolitični uremični sindrom (ahus) |
| CA2981321A1 (en) | 2015-04-06 | 2016-10-13 | True North Therapeutics, Inc. | Humanized anti-c1s antibodies and methods of use thereof |
| MX2017016835A (es) * | 2015-06-26 | 2018-08-01 | Bioverativ Usa Inc | Métodos de tratamiento de trastornos autoinmunitarios y aloinmunitarios. |
| JP6871948B2 (ja) | 2016-04-27 | 2021-05-19 | アッヴィ・インコーポレイテッド | 抗ｉｌ−１３抗体を使用する、ｉｌ−１３活性が有害である疾患の治療方法 |
| CA3024618A1 (en) | 2016-05-27 | 2017-11-30 | Alexion Pharmaceuticals, Inc. | Methods for treatment of refractory generalized myasthenia gravis |
| CN116769024A (zh) | 2016-06-14 | 2023-09-19 | 瑞泽恩制药公司 | 抗c5抗体及其用途 |
| JOP20170154B1 (ar) | 2016-08-01 | 2023-03-28 | Omeros Corp | تركيبات وطرق لتثبيط masp-3 لعلاج أمراض واضطرابات مختلفة |
| CN110300520B (zh) | 2016-10-12 | 2022-10-04 | 美国比奥维拉迪维股份有限公司 | 抗C1s抗体及其使用方法 |
| CN118512588A (zh) | 2017-10-26 | 2024-08-20 | 亚力兄制药公司 | 用于治疗阵发性夜间性血红蛋白尿(pnh)和非典型溶血性尿毒症综合征(ahus)的抗c5抗体的剂量和施用 |
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2003
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- 2003-09-05 EP EP03752016.0A patent/EP1545611B1/en not_active Expired - Lifetime
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- 2003-09-05 ES ES03752016.0T patent/ES2614274T3/es not_active Expired - Lifetime
- 2003-09-05 AU AU2003270330A patent/AU2003270330B2/en not_active Ceased
- 2003-09-05 WO PCT/US2003/027808 patent/WO2004022096A1/en not_active Ceased
- 2003-09-05 US US10/655,861 patent/US20040115194A1/en not_active Abandoned
- 2003-09-05 CA CA2496834A patent/CA2496834C/en not_active Expired - Fee Related
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2009
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- 2010-07-09 JP JP2010157203A patent/JP2010215674A/ja not_active Withdrawn
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