JP2006342095A - Antiallergic agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an antiallergic agent, a histamine release inhibitor and a TNFα production inhibitor which are each new and safe and to provide medicines, cosmetics, beverages and foods, etc., having these functions. <P>SOLUTION: The antiallergic agent comprises an Euphoria longana extract as an active ingredient. The antiallergic agent has histamine release-inhibiting action and has action inhibiting production of TNFα involving allergic dermatitis. The antiallergic agent formulated with a medicine, a cosmetic, a food, etc. can be used in order to prevent and treat allergy. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an antiallergic agent comprising an extract of longan seeds, and is applied to, for example, pharmaceuticals, cosmetics, foods and the like for preventing and treating allergic diseases.

  In recent years, allergic diseases are increasing due to lifestyle changes, environmental deterioration, etc., and it is a social problem that it is said that one out of three people in the country has allergies. In particular, hay fever, allergic rhinitis, bronchial asthma, and atopic dermatitis may be accompanied by serious symptoms that hinder daily life and are listed as one of the modern diseases.

  The human body has an immune function as a bioregulatory function. Reactions that react excessively and interfere with the body are allergies, and are roughly classified into immediate hypersensitivity and delayed hypersensitivity, and are classified into types 1 to 4 according to the onset mechanism. Of these, type 1 allergy is the most frequently occurring allergy.

  It is known that type I allergy mainly involves immunoglobulin E (hereinafter, IgE) antibody. An immune function is activated by the invasion of an antigen from outside the body, and an IgE antibody is produced. IgE antibody adheres to mast cells distributed in the respiratory tract, skin and fire extinguisher system, or basophils in blood via a receptor, and becomes a sensitized state. In this sensitized state, contact with the antigen again causes degranulation to release chemical mediators such as histamine and serotonin. As a result, redness and edema with itchy skin, inflammation of the eyes and nose, bronchial asthma, etc. Causes allergic symptoms.

  On the other hand, through research on inflammation and allergic symptoms, contact hypersensitivity and atopic dermatitis are locally related to the production of tumor necrosis factor (Tumor Necrosis Factor), which is an inflammatory cytokine, and is deeply involved in the disease state. It is believed that

  Japanese Patent Laid-Open No. 7-215884 discloses a perilla extract having a TNFα production inhibitory action. The publication also discloses that the perilla extract is effective for allergic diseases such as atopic dermatitis.

Conventionally, degranulation release inhibitors such as diphenone hydramine, phenalanine maleate, and related substances have been used as antiallergic agents. These antiallergic agents can have side effects and require a physician's diagnosis during prescription and treatment.
Japanese Patent Laid-Open No. 7-215884

  An object of the present invention is to provide an antiallergic agent having no side effects and excellent in safety, and to provide a pharmaceutical, a cosmetic, a food and the like having these functions.

  As a result of intensive studies to achieve the above object, the present inventors have found that longan seed extract has excellent histamine release inhibitory action and TNFα production inhibitory action and high safety. It came to complete.

  The extract obtained from the longan seed of the present invention has remarkably an inhibitory effect on histamine release and an inhibitory effect on TNFα production. Therefore, the use of the longan seed extract of the present invention as an antiallergic agent has a great effect on the prevention and treatment of allergic diseases.

Longan (Euphoria
longana) is a plant belonging to the order of Sapindaceae and is widely cultivated as a fruit tree in tropical America and Southeast Asia. Inside the yellowish-brown skin is a jelly-like pulp that wraps around a 1cm-sized seed. This pulp is used as a traditional Chinese medicine that is raw or dried and has a tonic and sedative effect, and is also incorporated in cosmetics as a longan extract.

  The longan seed extract used in the present invention can be prepared by extracting longan seeds with water or a mixture of water and a hydrophilic organic solvent, and using them in a solution form. However, it can also be used as a powdered product obtained by drying these solutions. In the extraction of longan seeds, it is also possible to use a buffer solution, dilute acid and dilute alkali instead of water.

  It is desirable to extract the antiallergic agent of the present invention after drying longan seeds and thoroughly washing impurities with water. The longan seeds from which impurities have been removed can be extracted as is, but can also be subjected to an extraction operation after being pulverized. Longan seed extract is prepared by washing washed longan seeds with water, methanol, ethanol, isopropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol and other natural alcohols, 2-hexyldecanol, isostearyl alcohol. , Synthetic alcohols such as 2-octyldodecanol, ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, Propylene glycol, polypropylene glycol, 1,3-butyl Polyhydric alcohols such as lenglycol, glycerin, pentaerythritol, sorbitol, mannitol, ketones such as acetone, diethyl ether, dioxane, acetonitrile, ethyl acetate, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate , Myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, monostearic acid Esters such as propylene glycol and propylene glycol dioleate, pyridine, chloroform, benzene, toluene, xylene, Organic solvents such as chlorohexane, hexane, avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange raffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil , Safflower oil, shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, Oils and fats such as owl, palm oil, beef tallow and lard, or hydrogenated products of these oils (hardened oil, etc.), beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax Waxes, liquid paraffin, petrolatum, paraffin, ozokelide, Mineral oils such as resin, microcristan wax, squalene, squalane, pristane, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, etc. Natural fatty acids, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid and other synthetic fatty acids, citrate buffer, phosphate buffer, borate buffer In addition to buffer solutions such as Tris-HCl buffer, dilute caustic soda, dilute caustic potash, sodium carbonate, dilute alkalis such as ammonia, dilute hydrochloric acid, dilute citric acid, dilute acetic acid, dilute lactic acid and mixtures thereof, or -30 Can be obtained by stirring at ~ 110 ° C for 1 hour to 2 months

  In the above extract, a preferable extraction solvent includes an aqueous solution of water and a hydrophilic solvent, for example, an aqueous solution of ethanol, 1,3-butylene glycol, methanol, acetone or the like. In particular, water-containing ethanol and water-containing 1,3-butylene glycol can efficiently extract active ingredients, and it is desirable to use them as extraction solvents. The concentration of these alcohol-water mixtures is preferably an alcohol concentration of 25 to 75% (w / w). If it is less than 25% (w / w), extraction of the active ingredient is insufficient, and if it exceeds 75% (w / w), the extraction yield decreases.

  Although the extracted longan seed extract can be used as it is, it is preferable to further purify by a process such as filtration and centrifugation. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. What is necessary is just to use an activated carbon column etc., and what is necessary is just to select and select the usual means generally applied with an extraction substance. In addition, the obtained longan seed extract can be obtained as a dried product by a heat drying method such as a freeze drying method or a spray drying method.

  Cosmetics to which the antiallergic agent of the present invention is blended include lotions, milky lotions, beauty essences, general creams, cleansing creams, facial cleansers, packs, shaving creams, sun creams, sunscreen creams, sunscreen lotions, It can be used for various types of cosmetics such as tanning lotion, cosmetic soap, foundation, funny, powder, lipstick, lip balm, eyeliner, eye cream, eye shadow, mascara, bath cosmetics, shampoo, rinse, hair dye, hair cosmetics, etc. . The blending amount can be contained in the cosmetic composition from 0.001 to 100%, but is preferably from 0.01 to 10%.

The antiallergic agent of the present invention is produced by arbitrarily selecting and using in combination the various components and additives that are usually used in skin external preparations such as cosmetics as shown below. Can do.
For example, avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, safflower oil, shea fat , Soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, molasses, coconut oil, beef tallow, Fats and oils such as pork fat or hydrogenated products of these fats and oils (hardened oil etc.).

  Waxes such as beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax. Mineral oils such as liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microkristane wax, squalene, squalane and pristane. Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid.

  Synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid. Natural alcohols such as ethanol, isopropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol. Synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

  Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol , Polyhydric alcohols such as glycerin, pentaerythritol, sorbitol, mannitol.

  Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, phthalate Esters such as dibutyl acid, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate.

  Metal soap such as aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate.

  Gum arabic, benzoin rubber, danmar gum, guaiac gum, Irish moss, Karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose and its esters, trehalose and its derivatives, dextrin, gelatin, pectin, starch, Carrageenan, succinyl chitosan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan with addition of alkylene (C2-C4) oxide such as ethylene oxide, low molecular chitin or chitosan, chitosan salt, sulfated chitin or Chitosan, phosphorylated chitin or chitosan, alginic acid and its salt, hyaluronic acid and its salt, chondroitin sulfate and its salt, heparin, ethylcellulose, methylcellulose, carboxy Polyalkylene such as methyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene oxide Oxides or their cross-linked polymers, carboxyvinyl polymers, gums such as polyethyleneimine, sugars and water-soluble polymer compounds.

  Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkylamine salt, alkyl quaternary ammonium salt), amphoteric surfactant: carboxylic acid Type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant) Agent, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other surfactants (natural surfactant, protein Hydrolyzed derivatives, polymer surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants Surfactants such as.

  Retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin ( Vitamin B12), folic acids, nicotinic acids, pantothenic acids, biotins, choline, inositols, ascorbic acid and its derivatives, ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotachysterol, tocopherol and its Derivatives, ubiquinones, phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carni Down, ferulic acid, γ- oryzanol, orotic acid, vitamin P compounds (rutin, Elio citrine, hesperidin), vitamins such as vitamin U.

  Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine And amino acids such as sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acids.

  Microbial culture metabolites such as yeast metabolites, yeast extract, rice fermented extract, rice bran fermented extract, Euglena extract and trehalose or its derivatives.

  Α-hydroxy acids such as glycolic acid, citric acid, malic acid, tartaric acid and lactic acid.

  Silica, magnesium silicate, talc, kaolin, bentonite, mica, mica titanium, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide , Inorganic pigments such as Gunjo, chromium oxide, chromium hydroxide, carbon black, calamine.

  p-aminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, UV absorbers / blockers such as allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, benzophenones, oxybenzone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, urocanic acid derivatives, escalol, zinc oxide, talc, kaolin .

  p-aminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, Whitening agents such as allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine.

  Ascorbic acid and derivatives thereof, hydroquinone and glycosides thereof, kojic acid and derivatives thereof, placenta extract, silk peptide, plant extract (mulberry, honeysuckle, walnut mulberry, mugwort, honeysuckle, yellowfin, dokudami, matsuhod, pearl barley, hazelnut, hawthorn, Eucalyptus, Achillea millefolium, Altea, Keihi, Mankeishi, Hamameris, Yamagua, Prolonged grass, Kikyo, Toshishi, Seicho, Ishiboshi, Mao, Senkyu, Dokatsu, Psycho, Bowfish, Hamaboufu, Ogon, Peonies, Genus Shouko, Licorice, Pyrus Tyrosinase activity inhibitors such as aloe, shouma, safflower, and assen.

  Melanin pigment reducing / decomposing agents such as hydroquinone monobenzyl ether, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide.

  Hydroquinone, Lactic acid bacteria extract, Placenta extract, Ganoderma extract, Vitamin A, Vitamin E, Allantoin, Spleen extract, Thymus extract, Yeast extract, Fermented milk extract, Plant extract (Aloe, Ogon, Horsetail, Gentian, Burdock, Shikon, Carrot, Activators / cell activators of turnover, such as hamamelis, hops, yokuinin, nettle, sea bream, cypress, red bellflower, achacha, hypericum, cucumber, ginger, rosemary, parsley, etc.

  Astringents such as succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, and tannic acid (including catechin compounds).

  Active oxygen scavengers such as SOD, catalase, glutathione peroxidase.

  Ascorbic acid and its salt, stearic acid ester, tocopherol and its ester derivative, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol , Antioxidants such as sesamorin and gossypol.

  Lipid peroxide production inhibitors such as β-carotene, plant extracts (sesame cultured cells, amacha, hypericum, hamamelis, clove, melissa, enamel, birch, sage, rosemary, nantenami, kina, ages, ginkgo, etc.).

  Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid and its salt, glycyrrhetinic acid and its salt, Anti-inflammatory agents such as licorice extract ingredients, sicon extract, and ages extract.

  Acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, isopropylmethylphenol, triclosan, kudin Disinfectant / disinfectant.

  Moisturizing such as glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid and its salt, polyethylene glycol, chondroitin sulfate and its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid and its salt, sodium lactate, mini sasanishiki extract Agent.

  For hair such as selenium disulfide, alkylisoquinolinium bromide, zinc pyrithione, biphenamine, thianthol, castari tincture, ginger tincture, red pepper tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, sodium bromate, thioglycolic acid Agent.

  Antiandrogens such as follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone.

  Peripheral blood flow promoters such as vitamin E and its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil.

  Topical stimulants such as pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate.

  Photoactive element 301, hinokitiol, pantothenic acid and its derivatives, allantoin, placental extract, biotin, pentadecanoic acid glycerides and the like.

  Antiseborrheic agents such as pyridoxine and its derivatives, sulfur and vitamin B6.

  Keratolytic agents such as resorcin, salicylic acid and lactic acid.

  Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate Oxidants such as sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, and mushroom extract.

  Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate, etc. ) And other hair removal agents.

  Hair swelling agents such as ethanolamine, urea, and guanidine.

  5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol Paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picramate, N ′, N-bis (4-aminophenyl) -2,5-diamino-1, -4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorcresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, Orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitrosulfate Lutophenylenediamine, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, fluorologlucin, gallic acid , Resorcinol, tannic acid, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzozen-5'-sodium sulfonate, hematein and the like.

  Natural animal fragrances such as musk, civet, castrium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter Essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, western peppermint essential oil, dairy perfume essential oil, tuberose essential oil, Clove essential oil, orange flower essential oil, winter green essential oil, trout balsam essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, salmon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, peruvian balsa Essential oils, bois de rose essential oil, Yoshikusunoki essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, vegetable flavoring such as Japanese mint essential oils, perfumes and other synthetic fragrances.

  Red cabbage dye, red rice dye, red dye, anato dye, scum dye, turmeric dye, enju dye, krill dye, amber dye, caramel, gold, silver, gardenia dye, corn dye, onion dye, tamarind dye, spirulina dye, Pigments and colorants such as buckwheat whole pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment and rutin.

In addition, almond (nong peach), eye (indigo leaf), blue quail (Keifu Fuji), Aotsuki rafuji (wooden moth), aonoo agave, fuchlin agave, acacia, red currant fruit, red grape, redwood (logwood), red bud (red bud), Akane (Azalea), Akajiojio Jiou (Gizo), Agi (Atsu), Akinire (Chizome), Akebiki (Kitsu), Asa (Asako Jin), Maruasaagao or Asagao (Toshigyu), Ashitaba (Tomorrow) Leaf), azuki bean (red bean), acerola, asenyaku (Asen Yaku), anise, abemaki fruit, avocado, flax, achacha (Amacha), achacharu, amadokoro (tamatake), amigasayuri (shellfish mother), Altea, Arnica, aloe (蘆薈), aloe vera, angelica, apricot honanzu (Anzujin), Ansokkou (benzoic incense), igakozolina (Gold head), Japanese knotweed (tiger cane), strawberry, Fig (no flower fruit) or its leaves, Ichibi (Winter coconut), Ichiyakuso, Ginkgo (Ginkgo leaves, Ginkgo), Japanese peas (Garden), Carob, rice seed or seed coat, Inondo seed, Ibukizasou, nettle, ylang-ylang, fennel Ayaka), Ukiyagara (Sanryo), Uguisukagura fruit, Himewikyo, Turmeric (Urban), Usubasaishin Keirinsaishin (spicy), Usbeniaoi, Usubenitachiaoi, Morayella (Summer hay), Udo or Shishido )茸), Ebisu rush (Keiko), Elderberry fruit , Elemi, Elingi (pre-lotus eringi), Enju (槐花, 槐花 米), Ogi Kibanaogi (yellow 耆), Oulen (yellow ream), Okarasuuri (Karonin), Otsu ヅ rafuji (prevention), Psyllium (car) Maeko (carrot), toucan beetle (lion), Ovana okera okera (white birch), Obayayashabushi fruit, Oha hawthorn hawthorn (Yamakoko), Ohisanoyuki, Sasanoyuki, barley (barley), oguruma (overturn), okrajin, okraine・ Tochibaninjin (carrot), Hypericum, Kogomeba Otogiriso, Hypericum perforatum (brother cut grass), Odorikosou (interrupted), Onamomi (Circle ear), Onigurumi, Oninoyagara (Tempa), Onyuri Sasayuri, Hakatayuri (Lily)楡), Ominae (losing sauce), Dutch strawberry, Dutch mustard (watercress), Dutch jelly, Oran Honey bees, olives, oregano, orange fruit or skin, coconut moth (ripening yellow), cacao seeds, oysters or their leaves (crabs), scabbard (fish), cassia, casino berries (fruits), gadgets (crabs) , Oak wrinkles, oak leaves, cascarilla, cynomolgus (Kinshato), valerian (valerian), birch or fern birch (white birch), pumpkin, kapok seeds, kahoku salamander (carp), gama (carp yellow), chamomile・ Roman chamomile, Camille deer (weed), Cam cam / duck duck, Calla cucumber (Royal moth), Crow bishak (Half summer), Oats, Garana seeds, Caraho (Park), Karaya, Karin (Kiso), Garcinia, Kawayanagi, Kawaratake, Kawara mugwort (Sardine Chin), Kansui (Sweet), Licorice (licorice), Kantara Asa, Candelilla, Kantou, Kanna, Raspberry, Kiwi Fruit, Kikaras Cucumber (Koryo, Kikyo), Chrysanthemum (Chrysanthemum), Chrysanthemum (Cruciferous), Gigiri (Shione), Pheasant (Cultivation), Kizuta, Kidachi Aloe, Kidachi Hakka, Kina, Kinaki ), Yellowfin, yellowtail, cabbage, cabbage immature fruit, cucumber, Kiraja saponaria, quilla, kumquat fruit, betel, kinzhiki (Sentsukakusa), guava fruit, guayule, quellus infectria , Wolfberry (bamboo shoots, coconut tree, cocoon leaf, earth bone bark), cedar kazura (Tenmon winter), camphor tree, gooseberry fruit, gardenia (mountain lion), kunugi (bamboo grass), kumazasa, pine moth (clasp grass), clara (bitter) ), Cranberry fruit, chestnut or its astringent skin, curculigo latifolia fruit, grapefruit, buckthorn, black sage Ji (Necessary), Kurobana toukikoshi, Clove (Cycho, Dingko), Keigai (Akatsuki, Ayuho), Keito (Couple flower, Chicken clover), Bay bay (Laurel tree), Kenashi Sartori Ibara (Tsumago, Mountain return), Gentiana, Gennoshouko (Old-weed grass), Kouji / Tachibana / Obenimikan / Ponkan / Santara (Tachibana bark), Koshinbara (monthly flower), Kousei mint, Kozo fruit, Kocha (tea), Kohone (river bone), Kohon (Tsubakimoto, Karasumoto) ), Koryang, Cilantro fruit, Koganebana (Yellow Gon), Cowberry (Etsutachibana), Coconut fruit, Goshuyu (Golden cucumber), Gosho strawberry (Golden bonsai), Pepper (Pepper), Copaiba balsam, Coffee beans, Kobushi magnolia ), Burdock (beef bowl, beef eggplant), coconut lees, sesame seeds (sesame seeds), sesame seeds (genus ginseng), trash (savory), sanekazura, binankazura, matsubusa, Wheat (wheat), rice / rice bran (red cocoon, white birch), rice oil, cola acuminata seeds, cola vera seeds, fenugreek fruit, colombo, condurango, kombu, konjak, comfrey (sardine grass), sisal, sisal asa Leaf, flower, fruit, and bark (cherry tree) , Cherries, pomegranates, sasa, sasanqua, sasmodaka, sweet potatoes, sugar cane, sugar beet, saffron jujube (acid sour), saffron (bansho, west safflower), pomelo fruit, savanna, salmon berry, salamander ), Salvia (Sage), Sagaki Kyo (Sankyo) ), Sawagurumi (Sancho), Sanshinin carrot (37 ginseng), Sanshuyu (Yamamuro), Sansho (Yamamuro), Sandskon (Yamazune), Shea (Kalite), Cyano fruit, Shiitake mushroom (Shiitake), Sion ( (Purple), Dikitaris, Shikunshi (Amiko), Perilla, Ajizo, Chilemiso, Catamendizo (Shiyoha, Shisoko), Rosewood, Linden, Syringa, Sylemeng (ream), Shimakangi (Chrysanthemum flower), Shimeji (Himushiji, Shakashimeji) , Oshiroi shimeji, beech shimeji mushroom, shimotsukeso, potato, peonies (shakuyaku), shajin (shasan), janohi (barley winter), juzudama, palm fruit, ginger (ginger), ginger (root), Shozuk fruit, white-bellied seeds, white-faced butterfly seeds, white plant flowers, white minten (southern fruit), cinchonasacill La, cinnamon, watermelon (Sairan), honeysuckle (gold and silver flowers, Shinobu), sorrel (Acid), swimberry fruit, stevia, strawberry fruit, sugina (question), stevia, plum fruit, red pine cone, larch , Kizota, Prunus, Hawthorn, Dandelion, Horse Chestnut (Maronier), Pear fruit, Zodiac, Elder, Prunus, Milfoil, Rose Japanese butterfly, mistletoe, yellow mint, wild mint, horseradish, budgerigar (pepper), mallow, white-spotted moth, white-necked sword, senega, seri, celery, cucumber (river cucumber), sendan, senburi (this drug), senna fruit or , Ginseng (daikon), soka (grass), buckwheat seeds, potato monopods, daiou (dai yellow), radish, soybeans, daidai (orange peel, persimmon), takatodai (daikon), hawk abalone (dark spine), dark sweet cherry Fruits, hollyhock, red pepper (thyme, perilla), red willow, tamarind seeds, onion, red bean, cypress or its root bark, tanjin, dandelion or dandelion, dandelion, danmaru, cherry fruit , Chigaya or its root (Sone), Chikutsujinjin (Bamboo ginseng), Chicory, Ginseng (Gomi), Ginseng (Dahi), Ginseng (Ginseng), Ginseng (Ginseng), Ginseng (Ginseng), Choreimaitake (Tsubaki), camellia, Tsukuritake (mushroom), camellia, camellia, clover (lacquer) Grass), cypress (duck cocoon grass), vine azuki (red azuki bean), tsurudukudami (what's neck moth), tsuruna (apricot), tsuruminjin (four leaf ginseng), tsubebuki, deiko, teuchigurumi, dubery fruit, tengusa, tencha (boiled tea), tendai yak ( Glaze), Toga (Winter Lion), Pepper (Banban), Toki (Toyaki), Tokinsenka (Marigold), Corn or Corn Hair (Southern Shark), Toad Momochi (Sadako), Torindo (Ryobi) , Dokudami (10 medicines), Tokon (root), Toshishi-Mamedaoshi-Nenkakazura, Tochu (Tochu, Tochu), Tomato, Tragacanth, Triacanthus seeds, Tormentilla, Dronoki, Toro-aoi, Nigerian berry, Nagaimo yam (Medicine), nagii kada (butcher bloom), naginata koju, nazuna, rapeseed, jujube, jujube (large cicada), naniwa Thorns (Golden Cherry Blossoms), Nameko, Naruko Yuri (Yellow), Groundnuts (Peanuts), Nanten (Nami Tenmi), Nigaki (Nagi), Nigorigi (Nagiki), Nikuzuku, Kay Nikkei (Keishi), Keishi (Keishi) , Leek (lion), elderberry (bone graft) fruit / flower or stem / leaves, garlic (large coral), nurde (pentose), leek, white thistle (large coral), nobara (fruit), yarrow, nodake (maehu), Novara, Peach, Palm, Pineapple fruit, Hibiscus (Bussouge, Furinbussouge, Roselle), Hakamurabosi (Occultus), Hakusen (Shiroki), Hakuruberry fruit, Hakobe (Traditional), Hazel (Egg), Hasidorokoro (Roth root) , Basil, lotus (lotus, lotus meat, lotus), parsley (holland jellie), hadakamugi, batata, beech mushroom (bamboo bamboo), patchouli, mint (light load, light load leaf), pearl barley (yokuinin), hanasuge (knowledge) ), Banana, Hana-hakka, Vanilla Bins, Papaya, Pleurotus moth (Hagagusa), Hubgrass, Paprika, Amaranthus (Vulgaris), Hamasuge (Katsukiko), Amaranthus (Shitsuko), Hermanus (Maikai Flower), Hamaboufu (beach windbreak), hamamelis, rose (rose), agaric (agaric, white-faced agaric, Ukimorinokasa), parietaria, haruni (crustacea, cinnamon bark, coral leaf), breadfruit, lizard carrot (participant), pecan nut, ganbanana (Ishizuchi, Ryujushahua), Toki Oshishi (prolonged grass), Hishi (Rishimi), Pistachio, Beet, Hitotsuba (Ishizuchi), Hinata Taikozuchi (cow knee), Hinoki, Hiba, Castor, Sunflower, Pepper, Himegama (Kaori), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta fruit, Bikaku, Bakkyu, Ayu fruit, Bellows aoi, Hirohao Nagusa (bald eagle), loquat (bamboo shoots, coconut leaves), betel wax (large clothes, coconut), Japanese quail (southern rattan), Japanese cypress, Japanese dandelion (Japanese winter flower, Japanese winter lobster), Fujibamaama (Orchid), Japanese bean (Tanzu), Grape fruit or pericarp / seed / leaves, beech, Fuyumushinatsutake (Cycium Cordyceps), Brazilian licorice, black currant fruit, blackberry, plum fruit, fullceraria, blueberry, prune, blond psyllium, bundo (green bean) ), Loofah, safflower (safflower), henken, belladonna, berry fruit, pervian burger, boysenberry fruit, bow-fu (windproof), spinach, physalis (Torone), honoki (Japanese rustic, magnolia), bokeh (wooden), Hosobana Okera (bamboo shoots), Hosobabarengiku, Bodaiju (bamboo tree), buttons (peony, peony skin), jojoba, whittle berry fruit Honshimeji, Mizurutennansho (Tennansei), Maitake (Maiko), Maou (mao), Macadamia nuts, Macri (Seaman grass), Magwa (Mulberry white skin, Mulberry leaf), Magnolia sprengeri, Matatabi , Matsukasa, pine needles, Matsuhodo (茯苓), Mayorum (Hanahakka), Malvanojadin (Bitter), Mulberry fruit, Quince, Mango, Mangosteen, Manshugurumi, Mandarin fruit, Mannentake (Ganoderma), Citrus fruit (fruit) Mishima Psycho (Shibako), Mizokakushi (Half Lotus), Misohagi (Senka Green), Mitsuga Washi, Honey Bee, Midori Hakka, Mimosa, Ginger, Miracle Fruit Fruit, Myrrh, Milobaran, Mukage (Mushroom), Mukunoki, Mukuroji, Murasaki (Purple Root) ), Murasaki corn, Japanese marlin (beneficial herb), Japanese gooseberry, Melaroika, Melissa, Merirot, melon fruit , Moukoyomogi, bamboo, woodworking (climate), maple bar rhubarb,
Peach leaves (peach leaves), fruits and seeds (peach seeds), sprout, Morero cherry fruits, Moroheiya (yellow hemp), Yakawamurasaki, Yakuchi (masutachi), cornflower (cornflower), cornflower mint, yashabushi (yash), Yachiyanagi , Millipede (octagonal gold plate), mistletoe (willow infestation), willow leaves, japonica, yabukouji (purple gold beef), pokeweed (commercial land), yamahanoki (yamayama), bayberry (bamboo plum skin), bayberry, eucalyptus, yukinoshita ( (Tiger ear grass), Yucca flevifolia, yuzu fruit, lily, yorogusa, European raspberry, mugwort (bamboo leaf), lime fruit, rye, peanut seed coat, rakanka fruit, raspberry leaf / fruit, lavender, ryokcha (green tea), apple fruit, Gentian, Lubus Suabisimus (cool), lettuce, red currant fruit, lemon fruit, lemongrass, forsythia (ream), Roots, wax palm, locon (Yoshi: root) logan berry fruit, rosemary (mannenrou), rosehip (novara), wasabi, walremoko (ground), plants such as Chlorella vulgaris, Chlorella pyrenoid, Chlorella ellipso Green algae such as Ideia, Aonori (Usuba Aonori, Susiao Onori, Hira Aonori, Bow Aonori, Hosoeda Aonori), and Kombu (Macombu, Resilib, Hosocomb, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp Ferrari, Macrotis・ Integrifolia, Neocities Ruetkeana), brown algae such as hijiki, hibamata, and hijirimen, maca (tengusa), nettle, onyxa, okusa, kataobakusa, yatabegusa, yuikiri, shimate Rabbit, Tosaccharinus, Scarlet Rhinoceros, Amakisaki Rhinoceros, Giraffe Rhinoceros, Sandalin Giraffe Rhinoceros, Tsunomata, Obatsunomata, Tochauka (Yahazutsu Nomata), Ezotsunomata, Togetu no Mata, Hirakotoji, Kototsunomata, Suginotori, Ruri Seaweed such as red algae, Chlamydomonas, Akayukimo, Dunaliera, Chlorococcus, Quercus firaceae, Giant walnut, Volvo box, Palmera, Hizaori, Aomiduro, Tsurugidomiro, Himidomiro, Anaaaosa, Amiaosa, Nagaaosa, Kawanori , Kawasiogusa, marimo, tamagobaronia, tamabaronia, magamatamamo, fu Saiwata, Surichogita, Heraiwata, Kurokita, Hanemo, Mill, Chromil, Sakibuchimir, Nagamil, Hiramil, Casanori, Futojuzumo, Tamajusmo, Mizojusmo, Mikazukimo, Korekaete, Tsumugimogusa, Homogusa , Green algae such as Sumiremo, Hoshimidoro, Fushinashimidoro, blue-green algae such as water lily, watermelon, Kawatake, Ishi jellyfish, Hassai, Yuremo, Spirulina, Trichodesmium, etc. , Quercus cristatus, Amygusa, Sakibiro amiji, Sanadagusa, Fukurimamiji,
Common rush, Ezoyahaz, Yahazugusa, Uraboshiyahaz, Jigumigusa, Umiuchiwa, Konaumiuchiwa, Akabaumiuchichiwa, Hiranamimakura, Someraceae, Navaimo, Motsutsukisoumen, Matsumo, Nagamatsumomo, Nikumomokoku , Ichimegasa, zelkova, sea squirrel, urushigusa, keulushigusa, tobacco rush, kombumodoki, habamodoki, havanori, habanori, commonbukuro, ezoburo, fukuronori, cottonweed, chishimafukuronori, kamenomei, murachidori , Sujime, misji kombu, tsuba misji kombu, rattle comb, oyster kumbu, oni kombu Gohei comb, Nagacomb, pea comb, large comb, Toro kombu, Antokume, Kajime, Tsuruarame, Kurome, Kikuishicombu, Nejirebubu, Kuroshiome, Nekoashicombu, Arame, Ainuwakame, Chigaiso, Ezoishige, Yabanemoku, Mocha Isomoku, Nagashimamok, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawala, Tatsuri, Yatsumatamo, Umitoranomo, Obamoku, Fushishimoku, Hahamoku, Togemoku, Yoremoku, Mokomokumoku, Mokumokumoku , Funori no Ushike,
Asakusanoori, Susabinori, Upruinori, Onimanori, Tasa, Fuiritasa, Benitasa, Mirnoveni, Akebono Mozuku, Hikonahada, Yogorekonahada, Aokonahada,
Sea urchin, Tsukumonori, Anemone beetle, Benimozuku, Hosobenimozu, Kasamatsu, Fusanori, Nisefusanori, Sodegarami, Rattle, Rattlera, Hirohata Tadaki,
Tamaitadaki, Kainori, Kaikekenori, Himetengusa, Hytengusa, Oobusa, Nambugusa, Kohira, Yohira, Kinukusa, Hibirodo, Himebiro, Isomumedoki, Apis serrata, Ryumonso, Nisekareki, Naha Shiogusagoromo, Etukiikawanokawa, Kainokawa, Kaninote, Coral, Centipede, Suzymkade, Katanori, Hiramkade, Kyonohimo, Sakuranori, Nikkude, Tambanori, Tsurutsuru, Nuraksa, Chronulaxa, Omukadenori,
Hirakintoki, Matabou, Chabokintoki, Kintoki, Matsunori, Rice, Tosakamatsu, Hitomitsu, Obakintoki, Itonori, Nagaobane, Hanafnori, Ochonori, Makofori, Karekigusa, Shirotodomo , Nezushinosakamodoki, Kinusada, Ezotosaka, Enashikarimenia, Otsukasanori, Hanagakarimenia, Honoo, Hikagenoito, Usuginu, Nikuhounoo, Venetianago, Suscabeni, Porcupine, Mirin, Ezodari Tachiibara, Kagibaranori, Pheasant, Isodantsu, Atsubanori,
Steller's beetle, Crassulamo, Shiramo, Giant scorpion, Mizookonori, Birch, Bee crabs, Fushikurenori, Namiiwatake, Sponge, Periwinkle, Itabusa, Saimi, Hari,
Spinach, Ikanoashi, Hoboibonori, Nobonori, Black Hagininso, Akabaginanso, Hoshibukuro, Togemadara, Etsukimadara, Tasagisou, Hanasakura, Fukuronagi, Sugikonadori, Hiratakayagi, Hiratakayagi , Sunflower Egret, Usbah Egret, Igis, Keigis, Harigis, Haneigis, Aneixa, Egonori, Futogigis, Saeda, Chile Momiji,
Habutenori, Konohanori, Suzuronori, Usbeni, Hasujiginu, Nagakonohanori, Suzyginu, Atsubasiginu, Kagiusbanori, Yareusbanori, Susiusbanori, Heiusbanori, Usubanorimodoki, Ayadaji, Mosada
Macri, Hana willow, Yuna, Willow tree, Motsure Yuna, Veneer coriander, Mosana willow, Sasabayagi nori, Kurosozo, Kisosozo, Hanesozo, Sozonohana, Hanegusa, Kehanegusa, Kozanemo, Hisogoseo , Fuji Matsumo, Hazel Mushroom,
Red algae such as Kawamoku, Aokawa Mozuku, Himekawa Mozuku, Ideyugogome, Okimozuk, Chinorimo, Chisujinori, and yellow algae such as Shajikumo, Shiratamamo, Hoshitsurimo, Lyxnotumnus, Himeflaskmo, Chaboflaskmo, Tripera, etc. Other algae and chicken crown extracts, bovine and human placenta extracts, porcine and bovine stomach and duodenum or intestinal extracts or their degradation products, pork and bovine spleen extracts or their degradation products, Extracts of bovine brain tissue, collagen derivatives such as water-soluble collagen and acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its degradation products or derivatives thereof, silk proteins and Degradation products or derivatives thereof, pig and cow blood cell protein Degradation products (globin peptides), porcine and bovine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its degradation products or their derivatives, skim milk powder and their degradation products or their derivatives, Materials derived from animal materials such as lactoferrin or its degradation products, egg components, and fish meat degradation products are processed in a conventional manner according to the product type and form to be added (for example, grinding, milling, washing, Decomposition, fermentation, purification, pressing, extraction, fractionation, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. It can be arbitrarily selected from the above. In addition, the solvent used for extraction may be selected in consideration of processing performed later. Usually, water, a water-soluble organic solvent (for example, ethanol, propylene glycol, 1,3-butylene glycol, etc.) It is desirable to use one or a mixture of two or more selected from among the above. However, when it is not preferable to contain an organic solvent depending on the application, only water may be used, or ethanol that can be easily removed after extraction may be used alone or in any mixture with water.

  Others, moisturizers, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic and antibacterial agents, cooling agents, stabilizers, emulsifiers, animal and vegetable proteins and their degradation products, animals and plants Sugars and their degradation products, animal and plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, antiallergic agents, cell activators, keratolytic agents, wound treatment agents, foam enhancers, thickeners, oral cavity Additives, deodorizing / deodorizing agents, bittering agents, enzymes and the like can be raised, and in combination with these, various additive and synergistic effects can be expected.

  When the antiallergic agent of the present invention is used as a pharmaceutical product, its administration form is not particularly limited, and can be administered orally or parenterally. For example, rectal administration, intranasal administration, buccal administration, sublingual administration, intravaginal administration, intramuscular administration, subcutaneous administration, and intravenous administration can be performed. Among them, the antiallergic agent of the present invention is preferably administered orally, subcutaneously or transdermally. In addition, the dosage form of the antiallergic agent of the present invention is not particularly limited, and can be appropriately selected depending on the administration route and the like. For example, tablets, capsules, powders, fine granules, granules, solutions, syrups and the like can be mentioned as preparations suitable for oral administration, and injections, drops, Suppositories, inhalants, transdermal absorbents, transmucosal absorbents, patches and the like can be mentioned. The injection may be used for any of intravenous injection, intramuscular injection, subcutaneous injection, infusion and the like. The antiallergic agent of the present invention is particularly preferably any of oral preparations, injections and patches.

  If necessary, pharmacologically and pharmaceutically acceptable additives can be added to the antiallergic agent of the present invention. For example, excipients, disintegrants or disintegration aids, binders, lubricants, coating agents, dyes, diluents, bases, solubilizers or solubilizers, isotonic agents, pH adjusters, stabilizers A propellant, an adhesive, a wetting agent, and the like can be used. By using these additives in appropriate combinations, the pharmaceutical composition of the present invention can have various additional functions. For example, the antiallergic agent of the present invention can be designed so as to be released as required. Moreover, it can also be designed so that the antiallergic agent of the present invention is released intensively at a necessary place in the body. Such sustained-release preparations and drug delivery systems can be designed and manufactured according to methods well known in the pharmaceutical industry.

  In addition, an organic or inorganic carrier can be used for the antiallergic agent of the present invention. Examples of such carriers include lactose, starch, vegetable and animal fats and oils. The dose of the antiallergic agent of the present invention is appropriately determined according to various conditions such as the purpose of treatment or prevention, the sex, weight, age, type and degree of disease, dosage form, administration route, number of administrations, etc. of the patient. . For example, in the case of oral administration, the antiallergic agent of the present invention can be administered to an adult at a dose of 0.1 to 1000 mg / day, once to several times a day. When administered as an injection, the antiallergic agent of the present invention can be administered to an adult at 0.05 to 500 mg / day, once a day or several times a day. Depending on the circumstances, dosages outside these ranges can be employed.

  When preparing the food containing the antiallergic agent of the present invention, for example, it can be made into tea, soft drinks, juice, candy, starchy food, various processed foods, and the like. The addition amount of the antiallergic agent of the present invention can be set within a range of about 0.1 to 99% by weight. In addition, sweeteners, coloring agents, preservatives, thickeners, pastes, antioxidants, yeast foods, gum bases, bittering agents, enzymes, brighteners, fragrances, acidulants, seasonings, coagulants as necessary Additives such as emulsifiers, pH adjusters and gelling agents can also be added.

  The method for adding the antiallergic agent of the present invention may be added in advance or during the production, and may be appropriately selected in consideration of workability.

  EXAMPLES Hereinafter, although an Example demonstrates this invention, this invention is not limited by this Example.

Production Example 1
The dried longan seeds were pulverized, and 10 g was immersed in 100 mL of water and extracted at 60 ° C. for 24 hours. The precipitate was removed by centrifugal separation (10000 G, 10 minutes) to obtain a light brown clear longan seed extract.

Production Example 2
The longan seed extract obtained in Production Example 1 was freeze-dried in vacuo to obtain a longan seed extract freeze-dried powder.

Production Example 3
The dried longan seeds were pulverized, and 10 g was immersed in 100 mL of 50% aqueous ethanol (w / w) and extracted at 60 ° C. for 24 hours. The precipitate was removed by centrifugal separation (10000 G, 10 minutes) to obtain a light brown clear longan seed extract.

Production Example 4
The longan seed extract obtained in Production Example 3 was lyophilized in vacuum to obtain a longan seed extract lyophilized powder.

Production Example 5
The dried longan seeds were pulverized, and 10 g was immersed in 100 mL of ethanol and extracted at 60 ° C. for 24 hours. The precipitate was removed by centrifugal separation (10000 G, 10 minutes) to obtain a light brown clear longan seed extract.

Production Example 6
The dried longan seeds were pulverized, and 10 g was immersed in 100 mL of 50% 1,3-butylene glycol aqueous solution (w / w) and extracted at room temperature for 2 weeks. The precipitate was removed by centrifugal separation (10000 G, 10 minutes) to obtain a light brown clear longan seed extract.

Production Example 7
The dried longan seeds were pulverized, and 10 g was immersed in 100 mL of 1,3-butylene glycol and extracted at 60 ° C. for 24 hours. The precipitate was removed by centrifugal separation (10000 G, 10 minutes) to obtain a light brown clear longan seed extract.

Example 1
<Histamine release inhibitory action>
About the freeze-dried powder of the longan seed extract prepared in Production Example 2 and Production Example 4, the histamine release inhibitory action was examined by the following method using the hexosaminidase release inhibition rate as an index.

Test method: Inoculate 2.5 × 10 ⁵ RBL-2H3 cells into DMEM medium supplemented with 10% FBS, add 1 mL to a 24-well plate, incubate at 37 ° C. under 5% CO ₂ for 24 hours, remove the supernatant, and then mouse monoclonal An anti-dinitrophenyl group IgE (DNP-IgE: concentration 50 ng / mL) was added at 500 μL / well, and the cells were cultured at 37 ° C. for 2 hours under 5% CO ₂ . After completion of the culture, the medium in each well was removed and washed with Modified Tyrode's buffer (500 μL × 2 times). Next, 490 μL of the sample solution diluted with the above buffer was added, and incubated at 37 ° C. for 10 minutes. Then, 10 μL of dinitrophenylated human serum albumin (DNP-HSA) solution was added and incubated at 37 ° C. for 30 minutes. 50 μL of the supernatant was transferred to a new 96-well plate, to which 100 μL of a 3.3 mM p-nitrophenyl-2-acetamino 2-deoxy-β-D-glucopyranoside solution was added and incubated at 37 ° C. for 25 minutes. After completion of the reaction, 100 μL of 2M glycine aqueous solution was added, and the absorbance at 405 nm was measured with a microplate reader. The same treatment and absorbance measurement were performed on the cell suspension without addition of the sample solution (the absorbance measured at this time is B). Further, the same treatment and absorbance measurement were performed using the above buffer solution instead of the cell suspension (the absorbance measured at this time is C). And the hexosaminidase release inhibition rate was computed by following Formula. A test using baicalin as a positive control was also conducted in the same manner.
Inhibition rate of hexosaminidase release (%) = [1- (A−C) / (B−C)] × 100

(Test results)
The test results are as shown in Table 1. It was confirmed that the longan extract has a stronger activity than baicalin, which is a known active substance, and has a remarkable histamine release inhibitory action. In particular, the activity of the longan extract prepared in Production Example 4 was high, and a strong activity was confirmed even when compared with the longan extract prepared in Production Example 2.

Example 2
<TNFα production inhibitory action>
The freeze-dried powder of the longan seed extract prepared in Production Example 4 was examined for its TNFα production inhibitory effect by the following method for measuring the amount of TNFα produced by the production of mouse macrophage-like cells RAW246.7 cells by lipopolysaccharide.

Test method: 5 × 10 ⁴ RAW246.7 cells were inoculated into RPMI1640 medium supplemented with 10% FBS, 100 μL was added to a 96-well plate, cultured at 37 ° C. under 5% CO ₂ for 24 hours, and the supernatant was removed. Next, the longan seed extract freeze-dried powder prepared in Production Example 4 was prepared to 100, 10, and 1 μg / mL using RPMI1640 serum-free medium, and used as a sample solution. Lipopolysaccharide was dissolved in this sample solution to 2 ng / mL, added to 100 μL / well, and cultured at 37 ° C. under 5% CO ₂ for 6 hours. 25 μL of the supernatant was collected, and the amount of released TNFα produced was measured using an ELISA measurement kit (Biosience).

(Test results)
The test results are shown in FIG. The longan extract suppressed TNFα production in a concentration-dependent manner.

Example 3
<Auricular tumor test>
The long-eye seed extract freeze-dried powder prepared in Production Example 4 was examined for its type 4 allergy-suppressing effect by a skin inflammation model by the following method.

  Test method: A ddy male mouse (8 weeks old; 5 mice per group) bred preliminarily for 1 week was shaved in an area of 25 × 20 mm, 100 μL of 7% picryl chloride / ethanol solution was dropped and applied evenly. . After 6 days, the thickness of the right auricle was measured, and then 20 μL of a 1% picryl chloride / olive oil solution was applied to the front and back of the right auricle to perform primary induction, and the thickness of the right auricle was measured 24 hours later. Next, 20 μL of the sample solution (1% aqueous solution) was applied to the front and back of the right auricle daily and applied continuously for 1 week, and then 100 μL of 7% picryl chloride / ethanol solution was again dropped onto the abdominal shaved area. , Sensitized. Thereafter, 20 μL of the sample solution was applied to the front and back of the right auricle every day and applied continuously for 1 week, and then the thickness t of the right auricle was measured. Thereafter, 20 μL of 1% picryl chloride / olive oil solution was applied to the front and back of the right pinna for induction, and the thickness T of the right pinna was measured 24 hours later. The edema rate [(T−t) / t × 100] was determined from the measured value. In the control group, water was applied instead of the sample solution, and the same measurement was performed.

  The test results are shown in FIG. It has been confirmed that the longan seed extract has a remarkable auricular edema inhibitory action, and it has been revealed that type 4 allergy is suppressed.

Example 4
<Manufacture of lotion>
According to the formulation shown in Table 2, (1) to (10) were stirred and dissolved to produce a lotion. All of the obtained lotions were stable for 3 months under the conditions of 40 ° C. and RH 75%. In addition, as a result of continuous application for 3 months to 10 men and women between the ages of 25 and 40 years old, the lotion application part of Example 5 suppressed the occurrence of wrinkles and sagging, and maintained the skin with the elasticity. It was confirmed that

Example 5
<Manufacture of cream>
According to the formulation shown in Table 3, (8), (10), and (11) were mixed and stirred at 80 ° C separately to those prepared by mixing and stirring (1) to (7) at 80 ° C, and then homogenized and stirred. While cooling to 30 ° C, (9) was further added and mixed and stirred to produce a cream. The obtained product was not sticky during use and moistened the skin.

Example 6
<Production of body gel> According to the formulation shown in Table 4, (1) to (8) were mixed and stirred at 80 ° C to obtain a body gel agent. The obtained product was not sticky during use and moistened the skin.

Example 7
<Manufacture of injections>
According to the formulation shown in Table 5, it was dissolved. The solution was filtered through a filter (pore size 0.2 μm) to produce an injection.

Example 8
According to the formulation shown in Table 6, (1) to (3) were mixed and sufficiently stirred. Capsules were made by filling this mixture into gelatin capsules.

Example 9
To 1 kg of commercially available orange juice, Compound 1 prepared in Production Example 4 was added to 0.1 wt% and mixed well to prepare orange juice containing the antiallergic agent of the present invention.

  The antiallergic agent of the present invention is extracted from longan seeds, and is applied to, for example, pharmaceuticals, cosmetics, foods and the like for preventing and treating allergic diseases.

It is a figure which shows TNF (alpha) production amount. It is a figure which shows the pinna edema rate.

Claims (6)

An antiallergic agent containing longan seed extract as an active ingredient. The antiallergic agent according to claim 1, wherein the longan seed extract is extracted using a mixture of a hydrophilic organic solvent and water as an extraction solvent. The antiallergic agent according to claim 2, wherein the extraction solvent is an alcohol-water mixture having an alcohol concentration of 25 to 75%. The antiallergic agent according to claim 3, wherein the alcohol is ethanol, 1,3-butylene glycol or a mixture thereof. 5. The antiallergic agent according to claim 1, which has a histamine release inhibitory action and a TNFα production inhibitory action. A pharmaceutical, cosmetic or food comprising the antiallergic agent according to claim 1.